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The map label for this gene is mepA [H]

Identifier: 18310466

GI number: 18310466

Start: 1738652

End: 1739980

Strand: Reverse

Name: mepA [H]

Synonym: CPE1484

Alternate gene names: 18310466

Gene position: 1739980-1738652 (Counterclockwise)

Preceding gene: 18310467

Following gene: 18310465

Centisome position: 57.4

GC content: 28.29

Gene sequence:

>1329_bases
ATGAACAAAAAATTAGATTTACTACAGGATAAAGAAAGTACATTATTAAGAAAATATATGATACCTTCAGTTCTAGGAAT
GTTAGGCTTATCAGTATGTATATTATTTGATACCATGTTTATAGGACATAAAATTGGAGATTTAGGTTTAGCTGCACTAA
ATATAGCCTTGCCAATATATAATTTATATAGTGCCATAGGTCTTACTATTGGAGTGGGAGGAGCAACAGCTCTATCCGTA
GCTATGGGGCAAAATAAATTTCATAGGGTAAATAGAATATTTACTTCGGCAATATTTGCAACTATCATATTTTGTATAAT
AATAAGTTTATTAGAAGTTTTCTTTTTAGATAAAATAGTTTATATGCTTGGAGCTTCAGAAGCAACCTTTCCTTTAGCTA
AAGAATACTTAAAGATTATTTTAGCCTTTAATCCTGCTTTTATTTTTGCATCTGCATTTATTGTTTTTGTTAGAAATGAT
AGAGAGCCTAAATTAGCTATGTACGCAGTAATAGGATCAAATACAACTAATATAGTACTAGACTATGTGTTTATATATAT
ATTTAATTTAGGAATGTTTGGAGCAGCCTTAGCAACATCTATAGGTCAATTGGTAGCCTTAGGAGTTTTATCAATACATT
TTATAAAGAAAAATAACACCATGCATATAGAGCTTGGAGGAATAAATTTAGACAATATAGGAAAGGTACTTAAAAATGGA
GTTCCTAGTTTCTTAAATGAAATATCAGCAGGTTTTGTTATATTTATTTTTAATATTGTAATATACAAATTTGAAGGCGA
CTTAGGAGTTTCAGCATATGGAATAATTACAAACATAGTTTTAATATTCATGGCAGTCTTTAATGGAGTATCCCAAGGGG
TTCAACCTTTAATAAGCGTAAATTTTGGAGCTAAAAAGGAAGAGCGTGTTAAAGAATTCTTAAGGTTAACAAGAATAATA
GTACTAATTTTAGGTGTAGGCTTCTTAGGTATGGGACTATTATTACCAAATCAAATGATAGGACTATTTACAAGTGATAG
GGGAAGATTATTAAGTATAACTAGACAGGGAATATATCTATACTTTATAGCATTCTTATTTAATGGAAGCAACATACTTA
ACATAGCTTATTTACAAGCAGTTGAAAAATCAAAGGAATCATCTCTTTTATCAACACTTAGAGGATTAGTATTTGTTATT
ATATTTATAATAGTCTTACCAAGAATTATAGGGGTTTATGGAGTATGGCTAACAATTCCAATAACTGAGTTAAGTACACT
TTTATTATTTTTAATATTTGAAATAAAAAGTAAAAGAAAAAATATATAA

Upstream 100 bases:

>100_bases
TGGATAAATTTAATGATGTACAAAAGTCAAAAGAAAAAAATAATATAGAAGAAAAAATTTTACTTATTTTAAAAGAATAA
GAATATAAAGGAGGGGTAAA

Downstream 100 bases:

>100_bases
AACAATAAAAACCGTTGATTATCAACGGTTTTTATTGTAAATGCAAAGAAGTAAATATAGTATAGTAAGAGTTATAGTGA
TTTTTTAAACAGGAGGTTAA

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MNKKLDLLQDKESTLLRKYMIPSVLGMLGLSVCILFDTMFIGHKIGDLGLAALNIALPIYNLYSAIGLTIGVGGATALSV
AMGQNKFHRVNRIFTSAIFATIIFCIIISLLEVFFLDKIVYMLGASEATFPLAKEYLKIILAFNPAFIFASAFIVFVRND
REPKLAMYAVIGSNTTNIVLDYVFIYIFNLGMFGAALATSIGQLVALGVLSIHFIKKNNTMHIELGGINLDNIGKVLKNG
VPSFLNEISAGFVIFIFNIVIYKFEGDLGVSAYGIITNIVLIFMAVFNGVSQGVQPLISVNFGAKKEERVKEFLRLTRII
VLILGVGFLGMGLLLPNQMIGLFTSDRGRLLSITRQGIYLYFIAFLFNGSNILNIAYLQAVEKSKESSLLSTLRGLVFVI
IFIIVLPRIIGVYGVWLTIPITELSTLLLFLIFEIKSKRKNI

Sequences:

>Translated_442_residues
MNKKLDLLQDKESTLLRKYMIPSVLGMLGLSVCILFDTMFIGHKIGDLGLAALNIALPIYNLYSAIGLTIGVGGATALSV
AMGQNKFHRVNRIFTSAIFATIIFCIIISLLEVFFLDKIVYMLGASEATFPLAKEYLKIILAFNPAFIFASAFIVFVRND
REPKLAMYAVIGSNTTNIVLDYVFIYIFNLGMFGAALATSIGQLVALGVLSIHFIKKNNTMHIELGGINLDNIGKVLKNG
VPSFLNEISAGFVIFIFNIVIYKFEGDLGVSAYGIITNIVLIFMAVFNGVSQGVQPLISVNFGAKKEERVKEFLRLTRII
VLILGVGFLGMGLLLPNQMIGLFTSDRGRLLSITRQGIYLYFIAFLFNGSNILNIAYLQAVEKSKESSLLSTLRGLVFVI
IFIIVLPRIIGVYGVWLTIPITELSTLLLFLIFEIKSKRKNI
>Mature_442_residues
MNKKLDLLQDKESTLLRKYMIPSVLGMLGLSVCILFDTMFIGHKIGDLGLAALNIALPIYNLYSAIGLTIGVGGATALSV
AMGQNKFHRVNRIFTSAIFATIIFCIIISLLEVFFLDKIVYMLGASEATFPLAKEYLKIILAFNPAFIFASAFIVFVRND
REPKLAMYAVIGSNTTNIVLDYVFIYIFNLGMFGAALATSIGQLVALGVLSIHFIKKNNTMHIELGGINLDNIGKVLKNG
VPSFLNEISAGFVIFIFNIVIYKFEGDLGVSAYGIITNIVLIFMAVFNGVSQGVQPLISVNFGAKKEERVKEFLRLTRII
VLILGVGFLGMGLLLPNQMIGLFTSDRGRLLSITRQGIYLYFIAFLFNGSNILNIAYLQAVEKSKESSLLSTLRGLVFVI
IFIIVLPRIIGVYGVWLTIPITELSTLLLFLIFEIKSKRKNI

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48792; Mature: 48792

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKLDLLQDKESTLLRKYMIPSVLGMLGLSVCILFDTMFIGHKIGDLGLAALNIALPIY
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLYSAIGLTIGVGGATALSVAMGQNKFHRVNRIFTSAIFATIIFCIIISLLEVFFLDKIV
HHHHHHHHHEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YMLGASEATFPLAKEYLKIILAFNPAFIFASAFIVFVRNDREPKLAMYAVIGSNTTNIVL
HHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCEEEEEEECCCCHHHHH
DYVFIYIFNLGMFGAALATSIGQLVALGVLSIHFIKKNNTMHIELGGINLDNIGKVLKNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCCHHHHHHHHHCC
VPSFLNEISAGFVIFIFNIVIYKFEGDLGVSAYGIITNIVLIFMAVFNGVSQGVQPLISV
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEC
NFGAKKEERVKEFLRLTRIIVLILGVGFLGMGLLLPNQMIGLFTSDRGRLLSITRQGIYL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCEEHHHHHHHHH
YFIAFLFNGSNILNIAYLQAVEKSKESSLLSTLRGLVFVIIFIIVLPRIIGVYGVWLTIP
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
ITELSTLLLFLIFEIKSKRKNI
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKKLDLLQDKESTLLRKYMIPSVLGMLGLSVCILFDTMFIGHKIGDLGLAALNIALPIY
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLYSAIGLTIGVGGATALSVAMGQNKFHRVNRIFTSAIFATIIFCIIISLLEVFFLDKIV
HHHHHHHHHEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YMLGASEATFPLAKEYLKIILAFNPAFIFASAFIVFVRNDREPKLAMYAVIGSNTTNIVL
HHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCEEEEEEECCCCHHHHH
DYVFIYIFNLGMFGAALATSIGQLVALGVLSIHFIKKNNTMHIELGGINLDNIGKVLKNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCCHHHHHHHHHCC
VPSFLNEISAGFVIFIFNIVIYKFEGDLGVSAYGIITNIVLIFMAVFNGVSQGVQPLISV
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEC
NFGAKKEERVKEFLRLTRIIVLILGVGFLGMGLLLPNQMIGLFTSDRGRLLSITRQGIYL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCEEHHHHHHHHH
YFIAFLFNGSNILNIAYLQAVEKSKESSLLSTLRGLVFVIIFIIVLPRIIGVYGVWLTIP
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
ITELSTLLLFLIFEIKSKRKNI
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA