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The map label for this gene is polC [H]

Identifier: 18310383

GI number: 18310383

Start: 1652165

End: 1653073

Strand: Reverse

Name: polC [H]

Synonym: CPE1401

Alternate gene names: 18310383

Gene position: 1653073-1652165 (Counterclockwise)

Preceding gene: 18310384

Following gene: 18310382

Centisome position: 54.53

GC content: 28.93

Gene sequence:

>909_bases
ATGGATTTTGTTGCAATAGACTTTGAAACTGCTAATGAGAAAAGAAATAGTGCGTGTTCTATTGGATTGACTGTTGTTAA
GGATAATAAAATTGTTGAAGAAAAATATTTTTTAATAAAGCCTTGTGAAATGAGATTTCAGCCCATGAATATATGGATAC
ATGGAATTAGACCAGAGGATGTTGAAAATGAGAGAACTTTTAATGAAATATGGGAAGAAATAAAGGATTACATAGATGGA
AATTTAGTAATAGCTCATAATGCAGCTTTTGATATTAGCGTTCTTAGAAAAACTTTAGATTTTTATGATATACCTTATCC
AGACTTTGAATATGCCTGTACAGTAGTTATGGCAAAGAATTATTATAAATCATTACCAAATCATAAATTAGGAACTGTAA
GTGAAGCTTTAGACTTTGAATTTTCTCATCACCATGCAGGGGAAGATGCAAGGGCTTGTGCTAACATATTACTTAATATA
TGCAAAGATTTAGATATAGAATCAGTTGAAGAGCTTTCAGATAAGCTCTCCATAAGAATAGGTGCTGTTTATGAAAATGG
ATATAAGTCTTCTGGAAGAAAGGGAGAATGCAAATATTCAAGCAATTTAAGACTTAAGGAAAAGAAGAAAGAGGGAGAAA
TATCTTTAAAATGTAAAAATGTAGTTTTTACAGGACCTTTAAGCTCTATGTCTAGAGGAGAAGCCATAGGAAATGTAATA
AGGTGTGGTGGTTTTGTCTCAAGTTCTGTAAGTAAAAAGACAAACTACTTAATTACAGGAATTAGGGATTTAAATAAATT
AAAAGAAAATGAAAAGAGTATTAAATTAAAAAAAGCAGAAAATTTAATAAAAGAAAATTTCGATATTAAGATAATAAATG
AAGAGGAATTTTTATCTATAATAGAATAA

Upstream 100 bases:

>100_bases
AGGTCTTTTTATTTTGAATTACATTTAAATAAATTAAAATAATAAAATAAAATGTGATATAATATTGTTTATTGTTACAT
AGAAAGGGAGAAAGACATAA

Downstream 100 bases:

>100_bases
ATAAACTTTAATTTTAGATCTAAATATTAATAAATAGCTCATTTAGGGGCTATTTTTGCTATTGTTAACAATAAGTTATT
TACAATAATATTTATTATGC

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MDFVAIDFETANEKRNSACSIGLTVVKDNKIVEEKYFLIKPCEMRFQPMNIWIHGIRPEDVENERTFNEIWEEIKDYIDG
NLVIAHNAAFDISVLRKTLDFYDIPYPDFEYACTVVMAKNYYKSLPNHKLGTVSEALDFEFSHHHAGEDARACANILLNI
CKDLDIESVEELSDKLSIRIGAVYENGYKSSGRKGECKYSSNLRLKEKKKEGEISLKCKNVVFTGPLSSMSRGEAIGNVI
RCGGFVSSSVSKKTNYLITGIRDLNKLKENEKSIKLKKAENLIKENFDIKIINEEEFLSIIE

Sequences:

>Translated_302_residues
MDFVAIDFETANEKRNSACSIGLTVVKDNKIVEEKYFLIKPCEMRFQPMNIWIHGIRPEDVENERTFNEIWEEIKDYIDG
NLVIAHNAAFDISVLRKTLDFYDIPYPDFEYACTVVMAKNYYKSLPNHKLGTVSEALDFEFSHHHAGEDARACANILLNI
CKDLDIESVEELSDKLSIRIGAVYENGYKSSGRKGECKYSSNLRLKEKKKEGEISLKCKNVVFTGPLSSMSRGEAIGNVI
RCGGFVSSSVSKKTNYLITGIRDLNKLKENEKSIKLKKAENLIKENFDIKIINEEEFLSIIE
>Mature_302_residues
MDFVAIDFETANEKRNSACSIGLTVVKDNKIVEEKYFLIKPCEMRFQPMNIWIHGIRPEDVENERTFNEIWEEIKDYIDG
NLVIAHNAAFDISVLRKTLDFYDIPYPDFEYACTVVMAKNYYKSLPNHKLGTVSEALDFEFSHHHAGEDARACANILLNI
CKDLDIESVEELSDKLSIRIGAVYENGYKSSGRKGECKYSSNLRLKEKKKEGEISLKCKNVVFTGPLSSMSRGEAIGNVI
RCGGFVSSSVSKKTNYLITGIRDLNKLKENEKSIKLKKAENLIKENFDIKIINEEEFLSIIE

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 34450; Mature: 34450

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50172 BRCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFVAIDFETANEKRNSACSIGLTVVKDNKIVEEKYFLIKPCEMRFQPMNIWIHGIRPED
CCEEEEEEECCCCCCCCEEEEEEEEEECCCEECCCEEEEECHHHEEEEEEEEEECCCCCC
VENERTFNEIWEEIKDYIDGNLVIAHNAAFDISVLRKTLDFYDIPYPDFEYACTVVMAKN
CCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YYKSLPNHKLGTVSEALDFEFSHHHAGEDARACANILLNICKDLDIESVEELSDKLSIRI
HHHHCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEE
GAVYENGYKSSGRKGECKYSSNLRLKEKKKEGEISLKCKNVVFTGPLSSMSRGEAIGNVI
EEEEECCCCCCCCCCCCEECCCCEEEECCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHH
RCGGFVSSSVSKKTNYLITGIRDLNKLKENEKSIKLKKAENLIKENFDIKIINEEEFLSI
HHCCHHHHHHHCCCCEEEECHHHHHHHHCCHHHEEHHHHHHHHHCCCCEEEECHHHHHHH
IE
CC
>Mature Secondary Structure
MDFVAIDFETANEKRNSACSIGLTVVKDNKIVEEKYFLIKPCEMRFQPMNIWIHGIRPED
CCEEEEEEECCCCCCCCEEEEEEEEEECCCEECCCEEEEECHHHEEEEEEEEEECCCCCC
VENERTFNEIWEEIKDYIDGNLVIAHNAAFDISVLRKTLDFYDIPYPDFEYACTVVMAKN
CCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YYKSLPNHKLGTVSEALDFEFSHHHAGEDARACANILLNICKDLDIESVEELSDKLSIRI
HHHHCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEE
GAVYENGYKSSGRKGECKYSSNLRLKEKKKEGEISLKCKNVVFTGPLSSMSRGEAIGNVI
EEEEECCCCCCCCCCCCEECCCCEEEECCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHH
RCGGFVSSSVSKKTNYLITGIRDLNKLKENEKSIKLKKAENLIKENFDIKIINEEEFLSI
HHCCHHHHHHHCCCCEEEECHHHHHHHHCCHHHEEHHHHHHHHHCCCCEEEECHHHHHHH
IE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9826752; 10360571 [H]