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The map label for this gene is thyX

Identifier: 18976912

GI number: 18976912

Start: 559431

End: 560165

Strand: Direct

Name: thyX

Synonym: PF0540

Alternate gene names: 18976912

Gene position: 559431-560165 (Clockwise)

Preceding gene: 33359485

Following gene: 18976913

Centisome position: 29.32

GC content: 42.45

Gene sequence:

>735_bases
ATGGTTCGTGTTACGCTCGTTAACTATACAAAGAGGCCCTTAGAAACAATAACTTGGGCTGCCCTTATAAGCTATTGGGG
GGAATGGAGCACGGAATCATTTGAAAGGATAAGTGAGAATGATGTAGAAAAGCATCTCCCTCGGATATTGGGTTATGGTC
ATGAGAGCATTTTGGAGCATGCAACGTTTACTTTCTCAATCGAAGGTTGTAGTAGGGTTTGTACTCATCAACTTGTGAGG
CATAGAATAGCCAGCTACACCCAGCAAAGCCAGCGTTACATTGTTCTTGACGAGGAGAACGTTGAGGAAACGTTTGTAAT
TCCTGAATCGATAAAGAAAGATAGAGAGCTTTATGAAAAATGGAAGAAGGTCATGGCTGAGACAATAAGCCTTTACAAGG
AGAGCATAAATAGGGGAGTTCACCAGGAAGATGCTCGATTCATTCTTCCTCAAGCTGTGAAAACGAAGATAATTGTGACG
ATGAACTTGAGAGAATTGAAGCACTTCTTTGGCCTTAGACTATGTGAAAGGGCTCAATGGGAGATTAGGGAAGTTGCATG
GAAGATGTTAGAGGAGATGGCGAAGAGGGATGATATAAGGCCGATAATAAAGTGGGCTAAACTTGGGCCTAGGTGCATTC
AGTTTGGCTATTGTCCCGAGAGAGATCTAATGCCTCCTGGGTGCTTAAAGAAAACTAGAAAAAAGTGGGAAAAAGTTGCG
GAAAGTAAGAGCTAA

Upstream 100 bases:

>100_bases
GTTTACTTAGTGGATTATTATGCCACTTATGATCTTTTCATAGGGGTTAGTATGGAAAACCATATCAAGATATTGAAGGA
CATGAAGTGGGGGGTAAGAA

Downstream 100 bases:

>100_bases
ATTGTTATATTGAGTAAAAGCTTTCTTTCTTTATTTGTCTTTATGGCAAAATCCCAGAAGTTCAGCTATTGAATTAGAGA
ACTGTTCGTCACTGAAAGTA

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MVRVTLVNYTKRPLETITWAALISYWGEWSTESFERISENDVEKHLPRILGYGHESILEHATFTFSIEGCSRVCTHQLVR
HRIASYTQQSQRYIVLDEENVEETFVIPESIKKDRELYEKWKKVMAETISLYKESINRGVHQEDARFILPQAVKTKIIVT
MNLRELKHFFGLRLCERAQWEIREVAWKMLEEMAKRDDIRPIIKWAKLGPRCIQFGYCPERDLMPPGCLKKTRKKWEKVA
ESKS

Sequences:

>Translated_244_residues
MVRVTLVNYTKRPLETITWAALISYWGEWSTESFERISENDVEKHLPRILGYGHESILEHATFTFSIEGCSRVCTHQLVR
HRIASYTQQSQRYIVLDEENVEETFVIPESIKKDRELYEKWKKVMAETISLYKESINRGVHQEDARFILPQAVKTKIIVT
MNLRELKHFFGLRLCERAQWEIREVAWKMLEEMAKRDDIRPIIKWAKLGPRCIQFGYCPERDLMPPGCLKKTRKKWEKVA
ESKS
>Mature_244_residues
MVRVTLVNYTKRPLETITWAALISYWGEWSTESFERISENDVEKHLPRILGYGHESILEHATFTFSIEGCSRVCTHQLVR
HRIASYTQQSQRYIVLDEENVEETFVIPESIKKDRELYEKWKKVMAETISLYKESINRGVHQEDARFILPQAVKTKIIVT
MNLRELKHFFGLRLCERAQWEIREVAWKMLEEMAKRDDIRPIIKWAKLGPRCIQFGYCPERDLMPPGCLKKTRKKWEKVA
ESKS

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_PYRFU (Q8U3C9)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578269.1
- ProteinModelPortal:   Q8U3C9
- SMR:   Q8U3C9
- EnsemblBacteria:   EBPYRT00000005268
- GeneID:   1468382
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF0540
- NMPDR:   fig|186497.1.peg.553
- GeneTree:   EBGT00050000022178
- HOGENOM:   HBG458114
- OMA:   QLGYCPE
- ProtClustDB:   PRK00847
- BRENDA:   2.1.1.148
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 28964; Mature: 28964

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVTLVNYTKRPLETITWAALISYWGEWSTESFERISENDVEKHLPRILGYGHESILEH
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ATFTFSIEGCSRVCTHQLVRHRIASYTQQSQRYIVLDEENVEETFVIPESIKKDRELYEK
HHHEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEECHHHHHHHHHHHHH
WKKVMAETISLYKESINRGVHQEDARFILPQAVKTKIIVTMNLRELKHFFGLRLCERAQW
HHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHEEEEEECHHHHHHHHHHHHHHHHHH
EIREVAWKMLEEMAKRDDIRPIIKWAKLGPRCIQFGYCPERDLMPPGCLKKTRKKWEKVA
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
ESKS
CCCC
>Mature Secondary Structure
MVRVTLVNYTKRPLETITWAALISYWGEWSTESFERISENDVEKHLPRILGYGHESILEH
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ATFTFSIEGCSRVCTHQLVRHRIASYTQQSQRYIVLDEENVEETFVIPESIKKDRELYEK
HHHEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEECHHHHHHHHHHHHH
WKKVMAETISLYKESINRGVHQEDARFILPQAVKTKIIVTMNLRELKHFFGLRLCERAQW
HHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHEEEEEECHHHHHHHHHHHHHHHHHH
EIREVAWKMLEEMAKRDDIRPIIKWAKLGPRCIQFGYCPERDLMPPGCLKKTRKKWEKVA
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
ESKS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA