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The map label for this gene is dapA

Identifier: 18977029

GI number: 18977029

Start: 668997

End: 669893

Strand: Reverse

Name: dapA

Synonym: PF0657

Alternate gene names: 18977029

Gene position: 669893-668997 (Counterclockwise)

Preceding gene: 18977030

Following gene: 18977028

Centisome position: 35.1

GC content: 39.13

Gene sequence:

>897_bases
ATGGAAGGAGTGATAGTTCCTTTGGTGACTCCTTTTAAGGAGGATTACTCGATAGACTTTGAGGCCTTAGAGTGGCATAT
AGAGTTTTTAGAAGATAAAGGAGTTCATGGAATATTCACTAATTCAACCACAGGAGAGTTTACAAGCTTGAGTTTTGAAG
AAAAGAAATTATTAGCAGAAAAAGGAAGGGAGCTCACATCAAAAGCTTACTATTTGGTTGGAACAGGTTCAACTAATACC
TTTGAAGTTATTGAGTTGACAAAACACGCAAAGGACATAGGGGCAGATGCCACTGTAATAGTCTCTCCATATTATTGTAA
ACTTAAGGATGAGGCAATCTTCAGACACTTCTCTATTGTTGCAGAAAGGGCGGATATTCCAATAATTCTCTATGCCATTC
CTTCCTGTGCAAACCCAATAAATGTAGAAATAGTGAGAAAATTAGCTCTTGAACACTCGAACATAATCGGAATAAAGGCT
AGCGTTGACAGCTTAACATACCTCGGCGAGCTCCTTGAAGTAAAGGAAGAAAGAAAAGATTTTAAGGTTTTTACTGGCTT
AGATCAATATTTCTTTACCCTCCTCACCCTGGGAGGAGACGGAGGGATCATGGCCTGTGCAAACTTTGCTCCAGAGATCC
ATCTGGAAATCTGGAACGCATTTAAGGAAAAGAACTTTAGAAGAGCAATAGAATTGGCGAGAGAACTCGTCAGGATAACA
AAAATTTACAAAATAGCTTCATCTTTCGCTTCAGCGGTAAAGCTTGCAATGGTAGCAAAGGGGTTCCCAATAAGGCCAGT
TTTGAGACCTCCATATGTTATTGATGGAGAAGAAGTTTTCAACGAAATTAGAGAAATTGTAGAGTGGAGGCAGATGTTAA
GAAAGGAAAGCTTATAG

Upstream 100 bases:

>100_bases
TTCTCACCAGGGAGGTCTTATAGTTGTAGTTGATAAAAAGGCCCTTGATGAAAGAGAATATGCCCTCTTGAGAAGAGTTT
TAGAGTAAGGGGGAGAGATA

Downstream 100 bases:

>100_bases
ATTTGTTATCCTAACTTTACCTAGATGGAGGCAACTGAGATGGAGTTCCTTGAAAAGTTTAAGGACGAGCCTGTTCTTGA
AGTTTTGCAAAAGGTCAGCC

Product: putative dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MEGVIVPLVTPFKEDYSIDFEALEWHIEFLEDKGVHGIFTNSTTGEFTSLSFEEKKLLAEKGRELTSKAYYLVGTGSTNT
FEVIELTKHAKDIGADATVIVSPYYCKLKDEAIFRHFSIVAERADIPIILYAIPSCANPINVEIVRKLALEHSNIIGIKA
SVDSLTYLGELLEVKEERKDFKVFTGLDQYFFTLLTLGGDGGIMACANFAPEIHLEIWNAFKEKNFRRAIELARELVRIT
KIYKIASSFASAVKLAMVAKGFPIRPVLRPPYVIDGEEVFNEIREIVEWRQMLRKESL

Sequences:

>Translated_298_residues
MEGVIVPLVTPFKEDYSIDFEALEWHIEFLEDKGVHGIFTNSTTGEFTSLSFEEKKLLAEKGRELTSKAYYLVGTGSTNT
FEVIELTKHAKDIGADATVIVSPYYCKLKDEAIFRHFSIVAERADIPIILYAIPSCANPINVEIVRKLALEHSNIIGIKA
SVDSLTYLGELLEVKEERKDFKVFTGLDQYFFTLLTLGGDGGIMACANFAPEIHLEIWNAFKEKNFRRAIELARELVRIT
KIYKIASSFASAVKLAMVAKGFPIRPVLRPPYVIDGEEVFNEIREIVEWRQMLRKESL
>Mature_298_residues
MEGVIVPLVTPFKEDYSIDFEALEWHIEFLEDKGVHGIFTNSTTGEFTSLSFEEKKLLAEKGRELTSKAYYLVGTGSTNT
FEVIELTKHAKDIGADATVIVSPYYCKLKDEAIFRHFSIVAERADIPIILYAIPSCANPINVEIVRKLALEHSNIIGIKA
SVDSLTYLGELLEVKEERKDFKVFTGLDQYFFTLLTLGGDGGIMACANFAPEIHLEIWNAFKEKNFRRAIELARELVRIT
KIYKIASSFASAVKLAMVAKGFPIRPVLRPPYVIDGEEVFNEIREIVEWRQMLRKESL

Specific function: Unknown

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=212, Percent_Identity=29.7169811320755, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI13540533, Length=280, Percent_Identity=25, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI87082415, Length=295, Percent_Identity=32.8813559322034, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1786463, Length=272, Percent_Identity=34.5588235294118, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1788823, Length=237, Percent_Identity=30.8016877637131, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1789620, Length=294, Percent_Identity=24.4897959183673, Blast_Score=94, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPA_PYRFU (Q8U319)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578386.1
- ProteinModelPortal:   Q8U319
- SMR:   Q8U319
- EnsemblBacteria:   EBPYRT00000004314
- GeneID:   1468502
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF0657
- NMPDR:   fig|186497.1.peg.673
- GeneTree:   EBGT00050000022675
- HOGENOM:   HBG358848
- OMA:   PAIITPF
- ProtClustDB:   CLSK253429
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 33751; Mature: 33751

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGVIVPLVTPFKEDYSIDFEALEWHIEFLEDKGVHGIFTNSTTGEFTSLSFEEKKLLAE
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCHHHHHHHHH
KGRELTSKAYYLVGTGSTNTFEVIELTKHAKDIGADATVIVSPYYCKLKDEAIFRHFSIV
HCHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEECHHHHHHHHHHH
AERADIPIILYAIPSCANPINVEIVRKLALEHSNIIGIKASVDSLTYLGELLEVKEERKD
HHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
FKVFTGLDQYFFTLLTLGGDGGIMACANFAPEIHLEIWNAFKEKNFRRAIELARELVRIT
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIYKIASSFASAVKLAMVAKGFPIRPVLRPPYVIDGEEVFNEIREIVEWRQMLRKESL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEGVIVPLVTPFKEDYSIDFEALEWHIEFLEDKGVHGIFTNSTTGEFTSLSFEEKKLLAE
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCHHHHHHHHH
KGRELTSKAYYLVGTGSTNTFEVIELTKHAKDIGADATVIVSPYYCKLKDEAIFRHFSIV
HCHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEECHHHHHHHHHHH
AERADIPIILYAIPSCANPINVEIVRKLALEHSNIIGIKASVDSLTYLGELLEVKEERKD
HHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHH
FKVFTGLDQYFFTLLTLGGDGGIMACANFAPEIHLEIWNAFKEKNFRRAIELARELVRIT
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIYKIASSFASAVKLAMVAKGFPIRPVLRPPYVIDGEEVFNEIREIVEWRQMLRKESL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA