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The map label for this gene is gmk [H]

Identifier: 18310730

GI number: 18310730

Start: 2025274

End: 2025933

Strand: Reverse

Name: gmk [H]

Synonym: CPE1748

Alternate gene names: 18310730

Gene position: 2025933-2025274 (Counterclockwise)

Preceding gene: 18310731

Following gene: 18310729

Centisome position: 66.83

GC content: 29.85

Gene sequence:

>660_bases
TTGTTGAAGATGATGAATAAGATACATAAGGATAATAGAGGTGTATTAATAGTTATTTCTGGTCCTTCAGGTGCAGGTAA
GGGAACTATTTGTAAAGCCTTATTAGAAAAACACGATGATATATTTATATCAATTTCTGCTACAACTAGAAACCCTAGAG
TAGGAGAAGTTGATGGAGTTAATTATCATTTCTTAACAAAAGAAGAATTTAAACAAAGAATAGCAGAGGATGATTTCCTT
GAGCATGCTGAAGTATATGGAAATTATTATGGAACTCCTAAATCAAGTGTTGAAAAAATGCTTGATGAAGGAAAAAACGT
AATATTAGAAATAGATATACAAGGTGCTTTAAAAGTTAAGGAAAAGGCTACTGATGGAGTATTTATCTTTATATTACCTC
CTTCAATGGAAGAGCTTAAGCAAAGAATAATAAAAAGAGGTAGCGAAACTCCAGAAAGTTTAATGACTAGATTTAAGTCA
GCTTATAAAGAAATTAATTATGTGTCAAAATACAATTATGCAGTAGTTAACGATAATGTAGAAGATGCAGTAAAGAAAAT
AGAAGCTATATTATTAGCAGAAAAATGTAGAGTAGATAGATTAAAAGAAAACTTATTAGAGTCAAAGGAGGACGAAATGC
ATGAACAACTCTATGATTAA

Upstream 100 bases:

>100_bases
AGAACAAGAGCCGTAATAATTACAGATTCAGATCATGTAATTCTTTCAGCTGTTCAACCTGAGACAGTGGCTCACAGATT
ATCAACTAAGGAAGAAGTAG

Downstream 100 bases:

>100_bases
TCCATCAATCGTTGATTTATTAAAAAGGGTAGAAGATAGATATTCTTTAGTAATATTAAGTGCTAAGAGAGCAAGACAAA
TAATTGACGGAGCAGAAACT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MLKMMNKIHKDNRGVLIVISGPSGAGKGTICKALLEKHDDIFISISATTRNPRVGEVDGVNYHFLTKEEFKQRIAEDDFL
EHAEVYGNYYGTPKSSVEKMLDEGKNVILEIDIQGALKVKEKATDGVFIFILPPSMEELKQRIIKRGSETPESLMTRFKS
AYKEINYVSKYNYAVVNDNVEDAVKKIEAILLAEKCRVDRLKENLLESKEDEMHEQLYD

Sequences:

>Translated_219_residues
MLKMMNKIHKDNRGVLIVISGPSGAGKGTICKALLEKHDDIFISISATTRNPRVGEVDGVNYHFLTKEEFKQRIAEDDFL
EHAEVYGNYYGTPKSSVEKMLDEGKNVILEIDIQGALKVKEKATDGVFIFILPPSMEELKQRIIKRGSETPESLMTRFKS
AYKEINYVSKYNYAVVNDNVEDAVKKIEAILLAEKCRVDRLKENLLESKEDEMHEQLYD
>Mature_219_residues
MLKMMNKIHKDNRGVLIVISGPSGAGKGTICKALLEKHDDIFISISATTRNPRVGEVDGVNYHFLTKEEFKQRIAEDDFL
EHAEVYGNYYGTPKSSVEKMLDEGKNVILEIDIQGALKVKEKATDGVFIFILPPSMEELKQRIIKRGSETPESLMTRFKS
AYKEINYVSKYNYAVVNDNVEDAVKKIEAILLAEKCRVDRLKENLLESKEDEMHEQLYD

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=38.2978723404255, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=38.2978723404255, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI226874831, Length=188, Percent_Identity=38.2978723404255, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI38570142, Length=179, Percent_Identity=32.4022346368715, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4505237, Length=177, Percent_Identity=29.3785310734463, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI262118259, Length=177, Percent_Identity=29.3785310734463, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI262118255, Length=177, Percent_Identity=29.3785310734463, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI262118263, Length=177, Percent_Identity=29.3785310734463, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI14780902, Length=183, Percent_Identity=28.9617486338798, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI186700627, Length=175, Percent_Identity=29.1428571428571, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI186700629, Length=175, Percent_Identity=29.1428571428571, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI186972120, Length=175, Percent_Identity=29.1428571428571, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI21361598, Length=194, Percent_Identity=25.7731958762887, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI148539578, Length=181, Percent_Identity=30.3867403314917, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI148539628, Length=181, Percent_Identity=30.3867403314917, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790080, Length=194, Percent_Identity=42.7835051546392, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=38.3333333333333, Blast_Score=126, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=38.3333333333333, Blast_Score=126, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71988041, Length=179, Percent_Identity=26.8156424581006, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71988048, Length=179, Percent_Identity=26.8156424581006, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557440, Length=183, Percent_Identity=26.775956284153, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=43.7158469945355, Blast_Score=154, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21356141, Length=167, Percent_Identity=41.9161676646707, Blast_Score=130, Evalue=8e-31,
Organism=Drosophila melanogaster, GI45554481, Length=186, Percent_Identity=25.8064516129032, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161077626, Length=186, Percent_Identity=25.8064516129032, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640542, Length=186, Percent_Identity=25.8064516129032, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI85724806, Length=186, Percent_Identity=25.8064516129032, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI116007136, Length=186, Percent_Identity=25.8064516129032, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45554489, Length=186, Percent_Identity=25.8064516129032, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI85816281, Length=206, Percent_Identity=25.2427184466019, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI85816106, Length=127, Percent_Identity=33.0708661417323, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45551002, Length=206, Percent_Identity=25.2427184466019, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221330162, Length=175, Percent_Identity=28, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221330166, Length=175, Percent_Identity=28, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221330164, Length=175, Percent_Identity=28, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24978; Mature: 24978

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKMMNKIHKDNRGVLIVISGPSGAGKGTICKALLEKHDDIFISISATTRNPRVGEVDGV
CCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCC
NYHFLTKEEFKQRIAEDDFLEHAEVYGNYYGTPKSSVEKMLDEGKNVILEIDIQGALKVK
CEEEECHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEH
EKATDGVFIFILPPSMEELKQRIIKRGSETPESLMTRFKSAYKEINYVSKYNYAVVNDNV
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCH
EDAVKKIEAILLAEKCRVDRLKENLLESKEDEMHEQLYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCC
>Mature Secondary Structure
MLKMMNKIHKDNRGVLIVISGPSGAGKGTICKALLEKHDDIFISISATTRNPRVGEVDGV
CCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCC
NYHFLTKEEFKQRIAEDDFLEHAEVYGNYYGTPKSSVEKMLDEGKNVILEIDIQGALKVK
CEEEECHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEH
EKATDGVFIFILPPSMEELKQRIIKRGSETPESLMTRFKSAYKEINYVSKYNYAVVNDNV
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCH
EDAVKKIEAILLAEKCRVDRLKENLLESKEDEMHEQLYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA