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The map label for this gene is lhr [C]

Identifier: 18977049

GI number: 18977049

Start: 686783

End: 688945

Strand: Reverse

Name: lhr [C]

Synonym: PF0677

Alternate gene names: 18977049

Gene position: 688945-686783 (Counterclockwise)

Preceding gene: 18977050

Following gene: 18977048

Centisome position: 36.1

GC content: 43.32

Gene sequence:

>2163_bases
ATGAGGGTTGATGAGCTGAGAGTTGATGAGAGGATAAAGAGTACTTTGAAGGAGAGAGGTATCGAATCCTTTTACCCTCC
CCAAGCCGAGGCCTTAAAGAGCGGGATATTGGAAGGTAAGAATGCATTAATTTCAATTCCAACGGCCAGCGGAAAAACAC
TAATTGCTGAGATTGCCATGGTTCATAGGATTTTGACCCAGGGAGGAAAGGCTGTATACATAGTCCCGCTGAAGGCCTTG
GCTGAAGAAAAGTTTCAGGAGTTCCAGGATTGGGAGAAGATTGGGTTAAGAGTAGCGATGGCCACTGGGGATTACGACTC
AAAGGATGAGTGGTTGGGGAAATACGACATAATCATTGCGACGGCTGAGAAGTTTGATTCCCTTTTAAGGCATGGCTCAA
GTTGGATTAAGGATGTGAAGATTTTAGTTGCTGACGAGATTCATTTGATTGGTTCAAGAGACAGAGGAGCTACGCTTGAA
GTTATCCTAGCTCATATGCTCGGAAAGGCCCAAATAATTGGACTCTCTGCAACGATAGGAAATCCAGAGGAGCTTGCGGA
GTGGTTAAATGCCGAGCTAATAGTCAGTGACTGGAGGCCCGTTAAGCTTAGAAGGGGAGTTTTTTACCAAGGCTTTGTTA
CCTGGGAAGATGGAAGTATAGACAGGTTTTCCTCCTGGGAAGAGTTAGTTTACGATGCAATTAGGAAGAAGAAAGGAGCG
CTAATTTTTGTAAACATGAGAAGGAAGGCTGAGAGAGTAGCTTTGGAGCTTTCTAAAAAAGTTAAGTCTCTCCTCACGAA
ACCTGAGATTAGAGCTTTAAATGAATTGGCTGATTCCCTCGAGGAAAATCCCACAAATGAAAAGCTAGCTAAGGCCATTA
GGGGTGGAGTTGCGTTCCACCACGCTGGTCTTGGGAGAGATGAGAGGGTTCTCGTGGAGGAGAACTTTAGAAAGGGTATA
ATAAAGGCCGTAGTTGCCACCCCAACACTTTCGGCGGGAATTAACACTCCAGCGTTTAGGGTGATTATAAGGGATATTTG
GAGGTACTCTGACTTTGGAATGGAGAGAATTCCGATAATCGAGGTTCACCAAATGCTTGGGAGAGCTGGAAGGCCGAAGT
ATGATGAGGTTGGGGAGGGAATAATAGTTTCTACAAGCGATGATCCGAGAGAGGTAATGAATCACTACATATTTGGAAAG
CCTGAAAAACTGTTCTCCCAGCTCTCCAACGAGAGTAATTTGAGAAGTCAAGTTTTGGCCCTAATAGCGACCTTTGGCTA
TTCAACTGTGGAGGAGATTTTGAAGTTCATCTCAAACACATTCTATGCTTATCAAAGGAAGGACACATACTCTTTAGAGG
AGAAGATAAGGAACATACTCTACTTCCTCCTAGAGAATGAGTTCATAGAGATATCCTTAGAGGATAAAATAAGGCCGCTT
TCCCTGGGAATTAGGACTGCAAAGCTTTATATCGATCCCTATACGGCCAAGATGTTCAAGGATAAAATGGAGGAAGTTGT
TAAAGATCCAAATCCTATAGGAATATTTCACTTAATCTCCCTAACTCCGGATATAACCCCCTTCAACTACTCAAAGAGAG
AATTTGAAAGGCTCGAAGAGGAATACTACGAATTCAAGGATAGGTTATACTTTGACGATCCCTACATTTCGGGTTACGAC
CCCTACCTAGAGAGGAAGTTCTTCAGAGCTTTCAAAACTGCACTAGTGCTTCTGGCATGGATAAATGAAGTCCCTGAGGG
AGAAATAGTTGAAAAGTACTCGGTGGAACCTGGGGACATCTATAGGATAGTTGAGACGGCTGAGTGGCTGGTGTACTCTC
TAAAGGAAATTGCAAAAGTTCTTGGAGCTTATGAGATCGTTGATTATCTTGAAACATTGAGGGTTAGGGTCAAGTATGGG
ATTAGGGAGGAATTGATTCCCCTAATGCAACTCCCGTTGGTTGGAAGAAGGAGAGCTAGAGCTCTTTACAATAGCGGATT
TAGAAGTATAGAGGATATATCTCAAGCGAGGCCAGAAGAGCTTTTGAAAATCGAGGGGATAGGGGTCAAGACCGTTGAGG
CTATCTTCAAGTTTCTTGGTAAGAATGTGAAAATTTCGGAGAAACCTAGAAAAAGTACCCTTGATTACTTTCTCAAATCT
TGA

Upstream 100 bases:

>100_bases
GAACAAGATCTCCGTCTTCAGGTTCGACAAGAGCGGAGGTAAGAGAGTTATTCTCCTTAAGAGAGCCGCTTTACTTTGCT
ACAACTGCTGAGGGAGACGT

Downstream 100 bases:

>100_bases
TACATGAAAAGTAAAATTTTTACATTTAGCAACTTCCATTTCTCAGAAACCGCAGTTTTTTCATAAAAAAGTATTTTATG
GCTAACAAAGGCTTTTATGG

Product: ski2-like helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 720; Mature: 720

Protein sequence:

>720_residues
MRVDELRVDERIKSTLKERGIESFYPPQAEALKSGILEGKNALISIPTASGKTLIAEIAMVHRILTQGGKAVYIVPLKAL
AEEKFQEFQDWEKIGLRVAMATGDYDSKDEWLGKYDIIIATAEKFDSLLRHGSSWIKDVKILVADEIHLIGSRDRGATLE
VILAHMLGKAQIIGLSATIGNPEELAEWLNAELIVSDWRPVKLRRGVFYQGFVTWEDGSIDRFSSWEELVYDAIRKKKGA
LIFVNMRRKAERVALELSKKVKSLLTKPEIRALNELADSLEENPTNEKLAKAIRGGVAFHHAGLGRDERVLVEENFRKGI
IKAVVATPTLSAGINTPAFRVIIRDIWRYSDFGMERIPIIEVHQMLGRAGRPKYDEVGEGIIVSTSDDPREVMNHYIFGK
PEKLFSQLSNESNLRSQVLALIATFGYSTVEEILKFISNTFYAYQRKDTYSLEEKIRNILYFLLENEFIEISLEDKIRPL
SLGIRTAKLYIDPYTAKMFKDKMEEVVKDPNPIGIFHLISLTPDITPFNYSKREFERLEEEYYEFKDRLYFDDPYISGYD
PYLERKFFRAFKTALVLLAWINEVPEGEIVEKYSVEPGDIYRIVETAEWLVYSLKEIAKVLGAYEIVDYLETLRVRVKYG
IREELIPLMQLPLVGRRRARALYNSGFRSIEDISQARPEELLKIEGIGVKTVEAIFKFLGKNVKISEKPRKSTLDYFLKS

Sequences:

>Translated_720_residues
MRVDELRVDERIKSTLKERGIESFYPPQAEALKSGILEGKNALISIPTASGKTLIAEIAMVHRILTQGGKAVYIVPLKAL
AEEKFQEFQDWEKIGLRVAMATGDYDSKDEWLGKYDIIIATAEKFDSLLRHGSSWIKDVKILVADEIHLIGSRDRGATLE
VILAHMLGKAQIIGLSATIGNPEELAEWLNAELIVSDWRPVKLRRGVFYQGFVTWEDGSIDRFSSWEELVYDAIRKKKGA
LIFVNMRRKAERVALELSKKVKSLLTKPEIRALNELADSLEENPTNEKLAKAIRGGVAFHHAGLGRDERVLVEENFRKGI
IKAVVATPTLSAGINTPAFRVIIRDIWRYSDFGMERIPIIEVHQMLGRAGRPKYDEVGEGIIVSTSDDPREVMNHYIFGK
PEKLFSQLSNESNLRSQVLALIATFGYSTVEEILKFISNTFYAYQRKDTYSLEEKIRNILYFLLENEFIEISLEDKIRPL
SLGIRTAKLYIDPYTAKMFKDKMEEVVKDPNPIGIFHLISLTPDITPFNYSKREFERLEEEYYEFKDRLYFDDPYISGYD
PYLERKFFRAFKTALVLLAWINEVPEGEIVEKYSVEPGDIYRIVETAEWLVYSLKEIAKVLGAYEIVDYLETLRVRVKYG
IREELIPLMQLPLVGRRRARALYNSGFRSIEDISQARPEELLKIEGIGVKTVEAIFKFLGKNVKISEKPRKSTLDYFLKS
>Mature_720_residues
MRVDELRVDERIKSTLKERGIESFYPPQAEALKSGILEGKNALISIPTASGKTLIAEIAMVHRILTQGGKAVYIVPLKAL
AEEKFQEFQDWEKIGLRVAMATGDYDSKDEWLGKYDIIIATAEKFDSLLRHGSSWIKDVKILVADEIHLIGSRDRGATLE
VILAHMLGKAQIIGLSATIGNPEELAEWLNAELIVSDWRPVKLRRGVFYQGFVTWEDGSIDRFSSWEELVYDAIRKKKGA
LIFVNMRRKAERVALELSKKVKSLLTKPEIRALNELADSLEENPTNEKLAKAIRGGVAFHHAGLGRDERVLVEENFRKGI
IKAVVATPTLSAGINTPAFRVIIRDIWRYSDFGMERIPIIEVHQMLGRAGRPKYDEVGEGIIVSTSDDPREVMNHYIFGK
PEKLFSQLSNESNLRSQVLALIATFGYSTVEEILKFISNTFYAYQRKDTYSLEEKIRNILYFLLENEFIEISLEDKIRPL
SLGIRTAKLYIDPYTAKMFKDKMEEVVKDPNPIGIFHLISLTPDITPFNYSKREFERLEEEYYEFKDRLYFDDPYISGYD
PYLERKFFRAFKTALVLLAWINEVPEGEIVEKYSVEPGDIYRIVETAEWLVYSLKEIAKVLGAYEIVDYLETLRVRVKYG
IREELIPLMQLPLVGRRRARALYNSGFRSIEDISQARPEELLKIEGIGVKTVEAIFKFLGKNVKISEKPRKSTLDYFLKS

Specific function: Unknown

COG id: COG1204

COG function: function code R; Superfamily II helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain

Homologues:

Organism=Homo sapiens, GI139394648, Length=747, Percent_Identity=29.04953145917, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI110556640, Length=737, Percent_Identity=27.4084124830393, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI76880486, Length=537, Percent_Identity=32.4022346368715, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI40217847, Length=539, Percent_Identity=28.9424860853432, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI169218225, Length=402, Percent_Identity=31.8407960199005, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI130484567, Length=396, Percent_Identity=30.3030303030303, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI193211480, Length=483, Percent_Identity=25.6728778467909, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI67782311, Length=476, Percent_Identity=25.4201680672269, Blast_Score=114, Evalue=4e-25,
Organism=Escherichia coli, GI1787942, Length=387, Percent_Identity=25.3229974160207, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71995032, Length=736, Percent_Identity=25.8152173913043, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17537519, Length=535, Percent_Identity=31.0280373831776, Blast_Score=174, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17537127, Length=742, Percent_Identity=25.7412398921833, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI86563272, Length=413, Percent_Identity=28.8135593220339, Blast_Score=146, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17542826, Length=517, Percent_Identity=24.9516441005803, Blast_Score=119, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71995036, Length=429, Percent_Identity=25.1748251748252, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI133930973, Length=192, Percent_Identity=32.8125, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321020, Length=399, Percent_Identity=32.3308270676692, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321710, Length=742, Percent_Identity=26.9541778975741, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI9755332, Length=519, Percent_Identity=30.4431599229287, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322411, Length=494, Percent_Identity=24.8987854251012, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323430, Length=174, Percent_Identity=32.183908045977, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17933644, Length=749, Percent_Identity=26.0347129506008, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24660651, Length=772, Percent_Identity=26.5544041450777, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24647182, Length=413, Percent_Identity=33.4140435835351, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI28574898, Length=405, Percent_Identity=29.6296296296296, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17933658, Length=452, Percent_Identity=26.9911504424779, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17864608, Length=476, Percent_Identity=26.2605042016807, Blast_Score=121, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HELS_PYRFU (O73946)

Other databases:

- EMBL:   AB016521
- EMBL:   AE009950
- PIR:   T43854
- RefSeq:   NP_578406.1
- PDB:   2ZJ2
- PDB:   2ZJ5
- PDB:   2ZJ8
- PDB:   2ZJA
- PDBsum:   2ZJ2
- PDBsum:   2ZJ5
- PDBsum:   2ZJ8
- PDBsum:   2ZJA
- ProteinModelPortal:   O73946
- SMR:   O73946
- EnsemblBacteria:   EBPYRT00000005593
- GeneID:   1468523
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF0677
- NMPDR:   fig|186497.1.peg.694
- GeneTree:   EBGT00050000022149
- HOGENOM:   HBG496908
- OMA:   FLERTFY
- ProtClustDB:   PRK00254
- HAMAP:   MF_00442
- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR010995
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR022965
- InterPro:   IPR000445
- InterPro:   IPR003583
- SMART:   SM00487
- SMART:   SM00490
- SMART:   SM00278

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00633 HHH; SSF47794 Rad51_N

EC number: 3.6.1.-

Molecular weight: Translated: 82632; Mature: 82632

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVDELRVDERIKSTLKERGIESFYPPQAEALKSGILEGKNALISIPTASGKTLIAEIAM
CCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
VHRILTQGGKAVYIVPLKALAEEKFQEFQDWEKIGLRVAMATGDYDSKDEWLGKYDIIIA
HHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHCCCEEEEEE
TAEKFDSLLRHGSSWIKDVKILVADEIHLIGSRDRGATLEVILAHMLGKAQIIGLSATIG
EHHHHHHHHHCCHHHHHHHHHHEECCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCC
NPEELAEWLNAELIVSDWRPVKLRRGVFYQGFVTWEDGSIDRFSSWEELVYDAIRKKKGA
CHHHHHHHCCCEEEECCCCCCHHHCCEEEEEEEEECCCCCCHHCCHHHHHHHHHHCCCCC
LIFVNMRRKAERVALELSKKVKSLLTKPEIRALNELADSLEENPTNEKLAKAIRGGVAFH
EEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHEE
HAGLGRDERVLVEENFRKGIIKAVVATPTLSAGINTPAFRVIIRDIWRYSDFGMERIPII
ECCCCCCCEEEHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
EVHQMLGRAGRPKYDEVGEGIIVSTSDDPREVMNHYIFGKPEKLFSQLSNESNLRSQVLA
HHHHHHCCCCCCCHHHHCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHH
LIATFGYSTVEEILKFISNTFYAYQRKDTYSLEEKIRNILYFLLENEFIEISLEDKIRPL
HHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCH
SLGIRTAKLYIDPYTAKMFKDKMEEVVKDPNPIGIFHLISLTPDITPFNYSKREFERLEE
HCCEEEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHH
EYYEFKDRLYFDDPYISGYDPYLERKFFRAFKTALVLLAWINEVPEGEIVEKYSVEPGDI
HHHHHHHCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHH
YRIVETAEWLVYSLKEIAKVLGAYEIVDYLETLRVRVKYGIREELIPLMQLPLVGRRRAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHH
ALYNSGFRSIEDISQARPEELLKIEGIGVKTVEAIFKFLGKNVKISEKPRKSTLDYFLKS
HHHHCCCHHHHHHHHCCHHHHHEECCCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MRVDELRVDERIKSTLKERGIESFYPPQAEALKSGILEGKNALISIPTASGKTLIAEIAM
CCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
VHRILTQGGKAVYIVPLKALAEEKFQEFQDWEKIGLRVAMATGDYDSKDEWLGKYDIIIA
HHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHCCCEEEEEE
TAEKFDSLLRHGSSWIKDVKILVADEIHLIGSRDRGATLEVILAHMLGKAQIIGLSATIG
EHHHHHHHHHCCHHHHHHHHHHEECCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCC
NPEELAEWLNAELIVSDWRPVKLRRGVFYQGFVTWEDGSIDRFSSWEELVYDAIRKKKGA
CHHHHHHHCCCEEEECCCCCCHHHCCEEEEEEEEECCCCCCHHCCHHHHHHHHHHCCCCC
LIFVNMRRKAERVALELSKKVKSLLTKPEIRALNELADSLEENPTNEKLAKAIRGGVAFH
EEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHEE
HAGLGRDERVLVEENFRKGIIKAVVATPTLSAGINTPAFRVIIRDIWRYSDFGMERIPII
ECCCCCCCEEEHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
EVHQMLGRAGRPKYDEVGEGIIVSTSDDPREVMNHYIFGKPEKLFSQLSNESNLRSQVLA
HHHHHHCCCCCCCHHHHCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHH
LIATFGYSTVEEILKFISNTFYAYQRKDTYSLEEKIRNILYFLLENEFIEISLEDKIRPL
HHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCH
SLGIRTAKLYIDPYTAKMFKDKMEEVVKDPNPIGIFHLISLTPDITPFNYSKREFERLEE
HCCEEEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHH
EYYEFKDRLYFDDPYISGYDPYLERKFFRAFKTALVLLAWINEVPEGEIVEKYSVEPGDI
HHHHHHHCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHH
YRIVETAEWLVYSLKEIAKVLGAYEIVDYLETLRVRVKYGIREELIPLMQLPLVGRRRAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHH
ALYNSGFRSIEDISQARPEELLKIEGIGVKTVEAIFKFLGKNVKISEKPRKSTLDYFLKS
HHHHCCCHHHHHHHHCCHHHHHEECCCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA