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The map label for this gene is fdhA [H]

Identifier: 18977893

GI number: 18977893

Start: 1419794

End: 1421797

Strand: Reverse

Name: fdhA [H]

Synonym: PF1521

Alternate gene names: 18977893

Gene position: 1421797-1419794 (Counterclockwise)

Preceding gene: 18977894

Following gene: 18977892

Centisome position: 74.51

GC content: 40.57

Gene sequence:

>2004_bases
ATGTCTATAGGTGTGAGAATGAGTGTGAAAGTAGTTTGTCCCTACTGTGGTTTTGGTTGCAATCTTTTGGTAGATACAAT
TACAAAGAAAGTTAGGCCTTATAGGGGCGAGCCAAACAGGGGTAAGCTTTGTCCAAAAGGATTATTTGCACTTGAGCATG
TCTATTCAAAAGATAGACTTAGATACCCCCTAAAAAGAGAAGGCAGTGACTTTAAGAGAATATCCTGGGAGAGAGCAATT
TCCGAGATAGCTGAGAAGATAAGAGAAATTATTGAAAATTATGGACCGAGTTCAATAGCTTTTATTGCCTCATCAAAGAT
TACTAATGAAGAAAATTATTTGCTCCAAAAAATTGCGAGACTTTTGGGCACAAACAACATAGACAATTGTGCTAGATTGT
GTCATGAATCAAGTGTACACGCCTTAAAGCTAACTCTAGGAGCAGGGATTCAGACTAACCCCTACTCAGATTTGGAAAAG
TTCAAGGCACTCATGATATGGGGCTACAATCCAGCCGAAACTCATCCTGTCGTTATGCAATACATAATGAATGCCAAGAA
GAATGGGGCTAAGATTATTGTTGTGGACGTTCGGGAAACTACAACAATGAAATTTGGGGATTATAAGGTAATAATTCGTC
CTGGGACTGATATAACTTTGGCAAACGCCATAATGAATGTCATAATTGAAAATCGTTGGTACAATAAAGATTTCATTGAG
AAGAGGACTGTAGGATTTTCAGAGATAAGGATGGGAGTTAAGAAATACACTCCCGAATATGCTGAAAAGATTACGGGCGT
TCCAGCGAGGTTAATTAAAGAAATAGCTGAAGCTTTTGCAAAGGCTGGAAGTGGGGCTATATTATGGGGAATGGGAGTTA
CTCAGCAAATAGCGGGAGTTGAAAACGTTCTTGCTTTAATAAATATAGCTCTTCTCCTGGGATATTTTGGGGAAAAGGGT
GGATTATATCCCATGAGGGGACAGAATAATGTCCAAGGAGCAGCTTACATGGGAACTTTGAGCGAATTCCTTCCTGGTTA
TGTCCCTTTATCTGACTCAGAGTTCAGGAAGAAAGTTGCAAAATTGTGGGGAGTTGAAGATTTACCCACGGAGAGAGGTT
TGTACCTTACTGAATATTGGGATGCCATATTGAATGGTGATTTAAAGGTCCTCTACATCGTTGGTGAAAATCCTGCCATT
AGTGATGCAAATGTTCTAAAAGTTAGAAAGGCCCTAACTAAGCTCGAGTTATTGGTTGTTCAGGACATATTTCTCACAAG
AACAGCTAGGTACGCTCACTATGTCCTGCCAGCGGCCGCCTTCTGTGAGAAGGAAGGTTCTTACATGAACAGCGAGAGGA
GAATACAGTGGAGTCATAAAGCTTGCGAACCACTAGGGGAGAGCAAGCCAGATTGGGAGATTCTAACAATGTTGGCAAAT
GCTCTTGGGTTGAGGGGTTTTAACTACAAAAGGGTTGAGGAAATAACAGAGGAATACTTTAAGTTATTCCCAGAACTTGA
AAATAGGAGTGTAGAGGAACTGAAAAACTCTGAGGGCATTGTAATTCCATCACCCAGGTTGTATACCGATAGATTTTTGA
CTCCAGGTGGAAGGGCCCGATTTATATCAGTGGAACAAATAATGCCATGGGAAGAACCGAATGGAGAATATCCTCTCATT
CTTACAACGGTTAGGTTGATTACTCATTATAACACTGGAGAGATGACAATGAGGAGTCCGTCCTTGACAAAAATGATTGG
TGAACCGTTTGTACTAATTAGTAGGGAAGATGCCCAAGAGTACGGAATTAAAGAAGGAGACTACGTTGTAGTTGAAACGA
GAAGGGGAAACTTAACCCTCAAGGCAAAGATATCAAACATCCAAAGGGGTGTTATAGCAATACCCTTCCACTTTGAGGCC
AATGTATTAACCAACGATGCGTTAAATAAAGCAGGAACTCCAGAGCTCAAGTTTTCGGCAGCAAGAATAAGGAAAGTTTC
ATAA

Upstream 100 bases:

>100_bases
GATAGAACCAATTTCTATTGAAGATTGGCTGATGAAGATGTTTTAGATTTACATTTATGTGTAAATACAGACCAAAAAAC
TTTTAATTTTTGACATTATC

Downstream 100 bases:

>100_bases
CTCCTTAATCTAACAAACAATCATGAAGAGATTGTTGCCTTTATCACTTTTGTTCTTGGGGGTGTTTTTCTACCTTCCAA
TTTTCCTTATAGTCAAGGAG

Product: formate dehydrogenase alpha chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MSIGVRMSVKVVCPYCGFGCNLLVDTITKKVRPYRGEPNRGKLCPKGLFALEHVYSKDRLRYPLKREGSDFKRISWERAI
SEIAEKIREIIENYGPSSIAFIASSKITNEENYLLQKIARLLGTNNIDNCARLCHESSVHALKLTLGAGIQTNPYSDLEK
FKALMIWGYNPAETHPVVMQYIMNAKKNGAKIIVVDVRETTTMKFGDYKVIIRPGTDITLANAIMNVIIENRWYNKDFIE
KRTVGFSEIRMGVKKYTPEYAEKITGVPARLIKEIAEAFAKAGSGAILWGMGVTQQIAGVENVLALINIALLLGYFGEKG
GLYPMRGQNNVQGAAYMGTLSEFLPGYVPLSDSEFRKKVAKLWGVEDLPTERGLYLTEYWDAILNGDLKVLYIVGENPAI
SDANVLKVRKALTKLELLVVQDIFLTRTARYAHYVLPAAAFCEKEGSYMNSERRIQWSHKACEPLGESKPDWEILTMLAN
ALGLRGFNYKRVEEITEEYFKLFPELENRSVEELKNSEGIVIPSPRLYTDRFLTPGGRARFISVEQIMPWEEPNGEYPLI
LTTVRLITHYNTGEMTMRSPSLTKMIGEPFVLISREDAQEYGIKEGDYVVVETRRGNLTLKAKISNIQRGVIAIPFHFEA
NVLTNDALNKAGTPELKFSAARIRKVS

Sequences:

