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The map label for this gene is metE [H]

Identifier: 18977640

GI number: 18977640

Start: 1200806

End: 1201735

Strand: Direct

Name: metE [H]

Synonym: PF1268

Alternate gene names: 18977640

Gene position: 1200806-1201735 (Clockwise)

Preceding gene: 18977639

Following gene: 18977641

Centisome position: 62.93

GC content: 40.22

Gene sequence:

>930_bases
ATGATTGTTCCAGCCCTTATAGGAAGTTTGCCGAGACCAATAGGATTAGCTAAGAAACTTGAGCAATACTACATAGGAAG
ATTAGATGAGAGGAAGTTAGAAGAAGCGTATAGAGAATATACAAGAAGAGCTTTTGAGAAGCTTAGGGATGCAAAAATCA
AAGTCATAACAGATGGATTGTACAGGTGGGACGATATTTTCAACCCATTTATAAGGTTCATTGATGGTATAGAGGTGAAT
GGCCTCTTCAAATTCTATGAAAACAACTTCTTCTATAGATCTCCTGTAGTTAGGGGAGAGATAGCGTTGAAAGAAAACCC
AATTCCTGAGTGGATTTCAATAGCCCAGGAGATAAAGGAAGATGTTTATCCAGAGGCTACATTGAAGGCTGTGTTACCTG
GCCCCGTAACTCTTGCATACCACTCAATCAACGAGTACTATAAGACACTAACCGACCTTGCCGAAGCTTATGCCCAGGTG
ATAGGGGAGTTAATAAAAGAGTTAGATGTTAAAATCGTGGAACTTCAGGAACCATCTCTGGCGGCTGAGATAAGTGAAGC
TACTAAGAATATCGAGGACAGAGTAGATAAAGAAGTTGCAAAGAACATAATTGAAGACCTTGGAAGGATAAAGAAGTTGT
GGGTAGTAACGTACTTTGGAACTCCTCAAGTTTTACCTGAGGGAGTTATACTCAACGTTGATTTAATAGAAGGTTCAGTT
CCAGAAGAATACAGTGGAGAGATAGGGCTTGGAATAGTGGACGCCAGAACAACAAAAATGGAGAGGGCAGATAGGCTTAG
GGATAAGATTAGGAAGTACTTGGCAAAGTTTGAAACTATATACGTTACACCTAACACTCTTTTAGATTTCCTTCCTGAAA
GTGTCGCTTGGAAAAAGCTGAGACTTTTAGGTAGGCTTGGAGGTGAGTAA

Upstream 100 bases:

>100_bases
TGGGGGAATTAACGTCATTGTTTTTGAAGAGACTAGGTGGGAGGAAAAATTGAACGAGGTGTTAGATTTGCTGAAGGAAT
TGCTTTAGGGGGTGTAAGGA

Downstream 100 bases:

>100_bases
AATGGAGCTTCCTATTCTTCCTACAAGTGTTATAGGAAGTTACCCAAAGCCTAGATGGTTGCTTAGAATGTACAAGCTAA
GAGAACTAGGAAAAATTCCA

Product: 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase

Products: NA

Alternate protein names: Methionine synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MIVPALIGSLPRPIGLAKKLEQYYIGRLDERKLEEAYREYTRRAFEKLRDAKIKVITDGLYRWDDIFNPFIRFIDGIEVN
GLFKFYENNFFYRSPVVRGEIALKENPIPEWISIAQEIKEDVYPEATLKAVLPGPVTLAYHSINEYYKTLTDLAEAYAQV
IGELIKELDVKIVELQEPSLAAEISEATKNIEDRVDKEVAKNIIEDLGRIKKLWVVTYFGTPQVLPEGVILNVDLIEGSV
PEEYSGEIGLGIVDARTTKMERADRLRDKIRKYLAKFETIYVTPNTLLDFLPESVAWKKLRLLGRLGGE

Sequences:

>Translated_309_residues
MIVPALIGSLPRPIGLAKKLEQYYIGRLDERKLEEAYREYTRRAFEKLRDAKIKVITDGLYRWDDIFNPFIRFIDGIEVN
GLFKFYENNFFYRSPVVRGEIALKENPIPEWISIAQEIKEDVYPEATLKAVLPGPVTLAYHSINEYYKTLTDLAEAYAQV
IGELIKELDVKIVELQEPSLAAEISEATKNIEDRVDKEVAKNIIEDLGRIKKLWVVTYFGTPQVLPEGVILNVDLIEGSV
PEEYSGEIGLGIVDARTTKMERADRLRDKIRKYLAKFETIYVTPNTLLDFLPESVAWKKLRLLGRLGGE
>Mature_309_residues
MIVPALIGSLPRPIGLAKKLEQYYIGRLDERKLEEAYREYTRRAFEKLRDAKIKVITDGLYRWDDIFNPFIRFIDGIEVN
GLFKFYENNFFYRSPVVRGEIALKENPIPEWISIAQEIKEDVYPEATLKAVLPGPVTLAYHSINEYYKTLTDLAEAYAQV
IGELIKELDVKIVELQEPSLAAEISEATKNIEDRVDKEVAKNIIEDLGRIKKLWVVTYFGTPQVLPEGVILNVDLIEGSV
PEEYSGEIGLGIVDARTTKMERADRLRDKIRKYLAKFETIYVTPNTLLDFLPESVAWKKLRLLGRLGGE

Specific function: Catalyzes the transfer of a methyl group from methylcobalamin and methylcobinamide to homocysteine resulting in methionine formation [H]

COG id: COG0620

COG function: function code E; Methionine synthase II (cobalamin-independent)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the vitamin-B12 independent methionine synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022921
- InterPro:   IPR002629 [H]

Pfam domain/function: PF01717 Meth_synt_2 [H]

EC number: NA

Molecular weight: Translated: 35473; Mature: 35473

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVPALIGSLPRPIGLAKKLEQYYIGRLDERKLEEAYREYTRRAFEKLRDAKIKVITDGL
CCCHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECHH
YRWDDIFNPFIRFIDGIEVNGLFKFYENNFFYRSPVVRGEIALKENPIPEWISIAQEIKE
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEECCCEECEEEECCCCCHHHHHHHHHHHH
DVYPEATLKAVLPGPVTLAYHSINEYYKTLTDLAEAYAQVIGELIKELDVKIVELQEPSL
HCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHH
AAEISEATKNIEDRVDKEVAKNIIEDLGRIKKLWVVTYFGTPQVLPEGVILNVDLIEGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEEEEECCCC
PEEYSGEIGLGIVDARTTKMERADRLRDKIRKYLAKFETIYVTPNTLLDFLPESVAWKKL
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHCCHHHHHHHH
RLLGRLGGE
HHHHHCCCC
>Mature Secondary Structure
MIVPALIGSLPRPIGLAKKLEQYYIGRLDERKLEEAYREYTRRAFEKLRDAKIKVITDGL
CCCHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECHH
YRWDDIFNPFIRFIDGIEVNGLFKFYENNFFYRSPVVRGEIALKENPIPEWISIAQEIKE
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEECCCEECEEEECCCCCHHHHHHHHHHHH
DVYPEATLKAVLPGPVTLAYHSINEYYKTLTDLAEAYAQVIGELIKELDVKIVELQEPSL
HCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHH
AAEISEATKNIEDRVDKEVAKNIIEDLGRIKKLWVVTYFGTPQVLPEGVILNVDLIEGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEEEEECCCC
PEEYSGEIGLGIVDARTTKMERADRLRDKIRKYLAKFETIYVTPNTLLDFLPESVAWKKL
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHCCHHHHHHHH
RLLGRLGGE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA