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The map label for this gene is guaB [H]

Identifier: 18976657

GI number: 18976657

Start: 294806

End: 296263

Strand: Direct

Name: guaB [H]

Synonym: PF0285

Alternate gene names: 18976657

Gene position: 294806-296263 (Clockwise)

Preceding gene: 18976655

Following gene: 18976658

Centisome position: 15.45

GC content: 45.95

Gene sequence:

>1458_bases
ATGGGAAAATTCGTGGAGAAGCTTGAGAATGCAATTAGAGGGTATACATTCGACGACGTTCTCTTGATTCCTCAACCGAC
TGAAGTTGAGCCAAAAGATGTTGACGTTTCTACCCAAATTACACCCAATGTAAAGCTAAACATCCCAATTCTCAGTGCAG
CTATGGACACCGTTACAGAATGGGAAATGGCAGTTGCAATGGCTAGAGAAGGAGGATTGGGAGTAATTCATAGGAATATG
AGCATAGAGGAGCAGGTAGAACAAGTAAAAAGGGTGAAGAGAGCGGAGAGGTTTATAGTCGAGGACGTTATAACCATAGC
TCCAGATGAAACCATTGACTATGCACTCTTCTTAATGGAGAAGCATGGAATAGATGGTTTGCCAGTTGTTGAAGAGGATA
GAGTCGTTGGAATCATAACGAAAAAGGACATAGCGGCAAGAGAAGGAAGAACCGTCAAGGAACTAATGACAAGGGAAGTG
ATAACGGTTCCAGAGAGCGTTGATGTTGAAGAGGCCCTGAAGATAATGATGGAGAACAGAATAGATAGATTGCCAGTAGT
GAATGAGGATGGGAAATTAGTTGGTCTAATAACAATGAGCGACCTCGTGGCTAGAAAGAAGTATAAGAATGCCGTAAGAA
ACGAGAAAGGGGAGCTACTTGTCGCGGCCGCGGTTAGTCCTTTTGATTTAAGAAGGGCAATTGAACTTGACAGGGCTGGA
GTTGACGTTATAGTCGTTGATACTGCACATGCCCACAATTTAAAGGCAATAAAAGCGATGAAGGAAATGAGGCAAAAGGT
TAGTGCCGATTTCATAGTTGGAAACATAGCAAATCCGAAGGCTGTGGATGACTTAACGTTTGCAGATGCAGTTAAAGTTG
GCATAGGTCCTGGAAGCATATGCACGACGAGAATAGTTGCGGGAGTTGGAGTTCCTCAAATAACCGCAATAGCAATGGTT
GCAGATAGAGCCCAAGAGTATGGACTTTACGTCATAGCCGATGGAGGGATAAAGTATTCTGGTGACATAGTGAAGGCAAT
CGCCGCTGGGGCAGATGCAGTAATGCTTGGCAACCTCCTAGCTGGAACCAAGGAAGCCCCAGGAAAAGAGGTGATAATAA
ACGGAAGGAAGTACAAGCAGTACAGGGGAATGGGTTCCCTGGGAGCTATGATGAAGGGAGGGGCCGAGAGGTACTACCAG
GGAGGCTACATGAAGACGAGGAAGTTCGTTCCCGAGGGGGTTGAGGGAGTAGTCCCCTATAGGGGGACCGTCAGTGAAGT
TCTCTACCAGCTTGTTGGTGGGTTAAAGGCAGGAATGGGCTACGTTGGTGCCAGGAACATCAAGGAGCTAAAGGAGAAAG
GCGAATTCGTGATAATAACTTCGGCTGGTTTAAGGGAGAGTCATCCTCATGACATTATAATCACGAACGAAGCTCCGAAC
TATCCCTTGGAGAGGTGA

Upstream 100 bases:

>100_bases
CTCTTACTCAATATTGGGTATAAATGCATATTTAAATCTTTGCCAAAGGTTTTTATATCCACTGAATACTTCAAGAAAAA
GGGTGAAGGGGGAATAGGGA

Downstream 100 bases:

>100_bases
TTCTTTGGTTTCTTTCTCCTTTTGAGGCTTATCCTTCTTCACTCCACTAAGAACTTTTAGTGAAAGTACAATCATTTTAA
AAATTTAAATACGCTTAAAT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MGKFVEKLENAIRGYTFDDVLLIPQPTEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGVIHRNM
SIEEQVEQVKRVKRAERFIVEDVITIAPDETIDYALFLMEKHGIDGLPVVEEDRVVGIITKKDIAAREGRTVKELMTREV
ITVPESVDVEEALKIMMENRIDRLPVVNEDGKLVGLITMSDLVARKKYKNAVRNEKGELLVAAAVSPFDLRRAIELDRAG
VDVIVVDTAHAHNLKAIKAMKEMRQKVSADFIVGNIANPKAVDDLTFADAVKVGIGPGSICTTRIVAGVGVPQITAIAMV
ADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQ
GGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN
YPLER

Sequences:

>Translated_485_residues
MGKFVEKLENAIRGYTFDDVLLIPQPTEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGVIHRNM
SIEEQVEQVKRVKRAERFIVEDVITIAPDETIDYALFLMEKHGIDGLPVVEEDRVVGIITKKDIAAREGRTVKELMTREV
ITVPESVDVEEALKIMMENRIDRLPVVNEDGKLVGLITMSDLVARKKYKNAVRNEKGELLVAAAVSPFDLRRAIELDRAG
VDVIVVDTAHAHNLKAIKAMKEMRQKVSADFIVGNIANPKAVDDLTFADAVKVGIGPGSICTTRIVAGVGVPQITAIAMV
ADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQ
GGYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN
YPLER
>Mature_484_residues
GKFVEKLENAIRGYTFDDVLLIPQPTEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGLGVIHRNMS
IEEQVEQVKRVKRAERFIVEDVITIAPDETIDYALFLMEKHGIDGLPVVEEDRVVGIITKKDIAAREGRTVKELMTREVI
TVPESVDVEEALKIMMENRIDRLPVVNEDGKLVGLITMSDLVARKKYKNAVRNEKGELLVAAAVSPFDLRRAIELDRAGV
DVIVVDTAHAHNLKAIKAMKEMRQKVSADFIVGNIANPKAVDDLTFADAVKVGIGPGSICTTRIVAGVGVPQITAIAMVA
DRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLLAGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQG
GYMKTRKFVPEGVEGVVPYRGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPNY
PLER

Specific function: IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=468, Percent_Identity=35.4700854700855, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI34328930, Length=468, Percent_Identity=35.4700854700855, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI156616279, Length=468, Percent_Identity=35.4700854700855, Blast_Score=275, Evalue=8e-74,
Organism=Homo sapiens, GI34328928, Length=468, Percent_Identity=35.4700854700855, Blast_Score=275, Evalue=9e-74,
Organism=Homo sapiens, GI66933016, Length=467, Percent_Identity=34.475374732334, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI217035152, Length=452, Percent_Identity=35.8407079646018, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI217035148, Length=468, Percent_Identity=34.8290598290598, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI217035150, Length=468, Percent_Identity=33.1196581196581, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI50541956, Length=223, Percent_Identity=38.5650224215247, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI50541954, Length=223, Percent_Identity=38.5650224215247, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI50541952, Length=223, Percent_Identity=38.5650224215247, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI50541948, Length=223, Percent_Identity=38.5650224215247, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI156104880, Length=223, Percent_Identity=38.5650224215247, Blast_Score=145, Evalue=7e-35,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=47.3251028806584, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1786293, Length=354, Percent_Identity=29.3785310734463, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=490, Percent_Identity=33.469387755102, Blast_Score=234, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI71994389, Length=436, Percent_Identity=34.8623853211009, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17560440, Length=242, Percent_Identity=35.5371900826446, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322012, Length=492, Percent_Identity=33.3333333333333, Blast_Score=269, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6323464, Length=486, Percent_Identity=32.7160493827161, Blast_Score=257, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6323585, Length=492, Percent_Identity=32.3170731707317, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=32.9479768786127, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=37.6068376068376, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641071, Length=456, Percent_Identity=37.0614035087719, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24641073, Length=456, Percent_Identity=37.0614035087719, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI28571163, Length=415, Percent_Identity=37.8313253012048, Blast_Score=254, Evalue=7e-68,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52901; Mature: 52770

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKFVEKLENAIRGYTFDDVLLIPQPTEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTE
CCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHH
WEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKRAERFIVEDVITIAPDETIDYALFLME
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEH
KHGIDGLPVVEEDRVVGIITKKDIAAREGRTVKELMTREVITVPESVDVEEALKIMMENR
HCCCCCCCEECCCCEEEEEECCCHHHCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHC
IDRLPVVNEDGKLVGLITMSDLVARKKYKNAVRNEKGELLVAAAVSPFDLRRAIELDRAG
CCCCCEECCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCC
VDVIVVDTAHAHNLKAIKAMKEMRQKVSADFIVGNIANPKAVDDLTFADAVKVGIGPGSI
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHEEECCCCCHH
CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL
HHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEECCCEEECCHHHHHHHCCCCHHHHHHHH
AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY
CCCCCCCCCEEEECCCHHHHHCCCCHHHHHHCCCHHHHHCCCCHHHHHCCCCCCCCCCCC
RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCC
YPLER
CCCCC
>Mature Secondary Structure 
GKFVEKLENAIRGYTFDDVLLIPQPTEVEPKDVDVSTQITPNVKLNIPILSAAMDTVTE
CHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHH
WEMAVAMAREGGLGVIHRNMSIEEQVEQVKRVKRAERFIVEDVITIAPDETIDYALFLME
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEH
KHGIDGLPVVEEDRVVGIITKKDIAAREGRTVKELMTREVITVPESVDVEEALKIMMENR
HCCCCCCCEECCCCEEEEEECCCHHHCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHC
IDRLPVVNEDGKLVGLITMSDLVARKKYKNAVRNEKGELLVAAAVSPFDLRRAIELDRAG
CCCCCEECCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCC
VDVIVVDTAHAHNLKAIKAMKEMRQKVSADFIVGNIANPKAVDDLTFADAVKVGIGPGSI
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHEEECCCCCHH
CTTRIVAGVGVPQITAIAMVADRAQEYGLYVIADGGIKYSGDIVKAIAAGADAVMLGNLL
HHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEECCCEEECCHHHHHHHCCCCHHHHHHHH
AGTKEAPGKEVIINGRKYKQYRGMGSLGAMMKGGAERYYQGGYMKTRKFVPEGVEGVVPY
CCCCCCCCCEEEECCCHHHHHCCCCHHHHHHCCCHHHHHCCCCHHHHHCCCCCCCCCCCC
RGTVSEVLYQLVGGLKAGMGYVGARNIKELKEKGEFVIITSAGLRESHPHDIIITNEAPN
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCC
YPLER
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]