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The map label for this gene is ffh [H]

Identifier: 19746132

GI number: 19746132

Start: 958997

End: 960559

Strand: Reverse

Name: ffh [H]

Synonym: spyM18_1151

Alternate gene names: 19746132

Gene position: 960559-958997 (Counterclockwise)

Preceding gene: 19746133

Following gene: 19746130

Centisome position: 50.69

GC content: 39.8

Gene sequence:

>1563_bases
ATGGCTTTTGAAAGCTTAACCCAACGTTTGCAAGATGTGTTTAAACACATTCGCGGTAAAAAGAAATTATCAGAATCAGA
TGTTCAAGAAGTGACAAAAGAGATTCGTCTAGCTCTTTTAGAAGCCGATGTCGCTTTACCAGTTGTTAAAACCTTTATTA
AGCGCGTACGTGAGCGCGCTATTGGCCATGAGATTATTGATACTCTTGATCCAACAAAACAAATTCTTAAGATTGTTAAT
GAAGAATTAACGAGTATTTTAGGCTCAGAAACTGCAGAGATTGATAAATCTCCAAAAATTCCAACTATTATCATGATGGT
CGGTTTGCAAGGGGCTGGTAAAACAACTTTTGCAGGAAAACTCGCTAATAAATTAATTAAAGAAGAAGATGCGCGACCAC
TGATGATTGCTGCCGATATTTACCGTCCAGCGGCCATTGATCAGTTAAAAACACTGGGGCAACAAATCAATGTACCTGTT
TTTGATATGGGGACAGACCACTCAGCAGTCGATATTGTCAGAAAAGGTTTGGAACAGGCTCGTGAAAACCACAATGACTA
TGTCTTGATTGATACTGCGGGTCGCTTGCAAATTGATGAAAAACTGATGGAAGAGCTGCGCGATGTCAAGGCTTTAGCAC
AACCAAATGAAATTCTTTTGGTTGTAGATAGCATGATTGGTCAGGAAGCTGCCAATGTAGCCTACGAATTTAATCATCAG
TTGAGCATCACAGGGGTTGTGTTAACAAAGATTGATGGTGATACCCGTGGAGGTGCAGCGCTATCTGTCCGTGAAATCAC
TGGAAAACCAATTAAATTTACAGGTACTGGTGAAAGAATCACAGATATTGAAACATTTCATCCAGACCGCATGTCGAGTC
GTATATTGGGAATGGGTGACTTACTCACTCTTATTGAAAAAGCTAGCCAGGAATATGATGAGAAAAAATCCTTAGAGTTA
GCTGAAAAAATGCGTGAAAACACCTTTGATTTCAATGATTTTATTGAACAGTTAGATCAAGTGCAAAATATGGGGCCTAT
GGAAGACCTCTTGAAAATGATTCCAGGAATGGCTGGTAACCCAGCTTTGGCCAATATCAAAGTTGACGAAAACCAAATTG
CTCGCAAACGTGCTATTGTCTCTTCAATGACACCCGCTGAACGTGAAAATCCTGACTTACTAAACCCGAGTCGTCGCCGT
CGTATTGCAGCTGGTTCCGGGAACAGCTTTGTAGAAGTTAATAAATTTATCAAAGACTTTAATCAAGCCAAAAGCATGAT
GCAAGGGGTTATGTCGGGTGATATGTCTAAAATGATGAAAGATATGGGTATTAATCCCAATAATCTTCCTAAAAACATGC
CTGCTGGTATGCCAGATATGTCTTCCTTAGAAGGGATGATGGGACAAGGTGGTATGCCTGATTTATCTAGCCTTGGTGGT
GATATGGATATGAGTCAACTGTTTGGTGGTGGGTTCAAGGGGAAAATTGGACAATTTGCGATGAAACAGGCCATGAAACG
TCAAGCTAATAAACTAAAAAAAGCAAAGAAAAAACGAAAATAA

Upstream 100 bases:

>100_bases
TTGACGACATGATTGCTCACTACCCTCATGATGAGTATTTGCAAGAAAAAATTTCCATTTTAACCAGTATTGACAATAGA
GAGTAAGAGGAGTTTTGACT

Downstream 100 bases:

>100_bases
AAGAGACGAAAATTTTCGTCTCTTTTTGATGTGAAATTCATTTATCTTGTATACAAGATTATTAAAATTACGGAAGACCG
CGTTACATGCATGATGAGTT

Product: signal recognition particle -inhibited division protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTKQILKIVN
EELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGKLANKLIKEEDARPLMIAADIYRPAAIDQLKTLGQQINVPV
FDMGTDHSAVDIVRKGLEQARENHNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGTGERITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLEL
AEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRR
RIAAGSGNSFVEVNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSSLGG
DMDMSQLFGGGFKGKIGQFAMKQAMKRQANKLKKAKKKRK

Sequences:

>Translated_520_residues
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTKQILKIVN
EELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGKLANKLIKEEDARPLMIAADIYRPAAIDQLKTLGQQINVPV
FDMGTDHSAVDIVRKGLEQARENHNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGTGERITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLEL
AEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRR
RIAAGSGNSFVEVNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSSLGG
DMDMSQLFGGGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
>Mature_519_residues
AFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTKQILKIVNE
ELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGKLANKLIKEEDARPLMIAADIYRPAAIDQLKTLGQQINVPVF
DMGTDHSAVDIVRKGLEQARENHNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQL
SITGVVLTKIDGDTRGGAALSVREITGKPIKFTGTGERITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLELA
EKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRR
IAAGSGNSFVEVNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSSLGGD
MDMSQLFGGGFKGKIGQFAMKQAMKRQANKLKKAKKKRK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=452, Percent_Identity=31.1946902654867, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI226371618, Length=389, Percent_Identity=32.3907455012853, Blast_Score=189, Evalue=8e-48,
Organism=Homo sapiens, GI295424842, Length=307, Percent_Identity=28.3387622149837, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI23308697, Length=307, Percent_Identity=28.3387622149837, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI89061728, Length=146, Percent_Identity=36.986301369863, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1788963, Length=420, Percent_Identity=47.8571428571429, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1789874, Length=269, Percent_Identity=33.8289962825279, Blast_Score=148, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=488, Percent_Identity=27.6639344262295, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI193206261, Length=299, Percent_Identity=29.0969899665552, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=471, Percent_Identity=30.3609341825902, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=25.6329113924051, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17647949, Length=490, Percent_Identity=30.2040816326531, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24641198, Length=311, Percent_Identity=30.8681672025724, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 57578; Mature: 57446

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERA
CCHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGHEIIDTLDPTKQILKIVNEELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHH
LANKLIKEEDARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTDHSAVDIVRKGLEQA
HHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
RENHNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEECCE
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGTGERITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEHCCCCCCEEECCCCCCCCCHHHCCCHHHHHHHCCHHH
LLTLIEKASQEYDEKKSLELAEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRRIAAGSGNSFVEVNKFIKDF
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCEEECCCCCCHHHHHHHHHHH
NQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSSLGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHCCC
DMDMSQLFGGGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERA
CHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGHEIIDTLDPTKQILKIVNEELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHH
LANKLIKEEDARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTDHSAVDIVRKGLEQA
HHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
RENHNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEECCE
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGTGERITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEHCCCCCCEEECCCCCCCCCHHHCCCHHHHHHHCCHHH
LLTLIEKASQEYDEKKSLELAEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRRIAAGSGNSFVEVNKFIKDF
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCEEECCCCCCHHHHHHHHHHH
NQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSSLGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHCCC
DMDMSQLFGGGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]