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The map label for this gene is fhs [H]

Identifier: 19746146

GI number: 19746146

Start: 973763

End: 975433

Strand: Reverse

Name: fhs [H]

Synonym: spyM18_1165

Alternate gene names: 19746146

Gene position: 975433-973763 (Counterclockwise)

Preceding gene: 19746147

Following gene: 19746145

Centisome position: 51.47

GC content: 43.03

Gene sequence:

>1671_bases
ATGAAATCAGATATCGAAATTGCCCAAAGTGTCGCCCTACAACCAATCACTGACATTGTTAAAAAGGTTGGAATAGACGG
CGATGACATTGAGCTTTATGGCAAATATAAGGCTAAATTGTCTTTTGAGAAAATGAAAGCTGTCGAAGCTAATGAGCCTG
GAAAATTACTCTTGGTAACTGCTATTAACCCTACTCCAGCGGGAGAAGGAAAATCAACCATGTCTATTGGACTGGCAGAT
GCCTTAAATCAAATGGGAAAAAAAACCATGCTTGCCTTACGTGAACCCTCCCTTGGTCCTGTTATGGGGATTAAAGGCGG
GGCAGCAGGTGGTGGTTATGCCCAAGTATTGCCTATGGAAGACATTAATCTTCACTTTACTGGTGACATGCATGCCATTA
CAACCGCTAATAATGCATTATCTGCTTTGATTGACAATCATTTGCAGCAAGGAAACGATTTAGGAATTGATCCTCGCCGC
ATTATTTGGAAGCGCGTGTTGGACCTTAATGATCGTGCTCTTCGTCAGGTAATTGTTGGCTTAGGCAGTCCAGTGAATGG
TGTGCCACGCGAAGATGGGTTTGATATCACAGTAGCTTCTGAAATCATGGCAATTTTATGTTTGGCAACTGACTTGAAAG
ATCTAAAGAAACGTCTTGCTGATATCGTCGTGGCTTATACCTATGATCGTAAGCCTGTCTATGTGCGTGACTTGAAGGTT
GAAGGAGCATTGACATTAATTCTAAAAGATGCTATCAAGCCAAACTTGGTGCAGACTATTTATGGAACACCAGCTCTTAT
TCATGGGGGGCCATTTGCTAATATTGCTCATGGTTGTAATTCTGTCCTTGCTACCTCAACAGCTTTGCGATTAGCAGATT
ACACTGTTACCGAAGCAGGATTCGGGGCCGACCTAGGAGCTGAAAAATTCCTAAATATCAAAGTACCTAATCTTCCTAAA
GCACCAGATGCTATCGTCATTGTTGCAACCTTGCGCGCCCTTAAAATGCATGGAGGTGTCGCCAAATCAGATTTAGCCGC
TGAAAATTGTGAGGCTGTTCGCTTAGGATTTGCCAACTTAAAACGTCACGTGGAAAACATGCGCCAATTCAAAGTTCCAG
TTGTGGTGGCTATCAATGAATTTGTAGCAGATACCGAGGCTGAAATTGCTACCTTAAAAGCGCTTTGTGAAGAGATTAAG
GTTCCAGTAGAATTAGCCAGTGTTTGGGCAAATGGAGCTGAGGGAGGCTTAGCATTAGCTAAAACAGCGGTTCGTGTGAT
TGATCAAGAAGCTGCTGACTACAAACGTCTCTATTCAGATGAGGATACTTTGGAAGAAAAAGTGATCAATATCGTTACCC
AGATTTATGGTGGCAAAGCTGTTCAATTTGGCCCCAAGGCCAAAACACAATTGAAGCAGTTCGCAGAATTCGGTTGGGAT
AAATTGCCTGTTTGTATGGCTAAGACCCAATACAGTTTTTCAGATAACCCATCCTTGCTTGGAGCGCCAACCGATTTTGA
TATTACCATTCGTGAATTTGTTCCTAAAACAGGGGCAGGTTTTATTGTTGGTTTAACAGGTGATGTGATGACCATGCCTG
GTTTGCCTAAAGTTCCAGCTGCCATGGCAATGGACGTAGCAGAAAATGGCACAGCCCTCGGTCTCTTTTAG

Upstream 100 bases:

>100_bases
CGCGATTAAAAACGAACAATAATTGTTTTAATTCAAATAAATGTACGTATGATATGAATTGTGATATAATGACGTCATTA
CGTAAAATTGAGGAGTCATC

Downstream 100 bases:

>100_bases
GAAAAATTGCTCGAATAATTCGAGCAAGCGCTCCTTTCTTCCCGCTTTACTGTGATATAATAAGGTAAATGAGATTTTGG
AGGGATGATTATCAAAAAGA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase 1; FHS 1; FTHFS 1 [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEANEPGKLLLVTAINPTPAGEGKSTMSIGLAD
ALNQMGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRR
IIWKRVLDLNDRALRQVIVGLGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKV
EGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLNIKVPNLPK
APDAIVIVATLRALKMHGGVAKSDLAAENCEAVRLGFANLKRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIK
VPVELASVWANGAEGGLALAKTAVRVIDQEAADYKRLYSDEDTLEEKVINIVTQIYGGKAVQFGPKAKTQLKQFAEFGWD
KLPVCMAKTQYSFSDNPSLLGAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPAAMAMDVAENGTALGLF

Sequences:

>Translated_556_residues
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEANEPGKLLLVTAINPTPAGEGKSTMSIGLAD
ALNQMGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRR
IIWKRVLDLNDRALRQVIVGLGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKV
EGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLNIKVPNLPK
APDAIVIVATLRALKMHGGVAKSDLAAENCEAVRLGFANLKRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIK
VPVELASVWANGAEGGLALAKTAVRVIDQEAADYKRLYSDEDTLEEKVINIVTQIYGGKAVQFGPKAKTQLKQFAEFGWD
KLPVCMAKTQYSFSDNPSLLGAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPAAMAMDVAENGTALGLF
>Mature_556_residues
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEANEPGKLLLVTAINPTPAGEGKSTMSIGLAD
ALNQMGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRR
IIWKRVLDLNDRALRQVIVGLGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKV
EGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLNIKVPNLPK
APDAIVIVATLRALKMHGGVAKSDLAAENCEAVRLGFANLKRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIK
VPVELASVWANGAEGGLALAKTAVRVIDQEAADYKRLYSDEDTLEEKVINIVTQIYGGKAVQFGPKAKTQLKQFAEFGWD
KLPVCMAKTQYSFSDNPSLLGAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPAAMAMDVAENGTALGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=620, Percent_Identity=41.7741935483871, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI36796743, Length=622, Percent_Identity=41.6398713826367, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI310124614, Length=82, Percent_Identity=36.5853658536585, Blast_Score=68, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=608, Percent_Identity=41.4473684210526, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17568739, Length=608, Percent_Identity=41.4473684210526, Blast_Score=416, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=41.85303514377, Blast_Score=439, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=39.9366085578447, Blast_Score=429, Evalue=1e-121,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=40.7108239095315, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=40.7108239095315, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=40.7108239095315, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=40.7108239095315, Blast_Score=433, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59504; Mature: 59504

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00721 FTHFS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEANEPGKLLLVT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEHHHHHHHCCCCCCCEEEEE
AINPTPAGEGKSTMSIGLADALNQMGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPME
EECCCCCCCCCCEEEEHHHHHHHHHCHHHEEEECCCCCCCEEECCCCCCCCCCEEEEEEC
DINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRRIIWKRVLDLNDRALRQVIVG
CCEEEECCCEEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
LGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEEE
EGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAG
CCCEEEEEHHHCCCCHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCEEECCC
FGADLGAEKFLNIKVPNLPKAPDAIVIVATLRALKMHGGVAKSDLAAENCEAVRLGFANL
CCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHH
KRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIKVPVELASVWANGAEGGLALA
HHHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHH
KTAVRVIDQEAADYKRLYSDEDTLEEKVINIVTQIYGGKAVQFGPKAKTQLKQFAEFGWD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCC
KLPVCMAKTQYSFSDNPSLLGAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPA
CCCCEEEECCCCCCCCCCEEECCCCCCEEHHHHCCCCCCCEEEEECCCEEECCCCCCCCH
AMAMDVAENGTALGLF
HHHHHHHCCCCEECCC
>Mature Secondary Structure
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEANEPGKLLLVT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEHHHHHHHCCCCCCCEEEEE
AINPTPAGEGKSTMSIGLADALNQMGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPME
EECCCCCCCCCCEEEEHHHHHHHHHCHHHEEEECCCCCCCEEECCCCCCCCCCEEEEEEC
DINLHFTGDMHAITTANNALSALIDNHLQQGNDLGIDPRRIIWKRVLDLNDRALRQVIVG
CCEEEECCCEEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
LGSPVNGVPREDGFDITVASEIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEEE
EGALTLILKDAIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAG
CCCEEEEEHHHCCCCHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCEEECCC
FGADLGAEKFLNIKVPNLPKAPDAIVIVATLRALKMHGGVAKSDLAAENCEAVRLGFANL
CCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHH
KRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIKVPVELASVWANGAEGGLALA
HHHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHH
KTAVRVIDQEAADYKRLYSDEDTLEEKVINIVTQIYGGKAVQFGPKAKTQLKQFAEFGWD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCC
KLPVCMAKTQYSFSDNPSLLGAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPA
CCCCEEEECCCCCCCCCCEEECCCCCCEEHHHHCCCCCCCEEEEECCCEEECCCCCCCCH
AMAMDVAENGTALGLF
HHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]