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The map label for this gene is rbsK [C]

Identifier: 18978258

GI number: 18978258

Start: 1739367

End: 1740251

Strand: Direct

Name: rbsK [C]

Synonym: PF1886

Alternate gene names: 18978258

Gene position: 1739367-1740251 (Clockwise)

Preceding gene: 18978257

Following gene: 18978265

Centisome position: 91.15

GC content: 40.68

Gene sequence:

>885_bases
ATGAAACTAGACGTAATATGCATGGGAAATCTCAACTACGACATAACCTTTATGCTAGAAAGATTCCCTGAGTTCCACGA
AAAAGTAAATGCCAAAAAAGTTTACACAGGCTTAGGAGGTTCTGCAGGGAATACAGCAACTTGGTTGTCCTTCCTGGGAT
TAAGAGTCGGGTTCATTGGAGCTGTAGGAAATGATGACTTTGGAAGGCTACACTTGGAATTTTTCGAAAAGATAGGGGTA
GATACCAGGGGGATTAAAGTTGTAGATGAACCAACTGGAGTTGCCGTAATGATGGTAATTGGAGAAGATAAGAGGATTGT
CAAATACCCAGGAGCTAATAGATTTAAGGAAGTAAAGGAAAATTACCTAAAGCTCGCAAGACACCTTCACCTTTCTTCAA
ACCCTCTTCCACTTGTTGAAAAGGCCGTAAATTTAGCCAAAAATCTTGGTCTAACAGTGTCCTTCGACCCAGGTGAAATG
GAGGTTCCTAAGCATATTGAAGAAAAGATTGACATTCTAATGATGAATGAAGACGAATTCAAGAGGAAGTACGGAAGCTT
AGAAAAAATAACGGAGTTAAAGTCCAGAATAGCTATAGCAACTCTCAATGGTGGTGGAGCTTTAGTTAGGGATGAGAATG
GAAATGTTTATGAGATAAGAGGACTATCTGCAAAGGCCATCGATACAACTGGTGGAGGAGATTCCTTCGATGCTGGATTT
ATCTACGGCTATCTAAATGGATGGGATGTAAAGGATTCTGCCAAACTCGGAATGTTACTCGCCTATCTAACTGTCCAAAA
GGTGGGAGCGAGAAGTGCAGTAATTCCACTGGATGAAGTCAAAAAGATAGCAAAAGAGCTGGGCCTAGATCTACCATTTC
AATAA

Upstream 100 bases:

>100_bases
AAAAATATTCTTGGGACAAGATTGTTGTAGAGATAGAGAGAATTTACAGCGAAGTTTTGGAAGAGCAATCTTAATATATT
TTAGCCTTACATCTTCTCTT

Downstream 100 bases:

>100_bases
CTCTTAAGTCCAATCTCTCTTGCCCTTCTTTCTGCCCACCTGTAAGTGAGAACGCCCAACAATGTGTATATAATTGATAT
TAAGCTCAGATACATTATTT

Product: sugar kinase

Products: ADP; D-ribose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKLDVICMGNLNYDITFMLERFPEFHEKVNAKKVYTGLGGSAGNTATWLSFLGLRVGFIGAVGNDDFGRLHLEFFEKIGV
DTRGIKVVDEPTGVAVMMVIGEDKRIVKYPGANRFKEVKENYLKLARHLHLSSNPLPLVEKAVNLAKNLGLTVSFDPGEM
EVPKHIEEKIDILMMNEDEFKRKYGSLEKITELKSRIAIATLNGGGALVRDENGNVYEIRGLSAKAIDTTGGGDSFDAGF
IYGYLNGWDVKDSAKLGMLLAYLTVQKVGARSAVIPLDEVKKIAKELGLDLPFQ

Sequences:

>Translated_294_residues
MKLDVICMGNLNYDITFMLERFPEFHEKVNAKKVYTGLGGSAGNTATWLSFLGLRVGFIGAVGNDDFGRLHLEFFEKIGV
DTRGIKVVDEPTGVAVMMVIGEDKRIVKYPGANRFKEVKENYLKLARHLHLSSNPLPLVEKAVNLAKNLGLTVSFDPGEM
EVPKHIEEKIDILMMNEDEFKRKYGSLEKITELKSRIAIATLNGGGALVRDENGNVYEIRGLSAKAIDTTGGGDSFDAGF
IYGYLNGWDVKDSAKLGMLLAYLTVQKVGARSAVIPLDEVKKIAKELGLDLPFQ
>Mature_294_residues
MKLDVICMGNLNYDITFMLERFPEFHEKVNAKKVYTGLGGSAGNTATWLSFLGLRVGFIGAVGNDDFGRLHLEFFEKIGV
DTRGIKVVDEPTGVAVMMVIGEDKRIVKYPGANRFKEVKENYLKLARHLHLSSNPLPLVEKAVNLAKNLGLTVSFDPGEM
EVPKHIEEKIDILMMNEDEFKRKYGSLEKITELKSRIAIATLNGGGALVRDENGNVYEIRGLSAKAIDTTGGGDSFDAGF
IYGYLNGWDVKDSAKLGMLLAYLTVQKVGARSAVIPLDEVKKIAKELGLDLPFQ

Specific function: Ribose metabolism; first step. [C]

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family [H]

Homologues:

Organism=Homo sapiens, GI11545855, Length=290, Percent_Identity=24.4827586206897, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1790193, Length=291, Percent_Identity=24.0549828178694, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87082343, Length=299, Percent_Identity=25.4180602006689, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532905, Length=305, Percent_Identity=24.2622950819672, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319884, Length=338, Percent_Identity=26.0355029585799, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR002139 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: 2.7.1.15

Molecular weight: Translated: 32419; Mature: 32419

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00583 PFKB_KINASES_1 ; PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDVICMGNLNYDITFMLERFPEFHEKVNAKKVYTGLGGSAGNTATWLSFLGLRVGFIG
CEEEEEEECCCCCEEEHHHHHHHHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHHHHEEE
AVGNDDFGRLHLEFFEKIGVDTRGIKVVDEPTGVAVMMVIGEDKRIVKYPGANRFKEVKE
ECCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCCEEEECCCCHHHHHHHH
NYLKLARHLHLSSNPLPLVEKAVNLAKNLGLTVSFDPGEMEVPKHIEEKIDILMMNEDEF
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHCCEEEEEECCHHH
KRKYGSLEKITELKSRIAIATLNGGGALVRDENGNVYEIRGLSAKAIDTTGGGDSFDAGF
HHHHCCHHHHHHHHHCEEEEEECCCEEEEECCCCCEEEEECCCEEEEECCCCCCCCCCCE
IYGYLNGWDVKDSAKLGMLLAYLTVQKVGARSAVIPLDEVKKIAKELGLDLPFQ
EEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKLDVICMGNLNYDITFMLERFPEFHEKVNAKKVYTGLGGSAGNTATWLSFLGLRVGFIG
CEEEEEEECCCCCEEEHHHHHHHHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHHHHEEE
AVGNDDFGRLHLEFFEKIGVDTRGIKVVDEPTGVAVMMVIGEDKRIVKYPGANRFKEVKE
ECCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCCEEEECCCCHHHHHHHH
NYLKLARHLHLSSNPLPLVEKAVNLAKNLGLTVSFDPGEMEVPKHIEEKIDILMMNEDEF
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHCCEEEEEECCHHH
KRKYGSLEKITELKSRIAIATLNGGGALVRDENGNVYEIRGLSAKAIDTTGGGDSFDAGF
HHHHCCHHHHHHHHHCEEEEEECCCEEEEECCCCCEEEEECCCEEEEECCCCCCCCCCCE
IYGYLNGWDVKDSAKLGMLLAYLTVQKVGARSAVIPLDEVKKIAKELGLDLPFQ
EEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; D-ribose

Specific reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate

General reaction: Phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]