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The map label for this gene is guaAB

Identifier: 18977888

GI number: 18977888

Start: 1414031

End: 1414972

Strand: Reverse

Name: guaAB

Synonym: PF1516

Alternate gene names: 18977888

Gene position: 1414972-1414031 (Counterclockwise)

Preceding gene: 18977889

Following gene: 18977887

Centisome position: 74.15

GC content: 42.99

Gene sequence:

>942_bases
ATGAAGAGGTGGGTCAAGGTGTGGGAGAAGTTCATTGAAGAAAAGATTAGGGAAATTAGAGAGACTGTAGGAGACTCTAA
GGCGATAATTGCGCTCTCAGGGGGAGTTGATAGTTCAACTGCTGCAGTCTTAGCTCACAGAGCAATAGGGGATAGGCTTC
ATGCAGTATTCGTAAATACTGGATTCCTAAGGAAAGGAGAGCCGGAGTTTGTAATTAAAACCTTTAGGGACGAATTTGGC
ATGAACCTTCACTACGTTGATGCCCAGGACAGATTCTTCGCAGCTCTAAAGGGCGTTACAGATCCTGAAGAGAAAAGAAA
AATTATTGGAAGGGTATTCATAGAGGTGTTTGAGGAAGTTGCAAAGGACATTGGGGCGGAATATCTCATTCAGGGGACAA
TAGCACCAGATTGGATTGAAAGTCAAGGAAAAATCAAGAGCCATCACAACGTTGGAGGATTGCCGGAGAAGTTAAATCTA
AAGATAATAGAACCTCTTAGAGATCTCTATAAGGATGAGGTTAGACAATTAGCCAAGGAGTTAGGCCTTCCAGAGAAAAT
CTACAACAGAATGCCTTTCCCAGGCCCAGGACTTGCTGTCAGAGTTATTGGAGAAGTAACTCCTGAGAAGATAAGAATAG
TTAGAGAGGCAAATGCTATTGTGGAAGAGGAAATTGAAAAAGCTGGACTAAGGCCATGGCAAGCCTTTGCTGTTCTCCTT
GGAGTTAAAACTGTAGGCGTTCAGGGGGATATTAGGGCGTACAAGGAAACTATTGCAGTAAGAATTGTCGAAAGTGTAGA
TGGTATGACAGCAAATGCTATGAACGTCCCCTGGGAAGTTCTTCAGAGGATAGCTTTCAGAATAACTAGCGAGATTCCCG
AAGTTGGAAGGGTACTTTATGACATAACGAACAAGCCACCTGCAACAATAGAATTTGAGTGA

Upstream 100 bases:

>100_bases
CCTTATAATCTATTTTATCTAAAAATGTCCAGAGGGGAATTTGTTTACAACTTTATGTTTAATTTCGCAAGACTTTTAAT
AAAGTTTAGACAATCGTTTG

Downstream 100 bases:

>100_bases
GGGAGTGAGATGATCATTATAATGGACAATGGAGGGCAATATGTCCATAGGATATGGAGAACTCTTCGCTATTTAGGAGT
AGAAGCAAAGATAATCCCTA

Product: GMP synthase subunit B

Products: NA

Alternate protein names: GMP synthetase

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MKRWVKVWEKFIEEKIREIRETVGDSKAIIALSGGVDSSTAAVLAHRAIGDRLHAVFVNTGFLRKGEPEFVIKTFRDEFG
MNLHYVDAQDRFFAALKGVTDPEEKRKIIGRVFIEVFEEVAKDIGAEYLIQGTIAPDWIESQGKIKSHHNVGGLPEKLNL
KIIEPLRDLYKDEVRQLAKELGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEIEKAGLRPWQAFAVLL
GVKTVGVQGDIRAYKETIAVRIVESVDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNKPPATIEFE

Sequences:

>Translated_313_residues
MKRWVKVWEKFIEEKIREIRETVGDSKAIIALSGGVDSSTAAVLAHRAIGDRLHAVFVNTGFLRKGEPEFVIKTFRDEFG
MNLHYVDAQDRFFAALKGVTDPEEKRKIIGRVFIEVFEEVAKDIGAEYLIQGTIAPDWIESQGKIKSHHNVGGLPEKLNL
KIIEPLRDLYKDEVRQLAKELGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEIEKAGLRPWQAFAVLL
GVKTVGVQGDIRAYKETIAVRIVESVDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNKPPATIEFE
>Mature_313_residues
MKRWVKVWEKFIEEKIREIRETVGDSKAIIALSGGVDSSTAAVLAHRAIGDRLHAVFVNTGFLRKGEPEFVIKTFRDEFG
MNLHYVDAQDRFFAALKGVTDPEEKRKIIGRVFIEVFEEVAKDIGAEYLIQGTIAPDWIESQGKIKSHHNVGGLPEKLNL
KIIEPLRDLYKDEVRQLAKELGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEIEKAGLRPWQAFAVLL
GVKTVGVQGDIRAYKETIAVRIVESVDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNKPPATIEFE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=351, Percent_Identity=36.1823361823362, Blast_Score=171, Evalue=9e-43,
Organism=Escherichia coli, GI1788854, Length=314, Percent_Identity=51.9108280254777, Blast_Score=311, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI71992717, Length=369, Percent_Identity=33.0623306233062, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71992710, Length=369, Percent_Identity=33.0623306233062, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI133901714, Length=369, Percent_Identity=33.0623306233062, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323873, Length=320, Percent_Identity=51.5625, Blast_Score=299, Evalue=3e-82,
Organism=Drosophila melanogaster, GI281365319, Length=350, Percent_Identity=34.5714285714286, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAB_PYRFU (Q8U0R8)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579245.1
- ProteinModelPortal:   Q8U0R8
- SMR:   Q8U0R8
- EnsemblBacteria:   EBPYRT00000004306
- GeneID:   1469392
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1516
- NMPDR:   fig|186497.1.peg.1563
- GeneTree:   EBGT00050000022268
- HOGENOM:   HBG391775
- OMA:   QGTIAPD
- ProtClustDB:   PRK00919
- BRENDA:   6.3.5.2
- HAMAP:   MF_00345
- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00884

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 35282; Mature: 35282

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRWVKVWEKFIEEKIREIRETVGDSKAIIALSGGVDSSTAAVLAHRAIGDRLHAVFVNT
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEC
GFLRKGEPEFVIKTFRDEFGMNLHYVDAQDRFFAALKGVTDPEEKRKIIGRVFIEVFEEV
CCCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AKDIGAEYLIQGTIAPDWIESQGKIKSHHNVGGLPEKLNLKIIEPLRDLYKDEVRQLAKE
HHHCCHHEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEIEKAGLRPWQAFAVLL
CCCCHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GVKTVGVQGDIRAYKETIAVRIVESVDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLY
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DITNKPPATIEFE
HHCCCCCCEEECC
>Mature Secondary Structure
MKRWVKVWEKFIEEKIREIRETVGDSKAIIALSGGVDSSTAAVLAHRAIGDRLHAVFVNT
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEC
GFLRKGEPEFVIKTFRDEFGMNLHYVDAQDRFFAALKGVTDPEEKRKIIGRVFIEVFEEV
CCCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AKDIGAEYLIQGTIAPDWIESQGKIKSHHNVGGLPEKLNLKIIEPLRDLYKDEVRQLAKE
HHHCCHHEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREANAIVEEEIEKAGLRPWQAFAVLL
CCCCHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GVKTVGVQGDIRAYKETIAVRIVESVDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLY
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DITNKPPATIEFE
HHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA