BacMap

Definition	Streptococcus pyogenes MGAS8232, complete genome.
Accession	NC_003485
Length	1,895,017

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The map label for this gene is yvgN [H]

Identifier: 19746602

GI number: 19746602

Start: 1418661

End: 1419500

Strand: Reverse

Name: yvgN [H]

Synonym: spyM18_1704

Alternate gene names: 19746602

Gene position: 1419500-1418661 (Counterclockwise)

Preceding gene: 19746603

Following gene: 19746601

Centisome position: 74.91

GC content: 41.19

Gene sequence:

>840_bases
ATGGTAACAACAGTAAAAATGACAAGTGGCTATGAGATTCCCGTTTTAGGATTTGGAACTTACCAAGCAGCCGATGGTGA
GGAAGCTTACCAATCTACCTTAGCAGCCATCAAGGCTGGCTATCGTCATATTGATACTGCAGCTATTTATAAAAATGAAG
AAAGTGTGGGTCGTGCCATCAAGGATTCTGGGGTTCTACGAGAAGACTTATTTATTACAACTAAACTCTGGAATGACGCC
CATAGTTATGAAGGGGCAAAAGACGCTTTAGCTGCTTCTCTTGACCATCTTGGTCTGGATTATGTGGATCTCTATCTTAT
CCATTGGCCAAACCCAAAAGCTCTGCGTAACACTTGGAAAGAGGCAAATGCTCAAGCATGGCAATATATGGAAGAGGCGG
TTGAAGCAGGGCTCATTAAAAGCATTGGCGTCAGCAATTTTATGGTGCATCATCTAGAAGCTCTTCAAGAGACAGCTAAA
ATAACTCCAGCAATTAATCAGATTCGATTAGCCCCAGGTTGCTATCAAAAGGAAGTGGTTGATTATTGTAAGGCAAATGA
GATTTTATTGGAAGCTTGGAGTCCTCTAGGACAAGGGGAGATTTTTGATAATGAGACTATGCAGCAGTTAGCTAATAAAT
ATGACAAAACAGTGGCACAAGTTGCCTTAGCTTGGTCGCTGGCAGAAGGTTTTATTCCCTTGCCAAAATCGGTGCATGAT
GAGCGCATCAAGGAAAATATGGCTATTTTTGATGTGAGCTTGACACAAGAAGATAAAAAAACAATTCGCTATCTCTCAGG
AATGTCAGCGATTCCTAACCCTGATACTACAAGTTTTTAA

Upstream 100 bases:

>100_bases
AGCTATGTCTGGCAGGCCAATTCTTTTTGTATTTTCTTTCTTTATGATAGAATAGATTACAGTAATCGCTTACAGAGATT
GATAAAAGGAGGTTTTTGTG

Downstream 100 bases:

>100_bases
GAAAGTACAAAGATTTAGCCATAATTCGCTAAATCTTTTTTGAAAACGGTTTGACAAAGGTTTATCATTTAGCTATAATC
TTTATTAGTGTTTTGTGAAA

Product: reductase / dehydrogenase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MVTTVKMTSGYEIPVLGFGTYQAADGEEAYQSTLAAIKAGYRHIDTAAIYKNEESVGRAIKDSGVLREDLFITTKLWNDA
HSYEGAKDALAASLDHLGLDYVDLYLIHWPNPKALRNTWKEANAQAWQYMEEAVEAGLIKSIGVSNFMVHHLEALQETAK
ITPAINQIRLAPGCYQKEVVDYCKANEILLEAWSPLGQGEIFDNETMQQLANKYDKTVAQVALAWSLAEGFIPLPKSVHD
ERIKENMAIFDVSLTQEDKKTIRYLSGMSAIPNPDTTSF

Sequences:

>Translated_279_residues
MVTTVKMTSGYEIPVLGFGTYQAADGEEAYQSTLAAIKAGYRHIDTAAIYKNEESVGRAIKDSGVLREDLFITTKLWNDA
HSYEGAKDALAASLDHLGLDYVDLYLIHWPNPKALRNTWKEANAQAWQYMEEAVEAGLIKSIGVSNFMVHHLEALQETAK
ITPAINQIRLAPGCYQKEVVDYCKANEILLEAWSPLGQGEIFDNETMQQLANKYDKTVAQVALAWSLAEGFIPLPKSVHD
ERIKENMAIFDVSLTQEDKKTIRYLSGMSAIPNPDTTSF
>Mature_279_residues
MVTTVKMTSGYEIPVLGFGTYQAADGEEAYQSTLAAIKAGYRHIDTAAIYKNEESVGRAIKDSGVLREDLFITTKLWNDA
HSYEGAKDALAASLDHLGLDYVDLYLIHWPNPKALRNTWKEANAQAWQYMEEAVEAGLIKSIGVSNFMVHHLEALQETAK
ITPAINQIRLAPGCYQKEVVDYCKANEILLEAWSPLGQGEIFDNETMQQLANKYDKTVAQVALAWSLAEGFIPLPKSVHD
ERIKENMAIFDVSLTQEDKKTIRYLSGMSAIPNPDTTSF

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI310109920, Length=303, Percent_Identity=38.9438943894389, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI5453543, Length=303, Percent_Identity=38.6138613861386, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI310109922, Length=289, Percent_Identity=39.1003460207612, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI45446745, Length=303, Percent_Identity=38.2838283828383, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI4503285, Length=303, Percent_Identity=38.2838283828383, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI24497583, Length=290, Percent_Identity=38.2758620689655, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI24497585, Length=291, Percent_Identity=37.8006872852234, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI5174695, Length=294, Percent_Identity=35.7142857142857, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI223468663, Length=290, Percent_Identity=35.1724137931034, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=31.9587628865979, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=31.9587628865979, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI93277124, Length=296, Percent_Identity=33.445945945946, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=34.2960288808664, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI4502049, Length=290, Percent_Identity=35.1724137931034, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI291291012, Length=256, Percent_Identity=34.375, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI300116271, Length=281, Percent_Identity=31.6725978647687, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI310109926, Length=113, Percent_Identity=52.212389380531, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI207028673, Length=113, Percent_Identity=50.4424778761062, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI310109924, Length=157, Percent_Identity=34.3949044585987, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI87082198, Length=276, Percent_Identity=44.5652173913043, Blast_Score=228, Evalue=3e-61,
Organism=Escherichia coli, GI1786400, Length=265, Percent_Identity=36.6037735849057, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1788081, Length=267, Percent_Identity=27.3408239700375, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1788070, Length=320, Percent_Identity=24.0625, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI48994888, Length=247, Percent_Identity=27.1255060728745, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17537077, Length=289, Percent_Identity=37.0242214532872, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17561298, Length=270, Percent_Identity=37.4074074074074, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71998625, Length=269, Percent_Identity=36.4312267657993, Blast_Score=177, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17537075, Length=289, Percent_Identity=35.9861591695502, Blast_Score=173, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17552492, Length=256, Percent_Identity=33.59375, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17537079, Length=303, Percent_Identity=33.003300330033, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17564128, Length=292, Percent_Identity=33.9041095890411, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17562292, Length=280, Percent_Identity=34.6428571428571, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17550248, Length=284, Percent_Identity=38.0281690140845, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=34.1911764705882, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17561300, Length=276, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17566692, Length=283, Percent_Identity=34.2756183745583, Blast_Score=144, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6320576, Length=287, Percent_Identity=44.5993031358885, Blast_Score=219, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6324694, Length=302, Percent_Identity=39.0728476821192, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6322556, Length=266, Percent_Identity=36.4661654135338, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6319625, Length=283, Percent_Identity=34.982332155477, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6321896, Length=316, Percent_Identity=31.0126582278481, Blast_Score=142, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320079, Length=284, Percent_Identity=31.6901408450704, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24663317, Length=301, Percent_Identity=38.2059800664452, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24657054, Length=279, Percent_Identity=41.9354838709677, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI21356425, Length=298, Percent_Identity=39.9328859060403, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI20129731, Length=296, Percent_Identity=35.1351351351351, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24644950, Length=294, Percent_Identity=38.7755102040816, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45553081, Length=282, Percent_Identity=35.1063829787234, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI221378297, Length=314, Percent_Identity=36.9426751592357, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24662781, Length=280, Percent_Identity=38.9285714285714, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24662785, Length=272, Percent_Identity=39.7058823529412, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24662789, Length=288, Percent_Identity=35.0694444444444, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI281366140, Length=243, Percent_Identity=35.3909465020576, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31081; Mature: 31081

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTVKMTSGYEIPVLGFGTYQAADGEEAYQSTLAAIKAGYRHIDTAAIYKNEESVGRAI
CCEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KDSGVLREDLFITTKLWNDAHSYEGAKDALAASLDHLGLDYVDLYLIHWPNPKALRNTWK
HHCCCHHHHHEEEHHHHCCHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHH
EANAQAWQYMEEAVEAGLIKSIGVSNFMVHHLEALQETAKITPAINQIRLAPGCYQKEVV
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCHHHHHH
DYCKANEILLEAWSPLGQGEIFDNETMQQLANKYDKTVAQVALAWSLAEGFIPLPKSVHD
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ERIKENMAIFDVSLTQEDKKTIRYLSGMSAIPNPDTTSF
HHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MVTTVKMTSGYEIPVLGFGTYQAADGEEAYQSTLAAIKAGYRHIDTAAIYKNEESVGRAI
CCEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KDSGVLREDLFITTKLWNDAHSYEGAKDALAASLDHLGLDYVDLYLIHWPNPKALRNTWK
HHCCCHHHHHEEEHHHHCCHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHH
EANAQAWQYMEEAVEAGLIKSIGVSNFMVHHLEALQETAKITPAINQIRLAPGCYQKEVV
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCHHHHHH
DYCKANEILLEAWSPLGQGEIFDNETMQQLANKYDKTVAQVALAWSLAEGFIPLPKSVHD
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ERIKENMAIFDVSLTQEDKKTIRYLSGMSAIPNPDTTSF
HHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]