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The map label for this gene is ccmA [H]

Identifier: 18977462

GI number: 18977462

Start: 1037290

End: 1038027

Strand: Reverse

Name: ccmA [H]

Synonym: PF1090

Alternate gene names: 18977462

Gene position: 1038027-1037290 (Counterclockwise)

Preceding gene: 18977463

Following gene: 33359538

Centisome position: 54.4

GC content: 40.51

Gene sequence:

>738_bases
ATGGATCCTTGGATTTTTGTTGCCCTTTGTTTTTGGATTGCTACTTATAGAGATAGGATACGGACTCACTGGTATTATAT
TTTTGATAATCTCTCTTTCTGGCCTAAGAGGTCTTTGGGAGGGAGCAAAATGAAGCTTGAAATAAGAGAGCTAAGCGTTG
GCTACAAGAGGCCCCTTCTAGAAGATATTACACTTGAGCTGGAAAATGGTGATGCAGTAAACTTCTATGGCCCCAACGGG
ATAGGGAAAACCACCCTTCTAAAAACAATAGCCACTTATCTAAAACCTCTAAAAGGGGAGATTCTCTACAATGGTGCTCC
AATAAGGAAGGTTAGAGGGAAGATATTCTTCCTCCCCGAGAGTATTTTGGTCCCAAATAAGGTAAGGGCTAGAGACTATC
TTAAGGCAGTAGCCAGTTTATATGGTGTAAACCCAAGTATGGAGGAAGTGGTAAGGGCTCTTGATTTGGTTGGTATTTCC
GACGAGAATATAAAGTTTGAAAAATGTTCCCAGGGGATGAAGAGGAGAATTCAGTTGGCTTCAGCTCTACTCGTCAATGC
CGAAATATTTGTTCTAGACGATCCGGTTGTAGCTATAGATGAAGACTCAAAGCACGAAATATTAAAGGGAATTGTTGATA
CTCTTAAGAAGAGGGGCATCGTAATCATATCTTCCAGAGAAAAACTTCCATACTTTCCCATTAATGAGGATGTTGTAAAG
TACAAACCTAAGCTCTGA

Upstream 100 bases:

>100_bases
TTCCGATATCCTCACCTGTAGAAGTGAGAATTGACTATAAAAAGTTAGCATTTATATGGATTCCTCAAACTGATATTCCA
AACCAGAGATACATTATAGG

Downstream 100 bases:

>100_bases
ACTACAGAGTTTGACCTGAGTATAAATACCTCTACCTCCATTTAATTTTTGGTGGGATTTATGGAGGGGGTTAAAGAACT
AAAAGAAGTACTTGACAAGG

Product: putative ABC transporter

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MDPWIFVALCFWIATYRDRIRTHWYYIFDNLSFWPKRSLGGSKMKLEIRELSVGYKRPLLEDITLELENGDAVNFYGPNG
IGKTTLLKTIATYLKPLKGEILYNGAPIRKVRGKIFFLPESILVPNKVRARDYLKAVASLYGVNPSMEEVVRALDLVGIS
DENIKFEKCSQGMKRRIQLASALLVNAEIFVLDDPVVAIDEDSKHEILKGIVDTLKKRGIVIISSREKLPYFPINEDVVK
YKPKL

Sequences:

>Translated_245_residues
MDPWIFVALCFWIATYRDRIRTHWYYIFDNLSFWPKRSLGGSKMKLEIRELSVGYKRPLLEDITLELENGDAVNFYGPNG
IGKTTLLKTIATYLKPLKGEILYNGAPIRKVRGKIFFLPESILVPNKVRARDYLKAVASLYGVNPSMEEVVRALDLVGIS
DENIKFEKCSQGMKRRIQLASALLVNAEIFVLDDPVVAIDEDSKHEILKGIVDTLKKRGIVIISSREKLPYFPINEDVVK
YKPKL
>Mature_245_residues
MDPWIFVALCFWIATYRDRIRTHWYYIFDNLSFWPKRSLGGSKMKLEIRELSVGYKRPLLEDITLELENGDAVNFYGPNG
IGKTTLLKTIATYLKPLKGEILYNGAPIRKVRGKIFFLPESILVPNKVRARDYLKAVASLYGVNPSMEEVVRALDLVGIS
DENIKFEKCSQGMKRRIQLASALLVNAEIFVLDDPVVAIDEDSKHEILKGIVDTLKKRGIVIISSREKLPYFPINEDVVK
YKPKL

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI116734710, Length=198, Percent_Identity=26.2626262626263, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI46592964, Length=240, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI46592956, Length=240, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI46592915, Length=240, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI46592898, Length=240, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI46592978, Length=240, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI46592971, Length=240, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI255708477, Length=205, Percent_Identity=25.3658536585366, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI27436953, Length=168, Percent_Identity=22.6190476190476, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI148612844, Length=205, Percent_Identity=25.3658536585366, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI27477115, Length=175, Percent_Identity=24, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1786653, Length=182, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082064, Length=188, Percent_Identity=29.2553191489362, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790739, Length=199, Percent_Identity=25.6281407035176, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787112, Length=199, Percent_Identity=25.6281407035176, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788761, Length=202, Percent_Identity=26.7326732673267, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786803, Length=198, Percent_Identity=23.7373737373737, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788225, Length=191, Percent_Identity=25.6544502617801, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788165, Length=190, Percent_Identity=29.4736842105263, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786563, Length=169, Percent_Identity=31.3609467455621, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789032, Length=222, Percent_Identity=28.3783783783784, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787143, Length=204, Percent_Identity=26.4705882352941, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI48994943, Length=193, Percent_Identity=23.3160621761658, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71992290, Length=219, Percent_Identity=25.1141552511416, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17511077, Length=206, Percent_Identity=26.6990291262136, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17510237, Length=150, Percent_Identity=32, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17543740, Length=205, Percent_Identity=25.3658536585366, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17533971, Length=182, Percent_Identity=24.7252747252747, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115533592, Length=216, Percent_Identity=26.3888888888889, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17565938, Length=181, Percent_Identity=25.9668508287293, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193202349, Length=204, Percent_Identity=25, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24648314, Length=195, Percent_Identity=23.5897435897436, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573571, Length=172, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573573, Length=172, Percent_Identity=27.906976744186, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221512771, Length=156, Percent_Identity=26.2820512820513, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24582014, Length=172, Percent_Identity=25, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24582012, Length=172, Percent_Identity=25, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 28038; Mature: 28038

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPWIFVALCFWIATYRDRIRTHWYYIFDNLSFWPKRSLGGSKMKLEIRELSVGYKRPLL
CCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCH
EDITLELENGDAVNFYGPNGIGKTTLLKTIATYLKPLKGEILYNGAPIRKVRGKIFFLPE
HHEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHCCEEEECCC
SILVPNKVRARDYLKAVASLYGVNPSMEEVVRALDLVGISDENIKFEKCSQGMKRRIQLA
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SALLVNAEIFVLDDPVVAIDEDSKHEILKGIVDTLKKRGIVIISSREKLPYFPINEDVVK
HHHHHCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHC
YKPKL
CCCCC
>Mature Secondary Structure
MDPWIFVALCFWIATYRDRIRTHWYYIFDNLSFWPKRSLGGSKMKLEIRELSVGYKRPLL
CCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCH
EDITLELENGDAVNFYGPNGIGKTTLLKTIATYLKPLKGEILYNGAPIRKVRGKIFFLPE
HHEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHCCEEEECCC
SILVPNKVRARDYLKAVASLYGVNPSMEEVVRALDLVGISDENIKFEKCSQGMKRRIQLA
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SALLVNAEIFVLDDPVVAIDEDSKHEILKGIVDTLKKRGIVIISSREKLPYFPINEDVVK
HHHHHCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHC
YKPKL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA