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The map label for this gene is moaA [H]

Identifier: 18310772

GI number: 18310772

Start: 2068994

End: 2069965

Strand: Reverse

Name: moaA [H]

Synonym: CPE1790

Alternate gene names: 18310772

Gene position: 2069965-2068994 (Counterclockwise)

Preceding gene: 18310773

Following gene: 18310771

Centisome position: 68.28

GC content: 27.16

Gene sequence:

>972_bases
ATGAAAGATAAATATGGAAGAGAAATTGACTATTTAAGAATTTCTTTAACTGATAAATGTAATTTAAGATGTGCTTATTG
TATGGAGAAAGATCACAATGATTTTATTCACAATGATAAGCTTATGACTTTAGATGAGATTTTAAGAGTTGTTAAAGAAT
GTGCTTCTATTGGAATAAAAAAAGTAAGACTTACAGGTGGTGAGCCTCTTGTAAGAGAAGGTATAGTAGATTTAATAAAA
AATATAAATAAAATACCTGAGATAGAAGAGATTTGTTTAACCACTAATGGGATTTTACTAGGAGATAAAGTAAAGGAACT
TAGTGAAAATGGATTAAAGAGAGTAAATATAAGTTTAGATACATTAAAAGAAGATAGATTTAAGGAAATAACTAGGATAG
GAACCTTAGATAAAGTACTTTATTCAATAGAAAAGTGCTTAGAGAATAATGTTAAGGTAAAGATAAATACTGTAATATTA
GAAGATTTCAATAAAGATGAAATTTTAGATTTAATAAACTTAGCTTGTGAAAATCCAATAGATCTTAGATTTATAGAGCT
TATGCCTATTGGAGAAGGTAAAAAGTTTAAGGGCGTTACTAATAGTGAGATTTTAGAAATTATAAAGAAAGAAAAAAAGG
TATTAAGTGATGGAAAAACCTTAAGACTAAATGGTCCAGCTAAATACATAAGCATAGAAGGATTCAAAGGAAAAATAGGC
TTTATAAGTGCTATGAGTGATTGTTTTTGTGAGGATTGTAATAGAATAAGGGTCACTCCTGAAGGCTTTATGAAACAGTG
TTTACATTGGAAGTATGGAATAAACTTAAGAGATAAGATGAGAAATGGAATAAGTGATGAAGAACTTAGAGAGATAATTA
AAAAGAGTATTTATGAAAAGCCAGAAAAACATAACTTTAAAATGAAAGAAAAAGATGAAGATAAAAGATTTATGTATGAA
ATAGGAGGATAA

Upstream 100 bases:

>100_bases
GAAATTATTGTTAAAGATTAGAAAAAGTTTGGATAAAGAGATAAAATCATTATTCACCTAAAAGAGGGAATGGAATTTGT
ATAAAGAAGAAGGTGAGAAA

Downstream 100 bases:

>100_bases
AAATGAGCAAGGTAAGAGCTATTTGTATAAGTGAAAAGAAAGGTACAGCTAAAGTGCAAGTTCCTGAAGCTGAGTTTATA
GAAGATTTCGGAATTAAGGG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKDKYGREIDYLRISLTDKCNLRCAYCMEKDHNDFIHNDKLMTLDEILRVVKECASIGIKKVRLTGGEPLVREGIVDLIK
NINKIPEIEEICLTTNGILLGDKVKELSENGLKRVNISLDTLKEDRFKEITRIGTLDKVLYSIEKCLENNVKVKINTVIL
EDFNKDEILDLINLACENPIDLRFIELMPIGEGKKFKGVTNSEILEIIKKEKKVLSDGKTLRLNGPAKYISIEGFKGKIG
FISAMSDCFCEDCNRIRVTPEGFMKQCLHWKYGINLRDKMRNGISDEELREIIKKSIYEKPEKHNFKMKEKDEDKRFMYE
IGG

Sequences:

>Translated_323_residues
MKDKYGREIDYLRISLTDKCNLRCAYCMEKDHNDFIHNDKLMTLDEILRVVKECASIGIKKVRLTGGEPLVREGIVDLIK
NINKIPEIEEICLTTNGILLGDKVKELSENGLKRVNISLDTLKEDRFKEITRIGTLDKVLYSIEKCLENNVKVKINTVIL
EDFNKDEILDLINLACENPIDLRFIELMPIGEGKKFKGVTNSEILEIIKKEKKVLSDGKTLRLNGPAKYISIEGFKGKIG
FISAMSDCFCEDCNRIRVTPEGFMKQCLHWKYGINLRDKMRNGISDEELREIIKKSIYEKPEKHNFKMKEKDEDKRFMYE
IGG
>Mature_323_residues
MKDKYGREIDYLRISLTDKCNLRCAYCMEKDHNDFIHNDKLMTLDEILRVVKECASIGIKKVRLTGGEPLVREGIVDLIK
NINKIPEIEEICLTTNGILLGDKVKELSENGLKRVNISLDTLKEDRFKEITRIGTLDKVLYSIEKCLENNVKVKINTVIL
EDFNKDEILDLINLACENPIDLRFIELMPIGEGKKFKGVTNSEILEIIKKEKKVLSDGKTLRLNGPAKYISIEGFKGKIG
FISAMSDCFCEDCNRIRVTPEGFMKQCLHWKYGINLRDKMRNGISDEELREIIKKSIYEKPEKHNFKMKEKDEDKRFMYE
IGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=38.8379204892966, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=38.8379204892966, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1786999, Length=331, Percent_Identity=33.8368580060423, Blast_Score=190, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI32566329, Length=328, Percent_Identity=41.7682926829268, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI32566331, Length=309, Percent_Identity=42.3948220064725, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17561210, Length=325, Percent_Identity=40.6153846153846, Blast_Score=237, Evalue=6e-63,
Organism=Drosophila melanogaster, GI28574488, Length=330, Percent_Identity=39.6969696969697, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI28574490, Length=311, Percent_Identity=40.5144694533762, Blast_Score=237, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37336; Mature: 37336

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKYGREIDYLRISLTDKCNLRCAYCMEKDHNDFIHNDKLMTLDEILRVVKECASIGIK
CCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCE
KVRLTGGEPLVREGIVDLIKNINKIPEIEEICLTTNGILLGDKVKELSENGLKRVNISLD
EEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEECHHHHHHHHCCCEEEEEEHH
TLKEDRFKEITRIGTLDKVLYSIEKCLENNVKVKINTVILEDFNKDEILDLINLACENPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCC
DLRFIELMPIGEGKKFKGVTNSEILEIIKKEKKVLSDGKTLRLNGPAKYISIEGFKGKIG
CEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCHH
FISAMSDCFCEDCNRIRVTPEGFMKQCLHWKYGINLRDKMRNGISDEELREIIKKSIYEK
HHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCC
PEKHNFKMKEKDEDKRFMYEIGG
CCCCCCCCCCCCCCCCEEEECCC
>Mature Secondary Structure
MKDKYGREIDYLRISLTDKCNLRCAYCMEKDHNDFIHNDKLMTLDEILRVVKECASIGIK
CCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCE
KVRLTGGEPLVREGIVDLIKNINKIPEIEEICLTTNGILLGDKVKELSENGLKRVNISLD
EEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEECHHHHHHHHCCCEEEEEEHH
TLKEDRFKEITRIGTLDKVLYSIEKCLENNVKVKINTVILEDFNKDEILDLINLACENPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCC
DLRFIELMPIGEGKKFKGVTNSEILEIIKKEKKVLSDGKTLRLNGPAKYISIEGFKGKIG
CEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCHH
FISAMSDCFCEDCNRIRVTPEGFMKQCLHWKYGINLRDKMRNGISDEELREIIKKSIYEK
HHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCC
PEKHNFKMKEKDEDKRFMYEIGG
CCCCCCCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA