Definition Pyrococcus furiosus DSM 3638, complete genome.
Accession NC_003413
Length 1,908,256

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The map label for this gene is topA

Identifier: 18976866

GI number: 18976866

Start: 510566

End: 513748

Strand: Direct

Name: topA

Synonym: PF0494

Alternate gene names: 18976866

Gene position: 510566-513748 (Clockwise)

Preceding gene: 18976865

Following gene: 18976867

Centisome position: 26.76

GC content: 38.86

Gene sequence:

>3183_bases
ATGATCCTCGTTATTGCAGAGAAGCCAAACGTTGCTAGAAAAATAGCAATGGCACTAGCTGAGGTGAAGCCTATTAAGAA
AACTCTCTTTGGAGTTCCCTACTACGAGTTAATTAGGGATGGAAAAAGACTCATAGTTGCCTCAGCAGTTGGTCATTTAT
ACGGTTTAGCCCCCAAAAATGACTTTTTTGGATATCCGATATTTGATGTGGAATGGGTTCCTGTTTACATAGCTGAAAAA
GGAAAAGAATATGCAAAAGATTACATTAAGTTGCTTTCAGTCCTATCCAAAAGGGTTAGAGAATTTATTGTTGCCTGTGA
CTATGATACTGAAGGAGAGGTCATTGGTTATACTGCATTGAAGTATGCCTGTGGCGTGGATCCTGGGGTTGCTAAAAGAA
TGAAATTTTCTGCATTAACTAAGAGGGACTTAATCAAAGCATGGTACAATCTTGAGCCAACTATAAACTTTGGAATGGCA
AATGCTGGTATTGCCAGGCATATTTTGGACTGGTACTGGGGGGTTAACCTATCAAGGGCGTTAACCCATGCAATAAAGAG
GGCGAGTGGAAAGTGGGTTGTCCTTAGTACTGGAAGGGTACAAGGACCAACGCTCAAGTTCTTAGTTGATAGAGAAAGGG
AAATTCAAAGCTTTGTTCCCCAACCTTATTGGGTCATAAAGCTGATATTTGAAAAGAATGGGAAAAAGTACACGGCAAAC
TACGAAAAGGATAAGATTTGGGATGAAAATGAAGCAAAAAGAATTGTATTAGAGGTAAAAAAGGCCCCTGCAAGGGTAAC
AAATATTGAAGTTAAACAACAAAATAGGAATCCCCCTGTTCCCTTCGACCTGGGAACTCTTCAAAGGGAAGCCTATTCCG
CCTTTGGGTTTTCACCAAAGAAAACCTTAGATATAGCTCAGAGTCTTTATGAAAAGGGATTCTGCCTTCACCCGGACACC
TTGATCTTAACTTCCCAGGGGGTTAGGAAAATTAAAGAGTTGTCTCGAGAGGGGGAAGTCTTTGCTTTGGACTTTAATCT
AAAGTTGTCAAAAGCAAAGTATAGGCTTCTCGAGCGTGATGCAGATGAGCAAATGTATAAAGTTACACTTCTTGACGGGA
CGGAGTTGTATTTAACAGCAGATCATCCAGTTTTAGTGTACAGAGAGGGTAATTTGGCTTTTGTACCCGCTGATAAGCTT
AGAGAAACTGATCATGTGGTTTTAGTCCTTAATAAATCTGCCAGAGATAATTATGGATTTTTGGATCTTTTACTTGAGAT
AACTGATTCCCAGGAGGATTATGCAATTCTAGAGAATGGTGAAACACTATCGTTGCATTCCTTAAAAATGCTTGTGGAGA
GGGGGGAAATAAAAGACATTGCAGTGGTCGGATTTTCACACAATAACTTTGGTAAAGTGATGTTAAGAGATGAGTTGTGG
TACCTCATTGGATATTTAGCAGGAAAGGGAGGAGAGATCAAAGGTAATGGAGTTGTAATCAGCTCTAGAACAAAAGAAAT
TGTTGGTTTAACAAAATCTTTAAACATTGATTTAATTGAAACAGAAGAAGGAATTGTTTTAAGTAACAAATCATTTGTTA
GATTACTGCACCTAATTCATTATACTCCACGTGTTCCAGAAGTTTATGGAATAATAAACAATACTGAGTGGCTAAAGGCT
TTTTTGGCTGGATACTACGACGCAACTTTACTTGAGGGCTTAACTTTGGAGGCTCTTTACAAAATTAAAGTTTACCTACA
GCTTTTGGGTATAAGAGCAAAGATTGAAGATAACAAACTTAAGGTTCACCTGGAAGATCTACAACGCTTTAGAGAACTTC
TTGGAAAGTTTAGCCGGAGAAAATTATATGTAGAAACTTCACAAGTTCCTGTATTCACTGATTTTGACGAAAGAAGTTAT
GACTTTCCAAGAATACTTGGAGGGGATATCTACATTATTGGAATAAAGTCAATAGAGAAATTCCACTATAAGGGGAAGGT
CTATGATCTTGTAGTTGAAAATTACCACAACTTCATAGCCAATGGAATTGCGGTTCACAACTGTTCTTATCCCAGGACAG
AAAGCCAAAAGCTCCCCAAGAATCTAAACTATAAGTTTATCATTCAGAACTTAGCGAGAATTCCAGAGTACAGGCCTTAT
GCACACCTACTCCTGGGAATGCCCGAACTTAAGCCGGTAGAAGGAAAAAAGGAGGATCCTGCCCATCCGGCCATTTATCC
AACGGGTGAAATTCCCAGGCCTGGAGATTTAACTAAAGATGAAGCTCTGCTTTATGACATGATTGTTAGAAGATTCTTAG
CGGTATTTATGGAGCCAGCAGTTAGAGAAACCGTTAAAGTCACAATTTCTGCAGGAAAGCACAAGTTCTTCATTTCTGGA
GGAAGAACGGTTAAAGAAGGCTGGCTGAGGGTGTATGGAAAGTATGTTAAGTTCGATGAAGTTACACTTCCAACATTCTT
CATCGGTGAGAGAATTAAAGTCCTTCAAGTAAAGAGAGAAAAGAAAAAGACGAAGCCCCCCGCTAGATACTCCCCCGCTG
CAGTCATTAAAAAGATGGAAGATTTGGGATTGGGCACCAAGGCCACAAGAGCCCAAATACTTGAGACCCTATATCAGAGA
GGATATATAGAAGGAAAGAAATCGATAAAGGTAACTCCCCTAGGAATGAAAGTTATAGAAACTCTAGAAAAGTACGTTCC
AGAAATAATAAGTGTTGAGTTGACTAGAGAATTTGAAAAGAAGATGGAACTAATCATGGAAGGTAAACTAACAAAAGAGG
AAGTAATAGAGGAAGCCAAAATTAGGCTTACAAAAATACTTGAAGAGTTCAAAAAGAAGGAGCTTGAAATAGGTCTTGAA
CTGGCAAAGATTGTAGTTGGGGAAGAGAAGCCTCCATTAATTGTAGGGAAGTGCCCCAAGTGTGGAGGAGACTTAATTGT
TAAGTATAACGAAAAGACTGGGAAGAGGTTTGTAGGTTGTTCTAATTGGCCAAAATGTAATGTTACATACCCGATTCTTC
AGAGAGGGGAGATTATACCAACCAATAAAACTTGTTGTAACGGTGCCCCGGTAGTTATAATTCGAGAAAAAGATGGAAGA
GAATGGGAGATATGTCTAGATATGAATTGCAAGGAATATAATACTATTAAGAAAAAGAGATAG

Upstream 100 bases:

>100_bases
AAAAGAGAGAAAAAGAACTTGAAAGTGTTCTCAGAGTTATTGAAGAATACAAGATTGAGAGAATTAAAGAGTTAGTGAGA
AAAGCTGAGGAGGAGGGACA

Downstream 100 bases:

>100_bases
AAATAGCTTATTTCTAAAATACGGGGAGCTAGAAACCTTTTTAAGAACAAAAGTAGTGAACTTAGACTTAGAGGGAGAGC
ATTATGAAGGCAATATATAG

Product: DNA topoisomerase I

Products: NA

Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme; Pfu topA intein

Number of amino acids: Translated: 1060; Mature: 1060

Protein sequence:

>1060_residues
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEK
GKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMA
NAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTAN
YEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDT
LILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKL
RETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELW
YLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKA
FLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSY
DFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPY
AHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISG
GRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQR
GYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLE
LAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGR
EWEICLDMNCKEYNTIKKKR

Sequences:

>Translated_1060_residues
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEK
GKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMA
NAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTAN
YEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDT
LILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKL
RETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELW
YLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKA
FLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSY
DFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPY
AHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISG
GRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQR
GYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLE
LAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGR
EWEICLDMNCKEYNTIKKKR
>Mature_1060_residues
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEK
GKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMA
NAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTAN
YEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDT
LILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKL
RETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELW
YLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKA
FLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSY
DFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPY
AHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISG
GRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQR
GYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLE
LAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGR
EWEICLDMNCKEYNTIKKKR

Specific function: PI-pfuI is an endonuclease (Potential)

COG id: COG0550

COG function: function code L; Topoisomerase IA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain

Homologues:

Organism=Homo sapiens, GI10835218, Length=330, Percent_Identity=29.3939393939394, Blast_Score=133, Evalue=9e-31,
Organism=Homo sapiens, GI4507635, Length=342, Percent_Identity=27.4853801169591, Blast_Score=92, Evalue=3e-18,
Organism=Escherichia coli, GI1788061, Length=332, Percent_Identity=30.1204819277108, Blast_Score=107, Evalue=4e-24,
Organism=Escherichia coli, GI1787529, Length=346, Percent_Identity=25.7225433526012, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17555378, Length=267, Percent_Identity=31.0861423220974, Blast_Score=118, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32563869, Length=345, Percent_Identity=28.9855072463768, Blast_Score=106, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6323263, Length=375, Percent_Identity=24.2666666666667, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585251, Length=345, Percent_Identity=26.0869565217391, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24640096, Length=253, Percent_Identity=23.7154150197628, Blast_Score=89, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TOP1_PYRFU (O73954)

Other databases:

- EMBL:   AE009950
- EMBL:   AF042825
- RefSeq:   NP_578223.1
- ProteinModelPortal:   O73954
- EnsemblBacteria:   EBPYRT00000004301
- GeneID:   1468335
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF0494
- NMPDR:   fig|186497.1.peg.506
- GeneTree:   EBGT00050000022152
- HOGENOM:   HBG512935
- OMA:   SIEKFHY
- ProtClustDB:   CLSK253381
- BRENDA:   5.99.1.2
- GO:   GO:0005694
- InterPro:   IPR003586
- InterPro:   IPR003587
- InterPro:   IPR006142
- InterPro:   IPR004042
- InterPro:   IPR006141
- InterPro:   IPR003601
- InterPro:   IPR013497
- InterPro:   IPR013824
- InterPro:   IPR013825
- InterPro:   IPR013826
- InterPro:   IPR000380
- InterPro:   IPR003602
- InterPro:   IPR013498
- InterPro:   IPR005739
- InterPro:   IPR006171
- Gene3D:   G3DSA:1.10.460.10
- Gene3D:   G3DSA:2.70.20.10
- Gene3D:   G3DSA:1.10.290.10
- PANTHER:   PTHR11390
- PRINTS:   PR00379
- PRINTS:   PR00417
- SMART:   SM00305
- SMART:   SM00306
- SMART:   SM00437
- SMART:   SM00436
- SMART:   SM00493
- TIGRFAMs:   TIGR01443
- TIGRFAMs:   TIGR01445
- TIGRFAMs:   TIGR01057

Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom; SSF56712 Topo_IA_core

EC number: =5.99.1.2

Molecular weight: Translated: 121183; Mature: 121183

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50818 INTEIN_C_TER; PS50819 INTEIN_ENDONUCLEASE; PS50817 INTEIN_N_TER

Important sites: ACT_SITE 690-690

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKN
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEEHHHHHHCCCCCC
DFFGYPIFDVEWVPVYIAEKGKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTAL
CCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEHHHH
KYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMANAGIARHILDWYWGVNLSRA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCHHHH
LTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTAN
HHHHHHHCCCCEEEEECCCCCCCEEEEEECCHHHHHHHCCCCEEEEEEEEECCCCEEECC
YEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPK
CCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCH
KTLDIAQSLYEKGFCLHPDTLILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERD
HHHHHHHHHHHCCCEECCCEEEEECHHHHHHHHHCCCCCEEEEEEEEEEHHHHHHHHHCC
ADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKLRETDHVVLVLNKSARDNYGF
CCCCEEEEEEECCCEEEEEECCCEEEEECCCEEEECHHHCCCCCCEEEEEECCCCCCCCC
LDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELW
EEHHEECCCCCCCEEEEECCCEEEHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEHHHHH
YLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIH
HHHHHHCCCCCEECCCCEEEECCCHHHHEEHCCCCEEEEECCCCEEECCHHHHHHHHHHH
YTPRVPEVYGIINNTEWLKAFLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKL
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCEEEEECCEE
KVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSYDFPRILGGDIYIIGIKSIEK
EEEHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCCCCCCEECCCEEEEEECHHHH
FHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPY
HHCCCCEEEHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCH
AHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPA
HHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHH
VRETVKVTISAGKHKFFISGGRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKRE
HHCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHEEECCEECCCHHHCCCCEEHEEHHH
KKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIE
HHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHH
TLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIP
EEHHEECCCCCCEEEECCCCCCCCEEEEECCCCCCEEECCCCCCCCCEEHHHHCCCCCCC
TNKTCCNGAPVVIIREKDGREWEICLDMNCKEYNTIKKKR
CCCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHCCCC
>Mature Secondary Structure
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKN
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEEHHHHHHCCCCCC
DFFGYPIFDVEWVPVYIAEKGKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTAL
CCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEHHHH
KYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMANAGIARHILDWYWGVNLSRA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCHHHH
LTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTAN
HHHHHHHCCCCEEEEECCCCCCCEEEEEECCHHHHHHHCCCCEEEEEEEEECCCCEEECC
YEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPK
CCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCH
KTLDIAQSLYEKGFCLHPDTLILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERD
HHHHHHHHHHHCCCEECCCEEEEECHHHHHHHHHCCCCCEEEEEEEEEEHHHHHHHHHCC
ADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKLRETDHVVLVLNKSARDNYGF
CCCCEEEEEEECCCEEEEEECCCEEEEECCCEEEECHHHCCCCCCEEEEEECCCCCCCCC
LDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELW
EEHHEECCCCCCCEEEEECCCEEEHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEHHHHH
YLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIH
HHHHHHCCCCCEECCCCEEEECCCHHHHEEHCCCCEEEEECCCCEEECCHHHHHHHHHHH
YTPRVPEVYGIINNTEWLKAFLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKL
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCEEEEECCEE
KVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSYDFPRILGGDIYIIGIKSIEK
EEEHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCCCCCCEECCCEEEEEECHHHH
FHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPY
HHCCCCEEEHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCH
AHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPA
HHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHH
VRETVKVTISAGKHKFFISGGRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKRE
HHCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHEEECCEECCCHHHCCCCEEHEEHHH
KKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIE
HHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHH
TLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIP
EEHHEECCCCCCEEEECCCCCCCCEEEEECCCCCCEEECCCCCCCCCEEHHHHCCCCCCC
TNKTCCNGAPVVIIREKDGREWEICLDMNCKEYNTIKKKR
CCCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9524230