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The map label for this gene is napA [H]

Identifier: 18976640

GI number: 18976640

Start: 277117

End: 278250

Strand: Direct

Name: napA [H]

Synonym: PF0268

Alternate gene names: 18976640

Gene position: 277117-278250 (Clockwise)

Preceding gene: 18976637

Following gene: 18976641

Centisome position: 14.52

GC content: 41.71

Gene sequence:

>1134_bases
GTGTGCTTGGAAGTACTATTATTGCTTTCACTCATGCTTGCGGTAGCTAAAATAATGGGTTACATCTTTGAAAGGTTAGG
CCAGCCTGCAGTTTTAGGTCAAATATTTGGAGGTCTTTTACTTGGCTTATTTATTGAAACAAACCCAGTAATCTCGGAAT
TTGCTAACCTGGGTGTTCTTCTCCTTCTTTTTATTGCTGGATTGGAGAGTGAACTTGAAGAATTCAAAAAAGTAGGAAAG
AGGAGTGTTATTGTAGCAGTTTTTGGAGTTGTTGTGGCATTTCTCTTTGGCTTTCTCGTTGCCCTCCCATTTACATCTTT
TGAGAGGGCAATAATCTACGGGGCATTGATGACTCCCACAAGCGTGAGCATAACGGTAAAGGTTCTCATGGAGATGAGAA
AGCTCAACACCATAGAGGGAACAACAATCTTAGCGGCTGCTGTTGTGGATGATATCCTGGGAATAATAGTTCTTACATTT
GCAATATCAATAGCTAGAAGAGTCTCAATCGAGTACCTTAAGGTGATGGAAGTTCTAGTGTCCGTATCTGCCCTCATTTT
CTTCTTCCTTTACTTTGGCCCCAGGCTTGCCGAAACCTTCTTTAGGCGATTGAGGATTATTGATCTTCCAGAGGTTGAGA
CTGCTTTTGCAATTGTTTTTCTGGTTTTATTTTCCTATCTTGCGGAGCACTTAAACTTGGCTTCAATCTTGGGAGCTTAT
CTAGTGGGTTTGGCCATAGGCCAGACGTCCCAGAAAAAGGTGATACTAGATCATGTCAACATTTTGGGTTATTCTCTCTT
CATACCTGTTTTCTTCGTGGAAGTTGGGATGAAGATGAAGGCTCATCATCTCCTCCACGTTAGCAGTTTTGCCATTCTCT
ACACTTTAATGGCCATAGTTAGCAAGATAGTGGGGTGTGGCATTGGAGCTAAACTAAGTGGATTCAACTGGAGATCCTCT
CTTAAAATTGGAGTTGGGATGATACCCAGGATGGGTGTTGAGCTGGCAATGTTGAGCATTGCAATTTCTGCTGGAGTTAT
GGATCTGGCTAGCTTGACGGTGATAGTTGTGATGGTTTTTGTAACCACTTTAATAACTCCTCCACTCTTGAAAGTTGTCT
ATATGAAGACATGA

Upstream 100 bases:

>100_bases
TCTTCAGTTTCCATCTCTTCCATGAACTTTATTTTACGTTTGTGTTTTTAAATCTGAGGTAAAAGCTTAAACCTGGAAAG
ATAGAACTTAACCTAGGCGA

Downstream 100 bases:

>100_bases
AAAAATATATATTCCAAATGGGAAAATAGTAAAGTTGAATGATGAATCTGGAGCCCACTGATTTAATGATGACCTGTTCG
CGGGGCTGATGCTGTGATAA

Product: Na+/H+ antiporter - like protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MCLEVLLLLSLMLAVAKIMGYIFERLGQPAVLGQIFGGLLLGLFIETNPVISEFANLGVLLLLFIAGLESELEEFKKVGK
RSVIVAVFGVVVAFLFGFLVALPFTSFERAIIYGALMTPTSVSITVKVLMEMRKLNTIEGTTILAAAVVDDILGIIVLTF
AISIARRVSIEYLKVMEVLVSVSALIFFFLYFGPRLAETFFRRLRIIDLPEVETAFAIVFLVLFSYLAEHLNLASILGAY
LVGLAIGQTSQKKVILDHVNILGYSLFIPVFFVEVGMKMKAHHLLHVSSFAILYTLMAIVSKIVGCGIGAKLSGFNWRSS
LKIGVGMIPRMGVELAMLSIAISAGVMDLASLTVIVVMVFVTTLITPPLLKVVYMKT

Sequences:

>Translated_377_residues
MCLEVLLLLSLMLAVAKIMGYIFERLGQPAVLGQIFGGLLLGLFIETNPVISEFANLGVLLLLFIAGLESELEEFKKVGK
RSVIVAVFGVVVAFLFGFLVALPFTSFERAIIYGALMTPTSVSITVKVLMEMRKLNTIEGTTILAAAVVDDILGIIVLTF
AISIARRVSIEYLKVMEVLVSVSALIFFFLYFGPRLAETFFRRLRIIDLPEVETAFAIVFLVLFSYLAEHLNLASILGAY
LVGLAIGQTSQKKVILDHVNILGYSLFIPVFFVEVGMKMKAHHLLHVSSFAILYTLMAIVSKIVGCGIGAKLSGFNWRSS
LKIGVGMIPRMGVELAMLSIAISAGVMDLASLTVIVVMVFVTTLITPPLLKVVYMKT
>Mature_377_residues
MCLEVLLLLSLMLAVAKIMGYIFERLGQPAVLGQIFGGLLLGLFIETNPVISEFANLGVLLLLFIAGLESELEEFKKVGK
RSVIVAVFGVVVAFLFGFLVALPFTSFERAIIYGALMTPTSVSITVKVLMEMRKLNTIEGTTILAAAVVDDILGIIVLTF
AISIARRVSIEYLKVMEVLVSVSALIFFFLYFGPRLAETFFRRLRIIDLPEVETAFAIVFLVLFSYLAEHLNLASILGAY
LVGLAIGQTSQKKVILDHVNILGYSLFIPVFFVEVGMKMKAHHLLHVSSFAILYTLMAIVSKIVGCGIGAKLSGFNWRSS
LKIGVGMIPRMGVELAMLSIAISAGVMDLASLTVIVVMVFVTTLITPPLLKVVYMKT

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=403, Percent_Identity=27.5434243176179, Blast_Score=119, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 41155; Mature: 41155

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00287 CYSTATIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLEVLLLLSLMLAVAKIMGYIFERLGQPAVLGQIFGGLLLGLFIETNPVISEFANLGVL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LLLFIAGLESELEEFKKVGKRSVIVAVFGVVVAFLFGFLVALPFTSFERAIIYGALMTPT
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
SVSITVKVLMEMRKLNTIEGTTILAAAVVDDILGIIVLTFAISIARRVSIEYLKVMEVLV
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVSALIFFFLYFGPRLAETFFRRLRIIDLPEVETAFAIVFLVLFSYLAEHLNLASILGAY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGLAIGQTSQKKVILDHVNILGYSLFIPVFFVEVGMKMKAHHLLHVSSFAILYTLMAIV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
SKIVGCGIGAKLSGFNWRSSLKIGVGMIPRMGVELAMLSIAISAGVMDLASLTVIVVMVF
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTTLITPPLLKVVYMKT
HHHHHCHHHHHHHHCCC
>Mature Secondary Structure
MCLEVLLLLSLMLAVAKIMGYIFERLGQPAVLGQIFGGLLLGLFIETNPVISEFANLGVL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LLLFIAGLESELEEFKKVGKRSVIVAVFGVVVAFLFGFLVALPFTSFERAIIYGALMTPT
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
SVSITVKVLMEMRKLNTIEGTTILAAAVVDDILGIIVLTFAISIARRVSIEYLKVMEVLV
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVSALIFFFLYFGPRLAETFFRRLRIIDLPEVETAFAIVFLVLFSYLAEHLNLASILGAY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGLAIGQTSQKKVILDHVNILGYSLFIPVFFVEVGMKMKAHHLLHVSSFAILYTLMAIV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
SKIVGCGIGAKLSGFNWRSSLKIGVGMIPRMGVELAMLSIAISAGVMDLASLTVIVVMVF
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTTLITPPLLKVVYMKT
HHHHHCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]