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The map label for this gene is trpE [H]

Identifier: 18978081

GI number: 18978081

Start: 1586803

End: 1588101

Strand: Reverse

Name: trpE [H]

Synonym: PF1709

Alternate gene names: 18978081

Gene position: 1588101-1586803 (Counterclockwise)

Preceding gene: 18978082

Following gene: 18978080

Centisome position: 83.22

GC content: 39.57

Gene sequence:

>1299_bases
ATGCTTATCAAAGAGTTAGATCGAGTGTCTCCTCTTCGCTTATACCTTATTCTCAGACAACTTGAGTATCCTTTTATCCT
AATGTCAGCAGAAAAGCATAGCAAAAAGGCCAGATTCACTTACCTCTCAGCAGCACCTGAATTCATTGTGAGTATAAATG
AGAGAGGAACTTATTTAGATGGAAAAAAGGTATCAAAAGAAAGAAATCCATTTAAGGGGTTAAAGGGCTTTATAAAGCAC
TCAATAAGTGGAGAAAGATTCATGGGCGGCTTGGTTGGATATATAGCTTATGATGCCGTTCACAACTACATAGAGGGGAA
TGTTGAGGAGCCTTCAGTTTTTGGCTATTATCCATGGACATACATTTATGATCATTTAGAAAATAAACTCTACTTTGTTT
CCCTAGAAGAACCGCCATTTGATCCAGAAGCTATAGTGGAAAAGGCCAAAAGGGCAAAAATTCCCAGAGAGGATGGAGGA
AGTTCAATTTTAAAAACTGATGCAAATAAAGAAGAGTTTGTTGAAATTGTAGAAAAAGGAAAAGAGTACATATTTTCAGG
AGACGTATTTCAAGTAGTCCTTTCGAGAGAGTACGTAGTTGAGACGGACTTAGATCCTTTTACAATCTACCTTAGATTGC
TAGACATTAATCCATCGCCTTATACTTTTCTCCTTGAATTTGAAAAAGTAGTGGTGGGAGCGTCTCCTGAAACAATGGGC
TCTGTTGAAGGAAAAATTGTTAAGATAAACCCAATTGCCGGAACTATTCCAAGGGGAAAGAACGAGGAAGAAGACAAGGC
ACTTGAAAAAGCCCTACTCTCTGATGAGAAAGAAAGAGCGGAGCATGTAATGCTAGTGGATTTAGCTAGAAATGACGTTA
GGAGAGTTTCGAAACCCAGGAGTGTTAAGGTAGTGAGGTACTTTGATGTGGTCAAGTATAGCTATGTCCAGCACATTGAA
AGTGAGATAATTGGGGAGTTGGCCGAGGATAAAGACATGTTTGATGCAATTGAGGCAACTTTCCCAGCTGGAACATTGAC
AGGAGCTCCAAAAATTAGGGCAATGGAAATTATAGATGAACTGGAAAAAAGCAGGAGAAGAGTTTATGGAGGAGCTGTTG
GATATTTTTCCGTAACAGGCTATGCAGATTTTGCCATAGCGATAAGAATGGCGGAAATAGATAAGCACGCTCACATTAGA
GCGGGAGCAGGTATAGTTGCAGATTCAATTCCAGAAAAGGAGTTTTATGAAACTGAAAACAAGATGAGGGCTGTTCTAAA
AGCCTTTGGGGTGGAGTAG

Upstream 100 bases:

>100_bases
CACTTTATACAATAGGGATCGCCTCTGATTTGAAAGAAGGAGTAGAACTGGCTGAGAATGTTCTAGGAGAAAAAATAATA
AAGAAATTGGAGGAGATTGC

Downstream 100 bases:

>100_bases
CATGATTCTAATAATCAACAATAGAGATTCTTTTGTCTGGAATCTCGCTGAATACGTATCATTCTTTGATGAAGCAGTAG
TAGTTTCTAACAAGATAACC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MLIKELDRVSPLRLYLILRQLEYPFILMSAEKHSKKARFTYLSAAPEFIVSINERGTYLDGKKVSKERNPFKGLKGFIKH
SISGERFMGGLVGYIAYDAVHNYIEGNVEEPSVFGYYPWTYIYDHLENKLYFVSLEEPPFDPEAIVEKAKRAKIPREDGG
SSILKTDANKEEFVEIVEKGKEYIFSGDVFQVVLSREYVVETDLDPFTIYLRLLDINPSPYTFLLEFEKVVVGASPETMG
SVEGKIVKINPIAGTIPRGKNEEEDKALEKALLSDEKERAEHVMLVDLARNDVRRVSKPRSVKVVRYFDVVKYSYVQHIE
SEIIGELAEDKDMFDAIEATFPAGTLTGAPKIRAMEIIDELEKSRRRVYGGAVGYFSVTGYADFAIAIRMAEIDKHAHIR
AGAGIVADSIPEKEFYETENKMRAVLKAFGVE

Sequences:

>Translated_432_residues
MLIKELDRVSPLRLYLILRQLEYPFILMSAEKHSKKARFTYLSAAPEFIVSINERGTYLDGKKVSKERNPFKGLKGFIKH
SISGERFMGGLVGYIAYDAVHNYIEGNVEEPSVFGYYPWTYIYDHLENKLYFVSLEEPPFDPEAIVEKAKRAKIPREDGG
SSILKTDANKEEFVEIVEKGKEYIFSGDVFQVVLSREYVVETDLDPFTIYLRLLDINPSPYTFLLEFEKVVVGASPETMG
SVEGKIVKINPIAGTIPRGKNEEEDKALEKALLSDEKERAEHVMLVDLARNDVRRVSKPRSVKVVRYFDVVKYSYVQHIE
SEIIGELAEDKDMFDAIEATFPAGTLTGAPKIRAMEIIDELEKSRRRVYGGAVGYFSVTGYADFAIAIRMAEIDKHAHIR
AGAGIVADSIPEKEFYETENKMRAVLKAFGVE
>Mature_432_residues
MLIKELDRVSPLRLYLILRQLEYPFILMSAEKHSKKARFTYLSAAPEFIVSINERGTYLDGKKVSKERNPFKGLKGFIKH
SISGERFMGGLVGYIAYDAVHNYIEGNVEEPSVFGYYPWTYIYDHLENKLYFVSLEEPPFDPEAIVEKAKRAKIPREDGG
SSILKTDANKEEFVEIVEKGKEYIFSGDVFQVVLSREYVVETDLDPFTIYLRLLDINPSPYTFLLEFEKVVVGASPETMG
SVEGKIVKINPIAGTIPRGKNEEEDKALEKALLSDEKERAEHVMLVDLARNDVRRVSKPRSVKVVRYFDVVKYSYVQHIE
SEIIGELAEDKDMFDAIEATFPAGTLTGAPKIRAMEIIDELEKSRRRVYGGAVGYFSVTGYADFAIAIRMAEIDKHAHIR
AGAGIVADSIPEKEFYETENKMRAVLKAFGVE

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=280, Percent_Identity=42.1428571428571, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1788114, Length=436, Percent_Identity=31.1926605504587, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1786809, Length=267, Percent_Identity=28.0898876404494, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87082077, Length=267, Percent_Identity=24.7191011235955, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320935, Length=461, Percent_Identity=36.4425162689805, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6324361, Length=395, Percent_Identity=24.5569620253165, Blast_Score=107, Evalue=4e-24,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR010116
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 49020; Mature: 49020

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIKELDRVSPLRLYLILRQLEYPFILMSAEKHSKKARFTYLSAAPEFIVSINERGTYLD
CCCHHHHCCCHHHHHHHHHHCCCCEEEEECHHCCCCCEEEEEECCCEEEEEECCCCCCCC
GKKVSKERNPFKGLKGFIKHSISGERFMGGLVGYIAYDAVHNYIEGNVEEPSVFGYYPWT
CHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHH
YIYDHLENKLYFVSLEEPPFDPEAIVEKAKRAKIPREDGGSSILKTDANKEEFVEIVEKG
HHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHC
KEYIFSGDVFQVVLSREYVVETDLDPFTIYLRLLDINPSPYTFLLEFEKVVVGASPETMG
HHEEECCHHHHHHHCCCEEEECCCCCEEEEEEEEECCCCCEEEEEEEEEEEECCCCCCCC
SVEGKIVKINPIAGTIPRGKNEEEDKALEKALLSDEKERAEHVMLVDLARNDVRRVSKPR
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHEEEEEEHHHHHHHHHCCCC
SVKVVRYFDVVKYSYVQHIESEIIGELAEDKDMFDAIEATFPAGTLTGAPKIRAMEIIDE
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LEKSRRRVYGGAVGYFSVTGYADFAIAIRMAEIDKHAHIRAGAGIVADSIPEKEFYETEN
HHHHHHHHHCCEEEEEEECCCEEEEEEEEHHHHCCCCEEECCCCHHHCCCCCHHHHHHHH
KMRAVLKAFGVE
HHHHHHHHHCCC
>Mature Secondary Structure
MLIKELDRVSPLRLYLILRQLEYPFILMSAEKHSKKARFTYLSAAPEFIVSINERGTYLD
CCCHHHHCCCHHHHHHHHHHCCCCEEEEECHHCCCCCEEEEEECCCEEEEEECCCCCCCC
GKKVSKERNPFKGLKGFIKHSISGERFMGGLVGYIAYDAVHNYIEGNVEEPSVFGYYPWT
CHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHH
YIYDHLENKLYFVSLEEPPFDPEAIVEKAKRAKIPREDGGSSILKTDANKEEFVEIVEKG
HHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHC
KEYIFSGDVFQVVLSREYVVETDLDPFTIYLRLLDINPSPYTFLLEFEKVVVGASPETMG
HHEEECCHHHHHHHCCCEEEECCCCCEEEEEEEEECCCCCEEEEEEEEEEEECCCCCCCC
SVEGKIVKINPIAGTIPRGKNEEEDKALEKALLSDEKERAEHVMLVDLARNDVRRVSKPR
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHEEEEEEHHHHHHHHHCCCC
SVKVVRYFDVVKYSYVQHIESEIIGELAEDKDMFDAIEATFPAGTLTGAPKIRAMEIIDE
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LEKSRRRVYGGAVGYFSVTGYADFAIAIRMAEIDKHAHIRAGAGIVADSIPEKEFYETEN
HHHHHHHHHCCEEEEEEECCCEEEEEEEEHHHHCCCCEEECCCCHHHCCCCCHHHHHHHH
KMRAVLKAFGVE
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10628865 [H]