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The map label for this gene is dnaX [H]

Identifier: 19746336

GI number: 19746336

Start: 1148563

End: 1150233

Strand: Reverse

Name: dnaX [H]

Synonym: spyM18_1376

Alternate gene names: 19746336

Gene position: 1150233-1148563 (Counterclockwise)

Preceding gene: 19746337

Following gene: 19746335

Centisome position: 60.7

GC content: 40.69

Gene sequence:

>1671_bases
ATGTATCAAGCTCTTTATCGGAAATACCGGAGCCAAACGTTTGACGAAATGGTGGGACAATCGGTTATTTCCACAACTTT
AAAGCAGGCAGTTGAATCTGGCAAGATTAGCCATGCTTATCTTTTTTCAGGTCCTAGAGGGACTGGGAAAACAAGTGCGG
CAAAGATTTTTGCAAAGGCCATGAATTGTCCTAACCAAGTCGATGGTGAACCCTGTAATCAATGCGATATTTGCCGAGAT
ATCACGAATGGAAGCTTGGAAGATGTGATTGAAATTGATGCTGCCTCGAATAATGGTGTTGATGAAATTCGTGACATTCG
AGACAAATCAACCTATGCGCCGAGTCGTGCGACTTACAAGGTTTATATTATTGATGAGGTTCACATGTTATCAACAGGGG
CTTTTAATGCGCTTTTGAAAACTTTGGAAGAACCGACAGAAAATGTTGTCTTTATCTTGGCAACAACGGAATTGCATAAA
ATTCCAGCCACTATTTTATCTCGTGTGCAACGCTTTGAATTCAAAGCTATTAAGCAAAAAGCTATTCGAGAGCATTTAGC
CTGGGTTTTGGACAAAGAAGGTATTGCCTATGAGGTGGATGCTTTAAATCTCATTGCAAGGCGAGCAGAAGGAGGCATGC
GTGATGCTTTATCTATTTTAGATCAGGCTTTGAGCTTGTCACCAGATAATCAGGTCACCATTGCAATTGCCGAAGAAATT
ACAGGTTCTATTTCCATACTTGCTCTAGGTGGCTATGTTCGATATGTCTCCCAAGAACAGGCTACGCAAGCTCTGGCAGC
CTTAGAGACCATTTATGATAGTGGGAAGAGCATGAGCCGCTTTGCGACAGATTTATTGACCTATCTGCGTGATTTATTGG
TGGTTAAAGCTGGCGGCGACAATCAGCGTCAGTCAGCTGTTTTTGATACTAATTTGTCTCTCTCGATAGATCGTATATTC
CAAATGATAACAGTTGTTACTAGTCATCTCCCTGAAATCAAAAAGGGAACCCATCCTCGGATTTATGCCGAAATGATGAC
CATCCAATTAGCTCAGAAAGAGCAGATTTTGTCCCAAGCAAACTTGTCAGGAGAGTTAATCTCAGAGATTGAAACGCTCA
AAAATGAGTTGGCACAACTTAAACAACAATTGTCGCAGCTCCAATCGCGTCCTGATTCACTGGCAAGATCTGATAAAACG
AAACCTAAAACCACAAGCTACAGGGTTGATCGGGTTACCATTTTGAAAATCATGGAAGAAACGGTTCGAAATAGCCAACA
ATCTCGACAATATCTAGATGCTCTAAAAAATGCTTGGAATGAAATTCTAGATAACATTTCTGCCCAAGACAGAGCCTTAT
TGATGGGCTCTGAGCCTGTCTTAGCAAATAGTGAGAATGCGATTTTGGCTTTCGAGGCTGCCTTTAATGCAGAACAAGTC
ATGAGCCGAAATAATCTTAATGATATGTTTGGTAACATTATGAGTAAAGCTGCTGGTTTTTCTCCCAATATTCTGGCAGT
ACCAAGGACAGATTTTCAGCATATTCGTAAGGAATTTGCTCAGCAAATGAAATCGCAAAAAGACAGTGTTCAAGAAGAAC
AAGAAGTAGCGCTTGATATTCCAGAAGGGTTTGATTTTTTGCTCGATAAAATAAATACTATTGACGACTAA

Upstream 100 bases:

>100_bases
CTGATTATGATGAGGTTGATCAAGAATACTTAGAGACCTTTGTGGACCTACTTCTTGAAAAGACCACGTTTACCTTTAAC
ATGTTTGGAGTTAAAAACTG

Downstream 100 bases:

>100_bases
AACTGAAATACATAAGGGTAAGGTTTTGCCCTTACCCACGTTTTATCTCGTTACTTTTTTTCATAGTACAGTATTTTTTT
GTTATAATAAAGCTATGACT

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MYQALYRKYRSQTFDEMVGQSVISTTLKQAVESGKISHAYLFSGPRGTGKTSAAKIFAKAMNCPNQVDGEPCNQCDICRD
ITNGSLEDVIEIDAASNNGVDEIRDIRDKSTYAPSRATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFILATTELHK
IPATILSRVQRFEFKAIKQKAIREHLAWVLDKEGIAYEVDALNLIARRAEGGMRDALSILDQALSLSPDNQVTIAIAEEI
TGSISILALGGYVRYVSQEQATQALAALETIYDSGKSMSRFATDLLTYLRDLLVVKAGGDNQRQSAVFDTNLSLSIDRIF
QMITVVTSHLPEIKKGTHPRIYAEMMTIQLAQKEQILSQANLSGELISEIETLKNELAQLKQQLSQLQSRPDSLARSDKT
KPKTTSYRVDRVTILKIMEETVRNSQQSRQYLDALKNAWNEILDNISAQDRALLMGSEPVLANSENAILAFEAAFNAEQV
MSRNNLNDMFGNIMSKAAGFSPNILAVPRTDFQHIRKEFAQQMKSQKDSVQEEQEVALDIPEGFDFLLDKINTIDD

Sequences:

>Translated_556_residues
MYQALYRKYRSQTFDEMVGQSVISTTLKQAVESGKISHAYLFSGPRGTGKTSAAKIFAKAMNCPNQVDGEPCNQCDICRD
ITNGSLEDVIEIDAASNNGVDEIRDIRDKSTYAPSRATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFILATTELHK
IPATILSRVQRFEFKAIKQKAIREHLAWVLDKEGIAYEVDALNLIARRAEGGMRDALSILDQALSLSPDNQVTIAIAEEI
TGSISILALGGYVRYVSQEQATQALAALETIYDSGKSMSRFATDLLTYLRDLLVVKAGGDNQRQSAVFDTNLSLSIDRIF
QMITVVTSHLPEIKKGTHPRIYAEMMTIQLAQKEQILSQANLSGELISEIETLKNELAQLKQQLSQLQSRPDSLARSDKT
KPKTTSYRVDRVTILKIMEETVRNSQQSRQYLDALKNAWNEILDNISAQDRALLMGSEPVLANSENAILAFEAAFNAEQV
MSRNNLNDMFGNIMSKAAGFSPNILAVPRTDFQHIRKEFAQQMKSQKDSVQEEQEVALDIPEGFDFLLDKINTIDD
>Mature_556_residues
MYQALYRKYRSQTFDEMVGQSVISTTLKQAVESGKISHAYLFSGPRGTGKTSAAKIFAKAMNCPNQVDGEPCNQCDICRD
ITNGSLEDVIEIDAASNNGVDEIRDIRDKSTYAPSRATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFILATTELHK
IPATILSRVQRFEFKAIKQKAIREHLAWVLDKEGIAYEVDALNLIARRAEGGMRDALSILDQALSLSPDNQVTIAIAEEI
TGSISILALGGYVRYVSQEQATQALAALETIYDSGKSMSRFATDLLTYLRDLLVVKAGGDNQRQSAVFDTNLSLSIDRIF
QMITVVTSHLPEIKKGTHPRIYAEMMTIQLAQKEQILSQANLSGELISEIETLKNELAQLKQQLSQLQSRPDSLARSDKT
KPKTTSYRVDRVTILKIMEETVRNSQQSRQYLDALKNAWNEILDNISAQDRALLMGSEPVLANSENAILAFEAAFNAEQV
MSRNNLNDMFGNIMSKAAGFSPNILAVPRTDFQHIRKEFAQQMKSQKDSVQEEQEVALDIPEGFDFLLDKINTIDD

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=215, Percent_Identity=29.7674418604651, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI194306571, Length=218, Percent_Identity=29.3577981651376, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194306567, Length=218, Percent_Identity=29.3577981651376, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4506491, Length=340, Percent_Identity=23.2352941176471, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI31881687, Length=340, Percent_Identity=23.2352941176471, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI31563534, Length=224, Percent_Identity=28.125, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786676, Length=243, Percent_Identity=51.8518518518518, Blast_Score=260, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71986063, Length=298, Percent_Identity=25.1677852348993, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17554730, Length=230, Percent_Identity=27.3913043478261, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17541988, Length=218, Percent_Identity=27.9816513761468, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=225, Percent_Identity=32, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6322528, Length=302, Percent_Identity=23.1788079470199, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=217, Percent_Identity=25.8064516129032, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI18859927, Length=291, Percent_Identity=26.4604810996564, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19921076, Length=215, Percent_Identity=27.4418604651163, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17647857, Length=216, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 61998; Mature: 61998

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQALYRKYRSQTFDEMVGQSVISTTLKQAVESGKISHAYLFSGPRGTGKTSAAKIFAKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHH
MNCPNQVDGEPCNQCDICRDITNGSLEDVIEIDAASNNGVDEIRDIRDKSTYAPSRATYK
HCCCCCCCCCCCCHHHHHHHHCCCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCCCCEEE
VYIIDEVHMLSTGAFNALLKTLEEPTENVVFILATTELHKIPATILSRVQRFEFKAIKQK
EEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AIREHLAWVLDKEGIAYEVDALNLIARRAEGGMRDALSILDQALSLSPDNQVTIAIAEEI
HHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHH
TGSISILALGGYVRYVSQEQATQALAALETIYDSGKSMSRFATDLLTYLRDLLVVKAGGD
CCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCC
NQRQSAVFDTNLSLSIDRIFQMITVVTSHLPEIKKGTHPRIYAEMMTIQLAQKEQILSQA
CCCCCCEECCCCCEEHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
NLSGELISEIETLKNELAQLKQQLSQLQSRPDSLARSDKTKPKTTSYRVDRVTILKIMEE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEHHHHHHHHHHHH
TVRNSQQSRQYLDALKNAWNEILDNISAQDRALLMGSEPVLANSENAILAFEAAFNAEQV
HHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCEEEEECCCCHHHH
MSRNNLNDMFGNIMSKAAGFSPNILAVPRTDFQHIRKEFAQQMKSQKDSVQEEQEVALDI
HHHCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
PEGFDFLLDKINTIDD
CCCHHHHHHHHHCCCC
>Mature Secondary Structure
MYQALYRKYRSQTFDEMVGQSVISTTLKQAVESGKISHAYLFSGPRGTGKTSAAKIFAKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHH
MNCPNQVDGEPCNQCDICRDITNGSLEDVIEIDAASNNGVDEIRDIRDKSTYAPSRATYK
HCCCCCCCCCCCCHHHHHHHHCCCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCCCCEEE
VYIIDEVHMLSTGAFNALLKTLEEPTENVVFILATTELHKIPATILSRVQRFEFKAIKQK
EEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AIREHLAWVLDKEGIAYEVDALNLIARRAEGGMRDALSILDQALSLSPDNQVTIAIAEEI
HHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHH
TGSISILALGGYVRYVSQEQATQALAALETIYDSGKSMSRFATDLLTYLRDLLVVKAGGD
CCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCC
NQRQSAVFDTNLSLSIDRIFQMITVVTSHLPEIKKGTHPRIYAEMMTIQLAQKEQILSQA
CCCCCCEECCCCCEEHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
NLSGELISEIETLKNELAQLKQQLSQLQSRPDSLARSDKTKPKTTSYRVDRVTILKIMEE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEHHHHHHHHHHHH
TVRNSQQSRQYLDALKNAWNEILDNISAQDRALLMGSEPVLANSENAILAFEAAFNAEQV
HHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCEEEEECCCCHHHH
MSRNNLNDMFGNIMSKAAGFSPNILAVPRTDFQHIRKEFAQQMKSQKDSVQEEQEVALDI
HHHCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
PEGFDFLLDKINTIDD
CCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]