Click here to switch to the map view.

The map label for this gene is 18977435

Identifier: 18977435

GI number: 18977435

Start: 1016450

End: 1017484

Strand: Direct

Name: 18977435

Synonym: PF1063

Alternate gene names: NA

Gene position: 1016450-1017484 (Clockwise)

Preceding gene: 18977434

Following gene: 18977436

Centisome position: 53.27

GC content: 43.29

Gene sequence:

>1035_bases
ATGTTGCACGAAATACCAAAAGAAGAAATTCTCGAAAAGTTGAAAAATATAGGGGCAAAGAAAGTTCTAATCCAATCTCC
CGAAGGGTTAAGGCGAGAAGCAGAAGAACTCGCAGAATTTTTAGAAAAAAATGAAATTGAAGTTATACTTCACGGTGAAA
TTAATTATGGTGCTTGTGATCCTGCAGATCATGAAGCTAGATTGCTAGGTTGCGACGCCCTAATACACCTGGGACACTCC
TTCATGATGTTATCTTTAGAAGTACCCACTATTTTCGTTCCCGCGTTTGCCAAGGTTAATGTAGTTGAAGCCTTGAAAAA
GAACCTTCACGAGATCAAGAAGCTTGGGAAAAAGATAATCGTGACAACCACAGCCCAGCACATTCACCAACTTGAGAGGG
CAATAGAGTATCTTAAGTCCCAGGGATTCGAGCCAGTTGTGGGGAGGGGAGATAATAGGGTATCTTGGCCTAGCCAAGTT
TTGGGATGTAACTTTTCTGTTGCCAAGGTTGAGGGAGATGGAATACTATTCATAGGCTCTGGAACCTTCCACCCCCTGGG
ATTGGCCCTAGCAACTGGAAAAAGAGTTTTAGCTGTTAATCCCTATAGTGGGGATTGCCAGTGGATAAATGAGCTAGCGG
AAAGGTTTATCAGAAAAAGGTGGGCACAAATAGCCAAGGCTATGGACGCTAAAAGATTTGGAGTTGTGATAAGTACCAAG
AGAGGACAGTTAAGGCTAAATGAGGCAAAGAGAATAATCAAGCTTCTCAAAGACCATGGAAGAGAGGCCAAGTTAATTGC
AATGAACGACATAAGCTACTCGAAACTTGAAGGATTCAGCTTCGATGCTTACGTTATCGTTGCGTGCCCGAGGGTTCCAA
TAGATGATTATGAGAACTGGAGAAAACCGGTCTTAACTCCAAGGGAAGTCGAGATACTGTTGGGGTTGAGAGAAGAATAT
ATATTTGATGAGATCCCAGGTGGGGTGAGGGAGAAAGATGAACCTCTCGGAATATCCCTTCATAGCACCCGCTGA

Upstream 100 bases:

>100_bases
GGGGACGAAGTGGAGATCGTTATAAACTCCGTGAAGAGCAAGTACGCCTTTGCCCAGGTTATAGGGTGAAGTTTTTAACT
TCCTTTCCCTCTTTTTCTTC

Downstream 100 bases:

>100_bases
CTTTTTTGTCATATTACTGTCTACCATTATGTATTACGAGTTTCTAAAGACGGGCTTTGAAGTATTCACGTATAAGAGAC
CAAGAAAGTTCATCCTATTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLHEIPKEEILEKLKNIGAKKVLIQSPEGLRREAEELAEFLEKNEIEVILHGEINYGACDPADHEARLLGCDALIHLGHS
FMMLSLEVPTIFVPAFAKVNVVEALKKNLHEIKKLGKKIIVTTTAQHIHQLERAIEYLKSQGFEPVVGRGDNRVSWPSQV
LGCNFSVAKVEGDGILFIGSGTFHPLGLALATGKRVLAVNPYSGDCQWINELAERFIRKRWAQIAKAMDAKRFGVVISTK
RGQLRLNEAKRIIKLLKDHGREAKLIAMNDISYSKLEGFSFDAYVIVACPRVPIDDYENWRKPVLTPREVEILLGLREEY
IFDEIPGGVREKDEPLGISLHSTR

Sequences:

>Translated_344_residues
MLHEIPKEEILEKLKNIGAKKVLIQSPEGLRREAEELAEFLEKNEIEVILHGEINYGACDPADHEARLLGCDALIHLGHS
FMMLSLEVPTIFVPAFAKVNVVEALKKNLHEIKKLGKKIIVTTTAQHIHQLERAIEYLKSQGFEPVVGRGDNRVSWPSQV
LGCNFSVAKVEGDGILFIGSGTFHPLGLALATGKRVLAVNPYSGDCQWINELAERFIRKRWAQIAKAMDAKRFGVVISTK
RGQLRLNEAKRIIKLLKDHGREAKLIAMNDISYSKLEGFSFDAYVIVACPRVPIDDYENWRKPVLTPREVEILLGLREEY
IFDEIPGGVREKDEPLGISLHSTR
>Mature_344_residues
MLHEIPKEEILEKLKNIGAKKVLIQSPEGLRREAEELAEFLEKNEIEVILHGEINYGACDPADHEARLLGCDALIHLGHS
FMMLSLEVPTIFVPAFAKVNVVEALKKNLHEIKKLGKKIIVTTTAQHIHQLERAIEYLKSQGFEPVVGRGDNRVSWPSQV
LGCNFSVAKVEGDGILFIGSGTFHPLGLALATGKRVLAVNPYSGDCQWINELAERFIRKRWAQIAKAMDAKRFGVVISTK
RGQLRLNEAKRIIKLLKDHGREAKLIAMNDISYSKLEGFSFDAYVIVACPRVPIDDYENWRKPVLTPREVEILLGLREEY
IFDEIPGGVREKDEPLGISLHSTR

Specific function: Unknown

COG id: COG1736

COG function: function code J; Diphthamide synthase subunit DPH2

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI116686106, Length=321, Percent_Identity=29.2834890965732, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17552166, Length=327, Percent_Identity=26.605504587156, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6322088, Length=332, Percent_Identity=28.6144578313253, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24662841, Length=314, Percent_Identity=26.7515923566879, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21356957, Length=314, Percent_Identity=26.7515923566879, Blast_Score=111, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016435
- InterPro:   IPR002728
- InterPro:   IPR022428 [H]

Pfam domain/function: PF01866 Diphthamide_syn [H]

EC number: NA

Molecular weight: Translated: 38714; Mature: 38714

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHEIPKEEILEKLKNIGAKKVLIQSPEGLRREAEELAEFLEKNEIEVILHGEINYGACD
CCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
PADHEARLLGCDALIHLGHSFMMLSLEVPTIFVPAFAKVNVVEALKKNLHEIKKLGKKII
CCCCCCEEEHHHHHHHCCCCEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEE
VTTTAQHIHQLERAIEYLKSQGFEPVVGRGDNRVSWPSQVLGCNFSVAKVEGDGILFIGS
EEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCCEEEEEEC
GTFHPLGLALATGKRVLAVNPYSGDCQWINELAERFIRKRWAQIAKAMDAKRFGVVISTK
CCCCHHHHEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCEEEEECC
RGQLRLNEAKRIIKLLKDHGREAKLIAMNDISYSKLEGFSFDAYVIVACPRVPIDDYENW
CCCEEHHHHHHHHHHHHHCCCCEEEEEEECCCHHHCCCCCCCEEEEEECCCCCCCCHHHH
RKPVLTPREVEILLGLREEYIFDEIPGGVREKDEPLGISLHSTR
CCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MLHEIPKEEILEKLKNIGAKKVLIQSPEGLRREAEELAEFLEKNEIEVILHGEINYGACD
CCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
PADHEARLLGCDALIHLGHSFMMLSLEVPTIFVPAFAKVNVVEALKKNLHEIKKLGKKII
CCCCCCEEEHHHHHHHCCCCEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEE
VTTTAQHIHQLERAIEYLKSQGFEPVVGRGDNRVSWPSQVLGCNFSVAKVEGDGILFIGS
EEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCCEEEEEEC
GTFHPLGLALATGKRVLAVNPYSGDCQWINELAERFIRKRWAQIAKAMDAKRFGVVISTK
CCCCHHHHEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCEEEEECC
RGQLRLNEAKRIIKLLKDHGREAKLIAMNDISYSKLEGFSFDAYVIVACPRVPIDDYENW
CCCEEHHHHHHHHHHHHHCCCCEEEEEEECCCHHHCCCCCCCEEEEEECCCCCCCCHHHH
RKPVLTPREVEILLGLREEYIFDEIPGGVREKDEPLGISLHSTR
CCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]