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The map label for this gene is cysK [H]

Identifier: 18310304

GI number: 18310304

Start: 1563414

End: 1564316

Strand: Reverse

Name: cysK [H]

Synonym: CPE1322

Alternate gene names: 18310304

Gene position: 1564316-1563414 (Counterclockwise)

Preceding gene: 18310305

Following gene: 18310303

Centisome position: 51.6

GC content: 31.67

Gene sequence:

>903_bases
ATGGTTTTTAACAGTCTTTTAAGTTTAATAGGAAACACACCAATATTAAAAGCAAATAATTTATTTGAAGGGAATAATGT
ATTTGTTAAGCTTGAAAAATTTAATCCAGGAGGAAGTATAAAAGATAGAGCAGCTTTAGGAATGATAGAAGAAGCTGAAA
AAAATGGATTATTAAAAGAAAATGGAGTTATAGTAGAACCAACTAGTGGAAATACAGGAATTGCCATAGCTATGATTGGT
AAAATTAAAGGGTATAAAGTTATTATAACTATGCCAGAGACAATGAGTAAAGAAAGAAGAGATATGATCAAAGCTTATGG
TGCAGAGATAATTTTAACTGAAGGAAGCAAAGGAATGAAGGGAGCTATTGAAGAAGCAGAGAGGTTAGCTAGTACAAAGG
GATATTTCATGCCTCAACAGTTTTTAAATGAAGCTAATGCTAAAAAACATTATGAAACTACTGCGGAAGAAATAATAAGA
GATATTCCAGACTTAGATGTATTTATTGCAGGGGTAGGAACTGGAGGAACTATTACAGGAGTAGGAAGAAAATTAAAGGA
ATATAATCCTAATATAAAAATAGTTGCTGTAGAACCTAGTGATTCAGCTGTATTATCAGGAGAAAATTCTGGTCCTCATA
AAATTCAAGGAATAGGTGCTGGATTCATACCAAAGATATATGACTCATCAGTAGTTGATGAAATAATAAAGGTTAAAAAT
GAAGATGCATACACTATGGCAAAAAACTTTGCTGATAAAGAAGGAGTTTTAGTAGGTATATCTTCTGGAGCTGCACTAAA
AGGGGCAAAGGATATTTTAGAAAATATAGCAAAAGATAAAAAAGTGTTAGTTATAGCACCTGATGGAGGAGAAAAATATT
TTTCAACAGGGCTATATGAGTAA

Upstream 100 bases:

>100_bases
AGTGAGGTCTTTACCTAATTAGAGTGGAACCACGGAGTAAAAAGCTTCGTCTCTAAATAGTGTAAGGCCTTTTTATTATA
TTTTTAAGGAGGAAATTTAT

Downstream 100 bases:

>100_bases
TTTGTAGGAGTGAAAATTTTGTTCAAAAATTTAAAATATGATATAGAAAATGTTATGAAAAATGATCCAGCGGCTAGAAC
AAAACTAGAGGTTTTATTGC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MVFNSLLSLIGNTPILKANNLFEGNNVFVKLEKFNPGGSIKDRAALGMIEEAEKNGLLKENGVIVEPTSGNTGIAIAMIG
KIKGYKVIITMPETMSKERRDMIKAYGAEIILTEGSKGMKGAIEEAERLASTKGYFMPQQFLNEANAKKHYETTAEEIIR
DIPDLDVFIAGVGTGGTITGVGRKLKEYNPNIKIVAVEPSDSAVLSGENSGPHKIQGIGAGFIPKIYDSSVVDEIIKVKN
EDAYTMAKNFADKEGVLVGISSGAALKGAKDILENIAKDKKVLVIAPDGGEKYFSTGLYE

Sequences:

>Translated_300_residues
MVFNSLLSLIGNTPILKANNLFEGNNVFVKLEKFNPGGSIKDRAALGMIEEAEKNGLLKENGVIVEPTSGNTGIAIAMIG
KIKGYKVIITMPETMSKERRDMIKAYGAEIILTEGSKGMKGAIEEAERLASTKGYFMPQQFLNEANAKKHYETTAEEIIR
DIPDLDVFIAGVGTGGTITGVGRKLKEYNPNIKIVAVEPSDSAVLSGENSGPHKIQGIGAGFIPKIYDSSVVDEIIKVKN
EDAYTMAKNFADKEGVLVGISSGAALKGAKDILENIAKDKKVLVIAPDGGEKYFSTGLYE
>Mature_300_residues
MVFNSLLSLIGNTPILKANNLFEGNNVFVKLEKFNPGGSIKDRAALGMIEEAEKNGLLKENGVIVEPTSGNTGIAIAMIG
KIKGYKVIITMPETMSKERRDMIKAYGAEIILTEGSKGMKGAIEEAERLASTKGYFMPQQFLNEANAKKHYETTAEEIIR
DIPDLDVFIAGVGTGGTITGVGRKLKEYNPNIKIVAVEPSDSAVLSGENSGPHKIQGIGAGFIPKIYDSSVVDEIIKVKN
EDAYTMAKNFADKEGVLVGISSGAALKGAKDILENIAKDKKVLVIAPDGGEKYFSTGLYE

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=37.620578778135, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=37.620578778135, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=37.620578778135, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI11345492, Length=194, Percent_Identity=30.9278350515464, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1788754, Length=308, Percent_Identity=49.025974025974, Blast_Score=239, Evalue=1e-64,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=39.6666666666667, Blast_Score=215, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17535051, Length=297, Percent_Identity=47.8114478114478, Blast_Score=263, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI17562970, Length=296, Percent_Identity=47.972972972973, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI32566674, Length=291, Percent_Identity=47.4226804123711, Blast_Score=247, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI115535073, Length=298, Percent_Identity=46.6442953020134, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17561720, Length=296, Percent_Identity=45.2702702702703, Blast_Score=210, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=46.6981132075472, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17534315, Length=318, Percent_Identity=38.3647798742138, Blast_Score=180, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI25147552, Length=316, Percent_Identity=37.6582278481013, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17561716, Length=120, Percent_Identity=45.8333333333333, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=331, Percent_Identity=25.6797583081571, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=37.7777777777778, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321449, Length=321, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24643623, Length=305, Percent_Identity=38.0327868852459, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI20129101, Length=305, Percent_Identity=38.0327868852459, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32177; Mature: 32177

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00165 DEHYDRATASE_SER_THR ; PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFNSLLSLIGNTPILKANNLFEGNNVFVKLEKFNPGGSIKDRAALGMIEEAEKNGLLKE
CHHHHHHHHHCCCCEEECCCEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEC
NGVIVEPTSGNTGIAIAMIGKIKGYKVIITMPETMSKERRDMIKAYGAEIILTEGSKGMK
CCEEEECCCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCH
GAIEEAERLASTKGYFMPQQFLNEANAKKHYETTAEEIIRDIPDLDVFIAGVGTGGTITG
HHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHH
VGRKLKEYNPNIKIVAVEPSDSAVLSGENSGPHKIQGIGAGFIPKIYDSSVVDEIIKVKN
HHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCEEEECCCCCCCHHHCHHHHHHHHHHCC
EDAYTMAKNFADKEGVLVGISSGAALKGAKDILENIAKDKKVLVIAPDGGEKYFSTGLYE
CCHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCC
>Mature Secondary Structure
MVFNSLLSLIGNTPILKANNLFEGNNVFVKLEKFNPGGSIKDRAALGMIEEAEKNGLLKE
CHHHHHHHHHCCCCEEECCCEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEC
NGVIVEPTSGNTGIAIAMIGKIKGYKVIITMPETMSKERRDMIKAYGAEIILTEGSKGMK
CCEEEECCCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCH
GAIEEAERLASTKGYFMPQQFLNEANAKKHYETTAEEIIRDIPDLDVFIAGVGTGGTITG
HHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHH
VGRKLKEYNPNIKIVAVEPSDSAVLSGENSGPHKIQGIGAGFIPKIYDSSVVDEIIKVKN
HHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCEEEECCCCCCCHHHCHHHHHHHHHHCC
EDAYTMAKNFADKEGVLVGISSGAALKGAKDILENIAKDKKVLVIAPDGGEKYFSTGLYE
CCHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA