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The map label for this gene is purM

Identifier: 18976803

GI number: 18976803

Start: 439838

End: 440842

Strand: Direct

Name: purM

Synonym: PF0431

Alternate gene names: 18976803

Gene position: 439838-440842 (Clockwise)

Preceding gene: 18976800

Following gene: 18976804

Centisome position: 23.05

GC content: 41.49

Gene sequence:

>1005_bases
ATGCTGACTTATGCACAAGCAGGTGTCGATGAGGAGAAGACATCAAAGGCTTTGAGATTTATAATAGAGGCGGCCAGGAA
AACCTTTGAGTTTAGAAAAGGCAAACTTGGCGAACCTGGAGATATAGGGCATTATTCGGCACTCTTAGATTTTGGAAATT
ATTACCTTGCTATCACAACTGATGGAGTGGGGACTAAAGTTCTTGTGGCTGAAGCAGTAGGTAAGTTTGACACAATTGGA
ATAGATATGATAGCGATGAACGTTAACGACTTAATATGCGTTGGAGCAGAGCCAATAGCTCTCGTGGATTACTTTGCAAT
TAAAGAACCCAACGAGAGGGTTTTTGAGGAAGTTGCTAAAGGGCTATATAAAGGAGCTAAGGAAGCGGGAATTGCAATAG
TTGGAGGAGAGACGGCAGTAATGCCCGACCTTGTGAATGGCTACGACCTTGCGGGAACTGCGATAGGAATTGTGGAAAAG
GATAAGGTGATTACTGGAGAGAAGATAAGGCCTGGAGATGCCGTCATAGGAATTTCGAGCTCTGGAATTCACTCTAATGG
TCTAACCTTGGCAAGAAAGCTCCTAATCCCCAAATATGGACTTGACTATGAATACGAAAGTAGAAAGTTGTGGGAATGGC
TGTTAGAACCAACTAGAATTTATGTAAAGCCTATTCTAGAACTTTTAAAGAGTGTGGAGGTTCATGGACTGGCGCATATA
ACTGGAGGAGGCCTTCTAAACCTCAAGAGGATTACAAACTATGGATTTAGGTTAAACATGCCTCCCATAAATGGAATATT
TAAGCTAATACATGAGAACGGTGTTCCTTTAGAGGAAATGTTCAGGGTATTTAACATGGGTGTCGGTTTTGTTGTTGTAG
TTTCCCAGGAGGATAAGGAAGAGGCGCTTCAGATATTAAACAGATACTATGAGAGCTTTGAGCTTGGAACAGTTAGTGAA
AGACCTGGGATAATTGTCGAGAACTATGGTGTAAAGTTTATTTAA

Upstream 100 bases:

>100_bases
GCAGCCTATATTTAAGTCTTTTTTAGCATGAAAATGTTAACATAAAAATGTTAATGAATCTTTTTAAATAGACACAATTT
TATCAATTTTTGGTGATAAT

Downstream 100 bases:

>100_bases
GTACAGCTCAACACCGCTTAGGGATGGAAATGAGGATAGTCTTTGACATGGATGGGGTATTGTACAGAGGGAACACTCCA
ATAGAAGGTGCAAGGGAAGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLTYAQAGVDEEKTSKALRFIIEAARKTFEFRKGKLGEPGDIGHYSALLDFGNYYLAITTDGVGTKVLVAEAVGKFDTIG
IDMIAMNVNDLICVGAEPIALVDYFAIKEPNERVFEEVAKGLYKGAKEAGIAIVGGETAVMPDLVNGYDLAGTAIGIVEK
DKVITGEKIRPGDAVIGISSSGIHSNGLTLARKLLIPKYGLDYEYESRKLWEWLLEPTRIYVKPILELLKSVEVHGLAHI
TGGGLLNLKRITNYGFRLNMPPINGIFKLIHENGVPLEEMFRVFNMGVGFVVVVSQEDKEEALQILNRYYESFELGTVSE
RPGIIVENYGVKFI

Sequences:

>Translated_334_residues
MLTYAQAGVDEEKTSKALRFIIEAARKTFEFRKGKLGEPGDIGHYSALLDFGNYYLAITTDGVGTKVLVAEAVGKFDTIG
IDMIAMNVNDLICVGAEPIALVDYFAIKEPNERVFEEVAKGLYKGAKEAGIAIVGGETAVMPDLVNGYDLAGTAIGIVEK
DKVITGEKIRPGDAVIGISSSGIHSNGLTLARKLLIPKYGLDYEYESRKLWEWLLEPTRIYVKPILELLKSVEVHGLAHI
TGGGLLNLKRITNYGFRLNMPPINGIFKLIHENGVPLEEMFRVFNMGVGFVVVVSQEDKEEALQILNRYYESFELGTVSE
RPGIIVENYGVKFI
>Mature_334_residues
MLTYAQAGVDEEKTSKALRFIIEAARKTFEFRKGKLGEPGDIGHYSALLDFGNYYLAITTDGVGTKVLVAEAVGKFDTIG
IDMIAMNVNDLICVGAEPIALVDYFAIKEPNERVFEEVAKGLYKGAKEAGIAIVGGETAVMPDLVNGYDLAGTAIGIVEK
DKVITGEKIRPGDAVIGISSSGIHSNGLTLARKLLIPKYGLDYEYESRKLWEWLLEPTRIYVKPILELLKSVEVHGLAHI
TGGGLLNLKRITNYGFRLNMPPINGIFKLIHENGVPLEEMFRVFNMGVGFVVVVSQEDKEEALQILNRYYESFELGTVSE
RPGIIVENYGVKFI

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=352, Percent_Identity=39.4886363636364, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI209869995, Length=352, Percent_Identity=39.4886363636364, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI209869993, Length=352, Percent_Identity=39.4886363636364, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1788845, Length=326, Percent_Identity=38.3435582822086, Blast_Score=193, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17567511, Length=340, Percent_Identity=34.7058823529412, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321203, Length=354, Percent_Identity=37.0056497175141, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24582400, Length=297, Percent_Identity=35.6902356902357, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_PYRFU (Q8U3M6)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578160.1
- ProteinModelPortal:   Q8U3M6
- SMR:   Q8U3M6
- EnsemblBacteria:   EBPYRT00000005896
- GeneID:   1468269
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF0431
- NMPDR:   fig|186497.1.peg.440
- GeneTree:   EBGT00050000022555
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_A
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36754; Mature: 36754

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYAQAGVDEEKTSKALRFIIEAARKTFEFRKGKLGEPGDIGHYSALLDFGNYYLAITT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEEEE
DGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLICVGAEPIALVDYFAIKEPNERVFEEVAK
CCCCCEEHHHHHHCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHCCCCCHHHHHHHHH
GLYKGAKEAGIAIVGGETAVMPDLVNGYDLAGTAIGIVEKDKVITGEKIRPGDAVIGISS
HHHCCHHHCCEEEECCCCEECCHHCCCCCCCCCEEEEEECCCEECCCCCCCCCEEEEECC
SGIHSNGLTLARKLLIPKYGLDYEYESRKLWEWLLEPTRIYVKPILELLKSVEVHGLAHI
CCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCEEEE
TGGGLLNLKRITNYGFRLNMPPINGIFKLIHENGVPLEEMFRVFNMGVGFVVVVSQEDKE
CCCCEEEEHHHCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCHH
EALQILNRYYESFELGTVSERPGIIVENYGVKFI
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCEECC
>Mature Secondary Structure
MLTYAQAGVDEEKTSKALRFIIEAARKTFEFRKGKLGEPGDIGHYSALLDFGNYYLAITT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEEEE
DGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLICVGAEPIALVDYFAIKEPNERVFEEVAK
CCCCCEEHHHHHHCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHCCCCCHHHHHHHHH
GLYKGAKEAGIAIVGGETAVMPDLVNGYDLAGTAIGIVEKDKVITGEKIRPGDAVIGISS
HHHCCHHHCCEEEECCCCEECCHHCCCCCCCCCEEEEEECCCEECCCCCCCCCEEEEECC
SGIHSNGLTLARKLLIPKYGLDYEYESRKLWEWLLEPTRIYVKPILELLKSVEVHGLAHI
CCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCEEEE
TGGGLLNLKRITNYGFRLNMPPINGIFKLIHENGVPLEEMFRVFNMGVGFVVVVSQEDKE
CCCCEEEEHHHCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCHH
EALQILNRYYESFELGTVSERPGIIVENYGVKFI
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA