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The map label for this gene is prsA [H]

Identifier: 19746072

GI number: 19746072

Start: 899614

End: 900594

Strand: Reverse

Name: prsA [H]

Synonym: spyM18_1084

Alternate gene names: 19746072

Gene position: 900594-899614 (Counterclockwise)

Preceding gene: 19746073

Following gene: 19746071

Centisome position: 47.52

GC content: 37.92

Gene sequence:

>981_bases
ATGACTGAACGATATGCTGACAAGCAAATCAAACTGTTCTCACTCACATCAAATCTTCCAATTGCTGAAAAAATTGCTAA
AGCTGCTGGAATCCCTCTTGGAAAAATGTCTTCACGTCAATTTTCCGATGGAGAAATTATGATCAATATTGAAGAAACAG
TGCGTGGAGATCATATCTATATTATTCAATCCACTAGTTTTCCTGTCAATGATAATCTTTGGGAATTACTCATCATGATT
GATGCTTGTAAACGTGCAAGTGCTAATACCGTCAATATTGTATTGCCATACTTTGGTTACTCTCGTCAAGACCGTGTCGC
TAAGCCCCGCGAACCGATTACTGCTAAACTAGTAGCTAATATGCTGACTAAAGCTGGTATTGATCGTGTAGTGACGCTTG
ACTTACATGCTGTTCAGGTACAAGGTTTTTTTGATATTCCAGTGGATAACCTCTTTACAGTCCCTCTTTTTGCAGAACGT
TACAGTAAATTAGGCTTATCAGGTTCTGATGTTGTTGTCGTTAGCCCTAAAAATTCTGGAATTAAACGTGCTAGAAGCTT
GGCTGAATATCTTGATTCCCCGATTGCTATTATCGACTATGCACAAGATGATTCTGAACGTGAACAAGGTTATATTATTG
GTGATGTTTCTGGTAAAAAAGCCATTTTAATTGATGATATTTTAAATACTGGGAAAACCTTTGCAGAAGCTGCTAAAATT
CTTGAACGCTCAGGCGCTACTGATACTTACGCGGTCGCTAGCCATGGCTTATTTGCTGGTGGAGCTGCTGATGTATTAGA
AACAGCTCCAATCAAAGAAATTATCGTTACAGATTCTGTTAAAACTAAAAATCGTGTGCCAGAAAACGTTACTTATCTTA
GCGCCAGTGATTTAATCGCAGAAGCTATTATTCGTATCCATGAAAGAAAACCCTTAAGTCCACTTTTTTCTTATCAACCT
AAAGGCAAAAATAACGCATGA

Upstream 100 bases:

>100_bases
TCTGTTAAAATAGGGATGTCAATTAAACACTTTTGGGTAATGTGACTCATTAATAAAACAGTTTACCCAATTTTATTGAA
GTTAAGGAGCTAAATCTATC

Downstream 100 bases:

>100_bases
CTTACTTTGATAACGCCGCCACCACACCACTTAGTCCTAATGTGATTAGGGCGATGACAGCAGCTATGCAAGATAACTTT
GGTAACCCCTCTAGTATTCA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK 2; Phosphoribosyl pyrophosphate synthase 2; P-Rib-PP synthase 2; PRPP synthase 2 [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINIEETVRGDHIYIIQSTSFPVNDNLWELLIMI
DACKRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAER
YSKLGLSGSDVVVVSPKNSGIKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKI
LERSGATDTYAVASHGLFAGGAADVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIAEAIIRIHERKPLSPLFSYQP
KGKNNA

Sequences:

>Translated_326_residues
MTERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINIEETVRGDHIYIIQSTSFPVNDNLWELLIMI
DACKRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAER
YSKLGLSGSDVVVVSPKNSGIKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKI
LERSGATDTYAVASHGLFAGGAADVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIAEAIIRIHERKPLSPLFSYQP
KGKNNA
>Mature_325_residues
TERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINIEETVRGDHIYIIQSTSFPVNDNLWELLIMID
ACKRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAERY
SKLGLSGSDVVVVSPKNSGIKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKIL
ERSGATDTYAVASHGLFAGGAADVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIAEAIIRIHERKPLSPLFSYQPK
GKNNA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=41.5873015873016, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=41.0828025477707, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI28557709, Length=320, Percent_Identity=41.25, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=40.6940063091483, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=34.402332361516, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI194018537, Length=330, Percent_Identity=33.9393939393939, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=36.4285714285714, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=36.4285714285714, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=36.4285714285714, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=36.4285714285714, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=44.2675159235669, Blast_Score=263, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=40.9523809523809, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17554702, Length=315, Percent_Identity=40.9523809523809, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=41.0828025477707, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=40.7051282051282, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17570245, Length=349, Percent_Identity=33.2378223495702, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=40.4458598726115, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6319403, Length=321, Percent_Identity=39.5638629283489, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=39.0476190476191, Blast_Score=212, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6322667, Length=191, Percent_Identity=38.2198952879581, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324511, Length=107, Percent_Identity=42.9906542056075, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=42.2222222222222, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=39.3491124260355, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI281362873, Length=343, Percent_Identity=33.5276967930029, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24651454, Length=343, Percent_Identity=33.5276967930029, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24651458, Length=343, Percent_Identity=33.5276967930029, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24651456, Length=343, Percent_Identity=33.5276967930029, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24651462, Length=190, Percent_Identity=38.4210526315789, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24651464, Length=190, Percent_Identity=38.4210526315789, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45552010, Length=190, Percent_Identity=38.4210526315789, Blast_Score=127, Evalue=7e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35703; Mature: 35572

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINIEETVRGDHIY
CCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCEEE
IIQSTSFPVNDNLWELLIMIDACKRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVAN
EEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
MLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAERYSKLGLSGSDVVVVSPKNSG
HHHHCCCCEEEEEEEEEEEECCEEECCCCCEEECHHHHHHHHHCCCCCCCEEEECCCCCH
IKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKI
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEHHHHHCCHHHHHHHHH
LERSGATDTYAVASHGLFAGGAADVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIA
HHHCCCCCEEHHHCCCEECCCHHHHHHHCCCHHEEEECCCHHHCCCCCCEEEECHHHHHH
EAIIRIHERKPLSPLFSYQPKGKNNA
HHHHHHHCCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
TERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINIEETVRGDHIY
CCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCEEE
IIQSTSFPVNDNLWELLIMIDACKRASANTVNIVLPYFGYSRQDRVAKPREPITAKLVAN
EEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
MLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAERYSKLGLSGSDVVVVSPKNSG
HHHHCCCCEEEEEEEEEEEECCEEECCCCCEEECHHHHHHHHHCCCCCCCEEEECCCCCH
IKRARSLAEYLDSPIAIIDYAQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKI
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEHHHHHCCHHHHHHHHH
LERSGATDTYAVASHGLFAGGAADVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIA
HHHCCCCCEEHHHCCCEECCCHHHHHHHCCCHHEEEECCCHHHCCCCCCEEEECHHHHHH
EAIIRIHERKPLSPLFSYQPKGKNNA
HHHHHHHCCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]