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The map label for this gene is mvk

Identifier: 18978009

GI number: 18978009

Start: 1528186

End: 1529190

Strand: Reverse

Name: mvk

Synonym: PF1637

Alternate gene names: 18978009

Gene position: 1529190-1528186 (Counterclockwise)

Preceding gene: 18978010

Following gene: 18978008

Centisome position: 80.14

GC content: 41.69

Gene sequence:

>1005_bases
ATGAAAGTTATAGCCTCAGCTCCCGCAAAAGTTATTCTTTTTGGAGAGCATAGCGTAGTTTACGGAAAGCCAGCGATAGC
TGCTGCCATTGATTTACGAACTTTTGTGGAGGCTGAGCTAATTCGGGAGAAAAAAATAAGAATTGAAGCTCATGACATTA
AAGTTCCTGGACTTACGGTTTCATTTTCTGAAAATGAGATATATTTCGAGACAGATTATGGAAAAGCAGCTGAAGTTTTG
AGCTATGTTAGAGAGGCAATAAATTTAGTTTTAGAGGAGGCAGATAAGAAAAATGTTGGTATTAAGGTTAGCATAACTTC
TCAAATTCCAGTTGGTGCTGGATTGGGCTCTTCTGCTGCCGTGGCAGTAGCCACAATTGGGGCTGTATCAAAGTTACTAG
GACTTGAGCTAAGTAAGGAGGAAATAGCTAAGATGGGTCACAAGACTGAATTACTTGTTCAAGGTGCGTCAAGTGGTATA
GACCCAACGGTCTCTGCAATAGGGGGGTTTATATTCTATGAAAAGGGTAAATTTGAACACCTTCCCTTCATGGAGCTTCC
AATAGTTGTTGGATACACGGGCTCCTCAGGTCCAACTAAGGAGTTAGTTGCAATGGTTAGGAAAAGATATGAGGAGATGC
CCGAGTTGATTGTTCCCATATTAGAGGCTATGGGAAAAGTTGTCGAGAAAGCCAAGGATGTAATACTTTCAAATGTTGAT
AAGGAGGAAAAATTTGAAAGGCTTGGGGTTTTGATGAACATTAATCACGGTCTTTTAGATGCTTTGGGTGTTTCAACTAA
AAAGTTGAGTGAACTAGTGTACGCGGCTAGGGTTGCGGGAGCCCTAGGAGCTAAGATAACTGGGGCTGGGGGAGGAGGTT
GTATGTATGCCTTGGCACCGAACAAGCAGAGAGAAGTTGCTACAGCTATAAGAATTGCAGGGGGAACTCCTATGATAACT
GAAATCAGCAGAGAAGGGTTAAAAATTGAGGAGGTAATTAAATGA

Upstream 100 bases:

>100_bases
GAGCTTCTTCACTACACTACGAGCTTTGAAGTTAGTCGGAGCACAGATGCAATAGTGGGATACGCTAGCATAGTAATGAG
GAAGGCTTGAGGGGGTTAAG

Downstream 100 bases:

>100_bases
TCCTTGTAAAAATCGGAGGAAGTGTAATTAGCGATAAAACAAGGAAATTTCACTTCAGAGCAGAAGTAGTCAAGAGAATC
GCCTATGAGATTTCGAGATT

Product: mevalonate kinase

Products: NA

Alternate protein names: MK

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKVIASAPAKVILFGEHSVVYGKPAIAAAIDLRTFVEAELIREKKIRIEAHDIKVPGLTVSFSENEIYFETDYGKAAEVL
SYVREAINLVLEEADKKNVGIKVSITSQIPVGAGLGSSAAVAVATIGAVSKLLGLELSKEEIAKMGHKTELLVQGASSGI
DPTVSAIGGFIFYEKGKFEHLPFMELPIVVGYTGSSGPTKELVAMVRKRYEEMPELIVPILEAMGKVVEKAKDVILSNVD
KEEKFERLGVLMNINHGLLDALGVSTKKLSELVYAARVAGALGAKITGAGGGGCMYALAPNKQREVATAIRIAGGTPMIT
EISREGLKIEEVIK

Sequences:

>Translated_334_residues
MKVIASAPAKVILFGEHSVVYGKPAIAAAIDLRTFVEAELIREKKIRIEAHDIKVPGLTVSFSENEIYFETDYGKAAEVL
SYVREAINLVLEEADKKNVGIKVSITSQIPVGAGLGSSAAVAVATIGAVSKLLGLELSKEEIAKMGHKTELLVQGASSGI
DPTVSAIGGFIFYEKGKFEHLPFMELPIVVGYTGSSGPTKELVAMVRKRYEEMPELIVPILEAMGKVVEKAKDVILSNVD
KEEKFERLGVLMNINHGLLDALGVSTKKLSELVYAARVAGALGAKITGAGGGGCMYALAPNKQREVATAIRIAGGTPMIT
EISREGLKIEEVIK
>Mature_334_residues
MKVIASAPAKVILFGEHSVVYGKPAIAAAIDLRTFVEAELIREKKIRIEAHDIKVPGLTVSFSENEIYFETDYGKAAEVL
SYVREAINLVLEEADKKNVGIKVSITSQIPVGAGLGSSAAVAVATIGAVSKLLGLELSKEEIAKMGHKTELLVQGASSGI
DPTVSAIGGFIFYEKGKFEHLPFMELPIVVGYTGSSGPTKELVAMVRKRYEEMPELIVPILEAMGKVVEKAKDVILSNVD
KEEKFERLGVLMNINHGLLDALGVSTKKLSELVYAARVAGALGAKITGAGGGGCMYALAPNKQREVATAIRIAGGTPMIT
EISREGLKIEEVIK

Specific function: Galactose metabolism; first step. [C]

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily

Homologues:

Organism=Homo sapiens, GI167001643, Length=331, Percent_Identity=29.0030211480363, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4557769, Length=331, Percent_Identity=29.0030211480363, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323864, Length=368, Percent_Identity=31.5217391304348, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI78707210, Length=352, Percent_Identity=30.6818181818182, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KIME_PYRFU (Q8U0F3)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579366.1
- ProteinModelPortal:   Q8U0F3
- SMR:   Q8U0F3
- EnsemblBacteria:   EBPYRT00000005318
- GeneID:   1469514
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1637
- NMPDR:   fig|186497.1.peg.1685
- GeneTree:   EBGT00050000023109
- HOGENOM:   HBG646485
- OMA:   EIGKGEC
- ProtClustDB:   PRK03926
- BRENDA:   2.7.1.36
- GO:   GO:0005737
- HAMAP:   MF_00217
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10457:SF4
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00549

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.36

Molecular weight: Translated: 35606; Mature: 35606

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIASAPAKVILFGEHSVVYGKPAIAAAIDLRTFVEAELIREKKIRIEAHDIKVPGLTV
CCEECCCCCEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCEEE
SFSENEIYFETDYGKAAEVLSYVREAINLVLEEADKKNVGIKVSITSQIPVGAGLGSSAA
EECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHH
VAVATIGAVSKLLGLELSKEEIAKMGHKTELLVQGASSGIDPTVSAIGGFIFYEKGKFEH
HHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCEEEEECCCCCC
LPFMELPIVVGYTGSSGPTKELVAMVRKRYEEMPELIVPILEAMGKVVEKAKDVILSNVD
CCCEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KEEKFERLGVLMNINHGLLDALGVSTKKLSELVYAARVAGALGAKITGAGGGGCMYALAP
HHHHHHHCCEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECC
NKQREVATAIRIAGGTPMITEISREGLKIEEVIK
CCHHHHHHHEEECCCCCHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MKVIASAPAKVILFGEHSVVYGKPAIAAAIDLRTFVEAELIREKKIRIEAHDIKVPGLTV
CCEECCCCCEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCEEE
SFSENEIYFETDYGKAAEVLSYVREAINLVLEEADKKNVGIKVSITSQIPVGAGLGSSAA
EECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHH
VAVATIGAVSKLLGLELSKEEIAKMGHKTELLVQGASSGIDPTVSAIGGFIFYEKGKFEH
HHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCEEEEECCCCCC
LPFMELPIVVGYTGSSGPTKELVAMVRKRYEEMPELIVPILEAMGKVVEKAKDVILSNVD
CCCEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KEEKFERLGVLMNINHGLLDALGVSTKKLSELVYAARVAGALGAKITGAGGGGCMYALAP
HHHHHHHCCEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECC
NKQREVATAIRIAGGTPMITEISREGLKIEEVIK
CCHHHHHHHEEECCCCCHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA