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The map label for this gene is fhs [H]

Identifier: 18311451

GI number: 18311451

Start: 2825121

End: 2826791

Strand: Reverse

Name: fhs [H]

Synonym: CPE2469

Alternate gene names: 18311451

Gene position: 2826791-2825121 (Counterclockwise)

Preceding gene: 18311452

Following gene: 18311450

Centisome position: 93.25

GC content: 31.36

Gene sequence:

>1671_bases
ATGAAAAATGATATTGAAATAGCACAAAGTGCTAAAATGGAGCCAATAATAAATATTGCTAAAAAAATAGGTCTTGGAGA
AGATGATATTGAGCTTTATGGAAAATATAAATGTAAGATATCTTTAGATGCAATAAAAAAACTAGAAAATAATAAGGATG
GTAAGCTTGTTTTAGTTACAGCTATAAATCCAACACCGGCAGGAGAGGGAAAATCTACTGTTACAGTAGGATTAGGACAA
GCGTTAAATAAAATAGGAAAAAATACTGTTATAGCCTTAAGAGAGCCATCATTAGGACCTGTATTTGGAATAAAAGGTGG
AGCAGCTGGTGGTGGATATGCTCAAGTAGTTCCTATGGAAGATATAAATCTTCATTTTACAGGGGATATGCATGCAATAA
CTTCAGCTAATAATCTTTTATGTGCAGCTATAGATAACCATATTCATCAAGGTAATTTATTAAGAATAGATTCAAGAAGA
ATTGTATTTAAAAGAGTTATGGATATGAATGATAGAGCCTTAAGAAATATAGTTGTTGGAATGGGTGGTAAAATAAACGG
ATTCTTAAGAGAAGATGGATTTATGATCACTGTTGCATCAGAAATAATGGCTATATTATGTATGGCTAGTGATTTAGAAG
ACTTAAAAGAGAGAATGGGAAATATTTTAATTGCATATAACTTAGATGGAGAGCCTGTTTATGCTAAGGAATTAGAAGTT
CAAGGAGCTATGGCTTTACTTATGAAAGATGCCATAAAACCTAACCTTGTTCAAACTTTAGAAAATACTCCAGCAATAAT
TCATGGAGGCCCATTTGCCAATATAGCTCATGGATGTAATTCAATAATAGCAACTAAGACAGCTTTAAAAATGAGTGATA
TAACTATAACAGAAGCTGGTTTTGGAGCAGATTTAGGTGCAGAAAAATTCTTAGATATAAAATGTAGATACGGAAATTTA
AATCCTGATTGTGTAGTTTTAGTAGCTACTATAAGAGCTTTAAAACATCACGGTGGAGTAAAGAAAGATGAATTAAATAT
ATCAAATGTAGATGCTTTAAATAAAGGAATGAAAAACTTAGAAAAGCAAATAGAAAATATAAAAGCTTATGGAGTACCAG
TTGTTGTTGCTATAAATAAGTTTATAACTGATTCAGATGAAGAGGTTAAAGCTATAGAAGACTTCTGCAAAAATATAGGA
GTAGAAGTTAGCTTAACAGAAGTATGGGAAAAAGGTGGAGAAGGCGGAATTGATTTAGCTAATAAAGTTATAAAAACAAT
GGAAACCGAGCCTTCAAACTTTAAGATGATTTACGATTCAGAAGAATCAATAAAGGATAAAATACTAAAAATAGTTCAAA
CTATATATGGCGGAAAAGGAGTAAACTATACTCCTCAAGCTCTTAAACAAATAGCTGAAATTGAGAAATTTAATTTAGAT
AAGCTTCCAATATGTATGGCTAAAACACAGTATTCATTATCAGATAATCCAAGTCTTTTAGGAAGACCTGAAAACTTTGA
TATAACTGTTAAAGAGGTTAGAGTTTCAAATGGAGCTGGATTCATAGTTGTTTTAACAGGGGATGTTATGACAATGCCAG
GGTTACCTAAAGTTCCTGCTGCTAATAGAATGGATATAAAAGACAATGGAGAAATCGTAGGATTATTCTAA

Upstream 100 bases:

>100_bases
TTTTTATAAAATATATAAAAATGTTCGATAAAACTCTTTGTTTTTTAATAAATTATGGGTATAATATTAAGTAGATTACT
TTGGAATGAGGTGCGGAATT

Downstream 100 bases:

>100_bases
ATGTTTAGATAATTTTGAGGCTTATATGACGCTGTTAAAAAAATAGTCATATAAGCCTTTTTTTATTTAAAAACTAGTAA
TTGTAATTGCTTGACAAATG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MKNDIEIAQSAKMEPIINIAKKIGLGEDDIELYGKYKCKISLDAIKKLENNKDGKLVLVTAINPTPAGEGKSTVTVGLGQ
ALNKIGKNTVIALREPSLGPVFGIKGGAAGGGYAQVVPMEDINLHFTGDMHAITSANNLLCAAIDNHIHQGNLLRIDSRR
IVFKRVMDMNDRALRNIVVGMGGKINGFLREDGFMITVASEIMAILCMASDLEDLKERMGNILIAYNLDGEPVYAKELEV
QGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSIIATKTALKMSDITITEAGFGADLGAEKFLDIKCRYGNL
NPDCVVLVATIRALKHHGGVKKDELNISNVDALNKGMKNLEKQIENIKAYGVPVVVAINKFITDSDEEVKAIEDFCKNIG
VEVSLTEVWEKGGEGGIDLANKVIKTMETEPSNFKMIYDSEESIKDKILKIVQTIYGGKGVNYTPQALKQIAEIEKFNLD
KLPICMAKTQYSLSDNPSLLGRPENFDITVKEVRVSNGAGFIVVLTGDVMTMPGLPKVPAANRMDIKDNGEIVGLF

Sequences:

>Translated_556_residues
MKNDIEIAQSAKMEPIINIAKKIGLGEDDIELYGKYKCKISLDAIKKLENNKDGKLVLVTAINPTPAGEGKSTVTVGLGQ
ALNKIGKNTVIALREPSLGPVFGIKGGAAGGGYAQVVPMEDINLHFTGDMHAITSANNLLCAAIDNHIHQGNLLRIDSRR
IVFKRVMDMNDRALRNIVVGMGGKINGFLREDGFMITVASEIMAILCMASDLEDLKERMGNILIAYNLDGEPVYAKELEV
QGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSIIATKTALKMSDITITEAGFGADLGAEKFLDIKCRYGNL
NPDCVVLVATIRALKHHGGVKKDELNISNVDALNKGMKNLEKQIENIKAYGVPVVVAINKFITDSDEEVKAIEDFCKNIG
VEVSLTEVWEKGGEGGIDLANKVIKTMETEPSNFKMIYDSEESIKDKILKIVQTIYGGKGVNYTPQALKQIAEIEKFNLD
KLPICMAKTQYSLSDNPSLLGRPENFDITVKEVRVSNGAGFIVVLTGDVMTMPGLPKVPAANRMDIKDNGEIVGLF
>Mature_556_residues
MKNDIEIAQSAKMEPIINIAKKIGLGEDDIELYGKYKCKISLDAIKKLENNKDGKLVLVTAINPTPAGEGKSTVTVGLGQ
ALNKIGKNTVIALREPSLGPVFGIKGGAAGGGYAQVVPMEDINLHFTGDMHAITSANNLLCAAIDNHIHQGNLLRIDSRR
IVFKRVMDMNDRALRNIVVGMGGKINGFLREDGFMITVASEIMAILCMASDLEDLKERMGNILIAYNLDGEPVYAKELEV
QGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSIIATKTALKMSDITITEAGFGADLGAEKFLDIKCRYGNL
NPDCVVLVATIRALKHHGGVKKDELNISNVDALNKGMKNLEKQIENIKAYGVPVVVAINKFITDSDEEVKAIEDFCKNIG
VEVSLTEVWEKGGEGGIDLANKVIKTMETEPSNFKMIYDSEESIKDKILKIVQTIYGGKGVNYTPQALKQIAEIEKFNLD
KLPICMAKTQYSLSDNPSLLGRPENFDITVKEVRVSNGAGFIVVLTGDVMTMPGLPKVPAANRMDIKDNGEIVGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=623, Percent_Identity=43.9807383627608, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=44.4264943457189, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI310124614, Length=84, Percent_Identity=44.047619047619, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568737, Length=623, Percent_Identity=42.215088282504, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17568739, Length=623, Percent_Identity=42.215088282504, Blast_Score=449, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=43.2646592709984, Blast_Score=476, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=42.1725239616613, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=41.7741935483871, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=41.7741935483871, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=41.7741935483871, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=41.7741935483871, Blast_Score=449, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60254; Mature: 60254

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00721 FTHFS_1 ; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNDIEIAQSAKMEPIINIAKKIGLGEDDIELYGKYKCKISLDAIKKLENNKDGKLVLVT
CCCCHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEEEEEEEHHHHHHHCCCCCCCEEEEE
AINPTPAGEGKSTVTVGLGQALNKIGKNTVIALREPSLGPVFGIKGGAAGGGYAQVVPME
EECCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCCCEEEEEEEC
DINLHFTGDMHAITSANNLLCAAIDNHIHQGNLLRIDSRRIVFKRVMDMNDRALRNIVVG
CCEEEECCCEEEECCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHCCCHHHHHHHHCC
MGGKINGFLREDGFMITVASEIMAILCMASDLEDLKERMGNILIAYNLDGEPVYAKELEV
CCCCCCEEEECCCEEEEEHHHHHHHHHHHCCHHHHHHHHCCEEEEEECCCCCEEHHHHHH
QGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSIIATKTALKMSDITITEAG
HHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHEEEECEEEEECC
FGADLGAEKFLDIKCRYGNLNPDCVVLVATIRALKHHGGVKKDELNISNVDALNKGMKNL
CCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
EKQIENIKAYGVPVVVAINKFITDSDEEVKAIEDFCKNIGVEVSLTEVWEKGGEGGIDLA
HHHHHHHHHCCCEEEEEEHHHHCCCCHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCHHHH
NKVIKTMETEPSNFKMIYDSEESIKDKILKIVQTIYGGKGVNYTPQALKQIAEIEKFNLD
HHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
KLPICMAKTQYSLSDNPSLLGRPENFDITVKEVRVSNGAGFIVVLTGDVMTMPGLPKVPA
CCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCEEECCCCCCCCC
ANRMDIKDNGEIVGLF
CCCCEECCCCCEEEEC
>Mature Secondary Structure
MKNDIEIAQSAKMEPIINIAKKIGLGEDDIELYGKYKCKISLDAIKKLENNKDGKLVLVT
CCCCHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEEEEEEEHHHHHHHCCCCCCCEEEEE
AINPTPAGEGKSTVTVGLGQALNKIGKNTVIALREPSLGPVFGIKGGAAGGGYAQVVPME
EECCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCCCEEEEEEEC
DINLHFTGDMHAITSANNLLCAAIDNHIHQGNLLRIDSRRIVFKRVMDMNDRALRNIVVG
CCEEEECCCEEEECCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHCCCHHHHHHHHCC
MGGKINGFLREDGFMITVASEIMAILCMASDLEDLKERMGNILIAYNLDGEPVYAKELEV
CCCCCCEEEECCCEEEEEHHHHHHHHHHHCCHHHHHHHHCCEEEEEECCCCCEEHHHHHH
QGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSIIATKTALKMSDITITEAG
HHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHEEEECEEEEECC
FGADLGAEKFLDIKCRYGNLNPDCVVLVATIRALKHHGGVKKDELNISNVDALNKGMKNL
CCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
EKQIENIKAYGVPVVVAINKFITDSDEEVKAIEDFCKNIGVEVSLTEVWEKGGEGGIDLA
HHHHHHHHHCCCEEEEEEHHHHCCCCHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCHHHH
NKVIKTMETEPSNFKMIYDSEESIKDKILKIVQTIYGGKGVNYTPQALKQIAEIEKFNLD
HHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
KLPICMAKTQYSLSDNPSLLGRPENFDITVKEVRVSNGAGFIVVLTGDVMTMPGLPKVPA
CCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCEEECCCCCCCCC
ANRMDIKDNGEIVGLF
CCCCEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA