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The map label for this gene is hemC [H]

Identifier: 18310417

GI number: 18310417

Start: 1693000

End: 1693875

Strand: Reverse

Name: hemC [H]

Synonym: CPE1435

Alternate gene names: 18310417

Gene position: 1693875-1693000 (Counterclockwise)

Preceding gene: 18310418

Following gene: 18310416

Centisome position: 55.88

GC content: 30.37

Gene sequence:

>876_bases
ATGGAATTAATAATAGCGACTAGAAAAAGTAAGTTAGCACAAGTGCAAACTGAAAAAGTTATGGAACTTTTAAAGGGAAA
AGAAAATGTAGATAGTAAGAAACTTTTAGTTATGACAGAAGGTGATAGAAGACTAGATGTTTCATTAAATAAAATAGGTG
GAAAGGGTCTATTTGTAAAGGAGATAGAACTAGCTCTTTTAAATAAAGAAGCTCATGGAGCAGTTCATAGTATGAAAGAT
GTTCCTTTTGAACTTCCTAGCGAATTTGAGCTTGTTGCAATGCCTGAAAGAGAAGATATAAGAGATGCCTTTGTATCTTT
AAATGGATCCACTTTATCTAATTTAAGAAAAGGAGCTAGAATAGGAACTAGCAGTATAAGACGTGCAGAGCAATTAAAGT
TATTTAGAGATGACTTAGAGATTGTTCCAATTAGAGGTAATGTTCAAACTAGAATAAAAAAAATAACTGAAGAAAATTTA
GATGGAATAATTTTAGCGGCAGCAGGATTAAAAAGACTTGGTATGGAAGATGTAATAAGTGATTATTTTGATCCAAAGGT
ATTTTTACCTGCTATTGGTCAAGGAGCTTTAGGAATAGAGTGCTTAAAAGGTGGAGAATTTAATGACTATTTTAAAGCTT
TAGATAGCAAAGAGGTTAGAACTACTGTTGAAGCTGAAAGAAGCTTTATGAAGGTATTAAACGGAGGATGTCATAGTCTT
ATAGGTGCTTATTCAGAGGTTAAAGATAATGACTTATATATGATAGGTACATTTACTGTAAATAATAGAATAGTTAAAAA
AGATATATTAGGAAATAAAGAAGATAATATATTATTAGGAAAAAAACTTGCAGAAAAAATATTAGAAGAGGTATAG

Upstream 100 bases:

>100_bases
AGGAGAAGAATTAGCTAATTCATTAACTTTAGGATTAAAGTAATTATAACAGAATTTTTTATGAAAATATAAAAATAATC
AAAATGTGAGGTTTGGATTA

Downstream 100 bases:

>100_bases
GAGGAACTATGAGTAAAAAAGCATATATAATAGGGGCAGGTCCTGGAGATGAAGAGTTATTAACACTTAAAGCAATAAAT
GCATTACAAAAATGCACAGC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MELIIATRKSKLAQVQTEKVMELLKGKENVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKEIELALLNKEAHGAVHSMKD
VPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARIGTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENL
DGIILAAAGLKRLGMEDVISDYFDPKVFLPAIGQGALGIECLKGGEFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL
IGAYSEVKDNDLYMIGTFTVNNRIVKKDILGNKEDNILLGKKLAEKILEEV

Sequences:

>Translated_291_residues
MELIIATRKSKLAQVQTEKVMELLKGKENVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKEIELALLNKEAHGAVHSMKD
VPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARIGTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENL
DGIILAAAGLKRLGMEDVISDYFDPKVFLPAIGQGALGIECLKGGEFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL
IGAYSEVKDNDLYMIGTFTVNNRIVKKDILGNKEDNILLGKKLAEKILEEV
>Mature_291_residues
MELIIATRKSKLAQVQTEKVMELLKGKENVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVKEIELALLNKEAHGAVHSMKD
VPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGARIGTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENL
DGIILAAAGLKRLGMEDVISDYFDPKVFLPAIGQGALGIECLKGGEFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL
IGAYSEVKDNDLYMIGTFTVNNRIVKKDILGNKEDNILLGKKLAEKILEEV

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=258, Percent_Identity=39.922480620155, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI66933009, Length=258, Percent_Identity=39.922480620155, Blast_Score=171, Evalue=8e-43,
Organism=Escherichia coli, GI48994974, Length=290, Percent_Identity=44.4827586206897, Blast_Score=214, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6319996, Length=310, Percent_Identity=36.1290322580645, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI20130425, Length=259, Percent_Identity=40.1544401544402, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32393; Mature: 32393

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIIATRKSKLAQVQTEKVMELLKGKENVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVK
CCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEHH
EIELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGAR
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHCCC
IGTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVIS
CCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEHHHHHCCHHHHHH
DYFDPKVFLPAIGQGALGIECLKGGEFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL
HHCCCEEEECCCCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHH
IGAYSEVKDNDLYMIGTFTVNNRIVKKDILGNKEDNILLGKKLAEKILEEV
HHHHHHCCCCCEEEEEEEEECCEEEEHHHCCCCCCCEEECHHHHHHHHHHC
>Mature Secondary Structure
MELIIATRKSKLAQVQTEKVMELLKGKENVDSKKLLVMTEGDRRLDVSLNKIGGKGLFVK
CCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEHH
EIELALLNKEAHGAVHSMKDVPFELPSEFELVAMPEREDIRDAFVSLNGSTLSNLRKGAR
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHCCC
IGTSSIRRAEQLKLFRDDLEIVPIRGNVQTRIKKITEENLDGIILAAAGLKRLGMEDVIS
CCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCEEEEEEHHHHHCCHHHHHH
DYFDPKVFLPAIGQGALGIECLKGGEFNDYFKALDSKEVRTTVEAERSFMKVLNGGCHSL
HHCCCEEEECCCCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHH
IGAYSEVKDNDLYMIGTFTVNNRIVKKDILGNKEDNILLGKKLAEKILEEV
HHHHHHCCCCCEEEEEEEEECCEEEEHHHCCCCCCCEEECHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA