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The map label for this gene is drrB [H]

Identifier: 18976954

GI number: 18976954

Start: 601462

End: 602226

Strand: Reverse

Name: drrB [H]

Synonym: PF0582

Alternate gene names: 18976954

Gene position: 602226-601462 (Counterclockwise)

Preceding gene: 18976955

Following gene: 18976953

Centisome position: 31.56

GC content: 43.4

Gene sequence:

>765_bases
ATGAACGTCTTCTCAACGATGATCTACCGTGAGCTTAAGAGATTCGTGAGGTCACCTTCAAGAATCATGGGGAGCATCCT
AAACCCACTAATCTGGCTCATATTTTTCGGAAAGGGATGGAGTGGAGTCTTTAACTTTCCAATGGCAACGAGAATATTTG
GCGGAGTTGACTACATGACTTACTTGGTCCCAGGAGTTGTTGTAATGACTGTGTTCAACATGAGCTTTATGCAGGGATTA
ACAATAATTTGGGACAAGCAGTTTGGCTTCATGAAGGAAATACTTGTAGCTCCAGCGAGTAGAGTTGAAAGCATTCTAGG
AAGGATAACGGGAGGGGCAATAGTTGCGATGATCCAAGGATTCATAATGGTGGCACTAAGCTTTACCATAGCGGACTTAA
AAGTTTCAGGAATAATACCAGCTCTCGTATTGGCCTTCTTTGTGGGCATAGCAATAGCGGGATTGGGTGTTGCATTGGCC
CTCAGGATGAGCAGCATGGAAGGGTTCCAAGTAATAGTTATGATGCTAATGCTTCCAATGATGTTCCTCAGTGGTGCATT
CTACCCAGTAAAGACAATGCCAAATTGGATGCAGTGGCTAGCGAAGATAAACCCCCTAACGTATGCAGTTGATGGTGTTA
GGTACTATCTTGCAGGGGTAACTCCAACTTTTGGGATCATAAACGATTGGATAGTCTTAATAATCCTAGCTTTAGCGTTC
GCTGGAATTGCAGGCTTAGAATTTAGAAAGGCCTATCTTTCATGA

Upstream 100 bases:

>100_bases
ACAGACCTACGCTAAACGACGTCTTCTTGCACTTAACGGGGAGAGAGATAAGGGATGAAGCTTCTGATAGGTCAACAATG
CCAATGAGGAGGTGGGGAAG

Downstream 100 bases:

>100_bases
TTTTTGTTTATTTTAAAAAAAGTTAGATTAATAACAGCAAAAGTACAGAAAGATATATAGCTCCTGTTGTATAATATGAT
ACGACACAAAATAAAAGAGG

Product: daunorubicin resistance membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNVFSTMIYRELKRFVRSPSRIMGSILNPLIWLIFFGKGWSGVFNFPMATRIFGGVDYMTYLVPGVVVMTVFNMSFMQGL
TIIWDKQFGFMKEILVAPASRVESILGRITGGAIVAMIQGFIMVALSFTIADLKVSGIIPALVLAFFVGIAIAGLGVALA
LRMSSMEGFQVIVMMLMLPMMFLSGAFYPVKTMPNWMQWLAKINPLTYAVDGVRYYLAGVTPTFGIINDWIVLIILALAF
AGIAGLEFRKAYLS

Sequences:

>Translated_254_residues
MNVFSTMIYRELKRFVRSPSRIMGSILNPLIWLIFFGKGWSGVFNFPMATRIFGGVDYMTYLVPGVVVMTVFNMSFMQGL
TIIWDKQFGFMKEILVAPASRVESILGRITGGAIVAMIQGFIMVALSFTIADLKVSGIIPALVLAFFVGIAIAGLGVALA
LRMSSMEGFQVIVMMLMLPMMFLSGAFYPVKTMPNWMQWLAKINPLTYAVDGVRYYLAGVTPTFGIINDWIVLIILALAF
AGIAGLEFRKAYLS
>Mature_254_residues
MNVFSTMIYRELKRFVRSPSRIMGSILNPLIWLIFFGKGWSGVFNFPMATRIFGGVDYMTYLVPGVVVMTVFNMSFMQGL
TIIWDKQFGFMKEILVAPASRVESILGRITGGAIVAMIQGFIMVALSFTIADLKVSGIIPALVLAFFVGIAIAGLGVALA
LRMSSMEGFQVIVMMLMLPMMFLSGAFYPVKTMPNWMQWLAKINPLTYAVDGVRYYLAGVTPTFGIINDWIVLIILALAF
AGIAGLEFRKAYLS

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1787010, Length=202, Percent_Identity=25.2475247524752, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786320, Length=232, Percent_Identity=22.4137931034483, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 28113; Mature: 28113

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.9 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.9 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]