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The map label for this gene is Hgd [H]

Identifier: 18977088

GI number: 18977088

Start: 715679

End: 716515

Strand: Direct

Name: Hgd [H]

Synonym: PF0716

Alternate gene names: 18977088

Gene position: 715679-716515 (Clockwise)

Preceding gene: 18977086

Following gene: 18977089

Centisome position: 37.5

GC content: 44.44

Gene sequence:

>837_bases
ATGATAGGGTGGATTGGTCTAGGACACATAGGTAGAGCCATGGCGGAGAGGTTATCAGAGGAGTATGAACTTCTTGTTTG
GAATAGAACAATAGAGAAAGCTAACGGATTCAAAACTGTCGCTAGAACCCCAGAAGAAGTTGCTGAAAAATGTGATGTGA
TTTTTCTCTCCCTCTACGACAGCGAGGCAGTGCGGCAAGTTTCCGAGAGACTTCTTAGTGTTAATCTTAGAGGAAAGATA
ATCGTAGATACTACAACGAACCATCACGAGAAAGTCTTGGAGTTCCATGAAATATATAGGAACGTTGGAGCTTTCTACCT
CGAAAGCCCTGTTATTGGGAGCGTCATTCCGGCGAGAAACGGCCAACTGACGATTCTCGTAAGTGGGGAAAGAGAGGCCT
TTGAGAGAGTTCGTCCATACCTTCAGAAGCTTGGAAAAAGGATATTTTACTTTAATGAACCTGGGAAGGCTACTAAGCTT
AAGCTAATAAACAACTTTGTGCTTGGAGCCTTCATGGCTGCACTCGGTGAGGCGATAGCTCTAGGTGAAAAAGCAGGACT
ATCAAGGGAAGAAATTATAGAAATCCTTGAGAATGGGGCTGGCAATTCAATGGTATTGAGTGCAAAAAAGACTAAGCTTC
TCAATGATGACTACTCGACGCACTTCTCCGTGAAGAACCTCGTCAAGGATCTTTCTTACGCTTACGACTTAGCTGTGGCC
TCGAGAAAAGCAGTACCACTTAATGCAACGGTGAGGGAGATTTACAGGCTTGCTTTTGAGAAAGGTCTTGAGGAGCTCGA
CTTTTCGGTGGTGTACAGGCTATTCAGGGAGCTTTAA

Upstream 100 bases:

>100_bases
TATGCTCCGCCTCTTTTTGAGTACTTCAAAGAACTCCATCTTCACCACCGCTAAGATTTATAGCATAACGATTATAAGAC
TTTTTGAGAACCGATAGACT

Downstream 100 bases:

>100_bases
TCTCCTTTCATATTTTTAAATAAATAACGTAGAGGGACTAGTATTCTTGGAGGTTAAGAAGTTTATTTCCTCCGTAAACT
AGAAAATTGATTCAAAAGAC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MIGWIGLGHIGRAMAERLSEEYELLVWNRTIEKANGFKTVARTPEEVAEKCDVIFLSLYDSEAVRQVSERLLSVNLRGKI
IVDTTTNHHEKVLEFHEIYRNVGAFYLESPVIGSVIPARNGQLTILVSGEREAFERVRPYLQKLGKRIFYFNEPGKATKL
KLINNFVLGAFMAALGEAIALGEKAGLSREEIIEILENGAGNSMVLSAKKTKLLNDDYSTHFSVKNLVKDLSYAYDLAVA
SRKAVPLNATVREIYRLAFEKGLEELDFSVVYRLFREL

Sequences:

>Translated_278_residues
MIGWIGLGHIGRAMAERLSEEYELLVWNRTIEKANGFKTVARTPEEVAEKCDVIFLSLYDSEAVRQVSERLLSVNLRGKI
IVDTTTNHHEKVLEFHEIYRNVGAFYLESPVIGSVIPARNGQLTILVSGEREAFERVRPYLQKLGKRIFYFNEPGKATKL
KLINNFVLGAFMAALGEAIALGEKAGLSREEIIEILENGAGNSMVLSAKKTKLLNDDYSTHFSVKNLVKDLSYAYDLAVA
SRKAVPLNATVREIYRLAFEKGLEELDFSVVYRLFREL
>Mature_278_residues
MIGWIGLGHIGRAMAERLSEEYELLVWNRTIEKANGFKTVARTPEEVAEKCDVIFLSLYDSEAVRQVSERLLSVNLRGKI
IVDTTTNHHEKVLEFHEIYRNVGAFYLESPVIGSVIPARNGQLTILVSGEREAFERVRPYLQKLGKRIFYFNEPGKATKL
KLINNFVLGAFMAALGEAIALGEKAGLSREEIIEILENGAGNSMVLSAKKTKLLNDDYSTHFSVKNLVKDLSYAYDLAVA
SRKAVPLNATVREIYRLAFEKGLEELDFSVVYRLFREL

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=32.2695035460993, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=28.4246575342466, Blast_Score=118, Evalue=6e-27,
Organism=Escherichia coli, GI145693186, Length=286, Percent_Identity=27.2727272727273, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786719, Length=279, Percent_Identity=27.5985663082437, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=28.3276450511945, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790315, Length=284, Percent_Identity=27.4647887323944, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17557316, Length=303, Percent_Identity=25.7425742574257, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28574115, Length=279, Percent_Identity=27.9569892473118, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24655230, Length=289, Percent_Identity=27.681660899654, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI19922568, Length=289, Percent_Identity=27.681660899654, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 31377; Mature: 31377

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGWIGLGHIGRAMAERLSEEYELLVWNRTIEKANGFKTVARTPEEVAEKCDVIFLSLYD
CCCEEEHHHHHHHHHHHHHHHHEEEEEEHHHHHCCCCHHHHCCHHHHHHHHCEEEEEECC
SEAVRQVSERLLSVNLRGKIIVDTTTNHHEKVLEFHEIYRNVGAFYLESPVIGSVIPARN
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GQLTILVSGEREAFERVRPYLQKLGKRIFYFNEPGKATKLKLINNFVLGAFMAALGEAIA
CEEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGEKAGLSREEIIEILENGAGNSMVLSAKKTKLLNDDYSTHFSVKNLVKDLSYAYDLAVA
HCHHCCCCHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
SRKAVPLNATVREIYRLAFEKGLEELDFSVVYRLFREL
CCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MIGWIGLGHIGRAMAERLSEEYELLVWNRTIEKANGFKTVARTPEEVAEKCDVIFLSLYD
CCCEEEHHHHHHHHHHHHHHHHEEEEEEHHHHHCCCCHHHHCCHHHHHHHHCEEEEEECC
SEAVRQVSERLLSVNLRGKIIVDTTTNHHEKVLEFHEIYRNVGAFYLESPVIGSVIPARN
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GQLTILVSGEREAFERVRPYLQKLGKRIFYFNEPGKATKLKLINNFVLGAFMAALGEAIA
CEEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGEKAGLSREEIIEILENGAGNSMVLSAKKTKLLNDDYSTHFSVKNLVKDLSYAYDLAVA
HCHHCCCCHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
SRKAVPLNATVREIYRLAFEKGLEELDFSVVYRLFREL
CCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA