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The map label for this gene is mfnA

Identifier: 18977531

GI number: 18977531

Start: 1107965

End: 1109080

Strand: Reverse

Name: mfnA

Synonym: PF1159

Alternate gene names: 18977531

Gene position: 1109080-1107965 (Counterclockwise)

Preceding gene: 18977532

Following gene: 18977530

Centisome position: 58.12

GC content: 42.38

Gene sequence:

>1116_bases
GTGAAGTTCCCAAGAAAAGGTATCCCACAAGAGGAAGTTATGAGAGAATTAGAAAAATACACTTCCAAAGACTTATCATT
TTCATCTGGCAAGATCCTAGGTTCCATGTGCACTCTCCCGCACGAGTTGGCCAAAGAAGTGTTCTGTATGTACATGGATA
GAAATTTGGGCGATCCTGGGCTTCACCCAGGGACAAAGAAAATAGAAGAAGAAGTAATAGAAATGCTTTCAGATCTCTTA
CATTTAGAGAGAGGATATGGACATATTGTCTCAGGTGGGACTGAGGCAAATATCTTGGCTGTCAGAGCGTTTAGAAATCT
GGCAGATGTTGAAAATCCAGAGTTAATTTTGCCTAAGAGTGCACACTTCTCCTTCATAAAGGCTGGAGAAATGTTGGGAG
TTAAGTTGATTTGGGCTGACTTAAATCCAGACTATACTGTGGATGTAAAAGATGTTGAGGCAAAGATAAGTGAGAATACC
ATTGGCATAGTTGGAATAGCCGGAACTACAGGGCTTGGTGTCGTTGACGATATTCCAGCTTTGAGTGATCTAGCTAGGGA
CTATGGAATCCCTCTTCACGTTGACGCAGCATTTGGAGGATTTGTAATACCATTTGCTAAAGAACTCGGATATGACTTAC
CAGACTTTGACTTCAAGCTTAAAGGAGTTCAAAGTATAACAATAGATCCCCACAAGATGGGAATGGCCCCAATTCCGGCA
GGGGGAATAGTTTTTAGACATAAAAAATATCTAAGGGCAATAAGCGTTTTAGCTCCATATTTAGCTGGAGGGAAGATATG
GCAGGCGACAATAACGGGAACTAGACCAGGAGCTAGTGTGTTGGCTGTATGGGCTCTAATTAAGCATTTAGGATTTGAAG
GGTACATGGAGATTGTAGATAGGGCCATGAAGCTTTCTAGGTGGTTTGCTGAGGAGATAAAGAAAACTCCAGGAGCTTGG
CTGGTGAGAGAGCCCATGCTAAACATAGTCTCCTTTAAGACCAAGAACCTAAGGAGAGTTGAAAGGGAATTAAAATCAAG
GGGATGGGGAATTAGTGCCCATAGGGGGTATATAAGAATAGTTTCTCATGCCTCATGTGACGGAGGCCATGATTAG

Upstream 100 bases:

>100_bases
TTGTTGGAACGTTAGCAGAATTCTATGAAGTTCCTCCTGATGACAATTTTTCCTCTCAGCTTATAATAGCAATAACCCTA
TATCTCCTGGGGGTGAGATA

Downstream 100 bases:

>100_bases
GGAATTCTTGAAAGACTTGAGGGAGGTTATATGAAAACACTAAAAGTCTATATCCCAGGAATAAAATTCCCATCGATTTC
AGTCACTGGAAATTACTGTG

Product: L-tyrosine decarboxylase

Products: NA

Alternate protein names: TDC

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKFPRKGIPQEEVMRELEKYTSKDLSFSSGKILGSMCTLPHELAKEVFCMYMDRNLGDPGLHPGTKKIEEEVIEMLSDLL
HLERGYGHIVSGGTEANILAVRAFRNLADVENPELILPKSAHFSFIKAGEMLGVKLIWADLNPDYTVDVKDVEAKISENT
IGIVGIAGTTGLGVVDDIPALSDLARDYGIPLHVDAAFGGFVIPFAKELGYDLPDFDFKLKGVQSITIDPHKMGMAPIPA
GGIVFRHKKYLRAISVLAPYLAGGKIWQATITGTRPGASVLAVWALIKHLGFEGYMEIVDRAMKLSRWFAEEIKKTPGAW
LVREPMLNIVSFKTKNLRRVERELKSRGWGISAHRGYIRIVSHASCDGGHD

Sequences:

>Translated_371_residues
MKFPRKGIPQEEVMRELEKYTSKDLSFSSGKILGSMCTLPHELAKEVFCMYMDRNLGDPGLHPGTKKIEEEVIEMLSDLL
HLERGYGHIVSGGTEANILAVRAFRNLADVENPELILPKSAHFSFIKAGEMLGVKLIWADLNPDYTVDVKDVEAKISENT
IGIVGIAGTTGLGVVDDIPALSDLARDYGIPLHVDAAFGGFVIPFAKELGYDLPDFDFKLKGVQSITIDPHKMGMAPIPA
GGIVFRHKKYLRAISVLAPYLAGGKIWQATITGTRPGASVLAVWALIKHLGFEGYMEIVDRAMKLSRWFAEEIKKTPGAW
LVREPMLNIVSFKTKNLRRVERELKSRGWGISAHRGYIRIVSHASCDGGHD
>Mature_371_residues
MKFPRKGIPQEEVMRELEKYTSKDLSFSSGKILGSMCTLPHELAKEVFCMYMDRNLGDPGLHPGTKKIEEEVIEMLSDLL
HLERGYGHIVSGGTEANILAVRAFRNLADVENPELILPKSAHFSFIKAGEMLGVKLIWADLNPDYTVDVKDVEAKISENT
IGIVGIAGTTGLGVVDDIPALSDLARDYGIPLHVDAAFGGFVIPFAKELGYDLPDFDFKLKGVQSITIDPHKMGMAPIPA
GGIVFRHKKYLRAISVLAPYLAGGKIWQATITGTRPGASVLAVWALIKHLGFEGYMEIVDRAMKLSRWFAEEIKKTPGAW
LVREPMLNIVSFKTKNLRRVERELKSRGWGISAHRGYIRIVSHASCDGGHD

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily

Homologues:

Organism=Homo sapiens, GI31982936, Length=360, Percent_Identity=32.2222222222222, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI194294551, Length=328, Percent_Identity=27.4390243902439, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI197383062, Length=301, Percent_Identity=26.9102990033223, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787769, Length=357, Percent_Identity=26.890756302521, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789934, Length=357, Percent_Identity=26.890756302521, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17543922, Length=361, Percent_Identity=31.3019390581717, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17557272, Length=365, Percent_Identity=30.4109589041096, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25148342, Length=317, Percent_Identity=29.3375394321767, Blast_Score=144, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6320500, Length=398, Percent_Identity=33.1658291457286, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323905, Length=354, Percent_Identity=23.1638418079096, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21355963, Length=363, Percent_Identity=30.3030303030303, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24654344, Length=363, Percent_Identity=30.3030303030303, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI21356415, Length=276, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17136594, Length=313, Percent_Identity=25.5591054313099, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MFNA_PYRFU (Q8U1P6)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578888.1
- ProteinModelPortal:   Q8U1P6
- SMR:   Q8U1P6
- EnsemblBacteria:   EBPYRT00000004980
- GeneID:   1469028
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1159
- NMPDR:   fig|186497.1.peg.1199
- GeneTree:   EBGT00050000023338
- HOGENOM:   HBG497871
- OMA:   ILGSMCT
- ProtClustDB:   PRK13520
- BRENDA:   4.1.1.25
- HAMAP:   MF_01610
- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115
- InterPro:   IPR020931
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11999
- TIGRFAMs:   TIGR03812

Pfam domain/function: PF00282 Pyridoxal_deC; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.1.1.25

Molecular weight: Translated: 40996; Mature: 40996

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00392 DDC_GAD_HDC_YDC; PS00214 FABP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFPRKGIPQEEVMRELEKYTSKDLSFSSGKILGSMCTLPHELAKEVFCMYMDRNLGDPG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCC
LHPGTKKIEEEVIEMLSDLLHLERGYGHIVSGGTEANILAVRAFRNLADVENPELILPKS
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCEEECCC
AHFSFIKAGEMLGVKLIWADLNPDYTVDVKDVEAKISENTIGIVGIAGTTGLGVVDDIPA
CCHHHHHCCCEEEEEEEEEECCCCEEEEHHHHHHHHCCCCEEEEEECCCCCCCCHHCCHH
LSDLARDYGIPLHVDAAFGGFVIPFAKELGYDLPDFDFKLKGVQSITIDPHKMGMAPIPA
HHHHHHHCCCCEEEECCCCCCHHHHHHHCCCCCCCCCEEECCCEEEEECHHHCCCCCCCC
GGIVFRHKKYLRAISVLAPYLAGGKIWQATITGTRPGASVLAVWALIKHLGFEGYMEIVD
CCEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHH
RAMKLSRWFAEEIKKTPGAWLVREPMLNIVSFKTKNLRRVERELKSRGWGISAHRGYIRI
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
VSHASCDGGHD
EEECCCCCCCC
>Mature Secondary Structure
MKFPRKGIPQEEVMRELEKYTSKDLSFSSGKILGSMCTLPHELAKEVFCMYMDRNLGDPG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCC
LHPGTKKIEEEVIEMLSDLLHLERGYGHIVSGGTEANILAVRAFRNLADVENPELILPKS
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCEEECCC
AHFSFIKAGEMLGVKLIWADLNPDYTVDVKDVEAKISENTIGIVGIAGTTGLGVVDDIPA
CCHHHHHCCCEEEEEEEEEECCCCEEEEHHHHHHHHCCCCEEEEEECCCCCCCCHHCCHH
LSDLARDYGIPLHVDAAFGGFVIPFAKELGYDLPDFDFKLKGVQSITIDPHKMGMAPIPA
HHHHHHHCCCCEEEECCCCCCHHHHHHHCCCCCCCCCEEECCCEEEEECHHHCCCCCCCC
GGIVFRHKKYLRAISVLAPYLAGGKIWQATITGTRPGASVLAVWALIKHLGFEGYMEIVD
CCEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHH
RAMKLSRWFAEEIKKTPGAWLVREPMLNIVSFKTKNLRRVERELKSRGWGISAHRGYIRI
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
VSHASCDGGHD
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA