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The map label for this gene is glcK [H]

Identifier: 19746478

GI number: 19746478

Start: 1276929

End: 1277900

Strand: Reverse

Name: glcK [H]

Synonym: spyM18_1546

Alternate gene names: 19746478

Gene position: 1277900-1276929 (Counterclockwise)

Preceding gene: 19746479

Following gene: 19746477

Centisome position: 67.43

GC content: 43.21

Gene sequence:

>972_bases
ATGAGTCAAAAATTACTGGGGATTGATTTAGGTGGTACCACCATTAAATTTGGAATTTTAACAGCAGCAGGAGAAGTCCA
AGAAAAATGGGCAATTGAGACTAATATTTTAGAAGGAGGCAAGCATATTGTTCCCGATATTGTAGCTTCCATCAAACATC
GCTTAGACTTGTATGGTCTAAGCAGTGCTGATTTTGTGGGAATTGGTATGGGATCACCAGGAGCGGTTGACCGTGATACT
AATACAGTTACTGGGGCATTCAACCTTAATTGGAAAGAAACCCAAGAAGTCGGTTCCGTTGTTGAAAAAGAATTGGGCAT
TCCTTTTGCCATTGACAATGATGCTAATGTGGCTGCCCTTGGTGAACGTTGGGTAGGTGCTGGTGAAAATAACCCAGATG
TCGTCTTCATGACACTTGGAACAGGTGTCGGTGGAGGCATTATTGCTGATGGTAACTTGATTCATGGTGTTGCAGGAGCA
GGTGGTGAAATCGGCCACATGATTGTTGAGCCAGAAAATGGCTTTGCTTGTACTTGTGGCTCACACGGCTGTTTGGAAAC
AGTAGCTTCAGCAACAGGAGTTGTCAAAGTGGCACGTTTATTGGCAGAAGCTTATGAAGGGGATTCAGCCATCAAAGCAG
CTATTGACAACGGTGAAGGTGTTACCAGCAAAGATATTTTTATGGCAGCTGAAGCAGGGGATTCCTTTGCTGATTCTGTT
GTGGAAAAGGTTGGTTACTACCTTGGCCTTGCTTCAGCAAATATTTCCAATATATTGAATCCAGACTCAGTGGTTATCGG
TGGGGGTGTGTCAGCAGCAGGAGAATTTCTACGCTCACGTATTGAAAAATACTTTGTGACCTTCACTTTCCCACAAGTGA
GGTATTCAACTAAAATTAAGATTGCAGAGCTTGGCAATGATGCTGGAATTATCGGTGCAGCTAGCCTTGCTCGACAATTT
ATCACAAAATAG

Upstream 100 bases:

>100_bases
CTCTATGATAGCGGCTTATTGGATAAGAGGGATTACTTAAATGCGGAGTTAATTTTGCGACGTGAGCATAGATTAGAATT
GGAAAAAGAAGGATAGACAA

Downstream 100 bases:

>100_bases
GAGGGGGATATGTCTCCAATCACACTTATCTTATGGTTACTTCTTGTCGGCATTGTTGGTTATTATACATGGAACTATTT
CTCTTTTCGAAAAATGGCAA

Product: glucose kinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSQKLLGIDLGGTTIKFGILTAAGEVQEKWAIETNILEGGKHIVPDIVASIKHRLDLYGLSSADFVGIGMGSPGAVDRDT
NTVTGAFNLNWKETQEVGSVVEKELGIPFAIDNDANVAALGERWVGAGENNPDVVFMTLGTGVGGGIIADGNLIHGVAGA
GGEIGHMIVEPENGFACTCGSHGCLETVASATGVVKVARLLAEAYEGDSAIKAAIDNGEGVTSKDIFMAAEAGDSFADSV
VEKVGYYLGLASANISNILNPDSVVIGGGVSAAGEFLRSRIEKYFVTFTFPQVRYSTKIKIAELGNDAGIIGAASLARQF
ITK

Sequences:

>Translated_323_residues
MSQKLLGIDLGGTTIKFGILTAAGEVQEKWAIETNILEGGKHIVPDIVASIKHRLDLYGLSSADFVGIGMGSPGAVDRDT
NTVTGAFNLNWKETQEVGSVVEKELGIPFAIDNDANVAALGERWVGAGENNPDVVFMTLGTGVGGGIIADGNLIHGVAGA
GGEIGHMIVEPENGFACTCGSHGCLETVASATGVVKVARLLAEAYEGDSAIKAAIDNGEGVTSKDIFMAAEAGDSFADSV
VEKVGYYLGLASANISNILNPDSVVIGGGVSAAGEFLRSRIEKYFVTFTFPQVRYSTKIKIAELGNDAGIIGAASLARQF
ITK
>Mature_322_residues
SQKLLGIDLGGTTIKFGILTAAGEVQEKWAIETNILEGGKHIVPDIVASIKHRLDLYGLSSADFVGIGMGSPGAVDRDTN
TVTGAFNLNWKETQEVGSVVEKELGIPFAIDNDANVAALGERWVGAGENNPDVVFMTLGTGVGGGIIADGNLIHGVAGAG
GEIGHMIVEPENGFACTCGSHGCLETVASATGVVKVARLLAEAYEGDSAIKAAIDNGEGVTSKDIFMAAEAGDSFADSVV
EKVGYYLGLASANISNILNPDSVVIGGGVSAAGEFLRSRIEKYFVTFTFPQVRYSTKIKIAELGNDAGIIGAASLARQFI
TK

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI190014632, Length=273, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI298566325, Length=273, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI298566315, Length=269, Percent_Identity=31.2267657992565, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4885285, Length=273, Percent_Identity=30.7692307692308, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI298566312, Length=124, Percent_Identity=33.8709677419355, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786891, Length=320, Percent_Identity=28.75, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787878, Length=265, Percent_Identity=29.0566037735849, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87082127, Length=224, Percent_Identity=29.0178571428571, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787363, Length=325, Percent_Identity=28.9230769230769, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081733, Length=322, Percent_Identity=27.639751552795, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790522, Length=320, Percent_Identity=27.1875, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI87082230, Length=280, Percent_Identity=27.1428571428571, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33383; Mature: 33252

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKLLGIDLGGTTIKFGILTAAGEVQEKWAIETNILEGGKHIVPDIVASIKHRLDLYGL
CCCCEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEC
SSADFVGIGMGSPGAVDRDTNTVTGAFNLNWKETQEVGSVVEKELGIPFAIDNDANVAAL
CCCCEEEEECCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEECCCCCEEEE
GERWVGAGENNPDVVFMTLGTGVGGGIIADGNLIHGVAGAGGEIGHMIVEPENGFACTCG
CHHHCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCCCCCCEEEEECCCCEEEECC
SHGCLETVASATGVVKVARLLAEAYEGDSAIKAAIDNGEGVTSKDIFMAAEAGDSFADSV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHH
VEKVGYYLGLASANISNILNPDSVVIGGGVSAAGEFLRSRIEKYFVTFTFPQVRYSTKIK
HHHHHHHHEECCCCHHHCCCCCCEEEECCHHHHHHHHHHHHHHEEEEEECCCEEEECEEE
IAELGNDAGIIGAASLARQFITK
EEECCCCCCEEHHHHHHHHHHCC
>Mature Secondary Structure 
SQKLLGIDLGGTTIKFGILTAAGEVQEKWAIETNILEGGKHIVPDIVASIKHRLDLYGL
CCCEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEC
SSADFVGIGMGSPGAVDRDTNTVTGAFNLNWKETQEVGSVVEKELGIPFAIDNDANVAAL
CCCCEEEEECCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEECCCCCEEEE
GERWVGAGENNPDVVFMTLGTGVGGGIIADGNLIHGVAGAGGEIGHMIVEPENGFACTCG
CHHHCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCCCCCCEEEEECCCCEEEECC
SHGCLETVASATGVVKVARLLAEAYEGDSAIKAAIDNGEGVTSKDIFMAAEAGDSFADSV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHH
VEKVGYYLGLASANISNILNPDSVVIGGGVSAAGEFLRSRIEKYFVTFTFPQVRYSTKIK
HHHHHHHHEECCCCHHHCCCCCCEEEECCHHHHHHHHHHHHHHEEEEEECCCEEEECEEE
IAELGNDAGIIGAASLARQFITK
EEECCCCCCEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]