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The map label for this gene is yggV [C]

Identifier: 18976621

GI number: 18976621

Start: 257646

End: 258203

Strand: Direct

Name: yggV [C]

Synonym: PF0249

Alternate gene names: 18976621

Gene position: 257646-258203 (Clockwise)

Preceding gene: 18976620

Following gene: 18976622

Centisome position: 13.5

GC content: 37.81

Gene sequence:

>558_bases
ATGGAACTATTTTTTATTACTTCAAATGATGGAAAAGTTAGGGAGGCAAAGAAATTCTTGGAACCCCTGGGAATTAATGT
TATAAAAAAGCCTCTTGAATATCCAGAGATTCAGGCCGATACGTTGGAGGACGTGGTAGTTTTTGGGCTAAACTGGTTGA
AAGATAAAGTGGACAAGCCCTTCATAATTGAGGACTCAGGCCTGTTCATAGAAGCACTAAATGGTTTTCCCGGTGTCTAT
TCTGCCTATGTTTACAAGACAATAGGACTGGATGGGATATTGAAGCTTATGGAAGGAATTGAAAATCGAAAAGCCTACTT
TAAGAGTGTGATTGGATTCTATGATGGAGAAATACACCTTTTTGTGGGGGAAGTTCGAGGTAGAATATCTAACGAAAAGA
GGGGCTTGCATGGATTTGGATATGACCCAATTTTCGTTCCCGATGGATTTGATAAAACATTTGCCGAAATGTCAACAGAA
GAAAAAAATTCTGTATCTCATAGGGGAAAGGCTTTAAAGGAATTCTATAGATGGATGAAAGAAAACCTTAAAAAATGA

Upstream 100 bases:

>100_bases
ATGGAAAGGCTGCCACTAAGATTGAAACTGAGGAACAGAAGAAAGAGAGGAGAGAGCTAGTAGAAAAGATAGGTTATAAG
ATTGATTGAGGGATTTTTCT

Downstream 100 bases:

>100_bases
ATATGTGTCAAACATAATCTTGGTGGTTAAAATGGCAGAGCTCTTAGACAGGACTGATAAAATGTTGCTCGAAGAGCTCA
AGAAAAATGCGAGAGAAAAC

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MELFFITSNDGKVREAKKFLEPLGINVIKKPLEYPEIQADTLEDVVVFGLNWLKDKVDKPFIIEDSGLFIEALNGFPGVY
SAYVYKTIGLDGILKLMEGIENRKAYFKSVIGFYDGEIHLFVGEVRGRISNEKRGLHGFGYDPIFVPDGFDKTFAEMSTE
EKNSVSHRGKALKEFYRWMKENLKK

Sequences:

>Translated_185_residues
MELFFITSNDGKVREAKKFLEPLGINVIKKPLEYPEIQADTLEDVVVFGLNWLKDKVDKPFIIEDSGLFIEALNGFPGVY
SAYVYKTIGLDGILKLMEGIENRKAYFKSVIGFYDGEIHLFVGEVRGRISNEKRGLHGFGYDPIFVPDGFDKTFAEMSTE
EKNSVSHRGKALKEFYRWMKENLKK
>Mature_185_residues
MELFFITSNDGKVREAKKFLEPLGINVIKKPLEYPEIQADTLEDVVVFGLNWLKDKVDKPFIIEDSGLFIEALNGFPGVY
SAYVYKTIGLDGILKLMEGIENRKAYFKSVIGFYDGEIHLFVGEVRGRISNEKRGLHGFGYDPIFVPDGFDKTFAEMSTE
EKNSVSHRGKALKEFYRWMKENLKK

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=182, Percent_Identity=31.3186813186813, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI31657144, Length=158, Percent_Identity=32.2784810126582, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1789324, Length=194, Percent_Identity=32.4742268041237, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17556833, Length=181, Percent_Identity=31.4917127071823, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322529, Length=195, Percent_Identity=36.9230769230769, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI19920712, Length=174, Percent_Identity=34.4827586206897, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_PYRFU (Q8U446)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_577978.1
- ProteinModelPortal:   Q8U446
- SMR:   Q8U446
- EnsemblBacteria:   EBPYRT00000004434
- GeneID:   1468083
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF0249
- NMPDR:   fig|186497.1.peg.254
- GeneTree:   EBGT00050000022850
- HOGENOM:   HBG697237
- OMA:   FAYDSIF
- ProtClustDB:   PRK14821
- BRENDA:   3.6.1.15
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 21218; Mature: 21218

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELFFITSNDGKVREAKKFLEPLGINVIKKPLEYPEIQADTLEDVVVFGLNWLKDKVDKP
CEEEEEECCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
FIIEDSGLFIEALNGFPGVYSAYVYKTIGLDGILKLMEGIENRKAYFKSVIGFYDGEIHL
EEEECCCCEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
FVGEVRGRISNEKRGLHGFGYDPIFVPDGFDKTFAEMSTEEKNSVSHRGKALKEFYRWMK
EEEHHHHHHCCCCCCCCCCCCCCEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ENLKK
HHHCC
>Mature Secondary Structure
MELFFITSNDGKVREAKKFLEPLGINVIKKPLEYPEIQADTLEDVVVFGLNWLKDKVDKP
CEEEEEECCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
FIIEDSGLFIEALNGFPGVYSAYVYKTIGLDGILKLMEGIENRKAYFKSVIGFYDGEIHL
EEEECCCCEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
FVGEVRGRISNEKRGLHGFGYDPIFVPDGFDKTFAEMSTEEKNSVSHRGKALKEFYRWMK
EEEHHHHHHCCCCCCCCCCCCCCEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ENLKK
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA