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The map label for this gene is kbl [C]

Identifier: 18976637

GI number: 18976637

Start: 274108

End: 275295

Strand: Direct

Name: kbl [C]

Synonym: PF0265

Alternate gene names: 18976637

Gene position: 274108-275295 (Clockwise)

Preceding gene: 18976635

Following gene: 18976640

Centisome position: 14.36

GC content: 46.21

Gene sequence:

>1188_bases
ATGGGAAAGCTTGATTGGATTAGGGAAGAACTTGAGGAACTTAAGAAGAAGGGGCTTTACGTGACAATTAGAGTTCTTCA
AAGTGCCCAGGGCCCCTGGGTTATTGTGAATGGAAAGAAAGTTCTGAACATGTGTTCTAACAACTACCTAGGCTTAGCTG
CACACCCCAAGATTAAAGAGGCTGCCATAAGAGCCATACTCGACTATGGAGTTGGTGCTGGTGCCGTTAGAACCATAGCT
GGAACTATGGATCTCCACGTGGAGCTTGAAGAAAAATTGGCTAAGTTCAAGAAGAGAGAGGCAGCAATACTCTTCCAGAG
CGGTTACAACGCTAACCTTGGAGCTATAAGTGCCCTCCTAAGAAAGGGTGAGGACGGTGTATTCTTAAGTGAAGAGCTAA
ACCACGCAAGTATTATAGATGGAATGAGACTGAGTGGAGCTCCTAAGGTTATTTACAAACACTTGGATATGGAGGACCTT
AAGAAGAAGTTAGAGGAGAACAAGGACAAGAAGAAGAAAATCATTGTTACAGATGGAGTATTCTCAATGGACGGTGACCT
AGCTCCGCTTCCAGAGATAGTCGAGCTCGCTGAGCAGTACGATGCAATAGTTTACGTTGACGATGCCCACGGTGAGGGTG
TCCTGGGAAGCCACGGAAGGGGAATTGTAGACCACTTCAACCTACACGATAAAGTTGACTTTGAGATGGGTACACTAAGT
AAGGCCTTTGGTGTTATAGGAGGTTATGTAGCTGGTCCAGAGGAGGCAATTGAATACCTCAAGCAGAGGGCTAGGCCATT
CCTATTCTCAAGTGCTCCAAATCCACCCGACGTCGCTGCAGCAATAGCTGCAGTTGAGATACTCCAGAAGAGTGACGATT
TGGTTAAGAAGTTGTGGGACAACACCCACTTCCTCCAGAAGGGACTTAGGGACCTTGGCTATGATTTAGGAAACACAAAG
CACCCAATTACCCCAGTAATGTTATACGATGAGAAACTTGCCCAGGAATTCTCAAGGAGATTATTCGAGGAGTACAACAT
CTTTGCCCAGGCAATAGTTTATCCAACAGTCCCCCTGGGAACAGCTAGAATAAGGCTTGAGCCCTCAGCAGCCCACACTA
AGGAAGACCTCAAGTTAGTGATTGATGCATTCGAGGATCTTGGAAGGAAGACTGGCTTCCTGAAGTGA

Upstream 100 bases:

>100_bases
TCTCTCCCATTCCTTTACGCTCGAAAGCTTTAATAAATGCTTTTCGGTTTGGCCAAAAAGTTTTATACTTGTAAAATTTT
GTATTTACATGGTGGTTTCT

Downstream 100 bases:

>100_bases
GTTTAGTAGGTAACACGCTCTGATAAAAGTTGACTTATTTCCCCTTCTTTTTTGTTTTAACGGCTCGTTCGTCTTTGTTT
TTTAGTTTTGAGGGGTTATG

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MGKLDWIREELEELKKKGLYVTIRVLQSAQGPWVIVNGKKVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIA
GTMDLHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDGVFLSEELNHASIIDGMRLSGAPKVIYKHLDMEDL
KKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLS
KAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAPNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTK
HPITPVMLYDEKLAQEFSRRLFEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGRKTGFLK

Sequences:

>Translated_395_residues
MGKLDWIREELEELKKKGLYVTIRVLQSAQGPWVIVNGKKVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIA
GTMDLHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDGVFLSEELNHASIIDGMRLSGAPKVIYKHLDMEDL
KKKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLS
KAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAPNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTK
HPITPVMLYDEKLAQEFSRRLFEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGRKTGFLK
>Mature_394_residues
GKLDWIREELEELKKKGLYVTIRVLQSAQGPWVIVNGKKVLNMCSNNYLGLAAHPKIKEAAIRAILDYGVGAGAVRTIAG
TMDLHVELEEKLAKFKKREAAILFQSGYNANLGAISALLRKGEDGVFLSEELNHASIIDGMRLSGAPKVIYKHLDMEDLK
KKLEENKDKKKKIIVTDGVFSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLSK
AFGVIGGYVAGPEEAIEYLKQRARPFLFSSAPNPPDVAAAIAAVEILQKSDDLVKKLWDNTHFLQKGLRDLGYDLGNTKH
PITPVMLYDEKLAQEFSRRLFEEYNIFAQAIVYPTVPLGTARIRLEPSAAHTKEDLKLVIDAFEDLGRKTGFLK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=388, Percent_Identity=43.5567010309278, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI284448556, Length=414, Percent_Identity=40.8212560386473, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI4758668, Length=368, Percent_Identity=36.4130434782609, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI119220554, Length=420, Percent_Identity=34.2857142857143, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI83977440, Length=342, Percent_Identity=35.0877192982456, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI83977444, Length=342, Percent_Identity=35.0877192982456, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI83977442, Length=342, Percent_Identity=35.0877192982456, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4502025, Length=350, Percent_Identity=34.2857142857143, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI40316939, Length=350, Percent_Identity=34.2857142857143, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI5454084, Length=324, Percent_Identity=31.7901234567901, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1790046, Length=392, Percent_Identity=41.8367346938776, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1786993, Length=360, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=389, Percent_Identity=42.4164524421594, Blast_Score=308, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI32566772, Length=371, Percent_Identity=33.1536388140162, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17560914, Length=368, Percent_Identity=31.5217391304348, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17560912, Length=368, Percent_Identity=31.5217391304348, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71982617, Length=289, Percent_Identity=33.5640138408304, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71982625, Length=289, Percent_Identity=33.5640138408304, Blast_Score=158, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6320438, Length=370, Percent_Identity=34.8648648648649, Blast_Score=229, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=32.8804347826087, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323954, Length=285, Percent_Identity=30.5263157894737, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=42.9305912596401, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI17137420, Length=347, Percent_Identity=35.4466858789625, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17136286, Length=378, Percent_Identity=32.2751322751323, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24653280, Length=331, Percent_Identity=31.7220543806647, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24653276, Length=331, Percent_Identity=31.7220543806647, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24653278, Length=331, Percent_Identity=31.7220543806647, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43811; Mature: 43680

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLDWIREELEELKKKGLYVTIRVLQSAQGPWVIVNGKKVLNMCSNNYLGLAAHPKIKE
CCCHHHHHHHHHHHHHCCCEEEEEEHHCCCCCEEEECCHHHHHHHCCCCEEEECCCCHHH
AAIRAILDYGVGAGAVRTIAGTMDLHVELEEKLAKFKKREAAILFQSGYNANLGAISALL
HHHHHHHHHCCCCCHHHHHHHHHEEEEEHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHH
RKGEDGVFLSEELNHASIIDGMRLSGAPKVIYKHLDMEDLKKKLEENKDKKKKIIVTDGV
HCCCCCEEEHHCCCCHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCE
FSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLS
EECCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
KAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAPNPPDVAAAIAAVEILQKSDDLVKKLWD
HHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHC
NTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLFEEYNIFAQAIVYPTVPLG
CHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TARIRLEPSAAHTKEDLKLVIDAFEDLGRKTGFLK
CEEEEECCCHHCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GKLDWIREELEELKKKGLYVTIRVLQSAQGPWVIVNGKKVLNMCSNNYLGLAAHPKIKE
CCHHHHHHHHHHHHHCCCEEEEEEHHCCCCCEEEECCHHHHHHHCCCCEEEECCCCHHH
AAIRAILDYGVGAGAVRTIAGTMDLHVELEEKLAKFKKREAAILFQSGYNANLGAISALL
HHHHHHHHHCCCCCHHHHHHHHHEEEEEHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHH
RKGEDGVFLSEELNHASIIDGMRLSGAPKVIYKHLDMEDLKKKLEENKDKKKKIIVTDGV
HCCCCCEEEHHCCCCHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCE
FSMDGDLAPLPEIVELAEQYDAIVYVDDAHGEGVLGSHGRGIVDHFNLHDKVDFEMGTLS
EECCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
KAFGVIGGYVAGPEEAIEYLKQRARPFLFSSAPNPPDVAAAIAAVEILQKSDDLVKKLWD
HHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHC
NTHFLQKGLRDLGYDLGNTKHPITPVMLYDEKLAQEFSRRLFEEYNIFAQAIVYPTVPLG
CHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TARIRLEPSAAHTKEDLKLVIDAFEDLGRKTGFLK
CEEEEECCCHHCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA