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The map label for this gene is purL

Identifier: 18976571

GI number: 18976571

Start: 210357

End: 212471

Strand: Direct

Name: purL

Synonym: PF0199

Alternate gene names: 18976571

Gene position: 210357-212471 (Clockwise)

Preceding gene: 18976570

Following gene: 18976576

Centisome position: 11.02

GC content: 43.45

Gene sequence:

>2115_bases
ATGTTTCCCCATGAGGAAAAGTTAATTCGTGAGAAGCTTGGAAGAGAGCCTAACGATCTCGAAAAAGCCATGCTCGAGGT
CATGTGGAGTGAGCATGTCTCCTATAAGTCGAGCAGAAAATGGTTGAAGCTGTTACCCACAAAAAATGAGCACGTCATTT
TGGGCCCGGGAGAAGATGCTGGAATAATTAAATTTGACGATAAAACTTGGATCGTAATTGGAATAGAGAGTCACAATCAC
CCTTCCGCAGTTGAACCTTACGGTGGTGCTGCTACTGGGGTTGGTGGAATAGTTAGGGATATTTTATGTATGGGGGCCAG
GCCAATAGCTCTTCTTGACCCGATAAGGTTTGGCCCCTTGGAGAAGGAGAAGAACAGATATCTCTTTGAATACGTGGTTA
AGGGAATAGCTGATTATGGAAATAGAATAGGTGTCCCCACTGTGGGGGGAGAAACTGAATTTGATGAAAGCTTAGATAAC
TACACTTTAGTTAACGTTGCTTGTATTGGAATAATGAGACCCGAGCATCTCGTTCATAGCTATGTAACTGAGCCTGGTTT
AAAGCTGGTTATAGTTGGGAATAGGACTGGTAGAGATGGTATTCACGGGGTCACATTTGCTAGCGAAGAGTTGGGTGAAA
ATGCTGAAGAGGAGGATAGGTCAGCCGTTCAGATTCCAGATCCATTCACTGAGAAACTCTTAATTGAAGCAACGCTTGAA
GCCGTTTACACTGGAAAGGTCAAAGCTCTTAAGGACTTAGGTGGGGGAGGATTGACCTGTGCCGCTTCAGAAATGGTTGG
CAAGAGAGGCTTTGGTGCAATAATATATGCTGACAAAGTGCCCCTTAGAGAACCCGGGATGACTCCTCTTGAGGTAATGA
TTTCTGAAAGCCAGGAGAGAATGCTCTTCGCCATTAAACCTGAGGACGTTGAAGAGTTGGGGAAGATATTTGAGAAGTAT
GAGCTAGAATGGAGTGTTGTCGGGGAGGTTATAGAGGAGCCTAAGTTTATAGTTTATTGGAAGGGGAGAAAAGTTGCAGA
GCTCCCAATAGAGCTTCTAACAAATGTACCGACTATTGAATGGCCGATGAAAGAATATAGAATCGAAGAAGACGTTGAAA
CTCCTCAAATCTCCCTAGAAGAAGCCTTCGAAAAAGTTTGGAGAAGTCCCAATGTAATATCAAAGAGATGGGTTTGGGAG
CAGTATGATCATGAAGTTCAAGGTAGAACTGTTATAAAGCCGGGGTTTGACTCGGCAGTTTTGAAGATAAACGAAGAGTA
CGGTCTAGCAATTACAGCTGATGGAAATCCGACTCACTGCTATCTAAATCCCTATCACGGTGCAATGGGAGTTGTAGTTG
AGGTAGTTAGGAATCTTGTTAGTGTAGGTGCAAAACCTTTAGCCCTTGTAGACAATCTAAATTTCGCTTCTCCAGAGAGA
CCTGAAGTTTATTGGAGCTTCGTCGAGACGATAAAAGGTCTAGCAGACGCAGCTAAAGCTTTTGGATTGGCATATGTTAG
TGGGAATGTCAGCTTTTACAACGAGGTCGTAAATAAACCTGTAAAGCCAACCCCTGTAGTTGCGGGTGTTGGAAAGGTAA
AGCTTGAAAAGATTCCGAGGGGGCCTAGAGAGGGAGATTTGATTGGTTTAATAGGGGAGACCAGAAAGGAATTAGGAGGC
TCAGAGCTATACAGAGTTTTGGGGGTATCTAAAGGAATTGCTCCTAGGGTGGACTTGGAGGTTGAGAAGAGAAATGCAGA
AAGTGTTCTTAAATTGATTGAAGAGGGTTTAGTGAGCTTTGTTCATGATGTTTCACGTGGTGGGGTAGCAGTTGCTTTGG
CAGAGCTTTCTACATGGTTTAATGTAGGAATAAAATCCGAGATAACAACATCTCTCCTTCCACTGGACTTTGCCTTCAGC
GAGAGCCATGGAAGGTATATAGTGACTTTTCCAGAAGAGAACCTTGAGGCTGTGAAGAAAATAGCTCCAATAACCCTCCT
GGGAAGAATTGGAGGAGAGAAGTTTGAATTGAAGATAAATGGTGAAAAAGTTAGTAAGACAGTAAAGTGGCTGTCCGATG
TGCACTGGAATGAGCTGTATAGGATTATGGATTGA

Upstream 100 bases:

>100_bases
TCGCCCTGAAGGAGGCTTTTAGATTTTAACATTTTTAAGTCAAAACAAATCTTAAAAATTTAAAATTTTTACATTTTTCT
GACAATAAGGAGGTGTCAAG

Downstream 100 bases:

>100_bases
GTCTCTCGTGCCATCTAAGAATCAAGAACAGAAAAATGAAGAATATTACAATGTAGTAGCTCAGTTCATAGGGGAGATAT
CCGAGGATTCCCAGGGTGTA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 704; Mature: 704

Protein sequence:

>704_residues
MFPHEEKLIREKLGREPNDLEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGIIKFDDKTWIVIGIESHNH
PSAVEPYGGAATGVGGIVRDILCMGARPIALLDPIRFGPLEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDN
YTLVNVACIGIMRPEHLVHSYVTEPGLKLVIVGNRTGRDGIHGVTFASEELGENAEEEDRSAVQIPDPFTEKLLIEATLE
AVYTGKVKALKDLGGGGLTCAASEMVGKRGFGAIIYADKVPLREPGMTPLEVMISESQERMLFAIKPEDVEELGKIFEKY
ELEWSVVGEVIEEPKFIVYWKGRKVAELPIELLTNVPTIEWPMKEYRIEEDVETPQISLEEAFEKVWRSPNVISKRWVWE
QYDHEVQGRTVIKPGFDSAVLKINEEYGLAITADGNPTHCYLNPYHGAMGVVVEVVRNLVSVGAKPLALVDNLNFASPER
PEVYWSFVETIKGLADAAKAFGLAYVSGNVSFYNEVVNKPVKPTPVVAGVGKVKLEKIPRGPREGDLIGLIGETRKELGG
SELYRVLGVSKGIAPRVDLEVEKRNAESVLKLIEEGLVSFVHDVSRGGVAVALAELSTWFNVGIKSEITTSLLPLDFAFS
ESHGRYIVTFPEENLEAVKKIAPITLLGRIGGEKFELKINGEKVSKTVKWLSDVHWNELYRIMD

Sequences:

