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The map label for this gene is 18977190

Identifier: 18977190

GI number: 18977190

Start: 798141

End: 799148

Strand: Reverse

Name: 18977190

Synonym: PF0818

Alternate gene names: NA

Gene position: 799148-798141 (Counterclockwise)

Preceding gene: 18977191

Following gene: 18977189

Centisome position: 41.88

GC content: 45.34

Gene sequence:

>1008_bases
ATGATTGGCTCAATATTTTATTCCAAGAAGTTTAACCTCCATAGACCTAGTGAGTATCATCCAGAGAATCCCAAGAGACT
CGAAATCGTTCTTTCCAAGGTCAGAGAGCTTGGACTTGAAGAAAGAATAGAAGAACCAAACCCAGTTGAAGAGACTTTCG
TTGAGAAAATTCACGACAGGGATTACATCAACTTCGTTAAAGAGGCCGTTGAAAAAGGAATCACAAGACTTGATCCAGAC
ACTTATGTTTCTCCTGGGACTTGGAGTGCGGCATTGTTAGCTTTAGGAGCCGCAAGGAGTGCAGCTTTATCAGCCCTTCA
CTATGGAGGCCTCCACATGGCTCTAGTTAGGCCCCCTGGGCATCATGCAGGGAGAAGAGGAAGGGCCATGGGTGCCCCAA
CACTAGGCTTCTGCATCTTCAACAACGCGGCCTCTGCAGTTGTCACCTTGAAAGAAGAGGGAGTTGGAAAAGTTGTTGTA
ATAGATTTTGACGCTCATCATGGAAACGGGACTCAGGAAATATTCTGGAACGATCCCGATGTGATTCACATAGATCTACA
CGAGAGAGACATCTACCCAGGGAGTGGGGATGTGAGTGAAGTTGGAGGGTCAAATGCTTATGGGAGCAAGATAAACCTCC
CAATGCCCCACTATTCTGGGGATGGGGATTACATATATGTTTGGGACGAAATTGTGCTTCCAATAGTTGAAGAAGTTAAG
CCAAAGGTCATCGTAATTTCCGCGGGCTTTGATGGATTTAAAGGGGATGGTCTAACAACATTAAGGCTCACAGAAAGTTT
TTACTCTTATGCAGGGGCTACATTAAATAAATATCCCTTGGCATTTATATTGGAAGGCGGGTATGGAGTAGGGTTAGATA
AAGGTTTTCCGGCCTTCATAATGGGCTACGAAGAGGGTAAAGCGAAAGCTCGAGAAGAGCCAAGATATGAGACCCTAAAG
TTGGCGGAGGAGGTTAAGGACATCTTGAGTCCCTGGTGGTCGTTATAA

Upstream 100 bases:

>100_bases
GAGGAAGTTAGGGCTGCCCTTGAGAAGGCAGGAATAAGCCTTGCCTGATTTCTTATTCTTTTTAATAAAGTTTAAGTTTT
CCTACTTGTAATATTCTCTC

Downstream 100 bases:

>100_bases
GTTTTTAGAAGAATTATGGTGGGCCCGCGGGGCTTCGAACCCCGGACCTCCCGCTTATCAGGCGGGCGCTCTGACCAGGC
TGAGCCACGGGCCCATTTGG

Product: aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MIGSIFYSKKFNLHRPSEYHPENPKRLEIVLSKVRELGLEERIEEPNPVEETFVEKIHDRDYINFVKEAVEKGITRLDPD
TYVSPGTWSAALLALGAARSAALSALHYGGLHMALVRPPGHHAGRRGRAMGAPTLGFCIFNNAASAVVTLKEEGVGKVVV
IDFDAHHGNGTQEIFWNDPDVIHIDLHERDIYPGSGDVSEVGGSNAYGSKINLPMPHYSGDGDYIYVWDEIVLPIVEEVK
PKVIVISAGFDGFKGDGLTTLRLTESFYSYAGATLNKYPLAFILEGGYGVGLDKGFPAFIMGYEEGKAKAREEPRYETLK
LAEEVKDILSPWWSL

Sequences:

>Translated_335_residues
MIGSIFYSKKFNLHRPSEYHPENPKRLEIVLSKVRELGLEERIEEPNPVEETFVEKIHDRDYINFVKEAVEKGITRLDPD
TYVSPGTWSAALLALGAARSAALSALHYGGLHMALVRPPGHHAGRRGRAMGAPTLGFCIFNNAASAVVTLKEEGVGKVVV
IDFDAHHGNGTQEIFWNDPDVIHIDLHERDIYPGSGDVSEVGGSNAYGSKINLPMPHYSGDGDYIYVWDEIVLPIVEEVK
PKVIVISAGFDGFKGDGLTTLRLTESFYSYAGATLNKYPLAFILEGGYGVGLDKGFPAFIMGYEEGKAKAREEPRYETLK
LAEEVKDILSPWWSL
>Mature_335_residues
MIGSIFYSKKFNLHRPSEYHPENPKRLEIVLSKVRELGLEERIEEPNPVEETFVEKIHDRDYINFVKEAVEKGITRLDPD
TYVSPGTWSAALLALGAARSAALSALHYGGLHMALVRPPGHHAGRRGRAMGAPTLGFCIFNNAASAVVTLKEEGVGKVVV
IDFDAHHGNGTQEIFWNDPDVIHIDLHERDIYPGSGDVSEVGGSNAYGSKINLPMPHYSGDGDYIYVWDEIVLPIVEEVK
PKVIVISAGFDGFKGDGLTTLRLTESFYSYAGATLNKYPLAFILEGGYGVGLDKGFPAFIMGYEEGKAKAREEPRYETLK
LAEEVKDILSPWWSL

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=297, Percent_Identity=34.006734006734, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI20070354, Length=292, Percent_Identity=32.5342465753425, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI169234807, Length=154, Percent_Identity=39.6103896103896, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI148539870, Length=154, Percent_Identity=39.6103896103896, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI153085395, Length=280, Percent_Identity=31.0714285714286, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI17158039, Length=280, Percent_Identity=30.3571428571429, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI30795204, Length=280, Percent_Identity=30.3571428571429, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI30795202, Length=280, Percent_Identity=30.3571428571429, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI62750349, Length=278, Percent_Identity=30.9352517985612, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI62750347, Length=278, Percent_Identity=30.9352517985612, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI226529806, Length=289, Percent_Identity=31.1418685121107, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI13128860, Length=282, Percent_Identity=24.113475177305, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI293336691, Length=257, Percent_Identity=26.4591439688716, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI8923769, Length=311, Percent_Identity=24.4372990353698, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI13128862, Length=258, Percent_Identity=25.968992248062, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073088, Length=186, Percent_Identity=25.8064516129032, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI209862883, Length=243, Percent_Identity=27.9835390946502, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI262073092, Length=233, Percent_Identity=26.1802575107296, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193209491, Length=310, Percent_Identity=32.5806451612903, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17537347, Length=286, Percent_Identity=32.1678321678322, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540334, Length=358, Percent_Identity=27.6536312849162, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193206283, Length=358, Percent_Identity=27.6536312849162, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540332, Length=358, Percent_Identity=27.6536312849162, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17508561, Length=298, Percent_Identity=24.496644295302, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17561978, Length=282, Percent_Identity=23.4042553191489, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25154020, Length=179, Percent_Identity=34.6368715083799, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25154022, Length=220, Percent_Identity=32.2727272727273, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=301, Percent_Identity=26.578073089701, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324307, Length=308, Percent_Identity=30.1948051948052, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323999, Length=285, Percent_Identity=22.1052631578947, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321244, Length=293, Percent_Identity=23.8907849829352, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6325325, Length=169, Percent_Identity=30.1775147928994, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325141, Length=104, Percent_Identity=38.4615384615385, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24642146, Length=292, Percent_Identity=31.5068493150685, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24642144, Length=292, Percent_Identity=31.5068493150685, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24642142, Length=292, Percent_Identity=31.5068493150685, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI281360899, Length=294, Percent_Identity=31.6326530612245, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI281360799, Length=270, Percent_Identity=28.8888888888889, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24641720, Length=270, Percent_Identity=28.8888888888889, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360801, Length=270, Percent_Identity=28.8888888888889, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24657891, Length=282, Percent_Identity=25.177304964539, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24644244, Length=262, Percent_Identity=24.8091603053435, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37036; Mature: 37036

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGSIFYSKKFNLHRPSEYHPENPKRLEIVLSKVRELGLEERIEEPNPVEETFVEKIHDR
CCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCC
DYINFVKEAVEKGITRLDPDTYVSPGTWSAALLALGAARSAALSALHYGGLHMALVRPPG
HHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
HHAGRRGRAMGAPTLGFCIFNNAASAVVTLKEEGVGKVVVIDFDAHHGNGTQEIFWNDPD
CCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEEEEECCCCCCCCEEEECCCC
VIHIDLHERDIYPGSGDVSEVGGSNAYGSKINLPMPHYSGDGDYIYVWDEIVLPIVEEVK
EEEEEEECCCCCCCCCCHHHCCCCCCCCCEECCCCCCCCCCCCEEEEHHHHHHHHHHHCC
PKVIVISAGFDGFKGDGLTTLRLTESFYSYAGATLNKYPLAFILEGGYGVGLDKGFPAFI
CCEEEEECCCCCCCCCCEEEEEEHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEE
MGYEEGKAKAREEPRYETLKLAEEVKDILSPWWSL
EEECCCCHHCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIGSIFYSKKFNLHRPSEYHPENPKRLEIVLSKVRELGLEERIEEPNPVEETFVEKIHDR
CCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCC
DYINFVKEAVEKGITRLDPDTYVSPGTWSAALLALGAARSAALSALHYGGLHMALVRPPG
HHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
HHAGRRGRAMGAPTLGFCIFNNAASAVVTLKEEGVGKVVVIDFDAHHGNGTQEIFWNDPD
CCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEEEEECCCCCCCCEEEECCCC
VIHIDLHERDIYPGSGDVSEVGGSNAYGSKINLPMPHYSGDGDYIYVWDEIVLPIVEEVK
EEEEEEECCCCCCCCCCHHHCCCCCCCCCEECCCCCCCCCCCCEEEEHHHHHHHHHHHCC
PKVIVISAGFDGFKGDGLTTLRLTESFYSYAGATLNKYPLAFILEGGYGVGLDKGFPAFI
CCEEEEECCCCCCCCCCEEEEEEHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEE
MGYEEGKAKAREEPRYETLKLAEEVKDILSPWWSL
EEECCCCHHCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]