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The map label for this gene is purR [H]

Identifier: 18978107

GI number: 18978107

Start: 1610860

End: 1611573

Strand: Reverse

Name: purR [H]

Synonym: PF1735

Alternate gene names: 18978107

Gene position: 1611573-1610860 (Counterclockwise)

Preceding gene: 33359572

Following gene: 18978099

Centisome position: 84.45

GC content: 39.08

Gene sequence:

>714_bases
ATGAATCAACTTGAAGCGGTGAGAGAAAAGCTTAGGGTAATCAGGATGTTAAGGGTTTTAAAGAAAACATACACATATGA
AGATTTATCGGAGATTACTGGTCTCCCAGTAACAGTTCTCAATAGATATGTGAAAGGGAAAGTTCTTCCTAGTGTTGAGA
GAGCACGAGAGTTGTTTGAAAAGCTATCCCCCTATTTAAACTTGGAGGAAGAAGTGAAAAAGAGACTGAGATTTGATTCG
CATGGATTCTTTGATTCTATGAGCGTATTAAGTGATACAAACTTATTGGCTCTAATTTCTGAGGATGTTGCTTTGAAGTA
CATGAAGGTGGGAGTTGAAAAAATATTAACCGCGGCAACCGATGGCATTCCTTTAGCAGTTCAGATTGCGAATGAATTAG
GAGTTGATGTTGTTTATGCAAAGAAGAAGAAAGAGGTTGGAGTTGAAAGATTCTACGAAGTTAACTATATTCCAAGCGCT
TCAGGAAGTATCACAACCCTTTATCTTCCCACCTGGGCACTCAAAAAGGGGGAGAGAGTTTTAATAGTTGATGATGTTGT
CAGAAGTGGAGAAACTCAAAGAGCTCTAGTAGAGCTTTGCAGGCAGGCAGGAGCAATTCCAGTTGGAATGTTCTTCTTAA
TAAGTGTTGGTGATATTGTAGAAAGGCTCAAAGAAGAATACAACATTCCAGTAGAGGCACTGGTTAACCTCTAA

Upstream 100 bases:

>100_bases
TGGGTTTTTAAGGATTTCGAAGACTTCTTTGCTTTCTTTCCAAACCTTTCCGAAACTCATTTATACAAATTTTTGTTAAC
TTAAGATGGGGTGGCGGAGA

Downstream 100 bases:

>100_bases
GGTTCTAGTCTGAAGTCTTCTTTCACTATTTCTAATGCAACATGTGTATTTGTTTTTTCAACTCCATCAACGCTTAGCAC
GCTCTTTACGAACCTGTTCA

Product: adenine phosphoribosyltransferase

Products: AMP; Diphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNQLEAVREKLRVIRMLRVLKKTYTYEDLSEITGLPVTVLNRYVKGKVLPSVERARELFEKLSPYLNLEEEVKKRLRFDS
HGFFDSMSVLSDTNLLALISEDVALKYMKVGVEKILTAATDGIPLAVQIANELGVDVVYAKKKKEVGVERFYEVNYIPSA
SGSITTLYLPTWALKKGERVLIVDDVVRSGETQRALVELCRQAGAIPVGMFFLISVGDIVERLKEEYNIPVEALVNL

Sequences:

>Translated_237_residues
MNQLEAVREKLRVIRMLRVLKKTYTYEDLSEITGLPVTVLNRYVKGKVLPSVERARELFEKLSPYLNLEEEVKKRLRFDS
HGFFDSMSVLSDTNLLALISEDVALKYMKVGVEKILTAATDGIPLAVQIANELGVDVVYAKKKKEVGVERFYEVNYIPSA
SGSITTLYLPTWALKKGERVLIVDDVVRSGETQRALVELCRQAGAIPVGMFFLISVGDIVERLKEEYNIPVEALVNL
>Mature_237_residues
MNQLEAVREKLRVIRMLRVLKKTYTYEDLSEITGLPVTVLNRYVKGKVLPSVERARELFEKLSPYLNLEEEVKKRLRFDS
HGFFDSMSVLSDTNLLALISEDVALKYMKVGVEKILTAATDGIPLAVQIANELGVDVVYAKKKKEVGVERFYEVNYIPSA
SGSITTLYLPTWALKKGERVLIVDDVVRSGETQRALVELCRQAGAIPVGMFFLISVGDIVERLKEEYNIPVEALVNL

Specific function: Controls the transcription of the pur operon for purine biosynthetic genes [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR015265
- InterPro:   IPR010078
- InterPro:   IPR011991
- ProDom:   PD029816 [H]

Pfam domain/function: PF00156 Pribosyltran; PF09182 PuR_N [H]

EC number: 2.4.2.7 [C]

Molecular weight: Translated: 26741; Mature: 26741

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLEAVREKLRVIRMLRVLKKTYTYEDLSEITGLPVTVLNRYVKGKVLPSVERARELFE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHH
KLSPYLNLEEEVKKRLRFDSHGFFDSMSVLSDTNLLALISEDVALKYMKVGVEKILTAAT
HHCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DGIPLAVQIANELGVDVVYAKKKKEVGVERFYEVNYIPSASGSITTLYLPTWALKKGERV
CCCCEEEEEHHHHCCEEEEECHHHHHHHHHHHEECCCCCCCCCEEEEEECHHHHCCCCEE
LIVDDVVRSGETQRALVELCRQAGAIPVGMFFLISVGDIVERLKEEYNIPVEALVNL
EEEHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure
MNQLEAVREKLRVIRMLRVLKKTYTYEDLSEITGLPVTVLNRYVKGKVLPSVERARELFE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHH
KLSPYLNLEEEVKKRLRFDSHGFFDSMSVLSDTNLLALISEDVALKYMKVGVEKILTAAT
HHCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DGIPLAVQIANELGVDVVYAKKKKEVGVERFYEVNYIPSASGSITTLYLPTWALKKGERV
CCCCEEEEEHHHHCCEEEEECHHHHHHHHHHHEECCCCCCCCCEEEEEECHHHHCCCCEE
LIVDDVVRSGETQRALVELCRQAGAIPVGMFFLISVGDIVERLKEEYNIPVEALVNL
EEEHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): 560 [C]

Specific activity: 14

Km value (mM): 0.125 {5-phospho-alpha-D-ribose} 0.02 {adenine}} [C]

Substrates: Adenine; 5-Phospho-alpha-D-ribose 1-diphosphate [C]

Specific reaction: Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate --> AMP + Diphosphate [C]

General reaction: Pentosyl group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]