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The map label for this gene is msrA [H]

Identifier: 18311570

GI number: 18311570

Start: 2964045

End: 2964518

Strand: Direct

Name: msrA [H]

Synonym: CPE2588

Alternate gene names: 18311570

Gene position: 2964045-2964518 (Clockwise)

Preceding gene: 18311569

Following gene: 18311579

Centisome position: 97.78

GC content: 28.27

Gene sequence:

>474_bases
ATGAAAAAAATTATATTAGCAGGTGGTTGTTTTTGGGGTGTAGAAGAATTTCTTTCTAGAATCAATGGTGTAGTAAGCAC
TGAAGTTGGATATGCTAATGGACGTACTGAAAATCCTACTTATGAAGATATATGCACTAAAAATACTTACTTTGCTGAAG
TTTGTCTTGTAAATTATGATGAAAACATAATATCACTTAAAGAATTATTAGCTAAGTTTTGGACAATAATAGATCCAACC
TCATTAAATAAACAAGGTAATGATGTTGGTAGCCAATATAGAACTGGCATTTACTATGTAGATTCTTCAGATTTAGAAGA
TATTTTAAATAGTAAAGAAGAACTTCAAAAATCTTATTCAAAAAAAATAGTGACAGAGGTTAAGCCCTTAGAAAACTATT
ATAAAGCTGAAGAATATCATCAAAAATATCTTAAAAAGAATCCTAATGGGTACTGTCACATAAAGTTAGATTAA

Upstream 100 bases:

>100_bases
GTAGGTGGAAATCCAGCAAAAATTATTAAAAAAAGTTTGTGCTAAATAATCATAATTATTTTATAAATAGGAAAGCTAAA
ACTTATAAGGAGGGTTCGTT

Downstream 100 bases:

>100_bases
ACTAAGTAACTTCAACTAAGTACTTTTTGAAATTAGAAATTAAATCTTTAGACTCATTTGAAATTTTAGCAACATGATTA
ACAATATTGTCTATATGACA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKKIILAGGCFWGVEEFLSRINGVVSTEVGYANGRTENPTYEDICTKNTYFAEVCLVNYDENIISLKELLAKFWTIIDPT
SLNKQGNDVGSQYRTGIYYVDSSDLEDILNSKEELQKSYSKKIVTEVKPLENYYKAEEYHQKYLKKNPNGYCHIKLD

Sequences:

>Translated_157_residues
MKKIILAGGCFWGVEEFLSRINGVVSTEVGYANGRTENPTYEDICTKNTYFAEVCLVNYDENIISLKELLAKFWTIIDPT
SLNKQGNDVGSQYRTGIYYVDSSDLEDILNSKEELQKSYSKKIVTEVKPLENYYKAEEYHQKYLKKNPNGYCHIKLD
>Mature_157_residues
MKKIILAGGCFWGVEEFLSRINGVVSTEVGYANGRTENPTYEDICTKNTYFAEVCLVNYDENIISLKELLAKFWTIIDPT
SLNKQGNDVGSQYRTGIYYVDSSDLEDILNSKEELQKSYSKKIVTEVKPLENYYKAEEYHQKYLKKNPNGYCHIKLD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=45.4545454545455, Blast_Score=144, Evalue=2e-35,
Organism=Homo sapiens, GI208609995, Length=152, Percent_Identity=46.0526315789474, Blast_Score=144, Evalue=4e-35,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=46.2962962962963, Blast_Score=98, Evalue=4e-21,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=40.5228758169935, Blast_Score=124, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=134, Percent_Identity=34.3283582089552, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=44.3037974683544, Blast_Score=137, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=36.8794326241135, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=36.8794326241135, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=36.1702127659575, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18093; Mature: 18093

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIILAGGCFWGVEEFLSRINGVVSTEVGYANGRTENPTYEDICTKNTYFAEVCLVNYD
CCEEEEECCHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCHHHHHCCCCEEEEEEEEECC
ENIISLKELLAKFWTIIDPTSLNKQGNDVGSQYRTGIYYVDSSDLEDILNSKEELQKSYS
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHCCHHHHHHHHH
KKIVTEVKPLENYYKAEEYHQKYLKKNPNGYCHIKLD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKKIILAGGCFWGVEEFLSRINGVVSTEVGYANGRTENPTYEDICTKNTYFAEVCLVNYD
CCEEEEECCHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCHHHHHCCCCEEEEEEEEECC
ENIISLKELLAKFWTIIDPTSLNKQGNDVGSQYRTGIYYVDSSDLEDILNSKEELQKSYS
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHCCHHHHHHHHH
KKIVTEVKPLENYYKAEEYHQKYLKKNPNGYCHIKLD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA