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The map label for this gene is ndk

Identifier: 18310954

GI number: 18310954

Start: 2260966

End: 2261397

Strand: Reverse

Name: ndk

Synonym: CPE1972

Alternate gene names: 18310954

Gene position: 2261397-2260966 (Counterclockwise)

Preceding gene: 18310956

Following gene: 18310948

Centisome position: 74.6

GC content: 30.09

Gene sequence:

>432_bases
ATGAGGTTAGAAAAAAGTCTTGTTTTAATAAAACCTGATGCCGTTGAAAGAAATTTAATAGGTAAGATATTAGAAGTTTA
TGAGGGAGCAGGATTAAAGATAAAGGCTATGGAAATGAAGCAAATAAATAAGGAATTTGCTGAAAAACATTATGAAGAAC
ATAGAGATAAGCAATTTTTTAATTCTCTAATAAAATATATAACAAGAAGTCCTCTTGTAGCTTTAATTCTTGAAGGAGAA
GATGCTATAAATAAAATAAGATCTCTAAATGGGGCAACAAATCCAGAAAAGGCTGAGTTTGGAACAATAAGAAGAAGATT
TGCCTTAAGTGGAACAGAAAACTCAGTTCATGCATCAGATTCAATAGAAAGTGCTGAGAAAGAAATTAAGCTATGGTTCC
CAAAAGTATTTTATGAAGAAATTTGTGGATAA

Upstream 100 bases:

>100_bases
ACAATTAAATATTTAGTAATTTTCTTGTGAATGTTTACATAAATAGGAAATTATATGTATAATATATCTTAGAGGGAAAT
AATATTGAGGAGGAATTTCA

Downstream 100 bases:

>100_bases
TATAAAATGCATGTGCTTTTGCACATGCATTTTTTTAATAAACACACTTGATTTCTAACCAAGCTTCATCATATTTTCTA
AGTATTTTAGAAGGTAAATC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MRLEKSLVLIKPDAVERNLIGKILEVYEGAGLKIKAMEMKQINKEFAEKHYEEHRDKQFFNSLIKYITRSPLVALILEGE
DAINKIRSLNGATNPEKAEFGTIRRRFALSGTENSVHASDSIESAEKEIKLWFPKVFYEEICG

Sequences:

>Translated_143_residues
MRLEKSLVLIKPDAVERNLIGKILEVYEGAGLKIKAMEMKQINKEFAEKHYEEHRDKQFFNSLIKYITRSPLVALILEGE
DAINKIRSLNGATNPEKAEFGTIRRRFALSGTENSVHASDSIESAEKEIKLWFPKVFYEEICG
>Mature_143_residues
MRLEKSLVLIKPDAVERNLIGKILEVYEGAGLKIKAMEMKQINKEFAEKHYEEHRDKQFFNSLIKYITRSPLVALILEGE
DAINKIRSLNGATNPEKAEFGTIRRRFALSGTENSVHASDSIESAEKEIKLWFPKVFYEEICG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=130, Percent_Identity=41.5384615384615, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=40.4580152671756, Blast_Score=119, Evalue=7e-28,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=40.4580152671756, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=40.4580152671756, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=40.4580152671756, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=40.4580152671756, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI38045913, Length=130, Percent_Identity=39.2307692307692, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI4557797, Length=131, Percent_Identity=38.9312977099237, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=38.4615384615385, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=36.0294117647059, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=36.0294117647059, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI5031951, Length=149, Percent_Identity=36.241610738255, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI4505413, Length=142, Percent_Identity=30.2816901408451, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1788866, Length=142, Percent_Identity=43.6619718309859, Blast_Score=126, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17506807, Length=130, Percent_Identity=41.5384615384615, Blast_Score=118, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71995094, Length=131, Percent_Identity=30.5343511450382, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322783, Length=134, Percent_Identity=38.0597014925373, Blast_Score=117, Evalue=9e-28,
Organism=Drosophila melanogaster, GI45549037, Length=130, Percent_Identity=41.5384615384615, Blast_Score=122, Evalue=8e-29,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=34.0740740740741, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CLOP1 (Q0TNY9)

Other databases:

- EMBL:   CP000246
- RefSeq:   YP_696651.1
- ProteinModelPortal:   Q0TNY9
- SMR:   Q0TNY9
- STRING:   Q0TNY9
- GeneID:   4203247
- GenomeReviews:   CP000246_GR
- KEGG:   cpf:CPF_2227
- TIGR:   CPF_2227
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   CLSK899410
- BioCyc:   CPER195103:CPF_2227-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16401; Mature: 16401

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEKSLVLIKPDAVERNLIGKILEVYEGAGLKIKAMEMKQINKEFAEKHYEEHRDKQFF
CCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
NSLIKYITRSPLVALILEGEDAINKIRSLNGATNPEKAEFGTIRRRFALSGTENSVHASD
HHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCH
SIESAEKEIKLWFPKVFYEEICG
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLEKSLVLIKPDAVERNLIGKILEVYEGAGLKIKAMEMKQINKEFAEKHYEEHRDKQFF
CCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
NSLIKYITRSPLVALILEGEDAINKIRSLNGATNPEKAEFGTIRRRFALSGTENSVHASD
HHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCH
SIESAEKEIKLWFPKVFYEEICG
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA