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The map label for this gene is ygcA [C]

Identifier: 18977544

GI number: 18977544

Start: 1120410

End: 1121645

Strand: Direct

Name: ygcA [C]

Synonym: PF1172

Alternate gene names: 18977544

Gene position: 1120410-1121645 (Clockwise)

Preceding gene: 18977541

Following gene: 18977546

Centisome position: 58.71

GC content: 38.75

Gene sequence:

>1236_bases
ATGAGAGGGATAATAAAAAGACTCAATGATGACGGTTTTGGCATTCTTTATAACAAAATCTTAGTACCCTTTTCAGCCCC
AGGAGACGAGGTTGAGGTTCTAAAGACAGAGAAACAAAAAAGAGCAAAAATAGCAACTGAGTGGAGGTTACTTCGTTCTT
CTCCCATAAGGGTGGGAGCAAGATGCAAGGTTTTCGGAAAATGTGGAGGGTGCATTCTTCAACATATTAATTACAACTCC
CAACTAGAGTTTAAAAAAGAAAAGCTAAGAAAAATCCTGGGAAGAGAGGTTGAGATAATCCCTTCTCCTCGGATATTTGG
TCATAGGAACAGGATAGATCTTGCAGTTACAGTTAATGCAATAGGATTTAGAGAAAAAGGAAAGTGGTGGAGTGTTGTAG
ATGTTGAAGAATGCCCCGTTTTTGGGAAAACTTCAAAAAAGGCAATAGAAAGACTCAGGGAATACATAGAAGAGGAAAAA
GTTTCAACATGGAAAATTAGGGAAGATTCTGGGTTCCTAAGGTACATGGTTCTCAGAGAAGGTAAATTCACAGGAGAGAT
TATGGTGAACTTTGTTACAAAAGAGGGAGAACTACCAGATCCTACAAGTTATTTTGACTTTGCTGATTCAATTTATTGGA
GCATTAATAGGAGCAAGAGTGATGTCTCCTACGGCGACATCGAGAAGTATTGGGGAAAGGAATTTATAATGGAGGAATTA
GACGGCGTAAAGTACCTAATACACCCAAACTCCTTTTTCCAAACGAATAGCTATCAGGCAGTTAACCTAGTTAAAACAGT
TGAGAAATTCGTGGAAGGTGAAAAAGTTGTTGATATGTATTCAGGAGTTGGAACTTTTGGAGTTTACCTTGCTAAAAAAG
GAATGAAAGTTGTTGGATTTGATTCCAACGCTTTTGCAATTGAAATGGCAAACAAAAATGCTGAAATAAACAACGTTGAG
GCCGAGTTCTTTGTTGCAAGTGATAGAGAGGTAGACATCAAGGGCTTTGATACTGTGATAGTAGATCCTCCCAGGGCAGG
GTTGCATCCAAAGCTCGTGAAGAGACTGAATGACCATGGCCCCGAAACTATCGTTTACGTTTCATGCAATCCAAAGACGT
TTAAGGTAAATATTGAACAATTAAATAATTACATAATTGAAGAATTAATTGCACTTGACATGTTCCCCCACACTCCCCAC
ATAGAATTGGTAGGAAAGCTAAGGAGACTTGTCTAG

Upstream 100 bases:

>100_bases
TGCGGTGGTAGTCTAGCCTGGTCTAGGACGCCGGCCTCCCAAGCCGGCGACCCGGGTTCAAATCCCGGCCACCGCACCAA
CATTTTTCTACGTGATGACC

Downstream 100 bases:

>100_bases
GACGTGCTTGTCTAGAACATAGCAGTAAAACTTTCCTTCTAGTACAACTTCTTCTCCTCTGTAAACTTTCACATCAACTA
TCTTCTTTCTCCCTTGATCC

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MRGIIKRLNDDGFGILYNKILVPFSAPGDEVEVLKTEKQKRAKIATEWRLLRSSPIRVGARCKVFGKCGGCILQHINYNS
QLEFKKEKLRKILGREVEIIPSPRIFGHRNRIDLAVTVNAIGFREKGKWWSVVDVEECPVFGKTSKKAIERLREYIEEEK
VSTWKIREDSGFLRYMVLREGKFTGEIMVNFVTKEGELPDPTSYFDFADSIYWSINRSKSDVSYGDIEKYWGKEFIMEEL
DGVKYLIHPNSFFQTNSYQAVNLVKTVEKFVEGEKVVDMYSGVGTFGVYLAKKGMKVVGFDSNAFAIEMANKNAEINNVE
AEFFVASDREVDIKGFDTVIVDPPRAGLHPKLVKRLNDHGPETIVYVSCNPKTFKVNIEQLNNYIIEELIALDMFPHTPH
IELVGKLRRLV

Sequences:

>Translated_411_residues
MRGIIKRLNDDGFGILYNKILVPFSAPGDEVEVLKTEKQKRAKIATEWRLLRSSPIRVGARCKVFGKCGGCILQHINYNS
QLEFKKEKLRKILGREVEIIPSPRIFGHRNRIDLAVTVNAIGFREKGKWWSVVDVEECPVFGKTSKKAIERLREYIEEEK
VSTWKIREDSGFLRYMVLREGKFTGEIMVNFVTKEGELPDPTSYFDFADSIYWSINRSKSDVSYGDIEKYWGKEFIMEEL
DGVKYLIHPNSFFQTNSYQAVNLVKTVEKFVEGEKVVDMYSGVGTFGVYLAKKGMKVVGFDSNAFAIEMANKNAEINNVE
AEFFVASDREVDIKGFDTVIVDPPRAGLHPKLVKRLNDHGPETIVYVSCNPKTFKVNIEQLNNYIIEELIALDMFPHTPH
IELVGKLRRLV
>Mature_411_residues
MRGIIKRLNDDGFGILYNKILVPFSAPGDEVEVLKTEKQKRAKIATEWRLLRSSPIRVGARCKVFGKCGGCILQHINYNS
QLEFKKEKLRKILGREVEIIPSPRIFGHRNRIDLAVTVNAIGFREKGKWWSVVDVEECPVFGKTSKKAIERLREYIEEEK
VSTWKIREDSGFLRYMVLREGKFTGEIMVNFVTKEGELPDPTSYFDFADSIYWSINRSKSDVSYGDIEKYWGKEFIMEEL
DGVKYLIHPNSFFQTNSYQAVNLVKTVEKFVEGEKVVDMYSGVGTFGVYLAKKGMKVVGFDSNAFAIEMANKNAEINNVE
AEFFVASDREVDIKGFDTVIVDPPRAGLHPKLVKRLNDHGPETIVYVSCNPKTFKVNIEQLNNYIIEELIALDMFPHTPH
IELVGKLRRLV

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RNA M5U methyltransferase family

Homologues:

Organism=Homo sapiens, GI34222389, Length=356, Percent_Identity=24.438202247191, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI51173878, Length=356, Percent_Identity=24.438202247191, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI269784680, Length=378, Percent_Identity=23.5449735449735, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI269784676, Length=378, Percent_Identity=23.5449735449735, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI20149688, Length=378, Percent_Identity=23.5449735449735, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI269784678, Length=205, Percent_Identity=28.780487804878, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789148, Length=405, Percent_Identity=27.1604938271605, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787083, Length=380, Percent_Identity=26.0526315789474, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790403, Length=193, Percent_Identity=28.4974093264249, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322909, Length=396, Percent_Identity=24.7474747474747, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666579, Length=410, Percent_Identity=26.8292682926829, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1172_PYRFU (Q8U1N4)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578901.1
- ProteinModelPortal:   Q8U1N4
- SMR:   Q8U1N4
- EnsemblBacteria:   EBPYRT00000004407
- GeneID:   1469041
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1172
- NMPDR:   fig|186497.1.peg.1212
- GeneTree:   EBGT00050000022236
- HOGENOM:   HBG690163
- OMA:   NEACIDE
- ProtClustDB:   CLSK253194
- InterPro:   IPR001566
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF05958 tRNA_U5-meth_tr

EC number: NA

Molecular weight: Translated: 47129; Mature: 47129

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 369-369 BINDING 254-254 BINDING 280-280 BINDING 301-301 BINDING 342-342

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGIIKRLNDDGFGILYNKILVPFSAPGDEVEVLKTEKQKRAKIATEWRLLRSSPIRVGA
CCCHHHHCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECC
RCKVFGKCGGCILQHINYNSQLEFKKEKLRKILGREVEIIPSPRIFGHRNRIDLAVTVNA
EEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCCEECCCCEEEEEEEEEE
IGFREKGKWWSVVDVEECPVFGKTSKKAIERLREYIEEEKVSTWKIREDSGFLRYMVLRE
ECCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEC
GKFTGEIMVNFVTKEGELPDPTSYFDFADSIYWSINRSKSDVSYGDIEKYWGKEFIMEEL
CCCEEEEEEEEEECCCCCCCCCCHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
DGVKYLIHPNSFFQTNSYQAVNLVKTVEKFVEGEKVVDMYSGVGTFGVYLAKKGMKVVGF
CCCEEEECCCCEEECCCCHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCEEEEE
DSNAFAIEMANKNAEINNVEAEFFVASDREVDIKGFDTVIVDPPRAGLHPKLVKRLNDHG
CCCEEEEEEECCCCCCCCEEEEEEEECCCEEEECCCCEEEECCCCCCCCHHHHHHHHCCC
PETIVYVSCNPKTFKVNIEQLNNYIIEELIALDMFPHTPHIELVGKLRRLV
CCEEEEEEECCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MRGIIKRLNDDGFGILYNKILVPFSAPGDEVEVLKTEKQKRAKIATEWRLLRSSPIRVGA
CCCHHHHCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECC
RCKVFGKCGGCILQHINYNSQLEFKKEKLRKILGREVEIIPSPRIFGHRNRIDLAVTVNA
EEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCCEECCCCEEEEEEEEEE
IGFREKGKWWSVVDVEECPVFGKTSKKAIERLREYIEEEKVSTWKIREDSGFLRYMVLRE
ECCCCCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEC
GKFTGEIMVNFVTKEGELPDPTSYFDFADSIYWSINRSKSDVSYGDIEKYWGKEFIMEEL
CCCEEEEEEEEEECCCCCCCCCCHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
DGVKYLIHPNSFFQTNSYQAVNLVKTVEKFVEGEKVVDMYSGVGTFGVYLAKKGMKVVGF
CCCEEEECCCCEEECCCCHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCEEEEE
DSNAFAIEMANKNAEINNVEAEFFVASDREVDIKGFDTVIVDPPRAGLHPKLVKRLNDHG
CCCEEEEEEECCCCCCCCEEEEEEEECCCEEEECCCCEEEECCCCCCCCHHHHHHHHCCC
PETIVYVSCNPKTFKVNIEQLNNYIIEELIALDMFPHTPHIELVGKLRRLV
CCEEEEEEECCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA