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The map label for this gene is gppA [H]

Identifier: 18310644

GI number: 18310644

Start: 1935732

End: 1937240

Strand: Direct

Name: gppA [H]

Synonym: CPE1662

Alternate gene names: 18310644

Gene position: 1935732-1937240 (Clockwise)

Preceding gene: 18310642

Following gene: 18310648

Centisome position: 63.86

GC content: 27.97

Gene sequence:

>1509_bases
ATGGATAGAATAGGAGTAATAGACATAGGCTCTAACTCTGTAAGATTAACACTTGCTGAAGTTGAGAAGTCTGGATATTT
TAAAATAATTGATGAATTAAAAGAGCATATAAGACTTGGCTCTGATTTCTTCGCTTGCTCTGTTTTAGACGAAGAGAAAA
TTAAGCTTACAATCTCATCTATAAAAGCTTTTAAATCTATGTGCATCTCTTGTGGTGCATCAAAAATTATACTTATAGGT
TCAGAAAGCATTAAAAATGTAGATGAAAAAATTAATCTTAAAGAAATAATAAAAAAAGAACTTGGATTAGAACTTAGAAT
ATTATCTAATGAAGAAGAAATTAATTATAACTTTTTAGGAGCTAAAAATTCTCTTTATATAGATAATTCTCTTCTTTTAG
ATATAAACGGAAATAACACTCACTTATGTTGGTTAAAAAACAACGAAATTTATAAAGAAGTTACTCTACCCTTTGGATAT
GTAACTTTAACATCCTTATTCCAATTAAACGACATGATTGGATATGAAAATAATACAAACTGTGTTAATTATATTAAAGA
ACACCTTGAAAAAATAGATTGGCTTAAAGATAATTCATTTAAATCTGTTATAGGTGTTGGAGGTTCTTTCAGAAACCTAG
GAAAAATTGATAGACGTAGAAAAAGATATCCTATTGATATAGTTCATAATTATGTTCTTTATGACTATGATATTGATGAG
ATGTTTCACCTACTAAAAAGTAAAAATCTTCGTCAGAGACAAAAAATTGAAGGACTTTCTCCATCTAGAGCTGATGTCAT
AGTTGCTTCTACAGACTTAATAAAAGAAATTTTAAGCTTCACAAATACTAATGAAGTAATAATATGTGGTCGTGGTCTTA
GAGAAGGACTTATATATGAATATATAATAGATAGATTCCATACTTATGATGATATTTTAGATGTAAGTTTAAAGGGAATT
ATGGATACTTTAAACATAAATATTCCTCATGCTCAAAATGTATGTAAACTTGCTTTTTCACTATTTGAAGGTTTAAAACC
ACTTCATCATTTAGGAGATGAATTTAAGAATATATTAAAAACAGCCTCCTTACTTCATGATTGTGGTATAAGCATAAGAT
ATTATGATCACCACGTACACTCATTTTATATTATTTTAAACTCTCATATAAGCGGATTAACTCATAAAGAAATATTATTA
AGTGCCTTATGTGCCGCTTACCATAGAAATAACTCTTTCCAAGCTCCAATTGCTAAATATTCAACTATAATAAATAGATT
AGATGTAAAACATGTAGAGTATTTAGGAGTTATTCTTAAGCTTGCTGAAGGCTTAGACAGAGGGTTAACTGGCCATGTAG
AAAATGTTGATGTAATAATTAACGAAGATACTGTTAATTTAAAACTTCATTCTGAATATGATTTAGAATTAGAGCTTCGT
CAAGCTAGAAGAAGTTCTAAAGCCTTTGAAGAAGTTTATAATAAAAATCTAGTTATTGAAAAAGCCTAA

Upstream 100 bases:

>100_bases
TAATATTTTATTTTGAAATATCCATTGAAAACTTCTTTGAAATTCTATAGTATCAGTATTATAATCAAATTATATTTTAA
ACAAGTAGAGGGGAAAAGAA

Downstream 100 bases:

>100_bases
ATAAAAAAGTTTATGGGAAACTATTCTCCCATAAACTTTTTTAAACTTACATCCCTAAATTTATTTAAGCTTAAAGCACT
TTACTTTCCAATAAGCTTTA

Product: Ppx/GppA phosphatase family protein

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MDRIGVIDIGSNSVRLTLAEVEKSGYFKIIDELKEHIRLGSDFFACSVLDEEKIKLTISSIKAFKSMCISCGASKIILIG
SESIKNVDEKINLKEIIKKELGLELRILSNEEEINYNFLGAKNSLYIDNSLLLDINGNNTHLCWLKNNEIYKEVTLPFGY
VTLTSLFQLNDMIGYENNTNCVNYIKEHLEKIDWLKDNSFKSVIGVGGSFRNLGKIDRRRKRYPIDIVHNYVLYDYDIDE
MFHLLKSKNLRQRQKIEGLSPSRADVIVASTDLIKEILSFTNTNEVIICGRGLREGLIYEYIIDRFHTYDDILDVSLKGI
MDTLNINIPHAQNVCKLAFSLFEGLKPLHHLGDEFKNILKTASLLHDCGISIRYYDHHVHSFYIILNSHISGLTHKEILL
SALCAAYHRNNSFQAPIAKYSTIINRLDVKHVEYLGVILKLAEGLDRGLTGHVENVDVIINEDTVNLKLHSEYDLELELR
QARRSSKAFEEVYNKNLVIEKA

Sequences:

>Translated_502_residues
MDRIGVIDIGSNSVRLTLAEVEKSGYFKIIDELKEHIRLGSDFFACSVLDEEKIKLTISSIKAFKSMCISCGASKIILIG
SESIKNVDEKINLKEIIKKELGLELRILSNEEEINYNFLGAKNSLYIDNSLLLDINGNNTHLCWLKNNEIYKEVTLPFGY
VTLTSLFQLNDMIGYENNTNCVNYIKEHLEKIDWLKDNSFKSVIGVGGSFRNLGKIDRRRKRYPIDIVHNYVLYDYDIDE
MFHLLKSKNLRQRQKIEGLSPSRADVIVASTDLIKEILSFTNTNEVIICGRGLREGLIYEYIIDRFHTYDDILDVSLKGI
MDTLNINIPHAQNVCKLAFSLFEGLKPLHHLGDEFKNILKTASLLHDCGISIRYYDHHVHSFYIILNSHISGLTHKEILL
SALCAAYHRNNSFQAPIAKYSTIINRLDVKHVEYLGVILKLAEGLDRGLTGHVENVDVIINEDTVNLKLHSEYDLELELR
QARRSSKAFEEVYNKNLVIEKA
>Mature_502_residues
MDRIGVIDIGSNSVRLTLAEVEKSGYFKIIDELKEHIRLGSDFFACSVLDEEKIKLTISSIKAFKSMCISCGASKIILIG
SESIKNVDEKINLKEIIKKELGLELRILSNEEEINYNFLGAKNSLYIDNSLLLDINGNNTHLCWLKNNEIYKEVTLPFGY
VTLTSLFQLNDMIGYENNTNCVNYIKEHLEKIDWLKDNSFKSVIGVGGSFRNLGKIDRRRKRYPIDIVHNYVLYDYDIDE
MFHLLKSKNLRQRQKIEGLSPSRADVIVASTDLIKEILSFTNTNEVIICGRGLREGLIYEYIIDRFHTYDDILDVSLKGI
MDTLNINIPHAQNVCKLAFSLFEGLKPLHHLGDEFKNILKTASLLHDCGISIRYYDHHVHSFYIILNSHISGLTHKEILL
SALCAAYHRNNSFQAPIAKYSTIINRLDVKHVEYLGVILKLAEGLDRGLTGHVENVDVIINEDTVNLKLHSEYDLELELR
QARRSSKAFEEVYNKNLVIEKA

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=449, Percent_Identity=23.3853006681514, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1788848, Length=421, Percent_Identity=22.0902612826603, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321185, Length=457, Percent_Identity=23.6323851203501, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 57447; Mature: 57447

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRIGVIDIGSNSVRLTLAEVEKSGYFKIIDELKEHIRLGSDFFACSVLDEEKIKLTISS
CCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEHHH
IKAFKSMCISCGASKIILIGSESIKNVDEKINLKEIIKKELGLELRILSNEEEINYNFLG
HHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCCEEEEC
AKNSLYIDNSLLLDINGNNTHLCWLKNNEIYKEVTLPFGYVTLTSLFQLNDMIGYENNTN
CCCCEEECCEEEEEECCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCC
CVNYIKEHLEKIDWLKDNSFKSVIGVGGSFRNLGKIDRRRKRYPIDIVHNYVLYDYDIDE
HHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCEEEECEEEEECCHHH
MFHLLKSKNLRQRQKIEGLSPSRADVIVASTDLIKEILSFTNTNEVIICGRGLREGLIYE
HHHHHHCCCHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
YIIDRFHTYDDILDVSLKGIMDTLNINIPHAQNVCKLAFSLFEGLKPLHHLGDEFKNILK
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TASLLHDCGISIRYYDHHVHSFYIILNSHISGLTHKEILLSALCAAYHRNNSFQAPIAKY
HHHHHHHCCCEEEEEECEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHH
STIINRLDVKHVEYLGVILKLAEGLDRGLTGHVENVDVIINEDTVNLKLHSEYDLELELR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEEEECCCCCCHHHH
QARRSSKAFEEVYNKNLVIEKA
HHHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MDRIGVIDIGSNSVRLTLAEVEKSGYFKIIDELKEHIRLGSDFFACSVLDEEKIKLTISS
CCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEHHH
IKAFKSMCISCGASKIILIGSESIKNVDEKINLKEIIKKELGLELRILSNEEEINYNFLG
HHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCCEEEEC
AKNSLYIDNSLLLDINGNNTHLCWLKNNEIYKEVTLPFGYVTLTSLFQLNDMIGYENNTN
CCCCEEECCEEEEEECCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCC
CVNYIKEHLEKIDWLKDNSFKSVIGVGGSFRNLGKIDRRRKRYPIDIVHNYVLYDYDIDE
HHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCEEEECEEEEECCHHH
MFHLLKSKNLRQRQKIEGLSPSRADVIVASTDLIKEILSFTNTNEVIICGRGLREGLIYE
HHHHHHCCCHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
YIIDRFHTYDDILDVSLKGIMDTLNINIPHAQNVCKLAFSLFEGLKPLHHLGDEFKNILK
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TASLLHDCGISIRYYDHHVHSFYIILNSHISGLTHKEILLSALCAAYHRNNSFQAPIAKY
HHHHHHHCCCEEEEEECEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHH
STIINRLDVKHVEYLGVILKLAEGLDRGLTGHVENVDVIINEDTVNLKLHSEYDLELELR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEEEECCCCCCHHHH
QARRSSKAFEEVYNKNLVIEKA
HHHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA