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The map label for this gene is 18978313

Identifier: 18978313

GI number: 18978313

Start: 1793572

End: 1795095

Strand: Reverse

Name: 18978313

Synonym: PF1941

Alternate gene names: NA

Gene position: 1795095-1793572 (Counterclockwise)

Preceding gene: 18978314

Following gene: 33359584

Centisome position: 94.07

GC content: 38.91

Gene sequence:

>1524_bases
TTGAGAATTCTTCTTGTTACTGGTAGATTAGCGGAACCTCTAGTTAGAAAATACGGAAAAGGATGTGATGTTTTTGTAAC
TCCAGTTACGGTAGCTGCTTTTCTAACCCCCGAACTTATAGTGTACTATCTGAAAAAATCCAAAATAAACGTGAAGGAAT
ATGACCTAATATTGATTCCCGGTCTTGTAAAAGGATCAGCAGAAGTTATAGAGAGGGAGTTTGGGGTTCCTGCATATAAA
GGTCCAAAGAATGCTGTTGATATTCCCCAGGTGTTGAAAGCCATAAAACAGGGATTCAAGCTAAGCAAGATAGTGCCAGC
AGATGAGTTATTTTCTCAGGATGCGCTAAAGAAAGTTGAAGACATAAGAAACAAGGCTAAAAACAAGAGATACATAGAGA
AGGCTCTGAAGAGGCCTGGAAATATATTAATTGGAACTCTCCCTGTAGGGCTTGATTTCCCTACAAGGATAGTGGCTGAG
ATTGTTGACGCTCCTTCTCTAACAATAGAGGAAATAATGAGGAAAGCAAAATACTATCTAAGGGAAGGTGCTGATATAAT
CGACATAGGAATGGAAAGTGGGAAAACTAATGTGGAATTCCTTGAAAGTGTTCTTCCAGAAATCAAGGAGAAAATAAATG
CACCACTCTCCTTGGATACGCTTAACCCAAAGGAAATTGAAGCTGGGGAGAAGGAAGTAGATCTTATTTTGAGCGTTGAT
TTTGGGACAGTTGAGGAAATATTGCCCTCAAAGCCAGTAGTTTTAATTCCAACGAATATGAAGGAAGGAAAGTTTATAGA
AGATCCCATAGGAAGGGCAAAAGCGTTAGAAAAACTTAAGGAAAAGGCCCTAAATCTTGGATACAAGGGGTTGATACTTG
ACCCTATATTAGAGCATTATCCGAACTTTTCCAGGTCTCTAGTGGCGTTTTACTTATATAGGATGAGAAATCCTCAGGAT
ATTCTCCTCGCGGGGGTAGGAAATATTACCGAAATGATGGATGCAGACAGTGTGGGATTAAATGCTCTCTTGGCAAGTAT
AGCTGGTGAGCTTAAAATTTCGCTCCTTTTAACGACGGAAGTAAGCCCAAAAGCTACTGGAAGCGTTAGAGAGCTTAAAA
GAGGTATTGACATGGTTCTCTTGGGAGGAGTAAAAGACGTGGGTATTAACCTGCTTATCCTGAAAGAAAAACGAAGGAAG
GAGCAAAAGATTGAATTCGCTAAAACAATTATTAGGGCAAAGAAAAAGCCTGTAAAGTTGGAAGAAGTGTATTTTAAAAT
TTACGTTGTTGGAACAGAGCTTGCTGTAACGGCATATAAAGGAACAAATCCTGTTATGACGATCATCGGAAAGGAACCAA
ATGAAATCATAGACACAATACTAGAGCATTTTTCGATATCCCCTCGGCATGCATTTTACCTTGGTAGGGAGCTTGAGAAG
GCATATACTGGATTAAAAATAAGAAGATCCTATATTCAAGAAGAAGAGCTCTTTGGCGATTTTTATTTTGAGAAAGGTTT
ATAA

Upstream 100 bases:

>100_bases
TTTAAGCTTGCAAAGGATAAGGCATCCCTTCTAAGACTTGTTGAGGAGGCGATAACGGAAAGGTTTTTAGAGGCCCTGGG
AATGAGGGAGGGCACATAAT

Downstream 100 bases:

>100_bases
CTCATTATCGAGAAGTATAATCTGAGGGATCTTCATGCAACCAAGAAAGAAAATCAAGAAAGAGTTTGAAGAAGAAGAGG
AGCTTTTAGAAGAGATGGAG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MRILLVTGRLAEPLVRKYGKGCDVFVTPVTVAAFLTPELIVYYLKKSKINVKEYDLILIPGLVKGSAEVIEREFGVPAYK
GPKNAVDIPQVLKAIKQGFKLSKIVPADELFSQDALKKVEDIRNKAKNKRYIEKALKRPGNILIGTLPVGLDFPTRIVAE
IVDAPSLTIEEIMRKAKYYLREGADIIDIGMESGKTNVEFLESVLPEIKEKINAPLSLDTLNPKEIEAGEKEVDLILSVD
FGTVEEILPSKPVVLIPTNMKEGKFIEDPIGRAKALEKLKEKALNLGYKGLILDPILEHYPNFSRSLVAFYLYRMRNPQD
ILLAGVGNITEMMDADSVGLNALLASIAGELKISLLLTTEVSPKATGSVRELKRGIDMVLLGGVKDVGINLLILKEKRRK
EQKIEFAKTIIRAKKKPVKLEEVYFKIYVVGTELAVTAYKGTNPVMTIIGKEPNEIIDTILEHFSISPRHAFYLGRELEK
AYTGLKIRRSYIQEEELFGDFYFEKGL

Sequences:

>Translated_507_residues
MRILLVTGRLAEPLVRKYGKGCDVFVTPVTVAAFLTPELIVYYLKKSKINVKEYDLILIPGLVKGSAEVIEREFGVPAYK
GPKNAVDIPQVLKAIKQGFKLSKIVPADELFSQDALKKVEDIRNKAKNKRYIEKALKRPGNILIGTLPVGLDFPTRIVAE
IVDAPSLTIEEIMRKAKYYLREGADIIDIGMESGKTNVEFLESVLPEIKEKINAPLSLDTLNPKEIEAGEKEVDLILSVD
FGTVEEILPSKPVVLIPTNMKEGKFIEDPIGRAKALEKLKEKALNLGYKGLILDPILEHYPNFSRSLVAFYLYRMRNPQD
ILLAGVGNITEMMDADSVGLNALLASIAGELKISLLLTTEVSPKATGSVRELKRGIDMVLLGGVKDVGINLLILKEKRRK
EQKIEFAKTIIRAKKKPVKLEEVYFKIYVVGTELAVTAYKGTNPVMTIIGKEPNEIIDTILEHFSISPRHAFYLGRELEK
AYTGLKIRRSYIQEEELFGDFYFEKGL
>Mature_507_residues
MRILLVTGRLAEPLVRKYGKGCDVFVTPVTVAAFLTPELIVYYLKKSKINVKEYDLILIPGLVKGSAEVIEREFGVPAYK
GPKNAVDIPQVLKAIKQGFKLSKIVPADELFSQDALKKVEDIRNKAKNKRYIEKALKRPGNILIGTLPVGLDFPTRIVAE
IVDAPSLTIEEIMRKAKYYLREGADIIDIGMESGKTNVEFLESVLPEIKEKINAPLSLDTLNPKEIEAGEKEVDLILSVD
FGTVEEILPSKPVVLIPTNMKEGKFIEDPIGRAKALEKLKEKALNLGYKGLILDPILEHYPNFSRSLVAFYLYRMRNPQD
ILLAGVGNITEMMDADSVGLNALLASIAGELKISLLLTTEVSPKATGSVRELKRGIDMVLLGGVKDVGINLLILKEKRRK
EQKIEFAKTIIRAKKKPVKLEEVYFKIYVVGTELAVTAYKGTNPVMTIIGKEPNEIIDTILEHFSISPRHAFYLGRELEK
AYTGLKIRRSYIQEEELFGDFYFEKGL

Specific function: Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005236
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: NA

Molecular weight: Translated: 56717; Mature: 56717

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLVTGRLAEPLVRKYGKGCDVFVTPVTVAAFLTPELIVYYLKKSKINVKEYDLILIP
CEEEEEECHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GLVKGSAEVIEREFGVPAYKGPKNAVDIPQVLKAIKQGFKLSKIVPADELFSQDALKKVE
CCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHH
DIRNKAKNKRYIEKALKRPGNILIGTLPVGLDFPTRIVAEIVDAPSLTIEEIMRKAKYYL
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
REGADIIDIGMESGKTNVEFLESVLPEIKEKINAPLSLDTLNPKEIEAGEKEVDLILSVD
HCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCHHHCCCCCCEEEEEEEC
FGTVEEILPSKPVVLIPTNMKEGKFIEDPIGRAKALEKLKEKALNLGYKGLILDPILEHY
CCCHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
PNFSRSLVAFYLYRMRNPQDILLAGVGNITEMMDADSVGLNALLASIAGELKISLLLTTE
CCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHCCCCHHHHHHHHHHHCCEEEEEEEEEC
VSPKATGSVRELKRGIDMVLLGGVKDVGINLLILKEKRRKEQKIEFAKTIIRAKKKPVKL
CCCCCCCCHHHHHCCCCEEEECCCHHCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCH
EEVYFKIYVVGTELAVTAYKGTNPVMTIIGKEPNEIIDTILEHFSISPRHAFYLGRELEK
HHEEEEEEEEECEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AYTGLKIRRSYIQEEELFGDFYFEKGL
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRILLVTGRLAEPLVRKYGKGCDVFVTPVTVAAFLTPELIVYYLKKSKINVKEYDLILIP
CEEEEEECHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GLVKGSAEVIEREFGVPAYKGPKNAVDIPQVLKAIKQGFKLSKIVPADELFSQDALKKVE
CCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHH
DIRNKAKNKRYIEKALKRPGNILIGTLPVGLDFPTRIVAEIVDAPSLTIEEIMRKAKYYL
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
REGADIIDIGMESGKTNVEFLESVLPEIKEKINAPLSLDTLNPKEIEAGEKEVDLILSVD
HCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCHHHCCCCCCEEEEEEEC
FGTVEEILPSKPVVLIPTNMKEGKFIEDPIGRAKALEKLKEKALNLGYKGLILDPILEHY
CCCHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
PNFSRSLVAFYLYRMRNPQDILLAGVGNITEMMDADSVGLNALLASIAGELKISLLLTTE
CCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHCCCCHHHHHHHHHHHCCEEEEEEEEEC
VSPKATGSVRELKRGIDMVLLGGVKDVGINLLILKEKRRKEQKIEFAKTIIRAKKKPVKL
CCCCCCCCHHHHHCCCCEEEECCCHHCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCH
EEVYFKIYVVGTELAVTAYKGTNPVMTIIGKEPNEIIDTILEHFSISPRHAFYLGRELEK
HHEEEEEEEEECEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AYTGLKIRRSYIQEEELFGDFYFEKGL
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]