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The map label for this gene is napA [H]

Identifier: 18977536

GI number: 18977536

Start: 1110664

End: 1111845

Strand: Direct

Name: napA [H]

Synonym: PF1164

Alternate gene names: 18977536

Gene position: 1110664-1111845 (Clockwise)

Preceding gene: 18977535

Following gene: 18977537

Centisome position: 58.2

GC content: 36.29

Gene sequence:

>1182_bases
ATGAACTATATCCTACATCTTTCAATTTTGTTAGTCGTTGCCAAGTTACTTGAGTGGTTATTTGAGAAGAAGGACATTCA
TCCAATAATTGCCCACATATTAACCGGCATAATCCTGGGACCATTTCTCCTGGGGATAATTTATCCAAATGAAGAGCTAA
AGGTTCTAAGTGAGTTCGGACTAATTATGATGATGCTATACATGGGATTAACCAGCAACTTTTCCGCAATAGCTCAAAAT
AAAGTAAAGGCAATTGTTGTTGCTTCTTTAGGTGTGGCATTCTCTTTCATCTTAGGATTCACGACAGTATATCTATTTGG
GAAAGGAATTTCAGCTGCTCTTTTCGTTGGTATAACATTAGGAAATACAGCAATAGAAGTTACAAGTGGGGTTATAATGA
AGGAGAGAATCAAGAGAGAAATTTCTTCGGTTTTAATGGGAGCGGCTTTTGCTGACGATATTATTGCTGTCTATCTTATA
GGAATACTAACAGGTATGATCAAAGGACAGACCTCCTTACTTTCCCTGGCTATCCTCACGATAAAGATAGTAGCATTTAT
TCTTAGTGTACTGATATTTTCTGAATTTGTCTTCAAAAAATCTAGCCTCATTTATAATTTAGTGATAAAAGATCTGAATG
TATTCTTTACGTTTACAATAATCTTAACATTCTCTCTCGCTGTAATTGCGGAAGGAATAGGGCTTAATAGGATAATTGGA
GCATATTTAGCGGGTTTAACAATAAGCAGGCTGAGAGAAAGAAAAGATCCATTAATTATTAGCAGAATAAAGCTGAATGA
GTTGATAAATGAGTTGCAAGTTGTACTTACAGAATTCTTCATTCCATTGTTTTTTATATATGTAGGATTAATGTTTGACC
CAGACACTTCAGAGATAAATCTTCTGCTAATTGCTTTGCTTTATGCTTCGGCAATTCTTGGAAAGCTTATAGGCTGTGGC
CTTGGAGTTAAAGTGTTCAAAGGATCATGGAAAGATGCAGTCATTGTAGGTATAGGAATGGGAGGGAGGGGCAGTCTCGA
CTTGGCACTATTGAAGTTTGGACTTGAGAGTGGAATGATTGGGGAGGATTTATTTGCAACAACAGTCATAGTTTCCATGT
TAACTGCACTATCCACTCCAATATTCTTTAGGAAGACCGTAAAAAAATTAAGCGAAGAATGA

Upstream 100 bases:

>100_bases
GCGTTTGGAACCAAGAGAGGAGTTACCATAGCCATGATACTAGCTTTAGTTTTGATGATATCGTGGATAATACTTGCCCT
ACTCCAAAGGAGGATGTGAA

Downstream 100 bases:

>100_bases
TATAATTACCGGGGATAAGTATGGAGGAATTCGTTGGAATTGTAAGGGGGGAAGCGAGCTTCACAAGTTATGAGTTTTCA
ATAAATCCCTCCGCAAACGT

Product: putative Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNYILHLSILLVVAKLLEWLFEKKDIHPIIAHILTGIILGPFLLGIIYPNEELKVLSEFGLIMMMLYMGLTSNFSAIAQN
KVKAIVVASLGVAFSFILGFTTVYLFGKGISAALFVGITLGNTAIEVTSGVIMKERIKREISSVLMGAAFADDIIAVYLI
GILTGMIKGQTSLLSLAILTIKIVAFILSVLIFSEFVFKKSSLIYNLVIKDLNVFFTFTIILTFSLAVIAEGIGLNRIIG
AYLAGLTISRLRERKDPLIISRIKLNELINELQVVLTEFFIPLFFIYVGLMFDPDTSEINLLLIALLYASAILGKLIGCG
LGVKVFKGSWKDAVIVGIGMGGRGSLDLALLKFGLESGMIGEDLFATTVIVSMLTALSTPIFFRKTVKKLSEE

Sequences:

>Translated_393_residues
MNYILHLSILLVVAKLLEWLFEKKDIHPIIAHILTGIILGPFLLGIIYPNEELKVLSEFGLIMMMLYMGLTSNFSAIAQN
KVKAIVVASLGVAFSFILGFTTVYLFGKGISAALFVGITLGNTAIEVTSGVIMKERIKREISSVLMGAAFADDIIAVYLI
GILTGMIKGQTSLLSLAILTIKIVAFILSVLIFSEFVFKKSSLIYNLVIKDLNVFFTFTIILTFSLAVIAEGIGLNRIIG
AYLAGLTISRLRERKDPLIISRIKLNELINELQVVLTEFFIPLFFIYVGLMFDPDTSEINLLLIALLYASAILGKLIGCG
LGVKVFKGSWKDAVIVGIGMGGRGSLDLALLKFGLESGMIGEDLFATTVIVSMLTALSTPIFFRKTVKKLSEE
>Mature_393_residues
MNYILHLSILLVVAKLLEWLFEKKDIHPIIAHILTGIILGPFLLGIIYPNEELKVLSEFGLIMMMLYMGLTSNFSAIAQN
KVKAIVVASLGVAFSFILGFTTVYLFGKGISAALFVGITLGNTAIEVTSGVIMKERIKREISSVLMGAAFADDIIAVYLI
GILTGMIKGQTSLLSLAILTIKIVAFILSVLIFSEFVFKKSSLIYNLVIKDLNVFFTFTIILTFSLAVIAEGIGLNRIIG
AYLAGLTISRLRERKDPLIISRIKLNELINELQVVLTEFFIPLFFIYVGLMFDPDTSEINLLLIALLYASAILGKLIGCG
LGVKVFKGSWKDAVIVGIGMGGRGSLDLALLKFGLESGMIGEDLFATTVIVSMLTALSTPIFFRKTVKKLSEE

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=440, Percent_Identity=22.9545454545455, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 42923; Mature: 42923

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure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CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]