>Translated_667_residues
MSIGVRMSVKVVCPYCGFGCNLLVDTITKKVRPYRGEPNRGKLCPKGLFALEHVYSKDRLRYPLKREGSDFKRISWERAI
SEIAEKIREIIENYGPSSIAFIASSKITNEENYLLQKIARLLGTNNIDNCARLCHESSVHALKLTLGAGIQTNPYSDLEK
FKALMIWGYNPAETHPVVMQYIMNAKKNGAKIIVVDVRETTTMKFGDYKVIIRPGTDITLANAIMNVIIENRWYNKDFIE
KRTVGFSEIRMGVKKYTPEYAEKITGVPARLIKEIAEAFAKAGSGAILWGMGVTQQIAGVENVLALINIALLLGYFGEKG
GLYPMRGQNNVQGAAYMGTLSEFLPGYVPLSDSEFRKKVAKLWGVEDLPTERGLYLTEYWDAILNGDLKVLYIVGENPAI
SDANVLKVRKALTKLELLVVQDIFLTRTARYAHYVLPAAAFCEKEGSYMNSERRIQWSHKACEPLGESKPDWEILTMLAN
ALGLRGFNYKRVEEITEEYFKLFPELENRSVEELKNSEGIVIPSPRLYTDRFLTPGGRARFISVEQIMPWEEPNGEYPLI
LTTVRLITHYNTGEMTMRSPSLTKMIGEPFVLISREDAQEYGIKEGDYVVVETRRGNLTLKAKISNIQRGVIAIPFHFEA
NVLTNDALNKAGTPELKFSAARIRKVS
>Mature_666_residues
SIGVRMSVKVVCPYCGFGCNLLVDTITKKVRPYRGEPNRGKLCPKGLFALEHVYSKDRLRYPLKREGSDFKRISWERAIS
EIAEKIREIIENYGPSSIAFIASSKITNEENYLLQKIARLLGTNNIDNCARLCHESSVHALKLTLGAGIQTNPYSDLEKF
KALMIWGYNPAETHPVVMQYIMNAKKNGAKIIVVDVRETTTMKFGDYKVIIRPGTDITLANAIMNVIIENRWYNKDFIEK
RTVGFSEIRMGVKKYTPEYAEKITGVPARLIKEIAEAFAKAGSGAILWGMGVTQQIAGVENVLALINIALLLGYFGEKGG
LYPMRGQNNVQGAAYMGTLSEFLPGYVPLSDSEFRKKVAKLWGVEDLPTERGLYLTEYWDAILNGDLKVLYIVGENPAIS
DANVLKVRKALTKLELLVVQDIFLTRTARYAHYVLPAAAFCEKEGSYMNSERRIQWSHKACEPLGESKPDWEILTMLANA
LGLRGFNYKRVEEITEEYFKLFPELENRSVEELKNSEGIVIPSPRLYTDRFLTPGGRARFISVEQIMPWEEPNGEYPLIL
TTVRLITHYNTGEMTMRSPSLTKMIGEPFVLISREDAQEYGIKEGDYVVVETRRGNLTLKAKISNIQRGVIAIPFHFEAN
VLTNDALNKAGTPELKFSAARIRKVS

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=688, Percent_Identity=38.2267441860465, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI3868719, Length=670, Percent_Identity=28.5074626865672, Blast_Score=225, Evalue=8e-60,
Organism=Escherichia coli, GI3868720, Length=606, Percent_Identity=28.3828382838284, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1788534, Length=560, Percent_Identity=27.8571428571429, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1787778, Length=568, Percent_Identity=27.2887323943662, Blast_Score=165, Evalue=1e-41,
Organism=Escherichia coli, GI87081797, Length=723, Percent_Identity=24.4813278008299, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI171474008, Length=697, Percent_Identity=23.9598278335725, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1787870, Length=706, Percent_Identity=24.7875354107649, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI145693196, Length=508, Percent_Identity=24.4094488188976, Blast_Score=122, Evalue=1e-28,
Organism=Escherichia coli, GI87081994, Length=692, Percent_Identity=23.9884393063584, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1787231, Length=691, Percent_Identity=23.7337192474674, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI145693161, Length=518, Percent_Identity=24.5173745173745, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 75209; Mature: 75078

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIGVRMSVKVVCPYCGFGCNLLVDTITKKVRPYRGEPNRGKLCPKGLFALEHVYSKDRL
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
RYPLKREGSDFKRISWERAISEIAEKIREIIENYGPSSIAFIASSKITNEENYLLQKIAR
CCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHH
LLGTNNIDNCARLCHESSVHALKLTLGAGIQTNPYSDLEKFKALMIWGYNPAETHPVVMQ
HHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCEEEEECCCCCCCCHHHHH
YIMNAKKNGAKIIVVDVRETTTMKFGDYKVIIRPGTDITLANAIMNVIIENRWYNKDFIE
HHHCCCCCCCEEEEEEECCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHH
KRTVGFSEIRMGVKKYTPEYAEKITGVPARLIKEIAEAFAKAGSGAILWGMGVTQQIAGV
HHCCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHH
ENVLALINIALLLGYFGEKGGLYPMRGQNNVQGAAYMGTLSEFLPGYVPLSDSEFRKKVA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
KLWGVEDLPTERGLYLTEYWDAILNGDLKVLYIVGENPAISDANVLKVRKALTKLELLVV
HHCCCCCCCCCCCEEHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
QDIFLTRTARYAHYVLPAAAFCEKEGSYMNSERRIQWSHKACEPLGESKPDWEILTMLAN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHCCCCCCCCCHHHHHHHHH
ALGLRGFNYKRVEEITEEYFKLFPELENRSVEELKNSEGIVIPSPRLYTDRFLTPGGRAR
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEECCCCCCCCCCCCCCCCEE
FISVEQIMPWEEPNGEYPLILTTVRLITHYNTGEMTMRSPSLTKMIGEPFVLISREDAQE
EEEHHHCCCCCCCCCCCCHHHHEEHHHHCCCCCCEEECCCHHHHHHCCCEEEEECCCHHH
YGIKEGDYVVVETRRGNLTLKAKISNIQRGVIAIPFHFEANVLTNDALNKAGTPELKFSA
CCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEEEECCEEECHHHCCCCCCCCEECH
ARIRKVS
HHHEECC
>Mature Secondary Structure 
SIGVRMSVKVVCPYCGFGCNLLVDTITKKVRPYRGEPNRGKLCPKGLFALEHVYSKDRL
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
RYPLKREGSDFKRISWERAISEIAEKIREIIENYGPSSIAFIASSKITNEENYLLQKIAR
CCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHH
LLGTNNIDNCARLCHESSVHALKLTLGAGIQTNPYSDLEKFKALMIWGYNPAETHPVVMQ
HHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCEEEEECCCCCCCCHHHHH
YIMNAKKNGAKIIVVDVRETTTMKFGDYKVIIRPGTDITLANAIMNVIIENRWYNKDFIE
HHHCCCCCCCEEEEEEECCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHH
KRTVGFSEIRMGVKKYTPEYAEKITGVPARLIKEIAEAFAKAGSGAILWGMGVTQQIAGV
HHCCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHH
ENVLALINIALLLGYFGEKGGLYPMRGQNNVQGAAYMGTLSEFLPGYVPLSDSEFRKKVA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
KLWGVEDLPTERGLYLTEYWDAILNGDLKVLYIVGENPAISDANVLKVRKALTKLELLVV
HHCCCCCCCCCCCEEHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
QDIFLTRTARYAHYVLPAAAFCEKEGSYMNSERRIQWSHKACEPLGESKPDWEILTMLAN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHCCCCCCCCCHHHHHHHHH
ALGLRGFNYKRVEEITEEYFKLFPELENRSVEELKNSEGIVIPSPRLYTDRFLTPGGRAR
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEECCCCCCCCCCCCCCCCEE
FISVEQIMPWEEPNGEYPLILTTVRLITHYNTGEMTMRSPSLTKMIGEPFVLISREDAQE
EEEHHHCCCCCCCCCCCCHHHHEEHHHHCCCCCCEEECCCHHHHHHCCCEEEEECCCHHH
YGIKEGDYVVVETRRGNLTLKAKISNIQRGVIAIPFHFEANVLTNDALNKAGTPELKFSA
CCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEEEECCEEECHHHCCCCCCCCEECH
ARIRKVS
HHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3531194; 1378430 [H]