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The map label for this gene is pyrG [H]

Identifier: 19746815

GI number: 19746815

Start: 1625047

End: 1626651

Strand: Reverse

Name: pyrG [H]

Synonym: spyM18_1959

Alternate gene names: 19746815

Gene position: 1626651-1625047 (Counterclockwise)

Preceding gene: 19746816

Following gene: 19746814

Centisome position: 85.84

GC content: 40.62

Gene sequence:

>1605_bases
ATGACGAAATACATTTTTGTAACTGGTGGTGTTGTATCATCAATTGGCAAAGGAATTGTTGCGGCAAGTCTTGGCCGATT
GTTAAAAAATCGTGGACTTAAGGTGACGATTCAAAAATTTGATCCTTATATTAATATTGATCCAGGGACGATGAGCCCCT
ATCAGCATGGAGAAGTATATGTGACAGATGACGGTGCTGAAACCGACTTGGATTTGGGTCACTATGAACGTTTTATTGAT
ATCAATCTTAATAAATATTCCAATGTTACAACAGGTAAAATTTATAGTGAAGTCCTTCGTAAAGAACGTAAAGGTGAGTA
CCTTGGAGCGACTGTTCAGGTGATTCCTCATATCACAGATGCCCTTAAAGAAAAAATCAAACGCGCAGCTTCAACAACGG
ACTCTGATGTAATTATTACTGAGGTCGGGGGGACTGTTGGCGATATTGAAAGTTTACCGTTCTTAGAAGCTCTTCGTCAG
ATGAAAGCTGATGTTGGTTCTGAAAATGTGATGTATATTCACACCACCTTGTTGCCATATTTAAAGGCAGCGGGTGAAAT
GAAAACTAAGCCAACGCAACATTCCGTTAAAGAATTGCGTGGTTTAGGGATTCAACCGAATATGTTGGTTATTCGTACGG
AAGAGCCAGTTGAGCAGGGGATTAAAAATAAATTGGCTCAGTTCTGTGATGTGAATTCAGAAGCTGTTATCGAGTCACGT
GATGTAGAACACTTGTATCAAATTCCATTGAACTTGCAAGCTCAATCAATGGATCAGATTGTTTGTGATCATTTGAAATT
GAATGCGCCACAAGCTGATATGACCGAGTGGTCAGCTATGGTTGACAAGGTGATGAATTTAAGAAAAACAACAAAAATTG
CCTTGGTTGGTAAATATGTGGAATTGCCAGATGCCTACTTATCTGTTGTGGAAGCCTTGAAACATTCTGGTTATGCCAAT
GATACCGCAATTGACCTAAAATGGGTCAATGCTAACGATGTGACGGTGGAAAATGCAGCTGACTTGTTGGGAGATGCAGA
TGGGATTATTGTACCAGGTGGTTTTGGTCAACGTGGTACAGAAGGCAAGATCCAAGCGATTCGCTATGCCCGCGAAAATG
ATGTGCCAATGCTTGGTATCTGTCTTGGCATGCAGTTGACTTGTGTTGAATTTGCCCGCCATGTCCTCAATATGGAAGGT
GCAAACTCTTTTGAATTAGAGCCAAGTACTAAATACCCCATCATTGATATCATGCGTGATCAAATTGATATTGAAGATAT
GGGAGGTACGCTTCGTCTGGGATTGTACCCATGTAAATTGAAACCAGGTTCAAAAGCAGCAATGGCTTACAATAATCAAG
AGGTGGTGCAACGTCGTCATCGTCACCGTTATGAGTTCAACAACAAATTCCGCTCAGAATTTGAAGCAGCTGGCTTTGTT
TTCTCAGGAGTTTCACCTGACAATCGCTTAGTTGAAATTGTAGAATTGAAAGAGAAAAAATTCTTTGTAGCAGCTCAATA
CCACCCAGAATTGCAAAGCCGTCCAAATCGTCCTGAGGAGCTATACACCGCTTTTGTTACAGCTGCTATTAAAAATAGCA
ATTAG

Upstream 100 bases:

>100_bases
ATATTTAGAAAACTAAGGTGATACCTAACCAATGTGGAACCAACTAATAGGGAATTAACAAGAAAGCAATGCTTTTATTC
AGCTTATATAAAGGAGTACT

Downstream 100 bases:

>100_bases
TGGTTTTAAGGGTAAGTTTGTGGCATTCTGCTTGGCTGGCAGATACTGATAAAGATTACTAGCTATTAGAGGGATCTTTT
CTATAAAAATAGCATTAGAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQ
MKADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESR
DVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYVELPDAYLSVVEALKHSGYAN
DTAIDLKWVNANDVTVENAADLLGDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEG
ANSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRSEFEAAGFV
FSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN

Sequences:

>Translated_534_residues
MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQ
MKADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESR
DVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYVELPDAYLSVVEALKHSGYAN
DTAIDLKWVNANDVTVENAADLLGDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEG
ANSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRSEFEAAGFV
FSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN
>Mature_533_residues
TKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFIDI
NLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQM
KADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESRD
VEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYVELPDAYLSVVEALKHSGYAND
TAIDLKWVNANDVTVENAADLLGDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEGA
NSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRSEFEAAGFVF
SGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=47.3684210526316, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI28559085, Length=554, Percent_Identity=46.028880866426, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI28559083, Length=554, Percent_Identity=46.028880866426, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI221316689, Length=554, Percent_Identity=46.028880866426, Blast_Score=497, Evalue=1e-140,
Organism=Escherichia coli, GI1789142, Length=538, Percent_Identity=52.2304832713755, Blast_Score=572, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI25148299, Length=607, Percent_Identity=37.2322899505766, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319432, Length=562, Percent_Identity=44.8398576512456, Blast_Score=478, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322563, Length=559, Percent_Identity=44.1860465116279, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24664469, Length=552, Percent_Identity=45.1086956521739, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21357815, Length=497, Percent_Identity=42.6559356136821, Blast_Score=407, Evalue=1e-113,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59512; Mature: 59381

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVY
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITD
EECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGSENVMYIHTTLLPY
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHH
LKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESR
HHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHEECCC
DVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYV
CHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECHH
ELPDAYLSVVEALKHSGYANDTAIDLKWVNANDVTVENAADLLGDADGIIVPGGFGQRGT
HCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCCC
EGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEGANSFELEPSTKYPIIDIMRD
CCHHHHEEECCCCCCCEEEHHHCCCHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHH
QIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRSEFEAAGFV
HCCHHHCCCEEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCEE
FSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN
EECCCCCCHHHHHEECCCCEEEEEEECCCHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVY
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITD
EECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGSENVMYIHTTLLPY
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHH
LKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESR
HHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHEECCC
DVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYV
CHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECHH
ELPDAYLSVVEALKHSGYANDTAIDLKWVNANDVTVENAADLLGDADGIIVPGGFGQRGT
HCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCCC
EGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEGANSFELEPSTKYPIIDIMRD
CCHHHHEEECCCCCCCEEEHHHCCCHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHH
QIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRSEFEAAGFV
HCCHHHCCCEEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCEE
FSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN
EECCCCCCHHHHHEECCCCEEEEEEECCCHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA