| Definition | Streptococcus pyogenes MGAS8232, complete genome. |
|---|---|
| Accession | NC_003485 |
| Length | 1,895,017 |
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The map label for this gene is hylA
Identifier: 19746014
GI number: 19746014
Start: 839518
End: 841935
Strand: Reverse
Name: hylA
Synonym: spyM18_1014
Alternate gene names: NA
Gene position: 841935-839518 (Counterclockwise)
Preceding gene: 19746016
Following gene: 19746001
Centisome position: 44.43
GC content: 35.65
Gene sequence:
>2418_bases GTGAATACTTATTTTTGCACACACCATAAACAATTACTACTTTATTCAAACCTATTCCTTAGCTTTGCTATGATGGGCCA AGGAACTGCCATTTATGCCGATACACTGACTTCAAATTCAGAACCTAATAATACTTACTTTCAAACGCAAACGCTCACTA CTACAGATAGCGAAAAAAAGGTAGTACAGCCACAACAAAAAGACTACTATACTGAATTGTTAGACCAATGGAACAGTATT ATCGCAGGCAACGATGCTTATGATAAAACCAATCCTGACATGGTGACTTTTCATAATAAAGCTGAAAAGGATGCTCAAAA CATTATTAAAAGCTATCAAGGGCCTGACCACGAAAATAGAACTTACCTTTGGGAACATGCAAAGGATTATTCCGCTTCTA CTAATATCACGAAAACTTACCGCAATATTGAAAAAATAGCAAAACAGATCACTAATCCTGAATCATGCTATTATCAAGAT AGTAAAGCTATTGCTATTGTAAAAGACGGTATGGCCTTCATGTATGAACACGCTTATAATCTAGATCGTGAAAATCATCA AACAACTGGAAAAGAAAACAAAGAAAATTGGTGGGTTTATGAAATTGGAACTCCTCGTGCTATTAATAATACCTTATCCT TGATGTATCCTTATTTTACTCAAGAAGAAATTCTTAAATACACAGCTCCAATCGAAAAATTTGTGCCTGACCCTACTCGT TTTAGGGTTCGCGCTGCCAATTTTTCACCTTTTGAAGCCAGTAGCGGAAATTTAATTGATATGGGACGTGTGAAACTCAT TTCCGGTATTCTTCGTAAAGATGATCTCGAAATTAGTGATACAATCAAAGCAATTGAGAAAGTTTTCACGCTAGTTGACG AAGGAAATGGTTTTTACCAAGACGGTTCTTTAATTGATCACGTGATTACTAACGCTCAAAGTCCACTTTATAAAAAAGGC ATTGCTTACACTGGAGCTTACGGTAATGTGCTTATAGATGGCTTATCGCAATTAATTCCTATTATTCAAAAAACAAAGTC TCCTATAGAAGCGGATAAAATGGCTACTATCTATCATTGGATTAACCATTCTTTTTTCCCTATCATCGTTCGTGGAGAAA TGATGGATATGACTCAAGGGCGTTCTATCAGTCGTTTTAATGCCCAATCTCATGTTGCTGGCATTGAAGCACTTCGTGCT ATTTTACGTATTGCTGACATGTCTGAAGAGCCTCACCGTTTGGCACTTAAAACACGTATAAAAACACTCGTCACACAAGG GAATGCTTTTTACAATGTCTATGATAATTTGAAAACCTATCACGATATCAAACTTATGAAAGAACTACTAAGTGATACTT CTGTTCCAGTCCAAAAACTTGATAGTTACGTAGCTAGTTTCAATAGTATGGATAAATTGGCACTATATAATAATAAACAC GATTTTGCTTTTGGCCTATCAATGTTTTCGAATCGAACTCAAAATTATGAAGCTATGAATAATGAAAATCTTCATGGCTG GTTTACTTCTGATGGAATGTTTTACCTATACAATAACGATTTAGGACACTACAGTGAAAACTATTGGGCAACGGTAAATC CCTACCGCTTACCTGGAACCACAGAAACTGAGCAAAAACCACTAGAGGGAACTCCTGAGAATATTAAAACGAACTATCAA CAAGTTGGCATGACTAGTCTCTCTGATGACGCTTTTGTTGCAAGTAAAAAACTTAATAACACAAGTGCTCTAGCTGCTAT GACCTTCACTAATTGGAATAAAAGCCTCACTCTCAATAAAGGGTGGTTTATCTTAGGAAACAAAATAATCTTTGTTGGTA GCAATATCAAAAACCAATCATCTCACAAGGCGTATACAACTATTGAACAACGAAAAGAGAATCAAAAGCACCCTTACCAT GCTTATGTTAACAATCAACCCGTTGACTTGAATAATCAGCTAGTTGATTTTACAAACACTAAAAGTATTTTCCTTGAAAG TGATGATTCCGCTCAAAATATTGGTTACTACTTCTTCAAGCCAACAACACTTAGCATAAGTAAGGCACTTCAAACAGGGA AATGGCAAAACATAAAAGCTGATGACAAATCACCAGAAGCCATCAAAGAAGTTTCAAATACCTTTATCACTATCATGCAA AACCATACTCAAGATGACGATCGTTATGCCTATATGATGCTTCCAAATATGACTCGTCAAGAATTTGAAAACTATATTAG CAAGCTTGATATCGACTTGTTAGAAAACAATGACAAACTGGCCGCTGTCTACGATCATGATAGTCAACAGATGCACGTCA TTCACTATGAAAAAAAAGCAACGATGTTTTCAAATCATAATCTTTCTCATCAAGGCTTTTATAGTTTTCCTCATCCTGTC AAGCAAAATCAACAATAA
Upstream 100 bases:
>100_bases TTTATGTAAGGGTTTATAAAAATACTTTAACGTGGTATATTTTTACTTAGTAAACCAATTTACTTTTATTATCTCATTTT TATATTGGAGGAATTTATCA
Downstream 100 bases:
>100_bases AAGCTTGCTCATCAAGGAATTGCAGCTAAAAACAATGCTCTTAACTCTCATAAAATTCCCCACAAAAGACAACGACGCTT ACCGCATACTGGGTATCAGT
Product: extracellular hyaluronate lyase
Products: NA
Alternate protein names: Hyaluronidase; HYase [H]
Number of amino acids: Translated: 805; Mature: 805
Protein sequence:
>805_residues MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQTLTTTDSEKKVVQPQQKDYYTELLDQWNSI IAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENRTYLWEHAKDYSASTNITKTYRNIEKIAKQITNPESCYYQD SKAIAIVKDGMAFMYEHAYNLDRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTR FRVRAANFSPFEASSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQDGSLIDHVITNAQSPLYKKG IAYTGAYGNVLIDGLSQLIPIIQKTKSPIEADKMATIYHWINHSFFPIIVRGEMMDMTQGRSISRFNAQSHVAGIEALRA ILRIADMSEEPHRLALKTRIKTLVTQGNAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYNNKH DFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGTTETEQKPLEGTPENIKTNYQ QVGMTSLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNKGWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKHPYH AYVNNQPVDLNNQLVDFTNTKSIFLESDDSAQNIGYYFFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQ NHTQDDDRYAYMMLPNMTRQEFENYISKLDIDLLENNDKLAAVYDHDSQQMHVIHYEKKATMFSNHNLSHQGFYSFPHPV KQNQQ
Sequences:
>Translated_805_residues MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQTLTTTDSEKKVVQPQQKDYYTELLDQWNSI IAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENRTYLWEHAKDYSASTNITKTYRNIEKIAKQITNPESCYYQD SKAIAIVKDGMAFMYEHAYNLDRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTR FRVRAANFSPFEASSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQDGSLIDHVITNAQSPLYKKG IAYTGAYGNVLIDGLSQLIPIIQKTKSPIEADKMATIYHWINHSFFPIIVRGEMMDMTQGRSISRFNAQSHVAGIEALRA ILRIADMSEEPHRLALKTRIKTLVTQGNAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYNNKH DFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGTTETEQKPLEGTPENIKTNYQ QVGMTSLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNKGWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKHPYH AYVNNQPVDLNNQLVDFTNTKSIFLESDDSAQNIGYYFFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQ NHTQDDDRYAYMMLPNMTRQEFENYISKLDIDLLENNDKLAAVYDHDSQQMHVIHYEKKATMFSNHNLSHQGFYSFPHPV KQNQQ >Mature_805_residues MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQTLTTTDSEKKVVQPQQKDYYTELLDQWNSI IAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENRTYLWEHAKDYSASTNITKTYRNIEKIAKQITNPESCYYQD SKAIAIVKDGMAFMYEHAYNLDRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTR FRVRAANFSPFEASSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQDGSLIDHVITNAQSPLYKKG IAYTGAYGNVLIDGLSQLIPIIQKTKSPIEADKMATIYHWINHSFFPIIVRGEMMDMTQGRSISRFNAQSHVAGIEALRA ILRIADMSEEPHRLALKTRIKTLVTQGNAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYNNKH DFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGTTETEQKPLEGTPENIKTNYQ QVGMTSLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNKGWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKHPYH AYVNNQPVDLNNQLVDFTNTKSIFLESDDSAQNIGYYFFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQ NHTQDDDRYAYMMLPNMTRQEFENYISKLDIDLLENNDKLAAVYDHDSQQMHVIHYEKKATMFSNHNLSHQGFYSFPHPV KQNQQ
Specific function: Unknown
COG id: NA
COG function: NA
Gene ontology:
Cell location: Secreted, cell wall; Peptidoglycan-anchor (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the polysaccharide lyase 8 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR008929 - InterPro: IPR008979 - InterPro: IPR011013 - InterPro: IPR014718 - InterPro: IPR014756 - InterPro: IPR019931 - InterPro: IPR011071 - InterPro: IPR012970 - InterPro: IPR004103 - InterPro: IPR003159 - InterPro: IPR012329 [H]
Pfam domain/function: PF02278 Lyase_8; PF02884 Lyase_8_C; PF08124 Lyase_8_N [H]
EC number: =4.2.2.1 [H]
Molecular weight: Translated: 92579; Mature: 92579
Theoretical pI: Translated: 6.58; Mature: 6.58
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQTLTTTDSEKK CCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCH VVQPQQKDYYTELLDQWNSIIAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENR HCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCC TYLWEHAKDYSASTNITKTYRNIEKIAKQITNPESCYYQDSKAIAIVKDGMAFMYEHAYN CEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHEEECCCEEEEEECCHHHHHHHHHC LDRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTR CCCCCCCCCCCCCCCCEEEEECCCCCHHCCCHHEEECCCCHHHHHHHHCCHHHHCCCCCC FRVRAANFSPFEASSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQ EEEEECCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEE DGSLIDHVITNAQSPLYKKGIAYTGAYGNVLIDGLSQLIPIIQKTKSPIEADKMATIYHW CCCHHHHHHHCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH INHSFFPIIVRGEMMDMTQGRSISRFNAQSHVAGIEALRAILRIADMSEEPHRLALKTRI HCCCEEEEEEECCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH KTLVTQGNAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYNNKH HHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCC DFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGT CHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEECCEECCCC TETEQKPLEGTPENIKTNYQQVGMTSLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNK CCCCCCCCCCCCHHHHCCHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCEEEECC GWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKHPYHAYVNNQPVDLNNQLVDFTNT CEEEECCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCC KSIFLESDDSAQNIGYYFFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQ CEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEEEEE NHTQDDDRYAYMMLPNMTRQEFENYISKLDIDLLENNDKLAAVYDHDSQQMHVIHYEKKA CCCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCEEEEEEEECHH TMFSNHNLSHQGFYSFPHPVKQNQQ HEECCCCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQTLTTTDSEKK CCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCH VVQPQQKDYYTELLDQWNSIIAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENR HCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCC TYLWEHAKDYSASTNITKTYRNIEKIAKQITNPESCYYQDSKAIAIVKDGMAFMYEHAYN CEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHEEECCCEEEEEECCHHHHHHHHHC LDRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTR CCCCCCCCCCCCCCCCEEEEECCCCCHHCCCHHEEECCCCHHHHHHHHCCHHHHCCCCCC FRVRAANFSPFEASSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQ EEEEECCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEE DGSLIDHVITNAQSPLYKKGIAYTGAYGNVLIDGLSQLIPIIQKTKSPIEADKMATIYHW CCCHHHHHHHCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH INHSFFPIIVRGEMMDMTQGRSISRFNAQSHVAGIEALRAILRIADMSEEPHRLALKTRI HCCCEEEEEEECCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH KTLVTQGNAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYNNKH HHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCC DFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGT CHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEECCEECCCC TETEQKPLEGTPENIKTNYQQVGMTSLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNK CCCCCCCCCCCCHHHHCCHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCEEEECC GWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKHPYHAYVNNQPVDLNNQLVDFTNT CEEEECCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCC KSIFLESDDSAQNIGYYFFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQ CEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEEEEE NHTQDDDRYAYMMLPNMTRQEFENYISKLDIDLLENNDKLAAVYDHDSQQMHVIHYEKKA CCCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCEEEEEEEECHH TMFSNHNLSHQGFYSFPHPVKQNQQ HEECCCCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11463916; 8112843; 9573623 [H]