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The map label for this gene is rfbB [C]

Identifier: 18978160

GI number: 18978160

Start: 1662412

End: 1663335

Strand: Reverse

Name: rfbB [C]

Synonym: PF1788

Alternate gene names: 18978160

Gene position: 1663335-1662412 (Counterclockwise)

Preceding gene: 18978165

Following gene: 18978159

Centisome position: 87.17

GC content: 39.39

Gene sequence:

>924_bases
ATGAAGAATAAGTTAGTTGTTGTAACGGGAGGAGCGGGGTTCATAGGATCCCACATAGCTGAGGCCTTGGTTGAAGAGAA
TGAAGTTATTGTTATTGATAACCTGTACTCTGGAAAAATTGAAAACATCCCCCAGGGTGCAAAATTCATTGAGGCTGATA
TAAGGGATTACTCTTCAATAGCTGAGATAATAAGGGAAGCCGACTATGTTTTCCATGAGGCTGCTCAAATAAGCGTTGAG
GAGAGTGTTAGGGATCCTATCTTTACGGATGAAGTCAACGTTATTGGAACTTTGAATATTTTGAAAGCCCTAAGTGAGGG
GTCAGGAAAGATAATTTTTGCATCTTCTGCTGCTGTTTATGGAGAGAATAAGAACCTTCCACTTAAGGAGGATTATCTAC
CGAAGCCGATATCTCCATATGGAGTTAGCAAATTGGCAGGAGAGCATTATGTTAGGGTATTTTACGAGCTCTATGGAGTC
CCTGGTGTTATTCTTCGTTATTTTAACGTTTATGGTCCAAGGCAGAGTTCAGCATATGCTGGAGTGATAAGCATTTTCAT
GAAGAATGCCCTTAAAAATGAACCTTTAGTTATCTTTGGAGACGGAAAGCAAACGAGGGACTTTATATATGTAAAAGACG
TCGTTCAGGCCAATTTATTAGTTGCTGAGAAAGAGAGAGCCAATGGAAAGATTTTCAACGTTGCCACTGGAAAGGAAACA
TCGATACTTGAGCTGGCCTTAAAGATTATAGACCTCACAAGCTCCTCTTCTCAAATTTTATTTGCTCCTGAACGGCCTGG
GGATATAAAGAGAAGTGTTGCAGATATAAATGAAATTAGAAAGCTTGGATTCGAGCCTTCTTATTCTCTAGAGGAGGGGT
TAAAGGAAACACTTGAATGGTTTAAAAAATGGAAATACTTTTAA

Upstream 100 bases:

>100_bases
TAAACTAGTGTTTCATCTACATCGAATATAACCCCTTTGATCATTTCAAACCCCAAAATCCTTTTATCTCAGAAACTTAA
ATCAGTTCCGGGTTCGAAAA

Downstream 100 bases:

>100_bases
CTACATGAAATTATTTGGAATTGTCAAGATTATGAGGTGAATTGAGATGGACAGGGTTGCTAAGGCTAGGGAAATTATCG
AAAAGGCAAAAGCTGAAAAT

Product: NDP-sugar dehydratase or epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKNKLVVVTGGAGFIGSHIAEALVEENEVIVIDNLYSGKIENIPQGAKFIEADIRDYSSIAEIIREADYVFHEAAQISVE
ESVRDPIFTDEVNVIGTLNILKALSEGSGKIIFASSAAVYGENKNLPLKEDYLPKPISPYGVSKLAGEHYVRVFYELYGV
PGVILRYFNVYGPRQSSAYAGVISIFMKNALKNEPLVIFGDGKQTRDFIYVKDVVQANLLVAEKERANGKIFNVATGKET
SILELALKIIDLTSSSSQILFAPERPGDIKRSVADINEIRKLGFEPSYSLEEGLKETLEWFKKWKYF

Sequences:

>Translated_307_residues
MKNKLVVVTGGAGFIGSHIAEALVEENEVIVIDNLYSGKIENIPQGAKFIEADIRDYSSIAEIIREADYVFHEAAQISVE
ESVRDPIFTDEVNVIGTLNILKALSEGSGKIIFASSAAVYGENKNLPLKEDYLPKPISPYGVSKLAGEHYVRVFYELYGV
PGVILRYFNVYGPRQSSAYAGVISIFMKNALKNEPLVIFGDGKQTRDFIYVKDVVQANLLVAEKERANGKIFNVATGKET
SILELALKIIDLTSSSSQILFAPERPGDIKRSVADINEIRKLGFEPSYSLEEGLKETLEWFKKWKYF
>Mature_307_residues
MKNKLVVVTGGAGFIGSHIAEALVEENEVIVIDNLYSGKIENIPQGAKFIEADIRDYSSIAEIIREADYVFHEAAQISVE
ESVRDPIFTDEVNVIGTLNILKALSEGSGKIIFASSAAVYGENKNLPLKEDYLPKPISPYGVSKLAGEHYVRVFYELYGV
PGVILRYFNVYGPRQSSAYAGVISIFMKNALKNEPLVIFGDGKQTRDFIYVKDVVQANLLVAEKERANGKIFNVATGKET
SILELALKIIDLTSSSSQILFAPERPGDIKRSVADINEIRKLGFEPSYSLEEGLKETLEWFKKWKYF

Specific function: DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=307, Percent_Identity=34.2019543973941, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI7657641, Length=327, Percent_Identity=37.6146788990826, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI56237023, Length=335, Percent_Identity=27.7611940298507, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI56118217, Length=335, Percent_Identity=27.7611940298507, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI189083684, Length=335, Percent_Identity=27.7611940298507, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI116268111, Length=275, Percent_Identity=28.7272727272727, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4504031, Length=339, Percent_Identity=25.0737463126844, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI193211614, Length=247, Percent_Identity=27.1255060728745, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI8393516, Length=247, Percent_Identity=27.1255060728745, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788353, Length=341, Percent_Identity=31.0850439882698, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI48994969, Length=334, Percent_Identity=29.940119760479, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1786974, Length=326, Percent_Identity=30.9815950920245, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1790049, Length=320, Percent_Identity=29.6875, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1788589, Length=339, Percent_Identity=25.6637168141593, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788365, Length=230, Percent_Identity=26.0869565217391, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788366, Length=270, Percent_Identity=27.037037037037, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17568069, Length=328, Percent_Identity=33.2317073170732, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17539532, Length=307, Percent_Identity=27.6872964169381, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI115532424, Length=325, Percent_Identity=28.6153846153846, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71982035, Length=340, Percent_Identity=27.3529411764706, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=342, Percent_Identity=27.1929824561404, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17507723, Length=345, Percent_Identity=24.3478260869565, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=268, Percent_Identity=26.865671641791, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=269, Percent_Identity=26.7657992565056, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=269, Percent_Identity=26.7657992565056, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539422, Length=268, Percent_Identity=26.865671641791, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=268, Percent_Identity=26.865671641791, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=338, Percent_Identity=26.6272189349112, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21356223, Length=306, Percent_Identity=31.6993464052288, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19923002, Length=339, Percent_Identity=27.4336283185841, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24158427, Length=281, Percent_Identity=26.6903914590747, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34144; Mature: 34144

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKLVVVTGGAGFIGSHIAEALVEENEVIVIDNLYSGKIENIPQGAKFIEADIRDYSSI
CCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
AEIIREADYVFHEAAQISVEESVRDPIFTDEVNVIGTLNILKALSEGSGKIIFASSAAVY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECEEEE
GENKNLPLKEDYLPKPISPYGVSKLAGEHYVRVFYELYGVPGVILRYFNVYGPRQSSAYA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHH
GVISIFMKNALKNEPLVIFGDGKQTRDFIYVKDVVQANLLVAEKERANGKIFNVATGKET
HHHHHHHHHHHCCCCEEEECCCCCCCCEEEEHHHHHHHHEEEECCCCCCCEEEEECCCCH
SILELALKIIDLTSSSSQILFAPERPGDIKRSVADINEIRKLGFEPSYSLEEGLKETLEW
HHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
FKKWKYF
HHHHCCC
>Mature Secondary Structure
MKNKLVVVTGGAGFIGSHIAEALVEENEVIVIDNLYSGKIENIPQGAKFIEADIRDYSSI
CCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
AEIIREADYVFHEAAQISVEESVRDPIFTDEVNVIGTLNILKALSEGSGKIIFASSAAVY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECEEEE
GENKNLPLKEDYLPKPISPYGVSKLAGEHYVRVFYELYGVPGVILRYFNVYGPRQSSAYA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHH
GVISIFMKNALKNEPLVIFGDGKQTRDFIYVKDVVQANLLVAEKERANGKIFNVATGKET
HHHHHHHHHHHCCCCEEEECCCCCCCCEEEEHHHHHHHHEEEECCCCCCCEEEEECCCCH
SILELALKIIDLTSSSSQILFAPERPGDIKRSVADINEIRKLGFEPSYSLEEGLKETLEW
HHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
FKKWKYF
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]