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The map label for this gene is comEB [H]

Identifier: 18977970

GI number: 18977970

Start: 1491167

End: 1491724

Strand: Direct

Name: comEB [H]

Synonym: PF1598

Alternate gene names: 18977970

Gene position: 1491167-1491724 (Clockwise)

Preceding gene: 18977969

Following gene: 18977978

Centisome position: 78.14

GC content: 39.07

Gene sequence:

>558_bases
ATGAGCATTGAAATATTTCTCGACAAGGAGAAAGCCGAGAAAATCAAAAAAATTCGACCTACAAAGGATGAATACTTTAT
GCTCATAGCAAAACTTGTCTCACTTAGAGCTACTTGTCCCAGGTTAAGAGTGGGAGCAGTTGCAGTAAAAGATGGATATA
TCCTGGCCACTGGATACAATGGAGCTCCAAGAAGCATGGATCACTGTATAGATAAGGGATGTATACTGGTCAATGGGCAT
TGTCATAGAGCAGTTCATGCAGAGCAAAATGTTATAGCTATGGCTGCCAGAAAGGGGATAAGCCTAGAAGGAGCTACCCT
ATACGTGACTCATTTCCCTTGCGATACTTGTTTTAAACTACTTATAAATGCAGGAATAAAGGAGATAGTTTACGAAGAGA
TGTACCCAAATGAAGTAACAGAGATGCTTCTCAAAGAAGCCCAGGAAAAGGGGTTAATTAAAATAAGACAGTTTAAGCTG
CCAAAAGAGAGAGTCTTGCAGTTTTTAGAGGAATTATTCCCAGAATTCTGTGGTTGTAAGAATGAAGAAAAAGACTAA

Upstream 100 bases:

>100_bases
CTATGACGAAAGAATAGCAAAAATAATGGCAATAGTTGAGATGTACAGAAGCTTAGAGATTTAGGAAAATATTTTTAATT
TGCTTTAATTATGCTTAAAC

Downstream 100 bases:

>100_bases
CGTCCAAATCTCCTTTCTCTCTTTTGAAATTCTCTAATTATTCTTAAAAAGTCAATTTTTCTAAATTCTGGGAAGTACAC
ATCGACAAAAAACAGTTCAC

Product: dCMP deaminase

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MSIEIFLDKEKAEKIKKIRPTKDEYFMLIAKLVSLRATCPRLRVGAVAVKDGYILATGYNGAPRSMDHCIDKGCILVNGH
CHRAVHAEQNVIAMAARKGISLEGATLYVTHFPCDTCFKLLINAGIKEIVYEEMYPNEVTEMLLKEAQEKGLIKIRQFKL
PKERVLQFLEELFPEFCGCKNEEKD

Sequences:

>Translated_185_residues
MSIEIFLDKEKAEKIKKIRPTKDEYFMLIAKLVSLRATCPRLRVGAVAVKDGYILATGYNGAPRSMDHCIDKGCILVNGH
CHRAVHAEQNVIAMAARKGISLEGATLYVTHFPCDTCFKLLINAGIKEIVYEEMYPNEVTEMLLKEAQEKGLIKIRQFKL
PKERVLQFLEELFPEFCGCKNEEKD
>Mature_184_residues
SIEIFLDKEKAEKIKKIRPTKDEYFMLIAKLVSLRATCPRLRVGAVAVKDGYILATGYNGAPRSMDHCIDKGCILVNGHC
HRAVHAEQNVIAMAARKGISLEGATLYVTHFPCDTCFKLLINAGIKEIVYEEMYPNEVTEMLLKEAQEKGLIKIRQFKLP
KERVLQFLEELFPEFCGCKNEEKD

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17557019, Length=146, Percent_Identity=34.2465753424658, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321938, Length=168, Percent_Identity=36.9047619047619, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24667298, Length=164, Percent_Identity=30.4878048780488, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24667302, Length=164, Percent_Identity=30.4878048780488, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 21024; Mature: 20893

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEIFLDKEKAEKIKKIRPTKDEYFMLIAKLVSLRATCPRLRVGAVAVKDGYILATGYN
CEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEECEEEEECCEEEEECCC
GAPRSMDHCIDKGCILVNGHCHRAVHAEQNVIAMAARKGISLEGATLYVTHFPCDTCFKL
CCCCHHHHHHCCCEEEECCCCCHHHHCCCHHHHHHHHCCCCCCCCEEEEEECCHHHHHHH
LINAGIKEIVYEEMYPNEVTEMLLKEAQEKGLIKIRQFKLPKERVLQFLEELFPEFCGCK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCC
NEEKD
CCCCC
>Mature Secondary Structure 
SIEIFLDKEKAEKIKKIRPTKDEYFMLIAKLVSLRATCPRLRVGAVAVKDGYILATGYN
EEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEECEEEEECCEEEEECCC
GAPRSMDHCIDKGCILVNGHCHRAVHAEQNVIAMAARKGISLEGATLYVTHFPCDTCFKL
CCCCHHHHHHCCCEEEECCCCCHHHHCCCHHHHHHHHCCCCCCCCEEEEEECCHHHHHHH
LINAGIKEIVYEEMYPNEVTEMLLKEAQEKGLIKIRQFKLPKERVLQFLEELFPEFCGCK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCC
NEEKD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]