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The map label for this gene is prs [H]

Identifier: 18310531

GI number: 18310531

Start: 1816133

End: 1817227

Strand: Direct

Name: prs [H]

Synonym: CPE1549

Alternate gene names: 18310531

Gene position: 1816133-1817227 (Clockwise)

Preceding gene: 18310521

Following gene: 18310535

Centisome position: 59.91

GC content: 31.32

Gene sequence:

>1095_bases
ATGAACGAACAAAATCATGGATTAGGTATTATAGCTTTAGAAAGTTGCACAGAACTTGGTAATGCTATAGACAAGCTTAT
ACAAGAGAAAAGAAATTGTGAGGAATCTTTTTTAATAAAAACTGATGAGATAAGATTCTCTAACGGTGAAGGAAAAGTAA
AAATACCTCAATCTGTAAGAGGAAGAGATATATACATTCTTTGTGATATAGGTAACTATAGTTGTACATATAAAATGTTT
GGTTTTGAAAATCATAAGGGACCAGATGAACATTTCCAAGACATAAAAAGAACAGTTTCTGCTATAAGAGGAAAAGCTAG
AAGAATAACTGTAATAATGCCTCTTTTATATGAATCAAGACAACATAGACGTAAAGGAAGAGAATCTCTAGATTGTGCTT
TAGCACTTCAAGAACTAGAAAGATTAGGCGTTGATGAAGTTTTAACTTTTGACGTTCACGACCCTAACGTTCAAAATGCT
ATCCCACTAATGTCCTTTGAAAACTTCTACCCAACTTATGATATAGTTAAATCTTTAATTCACAATGAAAAAGATTTAGA
GCTTGATAAGGAAAAATTACTTGTAATAAGTCCTGATACTGGTGCCATGGATAGAGCAATCTACTATTCAAGCGTACTAG
GTGTTGATGTTGGTTTATTCTACAAAAGAAGAGACCATTCACGTATAGTTAATGGTAAAAACCCAATAGTTAAACATGAA
TACATGGGAAGAGACGTTGATGGAAAAGATGTCTTAATCGTTGATGATATGATAGCTTCTGGAGAATCTGTACTTGATAT
TGCTAAAGAACTTAAAGGAAGAAATGCTAGAAATGTATATGTTGCTACTACTTTCTCATTCTTTACTGAAGGTTTAGAAA
AATTCAACAAATTCTTCAATGATGGAATAATTAAGAGCGTTTACTCAACAAATTTAACTTATATACCTGAGGAATTAAAT
GCTGCTCCTTGGTTTAAAGCTGTTGATTTATCTGATTTTATCGCAAGAATAATAAACAGATTAAACTATGATAAATCTGT
AGCATCATATATGGACGCTACTAACATAATCCAAAGATTATTAGACGAAAAATAA

Upstream 100 bases:

>100_bases
TTTAAAAGTAAATTATTCGTATATAATATAAATGACGATATCTTTAGTATTTACGATTGTAAAATATTTTAAATAAGCAT
TAAAAAAAGGAGATAGACGA

Downstream 100 bases:

>100_bases
TATGCTTAATTTAAAAGTGCTCTGCTTTTTTGCAGAGCACTTTTTTAGTCTATTCAAATAAAAATTCTAAAACACCTTTT
GCTTCCTTATGATTAAATGC

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MNEQNHGLGIIALESCTELGNAIDKLIQEKRNCEESFLIKTDEIRFSNGEGKVKIPQSVRGRDIYILCDIGNYSCTYKMF
GFENHKGPDEHFQDIKRTVSAIRGKARRITVIMPLLYESRQHRRKGRESLDCALALQELERLGVDEVLTFDVHDPNVQNA
IPLMSFENFYPTYDIVKSLIHNEKDLELDKEKLLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHSRIVNGKNPIVKHE
YMGRDVDGKDVLIVDDMIASGESVLDIAKELKGRNARNVYVATTFSFFTEGLEKFNKFFNDGIIKSVYSTNLTYIPEELN
AAPWFKAVDLSDFIARIINRLNYDKSVASYMDATNIIQRLLDEK

Sequences:

>Translated_364_residues
MNEQNHGLGIIALESCTELGNAIDKLIQEKRNCEESFLIKTDEIRFSNGEGKVKIPQSVRGRDIYILCDIGNYSCTYKMF
GFENHKGPDEHFQDIKRTVSAIRGKARRITVIMPLLYESRQHRRKGRESLDCALALQELERLGVDEVLTFDVHDPNVQNA
IPLMSFENFYPTYDIVKSLIHNEKDLELDKEKLLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHSRIVNGKNPIVKHE
YMGRDVDGKDVLIVDDMIASGESVLDIAKELKGRNARNVYVATTFSFFTEGLEKFNKFFNDGIIKSVYSTNLTYIPEELN
AAPWFKAVDLSDFIARIINRLNYDKSVASYMDATNIIQRLLDEK
>Mature_364_residues
MNEQNHGLGIIALESCTELGNAIDKLIQEKRNCEESFLIKTDEIRFSNGEGKVKIPQSVRGRDIYILCDIGNYSCTYKMF
GFENHKGPDEHFQDIKRTVSAIRGKARRITVIMPLLYESRQHRRKGRESLDCALALQELERLGVDEVLTFDVHDPNVQNA
IPLMSFENFYPTYDIVKSLIHNEKDLELDKEKLLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHSRIVNGKNPIVKHE
YMGRDVDGKDVLIVDDMIASGESVLDIAKELKGRNARNVYVATTFSFFTEGLEKFNKFFNDGIIKSVYSTNLTYIPEELN
AAPWFKAVDLSDFIARIINRLNYDKSVASYMDATNIIQRLLDEK

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=312, Percent_Identity=25.6410256410256, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4506127, Length=312, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=24.8407643312102, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI84875539, Length=315, Percent_Identity=22.8571428571429, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1787458, Length=339, Percent_Identity=28.3185840707965, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=25.0793650793651, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17554704, Length=315, Percent_Identity=25.0793650793651, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17554702, Length=315, Percent_Identity=25.0793650793651, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71989924, Length=315, Percent_Identity=25.0793650793651, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321776, Length=311, Percent_Identity=26.6881028938907, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320946, Length=317, Percent_Identity=25.5520504731861, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=24.6794871794872, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=24.7619047619048, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=22.7810650887574, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 41630; Mature: 41630

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQNHGLGIIALESCTELGNAIDKLIQEKRNCEESFLIKTDEIRFSNGEGKVKIPQSVR
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHEEEECCEEEECCCCCEECCCCCC
GRDIYILCDIGNYSCTYKMFGFENHKGPDEHFQDIKRTVSAIRGKARRITVIMPLLYESR
CCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHH
QHRRKGRESLDCALALQELERLGVDEVLTFDVHDPNVQNAIPLMSFENFYPTYDIVKSLI
HHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
HNEKDLELDKEKLLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHSRIVNGKNPIVKHE
CCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCEEHH
YMGRDVDGKDVLIVDDMIASGESVLDIAKELKGRNARNVYVATTFSFFTEGLEKFNKFFN
HCCCCCCCCCEEEEECHHHCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
DGIIKSVYSTNLTYIPEELNAAPWFKAVDLSDFIARIINRLNYDKSVASYMDATNIIQRL
CHHHHHHHHCCCEECHHHCCCCCCEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LDEK
HCCC
>Mature Secondary Structure
MNEQNHGLGIIALESCTELGNAIDKLIQEKRNCEESFLIKTDEIRFSNGEGKVKIPQSVR
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHEEEECCEEEECCCCCEECCCCCC
GRDIYILCDIGNYSCTYKMFGFENHKGPDEHFQDIKRTVSAIRGKARRITVIMPLLYESR
CCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHH
QHRRKGRESLDCALALQELERLGVDEVLTFDVHDPNVQNAIPLMSFENFYPTYDIVKSLI
HHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
HNEKDLELDKEKLLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHSRIVNGKNPIVKHE
CCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCEEHH
YMGRDVDGKDVLIVDDMIASGESVLDIAKELKGRNARNVYVATTFSFFTEGLEKFNKFFN
HCCCCCCCCCEEEEECHHHCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
DGIIKSVYSTNLTYIPEELNAAPWFKAVDLSDFIARIINRLNYDKSVASYMDATNIIQRL
CHHHHHHHHCCCEECHHHCCCCCCEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LDEK
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]