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The map label for this gene is rad50

Identifier: 18977539

GI number: 18977539

Start: 1114820

End: 1117468

Strand: Direct

Name: rad50

Synonym: PF1167

Alternate gene names: 18977539

Gene position: 1114820-1117468 (Clockwise)

Preceding gene: 18977538

Following gene: 18977540

Centisome position: 58.42

GC content: 38.32

Gene sequence:

>2649_bases
ATGAAGTTGGAGAGAGTGACTGTGAAAAACTTTAGGTCTCATAGCGATACTGTTGTAGAATTTAAGGAGGGCATTAACTT
AATAATTGGTCAAAATGGATCCGGAAAGAGTTCCCTTCTAGATGCAATCCTTGTCGGCCTTTACTGGCCTCTGAGAATTA
AAGATATCAAAAAAGACGAGTTCACAAAGGTTGGAGCAAGGGACACATACATTGACTTAATTTTTGAGAAAGATGGTACT
AAATACAGGATAACCCGAAGATTTTTGAAAGGTTACTCCTCAGGAGAAATTCATGCTATGAAAAGGCTTGTAGGAAATGA
ATGGAAGCATGTAACGGAGCCAAGCTCAAAGGCCATATCCGCTTTTATGGAAAAACTTATCCCGTACAACATATTCCTGA
ATGCCATCTACATCAGGCAGGGACAAATTGATGCCATACTTGAGAGCGATGAGGCTAGAGAGAAGGTTGTCAGAGAAGTT
TTAAATCTAGACAAGTTTGAGACTGCATACAAGAAGCTTTCCGAACTAAAGAAAACTATCAACAATAGAATAAAGGAGTA
CAGAGATATCCTTGCAAGGACAGAAAACATAGAGGAGCTGATAAAAGAAAATGAACAAGAGCTTATTCAAGTTCTCCAAG
AGATATCAAAGATAGAGGAAGTGCTTCCCAGTAAAAGGTCAAAGGTTGATATGCTTAGGAAAGAAGTCCTAAGACTTGAG
GAAACAAAGGTGGAGATAGAAAACAGTGAGCGTTTGCTAGAAAAAAGAAGAGGAGATAAGAGAACTCTTGAAGAGAGAAT
AAAAAACACTGAGGAATACTTAGAGAAGTTAAAAGAAAAAGAAAAGGAGCTTGAAGAGCAAGTTAAAGAAATCACCAGCA
TAAAGAAAGATGTTGATGCATATCTGGCCCTAAAAGAGTTCAAAAATGAGTACCTGGATAAAAAATATAAGATAGAAAAA
GAGCTGACTAGAGTAGAAGAGCTAATTAATGAGATTCAGAAGAGAATCGAGGAACTCAATGAGAAGGAATCAGAAAAGGA
GAAGCTCGAAAACGAGAAAAAAGAAATACTAAACAAGCTAGCTATTCTCGAAAAAGATCACCAATTGTATGAAGAGATAA
AAGCAAAGAAAGAAAATTTAAGGCAATTAAAAGAAAAGCTTGGAGACAAGTCTCCTGAAGACATTAAGAAATTACTAGAG
GAACTAGAGACTAAGAAAACAACAATAGAAGAGGAGAGAAATGAAATAACCCAGAGGATTGGAGAACTTAAAAACAAAAT
AGGGGATCTAAAAACGGCAATAGAAGAGCTCAAAAAAGCTAAAGGAAAGTGTCCAGTATGTGGAAGAGAGTTAACGGATG
AGCATAGAGAAGAGCTACTATCTAAATATCACCTCGATCTTAACAATAGCAAAAATACTTTAGCCAAACTAATCGATAGA
AAAAGCGAGCTCGAAAGAGAACTTCGAAGAATAGATATGGAAATAAAGCGATTAACGCCTCTTCTAACAGTAGCTGAACA
AATACGATCTATTGAAGAAGAATTGAATGTAGTGAACCTCGAGAAAATAGAGAAAAATGCCACGGAGTATGAAAAGCTTT
TAGAAGAGTTGCGCACCCTAGAGGGTAGAATTAGGGGCCTTGCAGAAGACCTGAAAAAGCTAGCTCCCCTAGAGAAGAAG
CTGGCCGCTCTTATCCATAAAAAGCAAGAACTAGAAAAAGAATTGAAAGAGCTTAACACTAAGCTAGAGTCTTTTGGATT
CAAATCAGTTGAAGATCTTGACTCTAAACTAAGAGAATTAGAGGAGATCTACAAAAGGTATCTTACCCTGTTAAATTCAA
AGAAAGAACTCGAAATAACCCAAAGGGAAATCGCCAAAGCTAAGGAAACTTTGGAGATGAGCTTCGAAGAACTTGCTGAA
GTAGAGGCGGACATTGAAAGGATAGAAAAGAAACTTAGCCAGCTAAAACAGAAATACAACGAAGAGGAATACAAGAAGAA
GAGAGAAGAAAAGGAGGAACTAGAAAAAGAGCTGGCTAGACTTGAAGCTCAAAAGAAAGAGTTAGAAAAGAGGAGAGACA
CAATAAAATCTACGCTGGAAAAGCTAAAAGCTGAAAAAGAAAACAGAGAAAGAGTAAAGAAAGAAATTAAAGACCTAGAA
AAAGCTAAAGATTTCACAGAAGAGTTGATTGAGAAAGTTAAGAAGTACAAGGCCTTGGCAAGGGAGGCCGCTCTCAGCAA
GATTGGAGAACTTGCCAGTGAAATATTCGCAGAATTTACTGAGGGTAAGTATTCGGAAGTTGTAGTGAGGGCCGAAGAGA
ATAAGGTAAGGTTATTTGTTGTGTGGGAAGGAAAAGAAAGGCCACTAACGTTTCTCAGCGGAGGGGAAAGGATAGCCCTT
GGATTGGCATTTAGGTTGGCAATGTCCCTATACCTAGCGGGAGAGATAAGCCTCCTGATTTTAGATGAGCCAACGCCTTA
TTTAGATGAGGAGAGAAGAAGAAAGCTCATCACGATCATGGAGAGGTACTTAAAGAAGATTCCACAAGTAATCCTCGTCT
CTCACGATGAAGAACTCAAGGATGCCGCAGATCACGTGATTAGGATAAGCCTTGAAAATGGATCCTCCAAGGTGGAGGTG
GTCTCTTGA

Upstream 100 bases:

>100_bases
AAAAAGTAAGTGAGGAGAAAGGAAAGACTGTGAGACAAAAAATTGAGAGTATTCCAAAGAAAAAGAGGGGAACGCTTGAT
AGCTGGCTTGGTGGTGCGAG

Downstream 100 bases:

>100_bases
GGCTTCTCTCCAAACAGAGCATAGAGAGAATAACAAAAATTCTCCTCGATGAGCTCGAGAACGTTAGGGAGAATGAGCAA
ATTAGGAACATAATTAACTC

Product: chromosome segregation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 882; Mature: 882

Protein sequence:

>882_residues
MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGT
KYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAISAFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREV
LNLDKFETAYKKLSELKKTINNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLE
ETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDAYLALKEFKNEYLDKKYKIEK
ELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKLAILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLE
ELETKKTTIEEERNEITQRIGELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDR
KSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTLEGRIRGLAEDLKKLAPLEKK
LAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLRELEEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAE
VEADIERIEKKLSQLKQKYNEEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLE
KAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIAL
GLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEV
VS

Sequences:

>Translated_882_residues
MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGT
KYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAISAFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREV
LNLDKFETAYKKLSELKKTINNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLE
ETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDAYLALKEFKNEYLDKKYKIEK
ELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKLAILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLE
ELETKKTTIEEERNEITQRIGELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDR
KSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTLEGRIRGLAEDLKKLAPLEKK
LAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLRELEEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAE
VEADIERIEKKLSQLKQKYNEEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLE
KAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIAL
GLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEV
VS
>Mature_882_residues
MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGT
KYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAISAFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREV
LNLDKFETAYKKLSELKKTINNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLE
ETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDAYLALKEFKNEYLDKKYKIEK
ELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKLAILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLE
ELETKKTTIEEERNEITQRIGELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDR
KSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTLEGRIRGLAEDLKKLAPLEKK
LAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLRELEEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAE
VEADIERIEKKLSQLKQKYNEEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLE
KAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIAL
GLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEV
VS

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of mre11 by unwinding and

COG id: COG0419

COG function: function code L; ATPase involved in DNA repair

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 zinc-hook domain

Homologues:

Organism=Homo sapiens, GI119466532, Length=678, Percent_Identity=21.3864306784661, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI28559088, Length=678, Percent_Identity=21.3864306784661, Blast_Score=85, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71991183, Length=670, Percent_Identity=22.2388059701493, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71991177, Length=670, Percent_Identity=22.2388059701493, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RAD50_PYRFU (P58301)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578896.1
- PDB:   1F2T
- PDB:   1F2U
- PDB:   1II8
- PDB:   1L8D
- PDB:   1US8
- PDBsum:   1F2T
- PDBsum:   1F2U
- PDBsum:   1II8
- PDBsum:   1L8D
- PDBsum:   1US8
- ProteinModelPortal:   P58301
- EnsemblBacteria:   EBPYRT00000005235
- GeneID:   1469036
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1167
- NMPDR:   fig|186497.1.peg.1207
- GeneTree:   EBGT00050000022195
- HOGENOM:   HBG726702
- OMA:   TEHLDEE
- ProtClustDB:   PRK03918
- GO:   GO:0005694
- HAMAP:   MF_00449
- InterPro:   IPR022982
- InterPro:   IPR007517
- InterPro:   IPR003395
- InterPro:   IPR013134

Pfam domain/function: PF04423 Rad50_zn_hook; PF02463 SMC_N

EC number: NA

Molecular weight: Translated: 103841; Mature: 103841

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS51131 ZN_HOOK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDE
CCCCHHHHHHHHCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHCCHHH
FTKVGARDTYIDLIFEKDGTKYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAIS
HHHCCCCCHHEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH
AFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREVLNLDKFETAYKKLSELKKTI
HHHHHHCCHHHHHHHHHEECCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
NNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLALKEFKNEYLDKKYKIEKELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLEELETKKTTIEEERNEITQRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
EGRIRGLAEDLKKLAPLEKKLAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLREL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
EEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAEVEADIERIEKKLSQLKQKYN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCEEEEE
VWEGKERPLTFLSGGERIALGLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIM
EECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHH
ERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEVVS
HHHHHHCCHHEEECCCHHHHHHHHHEEEEEEECCCCCEEECC
>Mature Secondary Structure
MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDE
CCCCHHHHHHHHCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHCCHHH
FTKVGARDTYIDLIFEKDGTKYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAIS
HHHCCCCCHHEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH
AFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREVLNLDKFETAYKKLSELKKTI
HHHHHHCCHHHHHHHHHEECCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
NNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLALKEFKNEYLDKKYKIEKELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLEELETKKTTIEEERNEITQRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
EGRIRGLAEDLKKLAPLEKKLAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLREL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
EEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAEVEADIERIEKKLSQLKQKYN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCEEEEE
VWEGKERPLTFLSGGERIALGLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIM
EECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHH
ERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEVVS
HHHHHHCCHHEEECCCHHHHHHHHHEEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11029422; 10892749