>Translated_704_residues
MFPHEEKLIREKLGREPNDLEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGIIKFDDKTWIVIGIESHNH
PSAVEPYGGAATGVGGIVRDILCMGARPIALLDPIRFGPLEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDN
YTLVNVACIGIMRPEHLVHSYVTEPGLKLVIVGNRTGRDGIHGVTFASEELGENAEEEDRSAVQIPDPFTEKLLIEATLE
AVYTGKVKALKDLGGGGLTCAASEMVGKRGFGAIIYADKVPLREPGMTPLEVMISESQERMLFAIKPEDVEELGKIFEKY
ELEWSVVGEVIEEPKFIVYWKGRKVAELPIELLTNVPTIEWPMKEYRIEEDVETPQISLEEAFEKVWRSPNVISKRWVWE
QYDHEVQGRTVIKPGFDSAVLKINEEYGLAITADGNPTHCYLNPYHGAMGVVVEVVRNLVSVGAKPLALVDNLNFASPER
PEVYWSFVETIKGLADAAKAFGLAYVSGNVSFYNEVVNKPVKPTPVVAGVGKVKLEKIPRGPREGDLIGLIGETRKELGG
SELYRVLGVSKGIAPRVDLEVEKRNAESVLKLIEEGLVSFVHDVSRGGVAVALAELSTWFNVGIKSEITTSLLPLDFAFS
ESHGRYIVTFPEENLEAVKKIAPITLLGRIGGEKFELKINGEKVSKTVKWLSDVHWNELYRIMD
>Mature_704_residues
MFPHEEKLIREKLGREPNDLEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDAGIIKFDDKTWIVIGIESHNH
PSAVEPYGGAATGVGGIVRDILCMGARPIALLDPIRFGPLEKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDN
YTLVNVACIGIMRPEHLVHSYVTEPGLKLVIVGNRTGRDGIHGVTFASEELGENAEEEDRSAVQIPDPFTEKLLIEATLE
AVYTGKVKALKDLGGGGLTCAASEMVGKRGFGAIIYADKVPLREPGMTPLEVMISESQERMLFAIKPEDVEELGKIFEKY
ELEWSVVGEVIEEPKFIVYWKGRKVAELPIELLTNVPTIEWPMKEYRIEEDVETPQISLEEAFEKVWRSPNVISKRWVWE
QYDHEVQGRTVIKPGFDSAVLKINEEYGLAITADGNPTHCYLNPYHGAMGVVVEVVRNLVSVGAKPLALVDNLNFASPER
PEVYWSFVETIKGLADAAKAFGLAYVSGNVSFYNEVVNKPVKPTPVVAGVGKVKLEKIPRGPREGDLIGLIGETRKELGG
SELYRVLGVSKGIAPRVDLEVEKRNAESVLKLIEEGLVSFVHDVSRGGVAVALAELSTWFNVGIKSEITTSLLPLDFAFS
ESHGRYIVTFPEENLEAVKKIAPITLLGRIGGEKFELKINGEKVSKTVKWLSDVHWNELYRIMD

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=644, Percent_Identity=25.9316770186335, Blast_Score=128, Evalue=2e-29,
Organism=Escherichia coli, GI48994899, Length=808, Percent_Identity=23.6386138613861, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17553022, Length=682, Percent_Identity=24.633431085044, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321498, Length=790, Percent_Identity=24.3037974683544, Blast_Score=127, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_PYRFU (Q8U491)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_577928.1
- ProteinModelPortal:   Q8U491
- SMR:   Q8U491
- EnsemblBacteria:   EBPYRT00000005246
- GeneID:   1468031
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF0199
- NMPDR:   fig|186497.1.peg.202
- GeneTree:   EBGT00050000022555
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 78230; Mature: 78230

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPHEEKLIREKLGREPNDLEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDA
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHCCCHHEECCCCCCEEEECCCCCC
GIIKFDDKTWIVIGIESHNHPSAVEPYGGAATGVGGIVRDILCMGARPIALLDPIRFGPL
CEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
EKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVACIGIMRPEHLVHS
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEEEEEEEECCCHHHHHHH
YVTEPGLKLVIVGNRTGRDGIHGVTFASEELGENAEEEDRSAVQIPDPFTEKLLIEATLE
HHCCCCCEEEEEECCCCCCCCCEEEECHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHH
AVYTGKVKALKDLGGGGLTCAASEMVGKRGFGAIIYADKVPLREPGMTPLEVMISESQER
HHHCCCHHHHHHCCCCCEEEEHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCC
MLFAIKPEDVEELGKIFEKYELEWSVVGEVIEEPKFIVYWKGRKVAELPIELLTNVPTIE
EEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCEEECCHHHHHCCCCCCC
WPMKEYRIEEDVETPQISLEEAFEKVWRSPNVISKRWVWEQYDHEVQGRTVIKPGFDSAV
CCHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCEE
LKINEEYGLAITADGNPTHCYLNPYHGAMGVVVEVVRNLVSVGAKPLALVDNLNFASPER
EEEECCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
PEVYWSFVETIKGLADAAKAFGLAYVSGNVSFYNEVVNKPVKPTPVVAGVGKVKLEKIPR
CHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCCCCCCEEECCCCEEHHHCCC
GPREGDLIGLIGETRKELGGSELYRVLGVSKGIAPRVDLEVEKRNAESVLKLIEEGLVSF
CCCCCCEEEECCHHHHHCCHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
VHDVSRGGVAVALAELSTWFNVGIKSEITTSLLPLDFAFSESHGRYIVTFPEENLEAVKK
HHHHCCCCCEEEHHHHHHHHCCCCCHHHHHHHEEEEEEEECCCCCEEEECCCHHHHHHHH
IAPITLLGRIGGEKFELKINGEKVSKTVKWLSDVHWNELYRIMD
HCCEEEEECCCCCEEEEEECHHHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MFPHEEKLIREKLGREPNDLEKAMLEVMWSEHVSYKSSRKWLKLLPTKNEHVILGPGEDA
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHCCCHHEECCCCCCEEEECCCCCC
GIIKFDDKTWIVIGIESHNHPSAVEPYGGAATGVGGIVRDILCMGARPIALLDPIRFGPL
CEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
EKEKNRYLFEYVVKGIADYGNRIGVPTVGGETEFDESLDNYTLVNVACIGIMRPEHLVHS
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEEEEEEEECCCHHHHHHH
YVTEPGLKLVIVGNRTGRDGIHGVTFASEELGENAEEEDRSAVQIPDPFTEKLLIEATLE
HHCCCCCEEEEEECCCCCCCCCEEEECHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHH
AVYTGKVKALKDLGGGGLTCAASEMVGKRGFGAIIYADKVPLREPGMTPLEVMISESQER
HHHCCCHHHHHHCCCCCEEEEHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCC
MLFAIKPEDVEELGKIFEKYELEWSVVGEVIEEPKFIVYWKGRKVAELPIELLTNVPTIE
EEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCEEECCHHHHHCCCCCCC
WPMKEYRIEEDVETPQISLEEAFEKVWRSPNVISKRWVWEQYDHEVQGRTVIKPGFDSAV
CCHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCEE
LKINEEYGLAITADGNPTHCYLNPYHGAMGVVVEVVRNLVSVGAKPLALVDNLNFASPER
EEEECCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
PEVYWSFVETIKGLADAAKAFGLAYVSGNVSFYNEVVNKPVKPTPVVAGVGKVKLEKIPR
CHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCCCCCCEEECCCCEEHHHCCC
GPREGDLIGLIGETRKELGGSELYRVLGVSKGIAPRVDLEVEKRNAESVLKLIEEGLVSF
CCCCCCEEEECCHHHHHCCHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
VHDVSRGGVAVALAELSTWFNVGIKSEITTSLLPLDFAFSESHGRYIVTFPEENLEAVKK
HHHHCCCCCEEEHHHHHHHHCCCCCHHHHHHHEEEEEEEECCCCCEEEECCCHHHHHHHH
IAPITLLGRIGGEKFELKINGEKVSKTVKWLSDVHWNELYRIMD
HCCEEEEECCCCCEEEEEECHHHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA