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The map label for this gene is hprT [H]

Identifier: 18311453

GI number: 18311453

Start: 2828873

End: 2829424

Strand: Reverse

Name: hprT [H]

Synonym: CPE2471

Alternate gene names: 18311453

Gene position: 2829424-2828873 (Counterclockwise)

Preceding gene: 18311454

Following gene: 18311452

Centisome position: 93.34

GC content: 28.08

Gene sequence:

>552_bases
ATGATAAGAGACATAAAAGATGATGTTAAAAAAGTTTTATATTCAGAAGAACAATTAGCTAAACGTGTAAAAGAGATGGC
TGAAGAAATTAGTAAAGATTATGCTGGAAAAGATTTATTAGTTGTTGGTATATTAAAAGGTTCAGTATTATTTACTTCAG
ACCTTATTAAAAATATAAGCATACCATGTGAAATAGATTTTATGGCTGTTTCAAGTTATGGCAACTCAGCTCAAACTTCA
GGAGTTGTTAGAATATTAAAAGACTTAGATAGTGATATAGAAAATAAGCATGTTCTTATAGTTGAAGATATAGTTGATAC
AGGAACAACTTTAAGCTATCTTTTAGAATATTTAAAAGCTAGAAAGGCAGCAAGTATAGAAATAGTTGCTCTATTAGATA
AAGAAGCTAGAAGAACTTCAAATGTTTCAGCAAAATACAAAGGATTTGATGTACCAGATGAATTCATAGTTGGATATGGA
ATAGACTATGCTGAAAAATATAGAAACTTACCATTCATCGGTGCTTTAAAAGAAGAAATTTATAATAAGTAA

Upstream 100 bases:

>100_bases
TAGCATGGATTGTAGGATCTAATGTTAGTGAAACATTTAAAGTTACAAATAAAACTAAAAAGGTAATTAAAATTACTTTT
AAAGGAAAGGAAAATTAATT

Downstream 100 bases:

>100_bases
TTCAAAATATTGTAAAATGTTATTTCTTATGTTAAAATTCATTAAAAATGATGGTCAGAGAGGGGGGCATAGAGATGAAA
AAATTACAAAGTATGATTAC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MIRDIKDDVKKVLYSEEQLAKRVKEMAEEISKDYAGKDLLVVGILKGSVLFTSDLIKNISIPCEIDFMAVSSYGNSAQTS
GVVRILKDLDSDIENKHVLIVEDIVDTGTTLSYLLEYLKARKAASIEIVALLDKEARRTSNVSAKYKGFDVPDEFIVGYG
IDYAEKYRNLPFIGALKEEIYNK

Sequences:

>Translated_183_residues
MIRDIKDDVKKVLYSEEQLAKRVKEMAEEISKDYAGKDLLVVGILKGSVLFTSDLIKNISIPCEIDFMAVSSYGNSAQTS
GVVRILKDLDSDIENKHVLIVEDIVDTGTTLSYLLEYLKARKAASIEIVALLDKEARRTSNVSAKYKGFDVPDEFIVGYG
IDYAEKYRNLPFIGALKEEIYNK
>Mature_183_residues
MIRDIKDDVKKVLYSEEQLAKRVKEMAEEISKDYAGKDLLVVGILKGSVLFTSDLIKNISIPCEIDFMAVSSYGNSAQTS
GVVRILKDLDSDIENKHVLIVEDIVDTGTTLSYLLEYLKARKAASIEIVALLDKEARRTSNVSAKYKGFDVPDEFIVGYG
IDYAEKYRNLPFIGALKEEIYNK

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=181, Percent_Identity=31.4917127071823, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI9910262, Length=182, Percent_Identity=35.1648351648352, Blast_Score=104, Evalue=4e-23,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=48.1927710843374, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17510817, Length=178, Percent_Identity=33.7078651685393, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20539; Mature: 20539

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRDIKDDVKKVLYSEEQLAKRVKEMAEEISKDYAGKDLLVVGILKGSVLFTSDLIKNIS
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHCC
IPCEIDFMAVSSYGNSAQTSGVVRILKDLDSDIENKHVLIVEDIVDTGTTLSYLLEYLKA
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCHHHHHHHHHHH
RKAASIEIVALLDKEARRTSNVSAKYKGFDVPDEFIVGYGIDYAEKYRNLPFIGALKEEI
HCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCHHHHEECCCCHHHHHCCCCCHHHHHHHH
YNK
CCC
>Mature Secondary Structure
MIRDIKDDVKKVLYSEEQLAKRVKEMAEEISKDYAGKDLLVVGILKGSVLFTSDLIKNIS
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHCC
IPCEIDFMAVSSYGNSAQTSGVVRILKDLDSDIENKHVLIVEDIVDTGTTLSYLLEYLKA
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCHHHHHHHHHHH
RKAASIEIVALLDKEARRTSNVSAKYKGFDVPDEFIVGYGIDYAEKYRNLPFIGALKEEI
HCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCHHHHEECCCCHHHHHCCCCCHHHHHHHH
YNK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]