| Definition | Streptococcus pyogenes MGAS8232, complete genome. |
|---|---|
| Accession | NC_003485 |
| Length | 1,895,017 |
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The map label for this gene is xseA [H]
Identifier: 19746454
GI number: 19746454
Start: 1249490
End: 1250830
Strand: Reverse
Name: xseA [H]
Synonym: spyM18_1518
Alternate gene names: 19746454
Gene position: 1250830-1249490 (Counterclockwise)
Preceding gene: 19746455
Following gene: 19746453
Centisome position: 66.01
GC content: 42.36
Gene sequence:
>1341_bases ATGGCAGATTATTTAACCGTCACTCATTTGACGAAATATTTAAAATTAAAATTTGACCGTGACCCTTATTTGGAACGGGT TTATCTGACTGGTCAAGTGTCCAATTTTCGAAAACGACCAACTCATCAATATTTTTCCTTAAAAGATGAAAGTGCTGTGA TTCAAGCCACCATGTGGGCAGGAGTCTATAAAAAACTAGGATTCGACCTAGAAGAAGGCATGAAAATTAATGTAATTGGG CGAGTCCAACTTTATGAACCTAGTGGCTCTTACTCTATCGTGATTGAAAAGGCAGAGCCAGATGGTATAGGTGCCTTGGC TTTGCAGTTTGAACAATTAAAGAAAAAATTAACGGCAGAAGGTTATTTTGAGCAAAAACACAAGCAGCCCTTGCCACAGT TTGTATCAAAAATTGGGGTCATTACAAGTCCTAGTGGTGCTGTGATTCGAGATATTATCACAACCGTTTCACGGCGTTTT CCAGGGGTTGAGATTTTATTATTCCCAACTAAAGTACAAGGTGATGGAGCCGCCCAAGAAGTAGTGGCTAATATTCGAAG AGCCAATCAAAGAGAGGATTTGGACTTGCTCATTGTCGGCCGTGGAGGTGGCTCGATAGAAGACCTTTGGGCCTTCAACG AGGAAATAGTGGTTCAGGCTATCTTTGAATCGCAACTTCCAGTGATTTCGAGTGTGGGTCATGAAACAGACACGACTTTA GCGGATTTTGTGGCAGATCGCAGAGCAGCCACACCAACTGCAGCAGCAGAGTTAGCAACGCCTATTACAAAAACAGATCT TATGTCTTGGATAGTAGAGCGGCAAAATCGTTCCTATCAGGCCTGCTTGAGGCGGATTAAGCAACGGCAAGAGTGGGTGG ATAAACTCTCGCAATCTGTTATTTTTAGGCAACCAGAACGATTATATGATGCCTACCTGCAAAAAATTGATCGCCTTAGC ATGACCCTGATGAATACGATGAAAGATCGTCTGAGTTCCGCCAAAGAAAACAAGGTTCAGTTGGACCATGCCTTGGCCAA TAGTCAATTACAGACAAAAATCGAGCGATACCAAGACCGTGTTGCTACCGCTAAGCGTTTACTGATGGCTAATATGGCTA GGCAATATGATAGTCAGCTGGCTCGCTTTGAAAAAGCACAGGATGCTTTGCTATCACTGGATGTCAGCCGAATTATCGCC CGTGGTTATGCAATGATTGAAAAAAATCAAGCACTGGTAGCCTCTGTAAGTCAGATAACAAAGGGTGATCAGTTAACCAT TAAGATGCGTGATGGACAATTAGATGTAGAGGTAAAAGATGTCAAAAACGAAAACATTTGA
Upstream 100 bases:
>100_bases CTTTTTTGTTTTTCTGCTCACTATTTATCCAGAAAAATGGTATAATTGCATTAGTATGCAAAGGGACTATGTCAGGTCCA ACTAAGTGAAAGGTGGCTTG
Downstream 100 bases:
>100_bases AGAAAATTTACAAGATTTAGAGACTATTGTGAACAAACTTGAAAATGGGGATGTCCCTTTGGAAGAAGCTATTTCAGAAT TTCAAAAAGGAATGCTTCTC
Product: exodeoxyribonuclease VII large subunit
Products: NA
Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]
Number of amino acids: Translated: 446; Mature: 445
Protein sequence:
>446_residues MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIG RVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRF PGVEILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTL ADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLS MTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDRVATAKRLLMANMARQYDSQLARFEKAQDALLSLDVSRIIA RGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI
Sequences:
>Translated_446_residues MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIG RVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRF PGVEILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTL ADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLS MTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDRVATAKRLLMANMARQYDSQLARFEKAQDALLSLDVSRIIA RGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI >Mature_445_residues ADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIGR VQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRFP GVEILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTLA DFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLSM TLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDRVATAKRLLMANMARQYDSQLARFEKAQDALLSLDVSRIIAR GYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI
Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]
COG id: COG1570
COG function: function code L; Exonuclease VII, large subunit
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the xseA family [H]
Homologues:
Organism=Escherichia coli, GI1788856, Length=455, Percent_Identity=35.3846153846154, Blast_Score=278, Evalue=5e-76,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003753 - InterPro: IPR020579 - InterPro: IPR004365 [H]
Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]
EC number: =3.1.11.6 [H]
Molecular weight: Translated: 50554; Mature: 50423
Theoretical pI: Translated: 9.47; Mature: 9.47
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWA CCCHHHHHHHHHHHHEECCCCCCCEEEEEECCHHHHHCCCCCHHCCCCCCCHHHHHHHHH GVYKKLGFDLEEGMKINVIGRVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAE HHHHHHCCCHHCCCEEEEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC GYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRFPGVEILLFPTKVQGDGAAQE HHHHHHHCCCHHHHHHHCCCEECCCCHHHHHHHHHHHHHCCCEEEEEEECEECCCCHHHH VVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTL HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCHHHHCCCCCCHHH ADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSV HHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH IFRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDR HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH VATAKRLLMANMARQYDSQLARFEKAQDALLSLDVSRIIARGYAMIEKNQALVASVSQIT HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC KGDQLTIKMRDGQLDVEVKDVKNENI CCCEEEEEEECCEEEEEEECCCCCCC >Mature Secondary Structure ADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWA CCHHHHHHHHHHHHEECCCCCCCEEEEEECCHHHHHCCCCCHHCCCCCCCHHHHHHHHH GVYKKLGFDLEEGMKINVIGRVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAE HHHHHHCCCHHCCCEEEEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC GYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRFPGVEILLFPTKVQGDGAAQE HHHHHHHCCCHHHHHHHCCCEECCCCHHHHHHHHHHHHHCCCEEEEEEECEECCCCHHHH VVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTL HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCHHHHCCCCCCHHH ADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSV HHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH IFRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDR HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH VATAKRLLMANMARQYDSQLARFEKAQDALLSLDVSRIIARGYAMIEKNQALVASVSQIT HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC KGDQLTIKMRDGQLDVEVKDVKNENI CCCEEEEEEECCEEEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11296296 [H]